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LDFALLPPKVNSTLMYSGPGSGSMLAAAAAWQALGAELQCTADSYRSLLSGLVSGPWSGPAAAAMSAAAA PHLAWLSATAAQAEQVGRQAAAAASAYEAAFAGMVPPAVVAANRAMLATLVATNLFGQNTPAIAVVEAEY AKMWAQDANAMYQYAATAAAAADLTSFVPPRPATTANGPAAQAAAVGRATGDLLAGDAQSLQQLVEQLPN ALRGLSEAALVPSLERILRALGLIGWKWTPNGDGIVLSGALGALIAGPTGSSTLDASTLSNTYIRLVSPF RLTTTALKDIDGLSHSLFPAAAHAGQEAAKAVEALPQALPKLSLSGVSSGLGGIGRAAQIGGLSVPNAWA SSMPGLGRVATVPLSSVAAAAAAADPSQHVFGGLPAHGTPARGFAASAAPPRYGFHPRVMTRPPAAG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_4195 | - | - | 100% (418) | PPE family protein |
| M. ulcerans Agy99 | MUL_3072 | - | 3e-72 | 40.45% (403) | PPE family protein |
| M. ulcerans Agy99 | MUL_3074 | - | 1e-70 | 41.55% (426) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1836 | PPE31 | 3e-78 | 43.95% (430) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 1e-33 | 40.82% (196) | PPE protein |
| M. tuberculosis H37Rv | Rv3621c | PPE65 | 1e-108 | 50.71% (420) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 3e-47 | 33.64% (440) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_2230c | - | 6e-33 | 31.52% (422) | PPE family protein |
| M. marinum M | MMAR_5117 | - | 0.0 | 98.80% (418) | PPE family protein, PPE65 |
| M. avium 104 | MAV_0535 | - | 1e-102 | 51.06% (423) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 3e-36 | 31.70% (429) | PPE family protein |
| M. thermoresistible (build 8) | TH_3113 | - | 2e-42 | 32.29% (415) | PUTATIVE PPE protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 8e-38 | 33.25% (424) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_4195|M.ulcerans_Agy99 ------------MLDFALLPPKVNSTLMYSGPGSGSMLAAAAAWQALGAE
MMAR_5117|M.marinum_M ------------MLDFALLPPEVNSTLMYSGPGSGSMLAAAAAWQALGAE
Rv3621c|M.tuberculosis_H37Rv ------------MLDFAQLPPEVNSALMYAGPGSGPMLAAAAAWEALAAE
MAV_0535|M.avium_104 -------MLNFGQLDFAQLPPEINSGLMYSGPGAGPLLAAAAAWNGLAAE
Mb1836|M.bovis_AF2122/97 -------------MDFATLPPEINSARMYSGAGSAPMLAAASAWHGLSAE
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
MAB_2230c|M.abscessus_ATCC_199 ----------MSAPIWMASPPEVHSALLSAGPGPGALLAAAAQWQALSVQ
TH_3113|M.thermoresistible__bu ----------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDE
.*: :* : *.*...: :*. * *. :
MUL_4195|M.ulcerans_Agy99 LQCTADSYRSLLSGLVSGPWSGPAAAAMSAAAAPHLAWLSATAAQAEQVG
MMAR_5117|M.marinum_M LQCTANSYRSLLSGLVSGPWSGPAAAAMSAAAAPHLAWLSATAAQAEQVG
Rv3621c|M.tuberculosis_H37Rv LQTTASTYDALITGLADGPWQGSSAASMVAAATPQVAWLRSTAGQAEQAG
MAV_0535|M.avium_104 LRSAAASFGSVITGVGDAGWQGPAASSMMAAAAPQLAWLSGTAGRAELAA
Mb1836|M.bovis_AF2122/97 LRASALSYSSVLSTLTGEEWHGPASASMTAAAAPYVAWMSVTAVRAEQAG
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLTT-FEGESAAALAERVTPYEKWLTQNAASAELTA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
MAB_2230c|M.abscessus_ATCC_199 YTTAATELTQLLAATGSGSWQGPSAAQYVASHAPYLAWLTQQSAMSATNA
TH_3113|M.thermoresistible__bu YRAAAVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAG
:* : : * .: * *: : . .
MUL_4195|M.ulcerans_Agy99 RQAAAAASAYEAAFAGMVPPAVVAANRAMLATLVATNLFGQNTPAIAVVE
MMAR_5117|M.marinum_M RQAAAAASAYEAAFAGMVPPAVVAANRAMLATLVATNLFGQNTPAIAVVE
Rv3621c|M.tuberculosis_H37Rv SQAVAAASAYEAAFFATVPPPEIAANRALLMALLATNFLGQNTAAIAATE
MAV_0535|M.avium_104 GQALAAVSAYETAFAETVPPPVIAANRALLLQLLATNFLGQNTPAIADVE
Mb1836|M.bovis_AF2122/97 AQAEAAAAAYEAAFAATVPPPVIEANRAQLMALIATNVLGQNAPAIAATE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
MAB_2230c|M.abscessus_ATCC_199 VLHETSAAAYTTALAAMPTLAELAANHMIHGVLLATNFFGINTIPIALNE
TH_3113|M.thermoresistible__bu AQLEAAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNE
.:. *: :*: . : *: *: :*.:* *: .** *
MUL_4195|M.ulcerans_Agy99 AEYAKMWAQDANAMYQYAATAAAAA-DLTSFVPPRPATTANGPAAQAAAV
MMAR_5117|M.marinum_M AEYAEMWAQDANAMYQYAATAAAAA-DLTSFVPPRPATTANGPAAQAAAV
Rv3621c|M.tuberculosis_H37Rv AQYAEMWAQDAAAMYGYAGASAAAT-QLSPFNPAAQTINPAGLASQAASV
MAV_0535|M.avium_104 AQYGEMWAQDAAAMYGYALASAAAS-TLPPFEPAKPATDPAGLARQAAAT
Mb1836|M.bovis_AF2122/97 AQYAEMWSQDAMAMYGYAGASAAAT-QLTPFTEPVQTTNASGLAAQSAAI
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEVVEE
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAAL-AATPTSAPAPSVLLPGVGEAGRAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAAL-AATPTATPAPFVLAPGVGEAGRAA
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAV-AAAPVSAPAPFLLKPGVGEAGSAS
MAB_2230c|M.abscessus_ATCC_199 ADYIRMWIQAATTMGVYQGVSTAAV-TSVAPTPPAPTIMAPG-GEMSRMS
TH_3113|M.thermoresistible__bu ADYARMWIQAATTMATYEAVASAAV-SATPRTVAPPPILGAGTGESATAA
*:* .** * * :* * * . . * .
MUL_4195|M.ulcerans_Agy99 GRATGDLLAGDAQSLQQLVEQLPNALRGLSEAALVPS----------LER
MMAR_5117|M.marinum_M GRATGDLLAGDAQSLQQLVEQLPNALRGLSEAALVPS----------LER
Rv3621c|M.tuberculosis_H37Rv GQAV-SGAAN-AQALT----DIPKALFGLSGIFTNEPPW--------LTD
MAV_0535|M.avium_104 AQAAGTGAGDSAQGLG----AAPQSMSTLAAGTNNPP------------A
Mb1836|M.bovis_AF2122/97 AHATGASAGAQQTTLSQLIAAIPSVLQGLSSSTAATS-------------
MLBr_01182|M.leprae_Br4923 VVEEVVEEVVEAEQAISQAALDQAVNEGMEATVVPQVDQ--------QVN
Mflv_0325|M.gilvum_PYR-GCK ADMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLRDP
Mvan_0415|M.vanbaalenii_PYR-1 ADVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLRDP
MSMEG_0619|M.smegmatis_MC2_155 ASVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGG-QAILDFLKDP
MAB_2230c|M.abscessus_ATCC_199 ADMSGMAAQAQAAESGMALDDSESFFDKLMR----------QIQEFFSDP
TH_3113|M.thermoresistible__bu ITGAHVTAELRAAESRTLLDEINELIDRLFAPLFPPG----FADALPDGL
:
MUL_4195|M.ulcerans_Agy99 ILRALGLIGWKWTPNGDGIVLSG---------------------------
MMAR_5117|M.marinum_M ILRALGLIGWKWTPNGDGIVLSG---------------------------
Rv3621c|M.tuberculosis_H37Rv LGKALGLTGHTWSSDGSGLIVGG---------------------------
MAV_0535|M.avium_104 ANPGFSLGGISLNPEGDGLVIGG---------------------------
Mb1836|M.bovis_AF2122/97 ASGPSGLLG----ILGSGSSWLD---------------------------
MLBr_01182|M.leprae_Br4923 VDVATPQTAVPDSSSAAAPQLWG---------------------------
Mflv_0325|M.gilvum_PYR-GCK IGNTFALITDFLTNPVQALITWGPFLLAVVYQA----VSWVGASILYPSL
Mvan_0415|M.vanbaalenii_PYR-1 LGNTIKLITDFLTNPAQALITWGPFLAAVAYQA----VSWVGASILYPSL
MSMEG_0619|M.smegmatis_MC2_155 LGNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNLVGWPTWGMIFASP
MAB_2230c|M.abscessus_ATCC_199 LGTLQKILQDFMRNPLEALVAWGPLLFFIAYEAFFIPFGFTFWGVMLSAP
TH_3113|M.thermoresistible__bu LGTLLAPLLPGATGDGPPMATIMSFLLMGLSNP----------AYLFPVL
MUL_4195|M.ulcerans_Agy99 -----------------ALGALIAGPTGSSTLDASTLSNTYIRLVSPFRL
MMAR_5117|M.marinum_M -----------------ALGALIAGLTGSSTLDASTLSNTYIRLVSPFRL
Rv3621c|M.tuberculosis_H37Rv -----------------VLGDFVQGVTGSAELDASVAMDTFGKWVSPARL
MAV_0535|M.avium_104 -----------------PLGDLLEGLTGSQTLDASTPFDAFIRLISPTRL
Mb1836|M.bovis_AF2122/97 -----------------KLWALLD--PNSNFWNTIASSGLFLPSN-----
MLBr_01182|M.leprae_Br4923 -----------------GFAQHLSPINDTLSMINNHAGMANAGLS-----
Mflv_0325|M.gilvum_PYR-GCK FLLPLLATT--LAIVAGVGQHLLSLLNTPPAEEAAEEPAPAQSAPSRPDQ
Mvan_0415|M.vanbaalenii_PYR-1 LLLPLVATT--LAIVLGVGAYLLENLPAPAEDAPAEEPAASSPAPTRADQ
MSMEG_0619|M.smegmatis_MC2_155 FLIPALAALGITGLVLLIDHVLNNPVDVPAEDEAPQEVAAAP----RTDQ
MAB_2230c|M.abscessus_ATCC_199 LWLPLLLVG---------LAQLVNPVPV-EADAPADEPAPQQARVERSSP
TH_3113|M.thermoresistible__bu VYLLFTGVVHTTVAVSGMLAQLVPLMPALLPVAVAALGGLAGVWAGLSGL
MUL_4195|M.ulcerans_Agy99 TTTALKDIDGLSHSLFPAAAHAGQEAA-KAVEALPQALP-----------
MMAR_5117|M.marinum_M TTTALKDIDGLSHSLFPAAAHAGQEAA-KAVEALPQALP-----------
Rv3621c|M.tuberculosis_H37Rv MVTQFKDYFGLAH-DLPKWASEGAKAAGEAAKALPAAVP-----------
MAV_0535|M.avium_104 FTTSFKDIQGIAQGMMPAAKSAGEGVAKAAEAVLPAAVPG---------A
Mb1836|M.bovis_AF2122/97 TIAPFLGLLGGVAAADAAGDVLGEATSGGLGGALVAPLG-----------
MLBr_01182|M.leprae_Br4923 ----LVNGMGSAMKSLAPTTTKAAESAFKAMGSAVQSTG----------R
Mflv_0325|M.gilvum_PYR-GCK QSFPATMSAPPPPSGAPIAANTVSAGSPPAPGAPAAAAAT--FVPYVVAG
Mvan_0415|M.vanbaalenii_PYR-1 PSPAIAVSAPPPPSSAAATVGTVATGTAPAPGAPAAATAS--FVPYAVAG
MSMEG_0619|M.smegmatis_MC2_155 P-LAVGISPAGVPGSAATAAAPAPAPAGTTVAAPAPAAAT--FVPYAVAN
MAB_2230c|M.abscessus_ATCC_199 QQQPFAMGGMPGGGGAPATPANAPATPANAPASPAAAAATPAYMVYAVQE
TH_3113|M.thermoresistible__bu AGLAGLTAVPAADGGASAAPVPAGGPSLPSGSSAPPAPTG---SAAPTTG
. . .
MUL_4195|M.ulcerans_Agy99 KLSLSGVSSGLGG-IGRAAQIGGLSVPNAWASSMPGLGRVATVPLSSVAA
MMAR_5117|M.marinum_M KLPLSGVSSGLGG-IGRAAQIGGLSVPNAWASSMPGLGRVATVPLSSVAA
Rv3621c|M.tuberculosis_H37Rv AIPSAG-LSGVAGAVGQAASVGGLKVPAVWTATTPAASPAVLAASNGLGA
MAV_0535|M.avium_104 GLGSLGSLGSIGGSVGKAASIGGLSVPASWASAAPTP-PSVAVALNGATT
Mb1836|M.bovis_AF2122/97 --SAGGLGGTVAAGLGNAATVGTLSVPPSWTAAAPLASPLGSALGGTPMV
MLBr_01182|M.leprae_Br4923 GLLGSSSGGHVTAQLGRAASIGSLRVPQTWTTASQPVTAATRALSPARVA
Mflv_0325|M.gilvum_PYR-GCK RDPYEGFSPTVRDSTGAKAPAGTIPAAASGIAASAAERRKRRRRQKEEIK
Mvan_0415|M.vanbaalenii_PYR-1 RDPGTGFSPTVRDSTSAKAPASGIPAAASGVAASAAERRKRRRRQKDEIA
MSMEG_0619|M.smegmatis_MC2_155 RDPGEGFTPTLGNKSQVAAPASGVPAAASGVAASLASRRKRRRKKGAQIE
MAB_2230c|M.abscessus_ATCC_199 DPPAARFGPTLNEGSGAKAPAAGISAAAA-AAASARSRARRKRGARIKDP
TH_3113|M.thermoresistible__bu TAPGGAGSPPPAGHSVPPAPHSAPPVGTSGPPYLIAAQPAPG-VARRSAG
* . . .
MUL_4195|M.ulcerans_Agy99 AAAAADPSQHVFGGLP--AHGTPARG-FAASAAPPRYGFHPRVMTRPP--
MMAR_5117|M.marinum_M AAAAADPSQHVFGGLP--AHGTPARG-FAASAAPPRYGFHPRVMTRPP--
Rv3621c|M.tuberculosis_H37Rv AAAAEG-STHAFGGMPLMGSG-AGR--AFNNFAAPRYGFKPTVIAQPP--
MAV_0535|M.avium_104 AGAAEH-AASAVGGVPMMPAGAAGRG-AGAHFVVPRYGFKPTVIAQPP--
Mb1836|M.bovis_AF2122/97 AP-----PPAVAAGMPGMPFGTMGG--QGFGRAVPQYGFRPNFVARPP--
MLBr_01182|M.leprae_Br4923 VATESESAPLLGGGLPMAPMVPGGGSGTGGVNTALRLQPRAFVMPRNP--
Mflv_0325|M.gilvum_PYR-GCK GRGYADAYADYEELPDDGPPEQPAPRVTASTRGAGPMGFAGTVSRGD--E
Mvan_0415|M.vanbaalenii_PYR-1 GRAYADAYADYEPEPDDEPPVRQEPRIAATERGAGPMGFAGTVSRDA--A
MSMEG_0619|M.smegmatis_MC2_155 ERGYADAYMDYEE-PDEDPAPQPEPRVRASERGSDAMGFTGTVTRHD--V
MAB_2230c|M.abscessus_ATCC_199 APQFMDMNSPVDP-DFSEPATRHTAGVGASGRGAGQLGFAGTLPRTTSTT
TH_3113|M.thermoresistible__bu ARRAASIVEPAGSAAAAAAARESAPIRRRRGQKDGLHGHRHEHQQPAS-M
MUL_4195|M.ulcerans_Agy99 -AAG----------------------------------------------
MMAR_5117|M.marinum_M -AAG----------------------------------------------
Rv3621c|M.tuberculosis_H37Rv -AGG----------------------------------------------
MAV_0535|M.avium_104 -AGG----------------------------------------------
Mb1836|M.bovis_AF2122/97 -AAG----------------------------------------------
MLBr_01182|M.leprae_Br4923 -AAG----------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK QAGGLTT-LAGDSFGGGPREPMLPGTWDPDATDDRHTDGRDGHDGHDGKE
Mvan_0415|M.vanbaalenii_PYR-1 QAGGLTT-LPGDPFGGGPKAPMLPGTWDPDTEPD------ERHNHHDGKD
MSMEG_0619|M.smegmatis_MC2_155 TAAGLTT-LTGDTFDDRPVTPMLPGTWDGDENPAP------SPDDPEGGP
MAB_2230c|M.abscessus_ATCC_199 SAAGLIEREAASEMDGTRTVPMLPTSWGTDPEPDPDRAPSVPAPDEDWPP
TH_3113|M.thermoresistible__bu SAATAPSAAGIRVLGGAGRISRTRGSVPHAEITPGDPTEPSSPTDRAHRP
*.
MUL_4195|M.ulcerans_Agy99 -------
MMAR_5117|M.marinum_M -------
Rv3621c|M.tuberculosis_H37Rv -------
MAV_0535|M.avium_104 -------
Mb1836|M.bovis_AF2122/97 -------
MLBr_01182|M.leprae_Br4923 -------
Mflv_0325|M.gilvum_PYR-GCK KP-----
Mvan_0415|M.vanbaalenii_PYR-1 SQ-----
MSMEG_0619|M.smegmatis_MC2_155 RR-----
MAB_2230c|M.abscessus_ATCC_199 GERGAST
TH_3113|M.thermoresistible__bu AEPN---