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VAGSVPRGIRKRTNSAGQARYQVRYLVRDPNSPSGWVETSSTFATMREARAFKADRDGEAAIGARRFDPR LGRASLSAIWTQYSASKQPAVSPKTWSGYAQHWELRISPRFGHVPVDEISRKDVQQFIGGLTVGPWAKLA TLRLLRSILDMAREDGRIHINPAQGVSSGRIPARERHRYLSATEVAALAHACGDQGDIVTILAFTGLRWS ELVGLRVGDIDLKARRLYVRQAAPDVEGRIIVGPPKTRAAVRTVPLPRIVIDALKPRIENRSTKEQAITS PNGGFLRSNNWRRHTHWNKALKKTGLAPLTIHDLRHTYASLARKSGADLRYVQKTMGHSTPTVTANIYSD LYSDELDHVATNLDRLNDVAKDQANGQEPDTPKHP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4848 | - | - | 100% (385) | prophage integrase |
| M. marinum M | MMAR_3607 | - | 1e-17 | 30.96% (281) | phage integrase |
| M. marinum M | MMAR_4442 | - | 2e-15 | 26.45% (431) | prophage integrase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2335c | - | 4e-13 | 35.04% (137) | hypothetical protein Mb2335c |
| M. gilvum PYR-GCK | Mflv_3899 | - | 1e-22 | 29.26% (311) | phage integrase family protein |
| M. tuberculosis H37Rv | Rv2659c | - | 4e-20 | 28.57% (343) | phiRv2 prophage integrase |
| M. leprae Br4923 | MLBr_01365 | xerD | 4e-10 | 25.00% (280) | site-specific tyrosine recombinase XerD |
| M. abscessus ATCC 19977 | MAB_1816c | - | 4e-12 | 29.82% (218) | Phage integrase |
| M. avium 104 | MAV_2217 | - | 5e-23 | 27.32% (366) | traSA:integrase fusion protein |
| M. smegmatis MC2 155 | MSMEG_5754 | - | 3e-15 | 25.85% (325) | gp41 protein |
| M. thermoresistible (build 8) | TH_1542 | xerD | 2e-10 | 26.70% (221) | tyrosine recombinase XerD |
| M. ulcerans Agy99 | MUL_0529 | - | 1e-175 | 75.65% (386) | prophage integrase |
| M. vanbaalenii PYR-1 | Mvan_4364 | - | 7e-17 | 27.76% (281) | phage integrase family protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4848|M.marinum_M ---MAGSVPRG--IRKRTN--SAGQARYQVR--YLVRDPNSPSGWVETSS
MUL_0529|M.ulcerans_Agy99 ---MAGNTPRG--IRKRLN--AAGEPRYQVR--YLIRDPDAPSGWVETSA
Mflv_3899|M.gilvum_PYR-GCK MARGTGRKDRAPGTFGSVD--KLATG-YRAR--YFGPDGRR----HKAPV
Rv2659c|M.tuberculosis_H37Rv MTQ-TGKRQRR--KFGRIR--QFNSGRWQAS--YTGPDGRV----YIAPK
Mvan_4364|M.vanbaalenii_PYR-1 ---MAGKKGHR--GWGWIR--QLPSKRYQAS--YIGPDLIR----HKAST
Mb2335c|M.bovis_AF2122/97 --------------------------------------------------
MAV_2217|M.avium_104 ---MDLWTKTVRDPDDTIR--TVPSARHGRG--MRWRATYVDDQSREHSR
MLBr_01365|M.leprae_Br4923 ----------------------------------MTT-------------
TH_1542|M.thermoresistible__bu ----------------------------------VTTSEQVPRSDEPPHP
MSMEG_5754|M.smegmatis_MC2_155 ---MLQRMARIPDYVKVID--LDSGRRYEVRPEVTGADGKRRQKRERFKT
MAB_1816c|M.abscessus_ATCC_199 ---MAGRPPLRIGQHGKISRQYVGGGVWVARCRYRDSDGVTR---IVERR
MMAR_4848|M.marinum_M TFATMREARAFKADRDGEAAIGARRFDPRLG----RASLSAIWTQYSASK
MUL_0529|M.ulcerans_Agy99 TFPTLREAKAFKSERDNEAALGARRFDPRLG----RTPLSRIWTQFSDSK
Mflv_3899|M.gilvum_PYR-GCK LFLTKTDARAWLAQR--HSEIVAQQWTPPN----AVEVPKTTFTEYADQW
Rv2659c|M.tuberculosis_H37Rv TFNAKIDAEAWLTDR--RREIDRQLWSPASG---QEDRPGAPFGEYAEGW
Mvan_4364|M.vanbaalenii_PYR-1 TFGARIDAEGWLSQE--RRSIELDTWTPPAQRAAEVKAKAVTLGEYSTKW
Mb2335c|M.bovis_AF2122/97 --------------------------------------------------
MAV_2217|M.avium_104 SFGRKVDAQRWLDEVT-AAVVTGQYVDPKAG--------QITFRDYAERW
MLBr_01365|M.leprae_Br4923 -AALQTQLQGYLDYLIIERSIAANTLSSYRR----------DLIRYSKHL
TH_1542|M.thermoresistible__bu HRVLDDQIQGYLDHLSIERGVAANTLSSYRR----------DLRRYAEHL
MSMEG_5754|M.smegmatis_MC2_155 LKEAVDHYTAIAGDRGRGVHVAPSELTVEDAVDSWLLGQRIRPKTMSAYI
MAB_1816c|M.abscessus_ATCC_199 GPVDDFDKHGKLAEDALIEALSDRRLPADTDTIGYDTLVMALVDQHIGRL
MMAR_4848|M.marinum_M Q-------PAVSPKTWSGYAQHWELRISPRFGHVPVDEISRKDVQQFIGG
MUL_0529|M.ulcerans_Agy99 K-------PAVSPKTWSGYNQHWELRIKPRFGHVPVDEITRADVRAFVDG
Mflv_3899|M.gilvum_PYR-GCK LLTRQVAGRPLKDRTREHYQALLDDHITATFGALPLASITADDVRQWYAR
Rv2659c|M.tuberculosis_H37Rv LKQ-----RGIKDRTRAHYRKLLDNHILATFADTDLRDITPAAVRRWYAT
Mvan_4364|M.vanbaalenii_PYR-1 IED-----RNVKPRTRSSYRDILRLHIEPRLGSMAMKNLTGEVVRSWYAG
Mb2335c|M.bovis_AF2122/97 --------------------------------------------------
MAV_2217|M.avium_104 RKM-----QVQRPSSRAHIETMLRRHAYPTLGDRQLTSILPSDVQAWVKG
MLBr_01365|M.leprae_Br4923 SDR------GIEDLAKVGEHDVSEFLVALRRGDPDSGVAALSAVSAARAL
TH_1542|M.thermoresistible__bu LAR------GIDDLAKVHESDVADFLVALRRGDPDTGAAGLSAVSAARAL
MSMEG_5754|M.smegmatis_MC2_155 TSLRPIVDHLGKRTVQSITKDDLEQVVQALRAGTSKMGTWNAPTKLTKAA
MAB_1816c|M.abscessus_ATCC_199 SDD------GRSPATVATYKFASDKLRNFLGGVRVSEAHAARMDAALRSM
MMAR_4848|M.marinum_M LTVG-PWAKLATLRLLR---SILDMAREDGRIHINPAQGVSSG-RIPARE
MUL_0529|M.ulcerans_Agy99 LTVG-PWAKVSTLRLLR---SILDVAHQDGRIHRNPALGVSAG-RIPERE
Mflv_3899|M.gilvum_PYR-GCK TLTDKPTMRSHAYGLLR---TILATAVSDGKISVNPCSIRGAG-TAKRVH
Rv2659c|M.tuberculosis_H37Rv TAVGTPTMRAHSYSLLR---AIMQTALADDLIDSNPCRISGAS-TARRVH
Mvan_4364|M.vanbaalenii_PYR-1 LGTDYPRRNSHAYGLLH---AVCATAVSDGLLQSNPCNIRRAM-NPPRRR
Mb2335c|M.bovis_AF2122/97 ----------------------------------MTGAGIVET-TTNRV-
MAV_2217|M.avium_104 LQLAPATVG-VVHGLVS---TVMKSAIRDRRLAANPCDGTKLP-KVQRP-
MLBr_01365|M.leprae_Br4923 IAVRGLHRFAVAEGLVD---LDVARAVRPPTPGRRLPKSLTVD-EVLALL
TH_1542|M.thermoresistible__bu IAVRGLHRFAAAEGVTE---LDVARSVKPPTPSRRLPKSLTVD-EVLALL
MSMEG_5754|M.smegmatis_MC2_155 KKVRSPWAASSINPMLARTRSIFEDLVNQGVVVRNVAALVKPL-ATDTEK
MAB_1816c|M.abscessus_ATCC_199 RTAHGTTMARQAKTILQG---GLQLAVMANVIPANPVRDVQSLRSKTRPK
MMAR_4848|M.marinum_M RHRYLSATEVAALAHAC--------GDQGDIVTILAFTGLRWSELVGLRV
MUL_0529|M.ulcerans_Agy99 RHRYLTAQEVRMLATAC--------GDQGDVVTILAYTGLRWSEPVGLRV
Mflv_3899|M.gilvum_PYR-GCK KVRPATVGEIGTIADAM-------PAQWSLMVLLAAWLAMRFGELTELRR
Rv2659c|M.tuberculosis_H37Rv KIRPATLDELETITKAM-------PDPYQAFVLMAAWLAMRYGELTELRR
Mvan_4364|M.vanbaalenii_PYR-1 DPVILAVADIAALAEAIQ------PRRLRCLVLLAAWCGVRWGEVSELRR
Mb2335c|M.bovis_AF2122/97 RHVPVPEPVSERLRDEL-------PTEPNALVFPSYRGGHLPIEEY----
MAV_2217|M.avium_104 QIVPLTTEQVEAVRAEL-------PAELQALVTLAAGTGLRQGECFGLTV
MLBr_01365|M.leprae_Br4923 ESVGGESRADGPLVLRN-----------RALLELLYSTGSRISEAVGLDV
TH_1542|M.thermoresistible__bu AGAGGDSESDGPLTLRN-----------RALLELLYSTGARISEAVGLDI
MSMEG_5754|M.smegmatis_MC2_155 TMNTLNAEQVTQLLAVT-------DSHCYGIAWRLAVLGLRRGEILALRW
MAB_1816c|M.abscessus_ATCC_199 GATALSADQLRTLLAEIRASEYCAGNDLADPLIILMATGLRRSELLALRW
: . *
MMAR_4848|M.marinum_M GDIDLKARRLYVRQAAPDVEG--RIIVGPPKTRAAVRTVPLPRIVIDALK
MUL_0529|M.ulcerans_Agy99 KDIDLTARRLYVRRAAPEVEG--HIVIGPPKTRAGIRTVPLPQVVVDIFK
Mflv_3899|M.gilvum_PYR-GCK KDIDLADEVVRVRRAVVRTDD--GFKVTTPKSDAGIRDIAIPPHLIPPIE
Rv2659c|M.tuberculosis_H37Rv KDIDLHGEVARVRRAVVRVGE--GFKVTTPKSDAGVRDISIPPHLIPAIE
Mvan_4364|M.vanbaalenii_PYR-1 KDLSDGCEVLSVSRAVTRRDG--VYRVDTPKSGKG-RAVVIPPHIREDVI
Mb2335c|M.bovis_AF2122/97 --------------------------------------------------
MAV_2217|M.avium_104 DRVRFLERVLTVDRQLVTVAGQ-APTFGPPKTRASNRAIPLPKVVADALA
MLBr_01365|M.leprae_Br4923 DDVDTQARTVLLQGKGGKQRL-------VPVGRPAVQALDAYLVRGRSDL
TH_1542|M.thermoresistible__bu DDVDTVARSVLLRGKGGKQRL-------VPIGRPAVSALDAYLVRGRPEL
MSMEG_5754|M.smegmatis_MC2_155 DAVDFDAGTLAISAARLATAG--GATTGAPKTKTSVRTLPMPEDLTAALR
MAB_1816c|M.abscessus_ATCC_199 SDFDANAGTLTVTGKLVRATGAGLQRIDEAKTAAGMRTVALPSFAVTALR
MMAR_4848|M.marinum_M PRIENRS---TKEQAITSPN------GGFLRSNNWRRHTHWNKALKKTGL
MUL_0529|M.ulcerans_Agy99 GRITGQA---PDQPAVTSTN------GAMLRSNNWRRHTHWNKALKSTDL
Mflv_3899|M.gilvum_PYR-GCK AHLSQHVGAKADALLFPAVG------GGHLAPATLYR-RFYT-ARERANR
Rv2659c|M.tuberculosis_H37Rv DHLHKHVNPGRESLLFPSVND----PNRHLAPSALYR-MFYK-ARKAAGR
Mvan_4364|M.vanbaalenii_PYR-1 NHLAENVESGPESLLFPAAR------GGHMNDRVFSR-EYFSDALKAIGR
Mb2335c|M.bovis_AF2122/97 --------------------------------RRAFDKGCKAVGIADLVP
MAV_2217|M.avium_104 AHLAAFPAEPDGLVFTQQGK---------PITRSTFGYRWRAAVKEAKLP
MLBr_01365|M.leprae_Br4923 ARRGPGMLATPAIFLNARGG---------RLSRQSAWQVLQDAAEHAGIT
TH_1542|M.thermoresistible__bu VRRGRG---TPAIFLNARGG---------RLSRQSAWQVLQDAAERAGIK
MSMEG_5754|M.smegmatis_MC2_155 RVRKRQKEYRLKLGSKWTDSGYVVVDEFGVAPYPDTLTAAWRKTLANAGL
MAB_1816c|M.abscessus_ATCC_199 HRQGRDYVGQQLMIFPSTAG---------TWRDPNNFGKQWRAVRDDLGV
MMAR_4848|M.marinum_M APLTIHDLRHTYASLARKSGADLRYVQKTMGHSTPTVTANIYSDLYSDEL
MUL_0529|M.ulcerans_Agy99 APLTIHDLRHTYASLARKSGADLRYVQKTMGHSTPTVTANIYSDLYADEL
Mflv_3899|M.gilvum_PYR-GCK KDLRWHDLRHSGAVLAAATGATLAELMARLGHSTPQAAL-RYQHAAQGRD
Rv2659c|M.tuberculosis_H37Rv PDLRVHDLRHSGAVLAASTGATLAELMQRLGHSTAGAAL-RYQHAAKGRD
Mvan_4364|M.vanbaalenii_PYR-1 QGVRVHDLRHFAGTQTAQV-ANLAESMARLGHSTVKASL-IYQGLVTGRD
Mb2335c|M.bovis_AF2122/97 HG-----LRHTTASLAISAGANVKVVQRLLGHATAAMTLDRHGHLLSDDL
MAV_2217|M.avium_104 HGTGFHALRHYYASLLIRHGESVKTVQARLGHASAVETLDTYSHLWPDSD
MLBr_01365|M.leprae_Br4923 SGVSPHMLRHSFATHLLEGGADIRVVQELMGHASVTTTQ-IYTLVTVQAL
TH_1542|M.thermoresistible__bu AGVSPHTLRHSFATHLLDGGADVRVVQELLGHASVTTTQ-IYTMVTVHAL
MSMEG_5754|M.smegmatis_MC2_155 PHVRLHDARHSCATLMHLSGVPTVVIAAWLGHQDPGFTLRTYAHSNHDAL
MAB_1816c|M.abscessus_ATCC_199 PGVTTHSFRKTMATLIDDNGLSARVGADQLGHAKVSMTQDRYMARG-KVH
*: . :** : :
MMAR_4848|M.marinum_M DHVATNLDRLNDVAKDQAN-GQEPDTPKHP-----
MUL_0529|M.ulcerans_Agy99 DQVATNLDQLHATEIQTPTTGQEPDEPNQPSSA--
Mflv_3899|M.gilvum_PYR-GCK RQIAALLSKIAENGGA-------------------
Rv2659c|M.tuberculosis_H37Rv REIAALLSKLAENQEM-------------------
Mvan_4364|M.vanbaalenii_PYR-1 AAIADALSQLAVGES--------------------
Mb2335c|M.bovis_AF2122/97 AGVAGLLVQAIKSAAASLRYSDPDSVAVENISAAS
MAV_2217|M.avium_104 DRTRDAIDSVLGSTAYRLRTGQPATS---------
MLBr_01365|M.leprae_Br4923 REVWAGAHPRAK-----------------------
TH_1542|M.thermoresistible__bu REVWAGAHPRAR-----------------------
MSMEG_5754|M.smegmatis_MC2_155 ADAAAMLGSITTGKKKEAK----------------
MAB_1816c|M.abscessus_ATCC_199 HEVADLLDATISDE---------------------