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TQTGKRQRRKFGRIRQFNSGRWQASYTGPDGRVYIAPKTFNAKIDAEAWLTDRRREIDRQLWSPASGQED RPGAPFGEYAEGWLKQRGIKDRTRAHYRKLLDNHILATFADTDLRDITPAAVRRWYATTAVGTPTMRAHS YSLLRAIMQTALADDLIDSNPCRISGASTARRVHKIRPATLDELETITKAMPDPYQAFVLMAAWLAMRYG ELTELRRKDIDLHGEVARVRRAVVRVGEGFKVTTPKSDAGVRDISIPPHLIPAIEDHLHKHVNPGRESLL FPSVNDPNRHLAPSALYRMFYKARKAAGRPDLRVHDLRHSGAVLAASTGATLAELMQRLGHSTAGAALRY QHAAKGRDREIAALLSKLAENQEM*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2659c | - | - | 100% (375) | PROBABLE phiRv2 PROPHAGE INTEGRASE |
| M. tuberculosis H37Rv | Rv2309c | - | 2e-08 | 34.62% (130) | hypothetical protein Rv2309c |
| M. tuberculosis H37Rv | Rv2894c | xerC | 6e-06 | 26.45% (310) | site-specific tyrosine recombinase XerC |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2335c | - | 2e-08 | 34.62% (130) | hypothetical protein Mb2335c |
| M. gilvum PYR-GCK | Mflv_3899 | - | 1e-120 | 60.64% (376) | phage integrase family protein |
| M. leprae Br4923 | MLBr_01600 | xerC | 3e-05 | 40.00% (55) | site-specific tyrosine recombinase XerC |
| M. abscessus ATCC 19977 | MAB_1723 | - | 2e-09 | 23.91% (389) | putative phage integrase |
| M. marinum M | MMAR_4848 | - | 6e-20 | 28.57% (343) | prophage integrase |
| M. avium 104 | MAV_1484 | - | 2e-63 | 40.32% (372) | integrase |
| M. smegmatis MC2 155 | MSMEG_5754 | - | 6e-08 | 26.26% (179) | gp41 protein |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_0529 | - | 1e-18 | 28.24% (262) | prophage integrase |
| M. vanbaalenii PYR-1 | Mvan_2508 | - | 1e-120 | 58.47% (378) | phage integrase family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3899|M.gilvum_PYR-GCK -------------MARGTGRKDRAPGTFGSVDKLATG-YRARYFGPDGRR
Mvan_2508|M.vanbaalenii_PYR-1 -------------MARGEGRKTRQAGTFGTVQQLPSGRYRAMYYGPDRRR
Rv2659c|M.tuberculosis_H37Rv --------------MTQTGKRQRRK--FGRIRQFNSGRWQASYTGPDGRV
MAV_1484|M.avium_104 ------------------------------MRQLPSGRWQASYLH-NGVV
MMAR_4848|M.marinum_M --------------MAGSVPRGIRKRTNSAGQARYQVRYLVRDPNSPSGW
MUL_0529|M.ulcerans_Agy99 --------------MAGNTPRGIRKRLNAAGEPRYQVRYLIRDPDAPSGW
Mb2335c|M.bovis_AF2122/97 --------------------------------------------------
MLBr_01600|M.leprae_Br4923 --------------------------------------------------
MSMEG_5754|M.smegmatis_MC2_155 --------------MLQRMARIPDYVKVIDLDSGRRYEVRPEVTGADGKR
MAB_1723|M.abscessus_ATCC_1997 MEQTERVKKRPACKCKHVYFAHPNEGPCNQCGDCPKYRERERRERGEGGL
Mflv_3899|M.gilvum_PYR-GCK HKAPV-------LFLTKTDARAWLAQRHSEIVAQ------QWTPP---NA
Mvan_2508|M.vanbaalenii_PYR-1 YKAPT-------TFRAKADARGWLALRQAEIISK------AWTPP---EA
Rv2659c|M.tuberculosis_H37Rv YIAPK-------TFNAKIDAEAWLTDRRREIDRQ------LWSPA---SG
MAV_1484|M.avium_104 FKALA-------TFPTKSSAGHWLQAEEDLIDLDRRRP-GEWTPPAERAA
MMAR_4848|M.marinum_M VETSS-------TFATMREARAFKADRDGEAAIG---------------A
MUL_0529|M.ulcerans_Agy99 VETSA-------TFPTLREAKAFKSERDNEAALG---------------A
Mb2335c|M.bovis_AF2122/97 --------------------------------------------------
MLBr_01600|M.leprae_Br4923 MAILD-------EFDEHLALRCGRSEHTRRAYLG----------------
MSMEG_5754|M.smegmatis_MC2_155 RQKRE-------RFKTLKEAVDHYTAIAGDRGRGVHVAPSELTVEDAVDS
MAB_1723|M.abscessus_ATCC_1997 FQRADGMWVGSVEVPSEDGLRRRQTVSAKDKGVALDKLR-DLRSAIRSGK
Mflv_3899|M.gilvum_PYR-GCK V-EVPKTTFTEYADQWLLTRQVAGRPLKDRTREHYQALLDDHITATFG-A
Mvan_2508|M.vanbaalenii_PYR-1 APKITRTTFADYARNWIKQ-----RDLKQHTREHYEVLLERHLISPFG-S
Rv2659c|M.tuberculosis_H37Rv QEDRPGAPFGEYAEGWLKQ-----RGIKDRTRAHYRKLLDNHILATFA-D
MAV_1484|M.avium_104 RRQAEKLTLRTYAKTWLDN----KTKLARRTRDNYQGHLDNHVLPALG-D
MMAR_4848|M.marinum_M RRFDPRLGRASLSAIWTQYSASKQPAVSPKTWSGYAQHWELRISPRFG-H
MUL_0529|M.ulcerans_Agy99 RRFDPRLGRTPLSRIWTQFSDSKKPAVSPKTWSGYNQHWELRIKPRFG-H
Mb2335c|M.bovis_AF2122/97 --------------------------------------------------
MLBr_01600|M.leprae_Br4923 -------DLRSLLTHLEGRGSRLDQLSLPVLRSWLATAAGAGAARTTL-A
MSMEG_5754|M.smegmatis_MC2_155 WLLGQRIRPKTMSAYITSLRPIVDHLGKRTVQSITKDDLEQVVQALRA-G
MAB_1723|M.abscessus_ATCC_1997 SPTSSKVHLEQWLNHWLETIQ--KPRVRPTTYKYYETTVRLYILPFIDGR
Mflv_3899|M.gilvum_PYR-GCK LPLASITADDVRQWYARTLTDKPTMRSHAYGLLR---TILATAVSDGKIS
Mvan_2508|M.vanbaalenii_PYR-1 LPLSSITVDDVRGWYATFATETPTLRSHTYGLLR---TILGTAASDGKIS
Rv2659c|M.tuberculosis_H37Rv TDLRDITPAAVRRWYATTAVGTPTMRAHSYSLLR---AIMQTALADDLID
MAV_1484|M.avium_104 LGLADITPEHVRTWFAGLGNEHETRNAQAYAVLN---GVFNTAVADDLID
MMAR_4848|M.marinum_M VPVDEISRKDVQQFIGGLTVG-PWAKLATLRLLR---SILDMAREDGRIH
MUL_0529|M.ulcerans_Agy99 VPVDEITRADVRAFVDGLTVG-PWAKVSTLRLLR---SILDVAHQDGRIH
Mb2335c|M.bovis_AF2122/97 --------------------------------------------------
MLBr_01600|M.leprae_Br4923 RRISAVKAFTAWAKWRGQLAADPAARLQVPRAYR---TLPAVLRQDQALQ
MSMEG_5754|M.smegmatis_MC2_155 TSKMGTWNAPTKLTKAAKKVRSPWAASSINPMLARTRSIFEDLVNQGVVV
MAB_1723|M.abscessus_ATCC_1997 TQLGKLTPAQVRKMIAKNGTRNAQKAHQTLVKALG------DAMDEGMLD
Mflv_3899|M.gilvum_PYR-GCK VNPCSIRGAGTAKRVHK--VRPATVGEIGTIADAMPAQWSLMVLLAAWLA
Mvan_2508|M.vanbaalenii_PYR-1 SNPCLIRGAGTTKRVKK--IRPATLPEIEKITTEMPEQYQAMILLAAWCA
Rv2659c|M.tuberculosis_H37Rv SNPCRISGASTARRVHK--IRPATLDELETITKAMPDPYQAFVLMAAWLA
MAV_1484|M.avium_104 RNPCRIRGAAQVKHARRS-VVLLDATQLTALAEKMPDDARLGVLLAGWCG
MMAR_4848|M.marinum_M INPAQGVSSGRIPARER--HRYLSATEVAALAHACGDQGDIVTILA-FTG
MUL_0529|M.ulcerans_Agy99 RNPALGVSAGRIPERER--HRYLTAQEVRMLATACGDQGDVVTILA-YTG
Mb2335c|M.bovis_AF2122/97 --------------------------------------------------
MLBr_01600|M.leprae_Br4923 IMAAAKSGAEQG--------------------DPLALRDRLIVEMLYATG
MSMEG_5754|M.smegmatis_MC2_155 RNVAALVKPLATDTEKT--MNTLNAEQVTQLLAVTDSHCYGIAWRLAVLG
MAB_1723|M.abscessus_ATCC_1997 KNVAAVVDKPKHVAIERQPFTFDEARQIIATAIKRNDPWATMWAAMFFTG
Mflv_3899|M.gilvum_PYR-GCK MRFGELTELRRKDIDLAD-----------EVVRVRRAVVRTDDGFKV--T
Mvan_2508|M.vanbaalenii_PYR-1 LRFGELTELRRKDIVLTTTVDLEGETVHMGVIRVERAVVRVDDGYLV--T
Rv2659c|M.tuberculosis_H37Rv MRYGELTELRRKDIDLHG-----------EVARVRRAVVRVGEGFKV--T
MAV_1484|M.avium_104 LRKGEVFALRRGDVAADG-----------SSVRIERSVTYREGRFEV--G
MMAR_4848|M.marinum_M LRWSELVGLRVGDIDLKA-----------RRLYVRQAAPDVEGRIIV--G
MUL_0529|M.ulcerans_Agy99 LRWSEPVGLRVKDIDLTA-----------RRLYVRRAAPEVEGHIVI--G
Mb2335c|M.bovis_AF2122/97 ----------------------------------------MTGAGIV--E
MLBr_01600|M.leprae_Br4923 IRVSELCGLDIDDVDTRH----------------------RLVRVLG--K
MSMEG_5754|M.smegmatis_MC2_155 LRRGEILALRWDAVDFDAG-----------TLAISAARLATAGGATT--G
MAB_1723|M.abscessus_ATCC_1997 ARQGEIIGMEWDRCDLEKGLFDFSWQLQQLPPELPRGFKHRPCHLSLAWT
Mflv_3899|M.gilvum_PYR-GCK TPKSDAGIRDIAIPPHLIPPIEAHLSQHVGAKADALLFPAVGG--GHLAP
Mvan_2508|M.vanbaalenii_PYR-1 TPKSDAGTRDVAIPPHLVPVIHDHLAVHVDGGPDALLFPAAHG--RHLAP
Rv2659c|M.tuberculosis_H37Rv TPKSDAGVRDISIPPHLIPAIEDHLHKHVNPGRESLLFPSVNDPNRHLAP
MAV_1484|M.avium_104 PTKTRESRRVVSVPPHVRPAVLEHLQRHVADGDDALVFVEPST--GSFAG
MMAR_4848|M.marinum_M PPKTRAAVRTVPLPRIVIDALKPRIENRS---TKEQAITSPNG--GFLRS
MUL_0529|M.ulcerans_Agy99 PPKTRAGIRTVPLPQVVVDIFKGRITGQA---PDQPAVTSTNG--AMLRS
Mb2335c|M.bovis_AF2122/97 TTTNR--VRHVPVPEPVSERLRDELPTEP----NALVFPSYRG--GHLPI
MLBr_01600|M.leprae_Br4923 GNKQRTAPFGVPAADALRGWLDDGRPALVTVESGPALLLGSRG--RRLDV
MSMEG_5754|M.smegmatis_MC2_155 APKTKTSVRTLPMPEDLTAALRRVRKRQK---EYRLKLGSKWTDSGYVVV
MAB_1723|M.abscessus_ATCC_1997 KPKTKAGARVAPMTKPLQAIMEAYAKTDTGPNPHGLVWRHPDG--HPISP
. . . : . .
Mflv_3899|M.gilvum_PYR-GCK ATLYR--------RFYT-ARERANRKDLRWHDLRHSGAVLAAATGATLAE
Mvan_2508|M.vanbaalenii_PYR-1 ATLYR--------QFYK-ARVAADRPDLRFHDLRHSGAVLAAATGATLAE
Rv2659c|M.tuberculosis_H37Rv SALYR--------MFYK-ARKAAGRPDLRVHDLRHSGAVLAASTGATLAE
MAV_1484|M.avium_104 EKRFR--------TAWESARAAIGQPDMHFHDLRHAAGVMAAQTGATVRE
MMAR_4848|M.marinum_M NNWRRH-------THWNKALKKTGLAPLTIHDLRHTYASLARKSGADLRY
MUL_0529|M.ulcerans_Agy99 NNWRRH-------THWNKALKSTDLAPLTIHDLRHTYASLARKSGADLRY
Mb2335c|M.bovis_AF2122/97 EEYRR---------AFDKGCKAVGIADLVPHGLRHTTASLAISAGANVKV
MLBr_01600|M.leprae_Br4923 RQART--------VVHQTVAVVAGAPDMGPHGLRHSAATHLLEGGADLRV
MSMEG_5754|M.smegmatis_MC2_155 DEFGVAPYPDTLTAAWRKTLANAGLPHVRLHDARHSCATLMHLSGVPTVV
MAB_1723|M.abscessus_ATCC_1997 TDASD---------AWRALVKAADVPYRSMHSARHTTATLLNNAGVSQET
. *. **: . *.
Mflv_3899|M.gilvum_PYR-GCK LMARLGHSTPQAALR-YQHAAQGRDRQIAALLSKIAENGGA---------
Mvan_2508|M.vanbaalenii_PYR-1 LMARLGHSTPQAAMR-YQHAAQGRDQAIAAALSKIALGQ-----------
Rv2659c|M.tuberculosis_H37Rv LMQRLGHSTAGAALR-YQHAAKGRDREIAALLSKLAENQEM---------
MAV_1484|M.avium_104 LMDRLGHTSPNMSMR-YQHTAEGRAAALADKLSALASTNP----------
MMAR_4848|M.marinum_M VQKTMGHSTPTVTANIYSDLYSDELDHVATNLDRLNDVAKDQAN-GQEPD
MUL_0529|M.ulcerans_Agy99 VQKTMGHSTPTVTANIYSDLYADELDQVATNLDQLHATEIQTPTTGQEPD
Mb2335c|M.bovis_AF2122/97 VQRLLGHATAAMTLDRHGHLLSDDLAGVAGLLVQAIKSAAASLRYSDPDS
MLBr_01600|M.leprae_Br4923 VQELLGHSS-LATTQLYTHVAVSRLRVVHDQAHPRA--------------
MSMEG_5754|M.smegmatis_MC2_155 IAAWLGHQDPGFTLRTYAHSNHDALADAAAMLGSITTGKKKEAK------
MAB_1723|M.abscessus_ATCC_1997 RMKVVGHSS-AVAQQIYVHVDHEPARAALSNLNELLS-------------
:** : : .
Mflv_3899|M.gilvum_PYR-GCK ----------
Mvan_2508|M.vanbaalenii_PYR-1 ----------
Rv2659c|M.tuberculosis_H37Rv ----------
MAV_1484|M.avium_104 ----------
MMAR_4848|M.marinum_M TPKHP-----
MUL_0529|M.ulcerans_Agy99 EPNQPSSA--
Mb2335c|M.bovis_AF2122/97 VAVENISAAS
MLBr_01600|M.leprae_Br4923 ----------
MSMEG_5754|M.smegmatis_MC2_155 ----------
MAB_1723|M.abscessus_ATCC_1997 ----------