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MAGNTPRGIRKRLNAAGEPRYQVRYLIRDPDAPSGWVETSATFPTLREAKAFKSERDNEAALGARRFDPR LGRTPLSRIWTQFSDSKKPAVSPKTWSGYNQHWELRIKPRFGHVPVDEITRADVRAFVDGLTVGPWAKVS TLRLLRSILDVAHQDGRIHRNPALGVSAGRIPERERHRYLTAQEVRMLATACGDQGDVVTILAYTGLRWS EPVGLRVKDIDLTARRLYVRRAAPEVEGHIVIGPPKTRAGIRTVPLPQVVVDIFKGRITGQAPDQPAVTS TNGAMLRSNNWRRHTHWNKALKSTDLAPLTIHDLRHTYASLARKSGADLRYVQKTMGHSTPTVTANIYSD LYADELDQVATNLDQLHATEIQTPTTGQEPDEPNQPSSA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_0529 | - | - | 100% (389) | prophage integrase |
| M. ulcerans Agy99 | MUL_1690 | xerD | 9e-08 | 26.11% (203) | site-specific tyrosine recombinase XerD |
| M. ulcerans Agy99 | MUL_2065 | xerC | 4e-07 | 29.90% (194) | site-specific tyrosine recombinase XerC |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2335c | - | 6e-11 | 34.75% (118) | hypothetical protein Mb2335c |
| M. gilvum PYR-GCK | Mflv_3899 | - | 1e-21 | 28.94% (311) | phage integrase family protein |
| M. tuberculosis H37Rv | Rv2659c | - | 1e-18 | 28.24% (262) | phiRv2 prophage integrase |
| M. leprae Br4923 | MLBr_01365 | xerD | 2e-09 | 27.32% (205) | site-specific tyrosine recombinase XerD |
| M. abscessus ATCC 19977 | MAB_1723 | - | 1e-10 | 23.51% (302) | putative phage integrase |
| M. marinum M | MMAR_4848 | - | 1e-175 | 75.65% (386) | prophage integrase |
| M. avium 104 | MAV_2217 | - | 2e-25 | 27.08% (384) | traSA:integrase fusion protein |
| M. smegmatis MC2 155 | MSMEG_5754 | - | 3e-13 | 25.60% (332) | gp41 protein |
| M. thermoresistible (build 8) | TH_1542 | xerD | 3e-09 | 26.60% (203) | tyrosine recombinase XerD |
| M. vanbaalenii PYR-1 | Mvan_2508 | - | 2e-22 | 28.32% (346) | phage integrase family protein |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_0529|M.ulcerans_Agy99 --------------------------------MAGNTPRGIRKRLNAAGE
MMAR_4848|M.marinum_M --------------------------------MAGSVPRGIRKRTNSAGQ
Mflv_3899|M.gilvum_PYR-GCK --------------------------------MARGTGRKDRAPGTFGSV
Mvan_2508|M.vanbaalenii_PYR-1 --------------------------------MARGEGRKTRQAGTFGTV
Rv2659c|M.tuberculosis_H37Rv ---------------------------------MTQTGKRQRRK--FGRI
Mb2335c|M.bovis_AF2122/97 --------------------------------------------------
MAV_2217|M.avium_104 -------------------------------MDLWTKTVRDPDDTIRTVP
MLBr_01365|M.leprae_Br4923 --------------------------------------------------
TH_1542|M.thermoresistible__bu --------------------------------------------------
MSMEG_5754|M.smegmatis_MC2_155 ---------------------------------MLQRMARIPDYVKVIDL
MAB_1723|M.abscessus_ATCC_1997 MEQTERVKKRPACKCKHVYFAHPNEGPCNQCGDCPKYRERERRERGEGGL
MUL_0529|M.ulcerans_Agy99 PRYQVRYLIRDPDAPSG-WVETSATFPTLREAKAFKSERDNEAALGARRF
MMAR_4848|M.marinum_M ARYQVRYLVRDPNSPSG-WVETSSTFATMREARAFKADRDGEAAIGARRF
Mflv_3899|M.gilvum_PYR-GCK DKLATG-YRARYFGPDGRRHKAPVLFLTKTDARAWLAQRHSEIVAQQWTP
Mvan_2508|M.vanbaalenii_PYR-1 QQLPSGRYRAMYYGPDRRRYKAPTTFRAKADARGWLALRQAEIISKAWTP
Rv2659c|M.tuberculosis_H37Rv RQFNSGRWQASYTGPDGRVYIAPKTFNAKIDAEAWLTDRRREIDRQLWSP
Mb2335c|M.bovis_AF2122/97 --------------------------------------------------
MAV_2217|M.avium_104 SARHGRGMRWRATYVDDQSREHSRSFGRKVDAQRWLDEVTAAVVTGQYVD
MLBr_01365|M.leprae_Br4923 --MTT--------------AALQTQLQGYLDYLIIERSIAANTLSSYRR-
TH_1542|M.thermoresistible__bu --VTTSEQVPRSDEPPHPHRVLDDQIQGYLDHLSIERGVAANTLSSYRR-
MSMEG_5754|M.smegmatis_MC2_155 DSGRRYEVRPEVTGADGKRRQKRERFKTLKEAVDHYTAIAGDRGRGVHVA
MAB_1723|M.abscessus_ATCC_1997 FQRADGMWVGSVEVPSEDGLRRRQTVSAKDKGVALDKLRDLRSAIRSGKS
MUL_0529|M.ulcerans_Agy99 DPRLGRTPLSRIWTQFSDSKKP---------------AVSPKTWSGYNQH
MMAR_4848|M.marinum_M DPRLGRASLSAIWTQYSASKQP---------------AVSPKTWSGYAQH
Mflv_3899|M.gilvum_PYR-GCK PNAV-EVPKTTFTEYADQWLLTRQ---------VAGRPLKDRTREHYQAL
Mvan_2508|M.vanbaalenii_PYR-1 PEAAPKITRTTFADYARNWIKQ--------------RDLKQHTREHYEVL
Rv2659c|M.tuberculosis_H37Rv ASGQEDRPGAPFGEYAEGWLKQ--------------RGIKDRTRAHYRKL
Mb2335c|M.bovis_AF2122/97 --------------------------------------------------
MAV_2217|M.avium_104 PKAG----QITFRDYAERWRKMQ--------------VQRPSSRAHIETM
MLBr_01365|M.leprae_Br4923 ----------DLIRYSKHLSDR---------------GIEDLAKVGEHDV
TH_1542|M.thermoresistible__bu ----------DLRRYAEHLLAR---------------GIDDLAKVHESDV
MSMEG_5754|M.smegmatis_MC2_155 PSELTVEDAVDSWLLGQRIRPKTMSAYITSLRPIVDHLGKRTVQSITKDD
MAB_1723|M.abscessus_ATCC_1997 PTSSKVHLEQWLNHWLETIQKP---------------RVRPTTYKYYETT
MUL_0529|M.ulcerans_Agy99 WELRIKPRF-GHVPVDEITRADVRAFVDGLTVG-PWAKVSTLRLLR---S
MMAR_4848|M.marinum_M WELRISPRF-GHVPVDEISRKDVQQFIGGLTVG-PWAKLATLRLLR---S
Mflv_3899|M.gilvum_PYR-GCK LDDHITATF-GALPLASITADDVRQWYARTLTDKPTMRSHAYGLLR---T
Mvan_2508|M.vanbaalenii_PYR-1 LERHLISPF-GSLPLSSITVDDVRGWYATFATETPTLRSHTYGLLR---T
Rv2659c|M.tuberculosis_H37Rv LDNHILATF-ADTDLRDITPAAVRRWYATTAVGTPTMRAHSYSLLR---A
Mb2335c|M.bovis_AF2122/97 --------------------------------------------------
MAV_2217|M.avium_104 LRRHAYPTL-GDRQLTSILPSDVQAWVKGLQLA-PATVGVVHGLVS---T
MLBr_01365|M.leprae_Br4923 SEFLVALRR-GDPDSGVAALSAVSAARALIAVR----GLHRFAVAE---G
TH_1542|M.thermoresistible__bu ADFLVALRR-GDPDTGAAGLSAVSAARALIAVR----GLHRFAAAE---G
MSMEG_5754|M.smegmatis_MC2_155 LEQVVQALR-AGTSKMGTWNAPTKLTKAAKKVRSPWAASSINPMLARTRS
MAB_1723|M.abscessus_ATCC_1997 VRLYILPFIDGRTQLGKLTPAQVRKMIAKNGTR--NAQKAHQTLVK----
MUL_0529|M.ulcerans_Agy99 ILDVAHQDGRIHRNPALGVSAG--RIPERERHRYLTAQEVRMLATACGDQ
MMAR_4848|M.marinum_M ILDMAREDGRIHINPAQGVSSG--RIPARERHRYLSATEVAALAHACGDQ
Mflv_3899|M.gilvum_PYR-GCK ILATAVSDGKISVNPCSIRGAG--TAKRVHKVRPATVGEIGTIADAMPAQ
Mvan_2508|M.vanbaalenii_PYR-1 ILGTAASDGKISSNPCLIRGAG--TTKRVKKIRPATLPEIEKITTEMPEQ
Rv2659c|M.tuberculosis_H37Rv IMQTALADDLIDSNPCRISGAS--TARRVHKIRPATLDELETITKAMPDP
Mb2335c|M.bovis_AF2122/97 -------------MTGAGIVET--TTNRV-RHVPVPEPVSERLRDELPTE
MAV_2217|M.avium_104 VMKSAIRDRRLAANPCDGTKLP--KVQRP-QIVPLTTEQVEAVRAELPAE
MLBr_01365|M.leprae_Br4923 LVDLDVARAVRPPTPGRRLPKS--LTVDEVLALLESVGGESRADGPLVLR
TH_1542|M.thermoresistible__bu VTELDVARSVKPPTPSRRLPKS--LTVDEVLALLAGAGGDSESDGPLTLR
MSMEG_5754|M.smegmatis_MC2_155 IFEDLVNQGVVVRNVAALVKPL--ATDTEKTMNTLNAEQVTQLLAVTDSH
MAB_1723|M.abscessus_ATCC_1997 ALGDAMDEGMLDKNVAAVVDKPKHVAIERQPFTFDEARQIIATAIKRNDP
MUL_0529|M.ulcerans_Agy99 -GDVVTILAYTGLRWSEPVGLRVKDIDLTAR-------------RLYVRR
MMAR_4848|M.marinum_M -GDIVTILAFTGLRWSELVGLRVGDIDLKAR-------------RLYVRQ
Mflv_3899|M.gilvum_PYR-GCK WSLMVLLAAWLAMRFGELTELRRKDIDLAD-------------EVVRVRR
Mvan_2508|M.vanbaalenii_PYR-1 YQAMILLAAWCALRFGELTELRRKDIVLTTTVDLE--GETVHMGVIRVER
Rv2659c|M.tuberculosis_H37Rv YQAFVLMAAWLAMRYGELTELRRKDIDLHG-------------EVARVRR
Mb2335c|M.bovis_AF2122/97 PNALVFPSYRGGHLPIEEY-------------------------------
MAV_2217|M.avium_104 LQALVTLAAGTGLRQGECFGLTVDRVRFLER------------VLTVDRQ
MLBr_01365|M.leprae_Br4923 NRALLELLYSTGSRISEAVGLDVDDVDTQAR------------------T
TH_1542|M.thermoresistible__bu NRALLELLYSTGARISEAVGLDIDDVDTVAR------------------S
MSMEG_5754|M.smegmatis_MC2_155 CYGIAWRLAVLGLRRGEILALRWDAVDFDAG-------------TLAISA
MAB_1723|M.abscessus_ATCC_1997 WATMWAAMFFTGARQGEIIGMEWDRCDLEKGLFDFSWQLQQLPPELPRGF
. . *
MUL_0529|M.ulcerans_Agy99 AAPEVEGHIVIGPPKTRAGIRTVPLPQVVVDIFKGRITGQA---PDQ---
MMAR_4848|M.marinum_M AAPDVEGRIIVGPPKTRAAVRTVPLPRIVIDALKPRIENRS---TKE---
Mflv_3899|M.gilvum_PYR-GCK AVVRTDDGFKVTTPKSDAGIRDIAIPPHLIPPIEAHLSQHVGAKADA---
Mvan_2508|M.vanbaalenii_PYR-1 AVVRVDDGYLVTTPKSDAGTRDVAIPPHLVPVIHDHLAVHVDGGPDA---
Rv2659c|M.tuberculosis_H37Rv AVVRVGEGFKVTTPKSDAGVRDISIPPHLIPAIEDHLHKHVNPGRES---
Mb2335c|M.bovis_AF2122/97 --------------------------------------------------
MAV_2217|M.avium_104 LVTVAGQAPTFGPPKTRASNRAIPLPKVVADALAAHLAAFPAEPDGL---
MLBr_01365|M.leprae_Br4923 VLLQGKGGKQRLVPVGRPAVQALDAYLVRGRSDLARRGPGMLATPAI---
TH_1542|M.thermoresistible__bu VLLRGKGGKQRLVPIGRPAVSALDAYLVRGRPELVRRGRG---TPAI---
MSMEG_5754|M.smegmatis_MC2_155 ARLATAGGATTGAPKTKTSVRTLPMPEDLTAALRRVRKRQKEYRLKLGSK
MAB_1723|M.abscessus_ATCC_1997 KHRPCHLSLAWTKPKTKAGARVAPMTKPLQAIMEAYAKTDTGPNPHG---
MUL_0529|M.ulcerans_Agy99 ---PAVTSTNGAMLRSNNWRRHTHWNKALKSTDLAPLTIHDLRHTYASLA
MMAR_4848|M.marinum_M ---QAITSPNGGFLRSNNWRRHTHWNKALKKTGLAPLTIHDLRHTYASLA
Mflv_3899|M.gilvum_PYR-GCK ---LLFPAVGG--GHLAPATLYRRFYTARERANRKDLRWHDLRHSGAVLA
Mvan_2508|M.vanbaalenii_PYR-1 ---LLFPAAHG--RHLAPATLYRQFYKARVAADRPDLRFHDLRHSGAVLA
Rv2659c|M.tuberculosis_H37Rv ---LLFPSVNDPNRHLAPSALYRMFYKARKAAGRPDLRVHDLRHSGAVLA
Mb2335c|M.bovis_AF2122/97 -------------RRAFDKGCKAVGIADLVPHG--------LRHTTASLA
MAV_2217|M.avium_104 ---VFTQQGKPITRSTFGYRWRAAVKEAKLPHGTG---FHALRHYYASLL
MLBr_01365|M.leprae_Br4923 ---FLNARGGRLSRQSAWQVLQDAAEHAGITSGVSP---HMLRHSFATHL
TH_1542|M.thermoresistible__bu ---FLNARGGRLSRQSAWQVLQDAAERAGIKAGVSP---HTLRHSFATHL
MSMEG_5754|M.smegmatis_MC2_155 WTDSGYVVVDEFGVAPYPDTLTAAWRKTLANAGLPHVRLHDARHSCATLM
MAB_1723|M.abscessus_ATCC_1997 -----LVWRHPDGHPISPTDASDAWRALVKAADVPYRSMHSARHTTATLL
. ** *
MUL_0529|M.ulcerans_Agy99 RKSGADLRYVQKTMGHSTPTVTANIYSDLYADELDQVATNLDQLHATEIQ
MMAR_4848|M.marinum_M RKSGADLRYVQKTMGHSTPTVTANIYSDLYSDELDHVATNLDRLNDVAKD
Mflv_3899|M.gilvum_PYR-GCK AATGATLAELMARLGHSTPQAAL---------RYQHAAQGRDRQIAALLS
Mvan_2508|M.vanbaalenii_PYR-1 AATGATLAELMARLGHSTPQAAM---------RYQHAAQGRDQAIAAALS
Rv2659c|M.tuberculosis_H37Rv ASTGATLAELMQRLGHSTAGAAL---------RYQHAAKGRDREIAALLS
Mb2335c|M.bovis_AF2122/97 ISAGANVKVVQRLLGHATAAMTLDRHGHLLSDDLAGVAGLLVQAIKSAAA
MAV_2217|M.avium_104 IRHGESVKTVQARLGHASAVETLDTYSHLWPDSDDRTRDAIDSVLGSTAY
MLBr_01365|M.leprae_Br4923 LEGGADIRVVQELMGHASVTTTQ--------IYTLVTVQALREVWAGAHP
TH_1542|M.thermoresistible__bu LDGGADVRVVQELLGHASVTTTQ--------IYTMVTVHALREVWAGAHP
MSMEG_5754|M.smegmatis_MC2_155 HLSGVPTVVIAAWLGHQDPGFTLR--------TYAHSNHDALADAAAMLG
MAB_1723|M.abscessus_ATCC_1997 NNAGVSQETRMKVVGHSSAVAQQ---------IYVHVDHEPARAALSNLN
* :**
MUL_0529|M.ulcerans_Agy99 TPTTGQEPDEPNQPSSA--
MMAR_4848|M.marinum_M QAN-GQEPDTPKHP-----
Mflv_3899|M.gilvum_PYR-GCK KIAENGGA-----------
Mvan_2508|M.vanbaalenii_PYR-1 KIALGQ-------------
Rv2659c|M.tuberculosis_H37Rv KLAENQEM-----------
Mb2335c|M.bovis_AF2122/97 SLRYSDPDSVAVENISAAS
MAV_2217|M.avium_104 RLRTGQPATS---------
MLBr_01365|M.leprae_Br4923 RAK----------------
TH_1542|M.thermoresistible__bu RAR----------------
MSMEG_5754|M.smegmatis_MC2_155 SITTGKKKEAK--------
MAB_1723|M.abscessus_ATCC_1997 ELLS---------------