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DLWTKTVRDPDDTIRTVPSARHGRGMRWRATYVDDQSREHSRSFGRKVDAQRWLDEVTAAVVTGQYVDPK AGQITFRDYAERWRKMQVQRPSSRAHIETMLRRHAYPTLGDRQLTSILPSDVQAWVKGLQLAPATVGVVH GLVSTVMKSAIRDRRLAANPCDGTKLPKVQRPQIVPLTTEQVEAVRAELPAELQALVTLAAGTGLRQGEC FGLTVDRVRFLERVLTVDRQLVTVAGQAPTFGPPKTRASNRAIPLPKVVADALAAHLAAFPAEPDGLVFT QQGKPITRSTFGYRWRAAVKEAKLPHGTGFHALRHYYASLLIRHGESVKTVQARLGHASAVETLDTYSHL WPDSDDRTRDAIDSVLGSTAYRLRTGQPATS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2217 | - | - | 100% (382) | traSA:integrase fusion protein |
| M. avium 104 | MAV_2266 | - | 1e-66 | 39.55% (397) | phage-related integrase |
| M. avium 104 | MAV_1484 | - | 6e-24 | 29.46% (336) | integrase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2335c | - | 5e-10 | 36.09% (133) | hypothetical protein Mb2335c |
| M. gilvum PYR-GCK | Mflv_2927 | - | 1e-65 | 41.51% (371) | phage integrase family protein |
| M. tuberculosis H37Rv | Rv2659c | - | 3e-24 | 28.19% (337) | phiRv2 prophage integrase |
| M. leprae Br4923 | MLBr_01365 | xerD | 3e-09 | 26.38% (254) | site-specific tyrosine recombinase XerD |
| M. abscessus ATCC 19977 | MAB_1723 | - | 2e-14 | 25.64% (312) | putative phage integrase |
| M. marinum M | MMAR_4848 | - | 6e-23 | 27.32% (366) | prophage integrase |
| M. smegmatis MC2 155 | MSMEG_5754 | - | 7e-14 | 25.26% (380) | gp41 protein |
| M. thermoresistible (build 8) | TH_1542 | xerD | 1e-07 | 25.19% (258) | tyrosine recombinase XerD |
| M. ulcerans Agy99 | MUL_0529 | - | 2e-25 | 27.08% (384) | prophage integrase |
| M. vanbaalenii PYR-1 | Mvan_2508 | - | 2e-28 | 28.16% (380) | phage integrase family protein |
CLUSTAL 2.0.9 multiple sequence alignment
MLBr_01365|M.leprae_Br4923 ------------------------------------------MTT-----
TH_1542|M.thermoresistible__bu ------------------------------------------VTTSEQVP
MAV_2217|M.avium_104 -------------MDLWTKTVRDPDDTIRTVPSARHGRGMRWRATYVDDQ
Mflv_2927|M.gilvum_PYR-GCK ---MQRRNRRSGVEDRWRKTVTRPDGTTERVPSARDGKGLRWLARYVDER
Rv2659c|M.tuberculosis_H37Rv --------------MTQTGKRQRRK--FGRIRQFNSG---RWQASYTGPD
Mvan_2508|M.vanbaalenii_PYR-1 -------------MARGEGRKTRQAGTFGTVQQLPSG---RYRAMYYGPD
MMAR_4848|M.marinum_M -------------MAGSVPRGIRKRTNSAGQARYQVR----YLVRDPNSP
MUL_0529|M.ulcerans_Agy99 -------------MAGNTPRGIRKRLNAAGEPRYQVR----YLIRDPDAP
Mb2335c|M.bovis_AF2122/97 --------------------------------------------------
MSMEG_5754|M.smegmatis_MC2_155 -----------------MLQRMARIPDYVKVIDLDSGRRYEVRPEVTGAD
MAB_1723|M.abscessus_ATCC_1997 MEQTERVKKRPACKCKHVYFAHPNEGPCNQCGDCPKYRERERRERGEGGL
MLBr_01365|M.leprae_Br4923 ---------AALQTQLQGYLDYLIIERSIAANTLSS--------------
TH_1542|M.thermoresistible__bu RSDEPPHPHRVLDDQIQGYLDHLSIERGVAANTLSS--------------
MAV_2217|M.avium_104 SR--EHSRSFGRKVDAQRWLDEVTAAVVTGQYVDP---------------
Mflv_2927|M.gilvum_PYR-GCK GR--EHSKSFARKPDAQQWLDGQTAAVVTGSHVAP---------------
Rv2659c|M.tuberculosis_H37Rv GRVYIAPKTFNAKIDAEAWLTDRRREIDRQLWSPASGQ------------
Mvan_2508|M.vanbaalenii_PYR-1 RRRYKAPTTFRAKADARGWLALRQAEIISKAWTPPEAA------------
MMAR_4848|M.marinum_M SGWVETSSTFATMREARAFKADRDGEAAIGARRFDP--------------
MUL_0529|M.ulcerans_Agy99 SGWVETSATFPTLREAKAFKSERDNEAALGARRFDP--------------
Mb2335c|M.bovis_AF2122/97 --------------------------------------------------
MSMEG_5754|M.smegmatis_MC2_155 GKRRQKRERFKTLKEAVDHYTAIAGDRGRGVHVAPSELTVEDAVDSWLLG
MAB_1723|M.abscessus_ATCC_1997 FQRADGMWVGSVEVPSEDGLRRRQTVSAKDKGVALDKLRDLRSAIRSGKS
MLBr_01365|M.leprae_Br4923 ---YRRDLIRYSKHLSD----RGIEDLAKVGEHDVSEFLVALRR-GDPDS
TH_1542|M.thermoresistible__bu ---YRRDLRRYAEHLLA----RGIDDLAKVHESDVADFLVALRR-GDPDT
MAV_2217|M.avium_104 -KAGQITFRDYAERWR--K-MQVQRPSSRAHIETMLRRHAYPTL-GDRQL
Mflv_2927|M.gilvum_PYR-GCK -RTAQMTVEQWCDTWIG-G-YAVNRESTVRQARTHIK-HIVAEF-GDQPL
Rv2659c|M.tuberculosis_H37Rv EDRPGAPFGEYAEGWLK-Q-RGIKDR-TRAHYRKLLDNHILATF-ADTDL
Mvan_2508|M.vanbaalenii_PYR-1 PKITRTTFADYARNWIK-Q-RDLKQH-TREHYEVLLERHLISPF-GSLPL
MMAR_4848|M.marinum_M -RLGRASLSAIWTQYSASK-QPAVSPKTWSGYAQHWELRISPRF-GHVPV
MUL_0529|M.ulcerans_Agy99 -RLGRTPLSRIWTQFSDSK-KPAVSPKTWSGYNQHWELRIKPRF-GHVPV
Mb2335c|M.bovis_AF2122/97 --------------------------------------------------
MSMEG_5754|M.smegmatis_MC2_155 QRIRPKTMSAYITSLRPIV-DHLGKRTVQSITKDDLEQVVQALR-AGTSK
MAB_1723|M.abscessus_ATCC_1997 PTSSKVHLEQWLNHWLETIQKPRVRPTTYKYYETTVRLYILPFIDGRTQL
MLBr_01365|M.leprae_Br4923 GVAALSAVSAARALIAVR-------GLHRFAVAEGLVDLDVARAVRPPTP
TH_1542|M.thermoresistible__bu GAAGLSAVSAARALIAVR-------GLHRFAAAEGVTELDVARSVKPPTP
MAV_2217|M.avium_104 TSILPSDVQAWVKGLQ----LAPATVGVVHGLVSTVMKSAIRDRRLAANP
Mflv_2927|M.gilvum_PYR-GCK SALRPSQVKAWVAGLKKAD-VAPSYVYALHSRLSQICGDAVHDGVLARNP
Rv2659c|M.tuberculosis_H37Rv RDITPAAVRRWYATTAVG---TPTMRAHSYSLLRAIMQTALADDLIDSNP
Mvan_2508|M.vanbaalenii_PYR-1 SSITVDDVRGWYATFATE---TPTLRSHTYGLLRTILGTAASDGKISSNP
MMAR_4848|M.marinum_M DEISRKDVQQFIGGLTVG----PWAKLATLRLLRSILDMAREDGRIHINP
MUL_0529|M.ulcerans_Agy99 DEITRADVRAFVDGLTVG----PWAKVSTLRLLRSILDVAHQDGRIHRNP
Mb2335c|M.bovis_AF2122/97 --------------------------------------------------
MSMEG_5754|M.smegmatis_MC2_155 MGTWNAPTKLTKAAKKVRSPWAASSINPMLARTRSIFEDLVNQGVVVRNV
MAB_1723|M.abscessus_ATCC_1997 GKLTPAQVRKMIAKNGTRN------AQKAHQTLVKALGDAMDEGMLDKNV
MLBr_01365|M.leprae_Br4923 GRRLPKS--LTVDEVLALLESVGGESRADGPLVLRNRALLELLYSTGSRI
TH_1542|M.thermoresistible__bu SRRLPKS--LTVDEVLALLAGAGGDSESDGPLTLRNRALLELLYSTGARI
MAV_2217|M.avium_104 CDGTKLP--KVQ-RPQIVPLTTEQVEAVRAELPAELQALVTLAAGTGLRQ
Mflv_2927|M.gilvum_PYR-GCK CSRRTAP--PMG-TQKPYVATTEQVWALHDAMPDHLRVAVLLGAFVGLRV
Rv2659c|M.tuberculosis_H37Rv CRISGAS--TARRVHKIRPATLDELETITKAMPDPYQAFVLMAAWLAMRY
Mvan_2508|M.vanbaalenii_PYR-1 CLIRGAG--TTKRVKKIRPATLPEIEKITTEMPEQYQAMILLAAWCALRF
MMAR_4848|M.marinum_M AQGVSSG--RIPARERHRYLSATEVAALAHACGDQ-GDIVTILAFTGLRW
MUL_0529|M.ulcerans_Agy99 ALGVSAG--RIPERERHRYLTAQEVRMLATACGDQ-GDVVTILAYTGLRW
Mb2335c|M.bovis_AF2122/97 --------------------------------------------MTGAGI
MSMEG_5754|M.smegmatis_MC2_155 AALVKPL--ATDTEKTMNTLNAEQVTQLLAVTDSHCYGIAWRLAVLGLRR
MAB_1723|M.abscessus_ATCC_1997 AAVVDKPKHVAIERQPFTFDEARQIIATAIKRNDPWATMWAAMFFTGARQ
.
MLBr_01365|M.leprae_Br4923 SEAVGLDVDD-------VDTQART-----------VLLQGKGGKQRLVPV
TH_1542|M.thermoresistible__bu SEAVGLDIDD-------VDTVARS-----------VLLRGKGGKQRLVPI
MAV_2217|M.avium_104 GECFGLTVDR-------VRFLERV-----LTVDRQLVTVAGQAPTFGPPK
Mflv_2927|M.gilvum_PYR-GCK AEVAALRVSD-------VDFIR------------GVVHPVQQWPDK-PLK
Rv2659c|M.tuberculosis_H37Rv GELTELRRKD-------IDLHGE------VARVRRAVVRVGEGFKVTTPK
Mvan_2508|M.vanbaalenii_PYR-1 GELTELRRKDIVLTT-TVDLEGETVHMG-VIRVERAVVRVDDGYLVTTPK
MMAR_4848|M.marinum_M SELVGLRVGD-------IDLKARR------LYVRQAAPDVEGRIIVGPPK
MUL_0529|M.ulcerans_Agy99 SEPVGLRVKD-------IDLTARR------LYVRRAAPEVEGHIVIGPPK
Mb2335c|M.bovis_AF2122/97 VETTTNRVRH----------------------------------------
MSMEG_5754|M.smegmatis_MC2_155 GEILALRWDA-------VDFDAGT------LAISAARLATAGGATTGAPK
MAB_1723|M.abscessus_ATCC_1997 GEIIGMEWDRCDLEKGLFDFSWQLQQLPPELPRGFKHRPCHLSLAWTKPK
*
MLBr_01365|M.leprae_Br4923 GRPAVQ--ALDAYLVRGRSDLARRGPGM------LATPAIFLNARGG--R
TH_1542|M.thermoresistible__bu GRPAVS--ALDAYLVRGRPELVRRGRG---------TPAIFLNARGG--R
MAV_2217|M.avium_104 TRASNRAIPLPKVVADALAAHLAAFPAE-------PDGLVFTQQGK---P
Mflv_2927|M.gilvum_PYR-GCK TDGSAQPVPIPNDLALLLSASVKRYPS--------PMMVTRGVAGE---T
Rv2659c|M.tuberculosis_H37Rv SDAGVRDISIPPHLIPAIEDHLHKHVNP------GRESLLFPSVNDPNRH
Mvan_2508|M.vanbaalenii_PYR-1 SDAGTRDVAIPPHLVPVIHDHLAVHVDG------GPDALLFPAAHG--RH
MMAR_4848|M.marinum_M TRAAVRTVPLPRIVIDALKPRIENRST---------KEQAITSPNGGFLR
MUL_0529|M.ulcerans_Agy99 TRAGIRTVPLPQVVVDIFKGRITGQAP---------DQPAVTSTNGAMLR
Mb2335c|M.bovis_AF2122/97 -------VPVPEPVSERLRDELPTEPN----------ALVFPSYRGG--H
MSMEG_5754|M.smegmatis_MC2_155 TKTSVRTLPMPEDLTAALRRVRKRQKEYRLKLGSKWTDSGYVVVDEFGVA
MAB_1723|M.abscessus_ATCC_1997 TKAGARVAPMTKPLQAIMEAYAKTDTGP--------NPHGLVWRHPDGHP
.: :
MLBr_01365|M.leprae_Br4923 LSRQSAWQVLQDAAEHAG-ITSGVSPHMLRHSFATHLLEGGADIRVVQEL
TH_1542|M.thermoresistible__bu LSRQSAWQVLQDAAERAG-IKAGVSPHTLRHSFATHLLDGGADVRVVQEL
MAV_2217|M.avium_104 ITRSTFGYRWRAAVKEAK-LPHGTGFHALRHYYASLLIRHGESVKTVQAR
Mflv_2927|M.gilvum_PYR-GCK APPWVIEREVRAARSSIDGLPEEFSFHDLRHYLASLLIASGADIKTVQAR
Rv2659c|M.tuberculosis_H37Rv LAPSALYRMFYKARKAAG--RPDLRVHDLRHSGAVLAASTGATLAELMQR
Mvan_2508|M.vanbaalenii_PYR-1 LAPATLYRQFYKARVAAD--RPDLRFHDLRHSGAVLAAATGATLAELMAR
MMAR_4848|M.marinum_M SNNWRRHTHWNKALKKTG--LAPLTIHDLRHTYASLARKSGADLRYVQKT
MUL_0529|M.ulcerans_Agy99 SNNWRRHTHWNKALKSTD--LAPLTIHDLRHTYASLARKSGADLRYVQKT
Mb2335c|M.bovis_AF2122/97 LPIEEYRRAFDKGCKAVG--IADLVPHGLRHTTASLAISAGANVKVVQRL
MSMEG_5754|M.smegmatis_MC2_155 PYPDTLTAAWRKTLANAG--LPHVRLHDARHSCATLMHLSGVPTVVIAAW
MAB_1723|M.abscessus_ATCC_1997 ISPTDASDAWRALVKAAD--VPYRSMHSARHTTATLLNNAGVSQETRMKV
* ** * *
MLBr_01365|M.leprae_Br4923 MGHAS-VTTTQIYTLVTVQALREVWAGAHPRAK-----------------
TH_1542|M.thermoresistible__bu LGHAS-VTTTQIYTMVTVHALREVWAGAHPRAR-----------------
MAV_2217|M.avium_104 LGHASAVETLDTYSHLWPDSDDRTRDAIDSVLGS------TAYRLRTGQP
Mflv_2927|M.gilvum_PYR-GCK MRHGSARTTLDTYGHLWPDADESTRTAIASVIAERMDSNGAADQLRTSGT
Rv2659c|M.tuberculosis_H37Rv LGHSTAGAALR-YQHAAKGRDREIAALLSKLAENQEM-------------
Mvan_2508|M.vanbaalenii_PYR-1 LGHSTPQAAMR-YQHAAQGRDQAIAAALSKIALGQ---------------
MMAR_4848|M.marinum_M MGHSTPTVTANIYSDLYSDELDHVATNLDRLNDVAKDQAN-GQEPDTPKH
MUL_0529|M.ulcerans_Agy99 MGHSTPTVTANIYSDLYADELDQVATNLDQLHATEIQTPTTGQEPDEPNQ
Mb2335c|M.bovis_AF2122/97 LGHATAAMTLDRHGHLLSDDLAGVAGLLVQAIKSAAASLRYSDPDSVAVE
MSMEG_5754|M.smegmatis_MC2_155 LGHQDPGFTLRTYAHSNHDALADAAAMLGSITTGKKKEAK----------
MAB_1723|M.abscessus_ATCC_1997 VGHSS-AVAQQIYVHVDHEPARAALSNLNELLS-----------------
: * : :
MLBr_01365|M.leprae_Br4923 ------
TH_1542|M.thermoresistible__bu ------
MAV_2217|M.avium_104 ATS---
Mflv_2927|M.gilvum_PYR-GCK D-----
Rv2659c|M.tuberculosis_H37Rv ------
Mvan_2508|M.vanbaalenii_PYR-1 ------
MMAR_4848|M.marinum_M P-----
MUL_0529|M.ulcerans_Agy99 PSSA--
Mb2335c|M.bovis_AF2122/97 NISAAS
MSMEG_5754|M.smegmatis_MC2_155 ------
MAB_1723|M.abscessus_ATCC_1997 ------