For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
DFGLLPPEVNSGRMYTGPGPESMLAAAAAWDTVAAELSAAAVSYGSVVSALILEPWMGSAAAAMTAAATP YVGWLAATAAQVKETAYQARMAASAFATAFASTVPPPRIAANRSRLMSLVAANILGQNSPAIAAIQAEYA EMWAQDAAAMHSYLGASATAATLTPFTEPIQSTDPPGSMAEAAAVAQAAGAAAPTITATRLAELFPGDLA DSLSTLTTAADPLTSGLLGIATSLNPQLTTAAAMTVPTPIGELDVLALYIAAVATGSIALSVTNTFRPWN YYGSDAHGGGSNPTHGGAISSTRKEDATDWGPFGGAAPVTVGVGHAALVGSLSVPHGWTTAAPEIQLAVE AMRTGASSRVDSTALNGMSAGLLGGAALAGWAARGTIGGGRSSATDKNPHPVW*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_2534 | - | - | 100% (404) | PPE family protein |
| M. marinum M | MMAR_1449 | - | e-118 | 57.75% (400) | PPE family protein |
| M. marinum M | MMAR_4612 | - | e-103 | 51.32% (417) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0939c | PPE14 | 1e-150 | 71.68% (392) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 2e-30 | 39.27% (191) | PPE protein |
| M. tuberculosis H37Rv | Rv0915c | PPE14 | 1e-150 | 71.68% (392) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 2e-43 | 34.76% (397) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_4783 | - | 1e-26 | 35.08% (191) | PPE family protein |
| M. avium 104 | MAV_2906 | - | 3e-76 | 42.17% (415) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 2e-29 | 36.32% (212) | PPE family protein |
| M. thermoresistible (build 8) | TH_3569 | - | 3e-30 | 37.07% (205) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_4463 | - | 4e-99 | 50.12% (413) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 2e-31 | 37.80% (209) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
TH_3569|M.thermoresistible__bu ---------MMTAPIWMALPPEVHSALLSSGPGPGSLLAAASAWHALSAE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MAB_4783|M.abscessus_ATCC_1997 ----------MTAPVWMAAPPEVHSALLSSGPGPGSLFAAADAWRSLSTE
Mb0939c|M.bovis_AF2122/97 -------------MDFGLLPPEVNSSRMYSGPGPESMLAAAAAWDGVAAE
Rv0915c|M.tuberculosis_H37Rv -------------MDFGLLPPEVNSSRMYSGPGPESMLAAAAAWDGVAAE
MMAR_2534|M.marinum_M -------------MDFGLLPPEVNSGRMYTGPGPESMLAAAAAWDTVAAE
MUL_4463|M.ulcerans_Agy99 ----------MLATDFGALPPEVNSGLLYAGPGAAPMLTAATAWDGLATV
MAV_2906|M.avium_104 -------------MDFGALPPEVNSGRMYGGAGSGPLLAAAAAWDALGAE
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
: .**.:* : *.*. .:::*. :* :.
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
TH_3569|M.thermoresistible__bu YASAAAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSAATA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MAB_4783|M.abscessus_ATCC_1997 YSSAANELTTTLGSVRAGVWDGASAEQYQTAHVPYLSWLHETSAVSAGVA
Mb0939c|M.bovis_AF2122/97 LTSAAVSYGSVVSTLIVEPWMGPAAAAMAAAATPYVGWLAATAALAKETA
Rv0915c|M.tuberculosis_H37Rv LTSAAVSYGSVVSTLIVEPWMGPAAAAMAAAATPYVGWLAATAALAKETA
MMAR_2534|M.marinum_M LSAAAVSYGSVVSALILEPWMGSAAAAMTAAATPYVGWLAATAAQVKETA
MUL_4463|M.ulcerans_Agy99 LNSAAASYASVVSGLTLESRMGPASASMAAAAAPYATWLAVANEQARQTA
MAV_2906|M.avium_104 LYSFAAAYTSTIAGLTVGSWLGPAATSMSAAAAPFIAWATTTAGQAEQVA
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLT-TFEGESAAALAERVTPYEKWLTQNAASAELTA
: * : : : * :: .*: * .*
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
TH_3569|M.thermoresistible__bu GRHETAAAAYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIPIALNE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MAB_4783|M.abscessus_ATCC_1997 AQTETAATAYSEALATMPTLGELAANHATHGALVATNFFGINTIPIAVNE
Mb0939c|M.bovis_AF2122/97 TQARAAAEAFGTAFAMTVPPSLVAANRSRLMSLVAANILGQNSAAIAATQ
Rv0915c|M.tuberculosis_H37Rv TQARAAAEAFGTAFAMTVPPSLVAANRSRLMSLVAANILGQNSAAIAATQ
MMAR_2534|M.marinum_M YQARMAASAFATAFASTVPPPRIAANRSRLMSLVAANILGQNSPAIAAIQ
MUL_4463|M.ulcerans_Agy99 AQARAAATAFETAFAVVVPPPLIAANRSQVASLVVANVLGQNTPAIETLQ
MAV_2906|M.avium_104 TQARLAAAAYETAFAATVPPPVIAANRSLLMTLIATNILGQNTAAIAAAE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
: ** *: *:: . : *:: *: :*.:* *: .* :
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA
TH_3569|M.thermoresistible__bu ADYVRMWIQAATSMSTYQAVAGTAVMSAPASSPAPLLLAPGVSEAADAMA
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA
MAB_4783|M.abscessus_ATCC_1997 ADYIRMWIQAATVMSTYQAVSESSVSAAPPTSPAPPVLSPDSGAAARTAA
Mb0939c|M.bovis_AF2122/97 AEYAEMWAQDAAVMYSYEGASAAASALPPFTPPV--------QGTGPAG-
Rv0915c|M.tuberculosis_H37Rv AEYAEMWAQDAAVMYSYEGASAAASALPPFTPPV--------QGTGPAG-
MMAR_2534|M.marinum_M AEYAEMWAQDAAAMHSYLGASATAATLTPFTEPI--------QSTDPPGS
MUL_4463|M.ulcerans_Agy99 AEYAEMWAQDAAVMYQYSAASEAASTLAAFTSPV--------QSTDPSR-
MAV_2906|M.avium_104 AEYAEMWAQDAAAMYAYAAASAAAAELTPFTEPP--------RTTESSAA
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLG-----VNEVGLAQ
*:* .** * *: * * . : . .
MSMEG_0619|M.smegmatis_MC2_155 SVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGGQ-AILDFLKDPL
TH_3569|M.thermoresistible__bu TTQQIGSQATAADSGTALNLSDLIANLLQYYQDYLDQLFGPIVDFLRDPI
Mflv_0325|M.gilvum_PYR-GCK DMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLRDPI
Mvan_0415|M.vanbaalenii_PYR-1 DVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLRDPL
MAB_4783|M.abscessus_ATCC_1997 -------QDATKPPPIVPDPNDPIEMLLKNSQHFL-GMYRALKGLITDPV
Mb0939c|M.bovis_AF2122/97 PAAAAAATQAAGAGAVADAQATLAQLPPGILSDILSALAANADPLTSGLL
Rv0915c|M.tuberculosis_H37Rv PAAAAAATQAAGAGAVADAQATLAQLPPGILSDILSALAANADPLTSGLL
MMAR_2534|M.marinum_M MAEAAAVAQAAGAAAPTITATRLAELFPGDLADSLSTLTTAADPLTSGLL
MUL_4463|M.ulcerans_Agy99 ----AQASTAAGAAAAGTTAQTTASQPTTAATDTAQGLAAEVPTIPAG--
MAV_2906|M.avium_104 ARQSAAVAQSA-ASDLPAQLSTLIDVTPTMLQGLATTPSAAAATPAASII
MLBr_01182|M.leprae_Br4923 EVVEEVVEEVVEEVVEAEQAISQAALDQAVNEGMEATVVPQVDQQVNVDV
.
MSMEG_0619|M.smegmatis_MC2_155 GNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNLVGWPTWGMIFASPF
TH_3569|M.thermoresistible__bu GNLFQLIDDFLTNPAGALVTWWPLLFAVAYQVFTNLVGWPTWAMILASPV
Mflv_0325|M.gilvum_PYR-GCK GNTFALITDFLTNPVQALITWGPFLLAVVYQAVSWVGASILYPSLFLLPL
Mvan_0415|M.vanbaalenii_PYR-1 GNTIKLITDFLTNPAQALITWGPFLAAVAYQAVSWVGASILYPSLLLLPL
MAB_4783|M.abscessus_ATCC_1997 GTIVRIIIDFSTNPAAAIVTWTPLFYVFAYAATFAVMGTPIYAAIMGPAA
Mb0939c|M.bovis_AF2122/97 GIASTLNPQVGS--AQPIVIPTPIGELDVIA-LYIASIATGSIALAITNT
Rv0915c|M.tuberculosis_H37Rv GIASTLNPQVGS--AQPIVIPTPIGELDVIA-LYIASIATGSIALAITNT
MMAR_2534|M.marinum_M GIATSLNPQLTT--AAAMTVPTPIGELDVLA-LYIAAVATGSIALSVTNT
MUL_4463|M.ulcerans_Agy99 -------SDLAA--PAAISIPTPVGELDLLA-AYIAVAATASLSLSAVNT
MAV_2906|M.avium_104 EAIYPITAALRPFFAAVTGAYSPIGAIILPGGWWLLSLQALGLAQNAPGV
MLBr_01182|M.leprae_Br4923 ATPQTAVPDSSS--AAAPQLWGGFAQHLSPINDTLSMINNHAGMANAGLS
. .
MSMEG_0619|M.smegmatis_MC2_155 LIPALAALGITGLVLLIDHVLNNPVDVPAEDEAPQEVAAAPRTDQPLAVG
TH_3569|M.thermoresistible__bu LIPLAITLGVAGLVMIADQAQP-----PAEEAAPEEDVAAP---------
Mflv_0325|M.gilvum_PYR-GCK LATTLAIVAGVGQHLLSLLNTP-PAEEAAEEPAPAQSAPSRPDQQSFPAT
Mvan_0415|M.vanbaalenii_PYR-1 VATTLAIVLGVGAYLLENLPAP-AEDAPAEEPAASSPAPTRADQPSPAIA
MAB_4783|M.abscessus_ATCC_1997 GISIPLAITLASLSQMPEAPPV---------DAPAETVPARIDQPHAVAM
Mb0939c|M.bovis_AF2122/97 ARPW-HIGLYGNA----GGLGP--------TQGHPLSSATDEPEPHWGPF
Rv0915c|M.tuberculosis_H37Rv ARPW-HIGLYGNA----GGLGP--------TQGHPLSSATDEPEPHWGPF
MMAR_2534|M.marinum_M FRPWNYYGSDAHG----GGSNP--------THGGAISSTRKEDATDWGPF
MUL_4463|M.ulcerans_Agy99 ARPWSYSTNNDHAQPNGGGVAP--------TQGNTLGTERPDAEVLVSAP
MAV_2906|M.avium_104 AELLGGGKAIAGG---LSPLAP--------LRGGYVSAVTPDAG------
MLBr_01182|M.leprae_Br4923 LVNGMGSAMKSLAPTTTKAAES---------AFKAMGSAVQSTGRGLLGS
MSMEG_0619|M.smegmatis_MC2_155 ISPAGVPGSAATAAAPAPAPAGTTVA---APAPAAATFVPYAVANRDPGE
TH_3569|M.thermoresistible__bu ----------VRAEPQNPLPLTXXX-------------------------
Mflv_0325|M.gilvum_PYR-GCK MSAPPPPSGAPIAANTVSAGSPPAPG---APAAAAATFVPYVVAGRDPYE
Mvan_0415|M.vanbaalenii_PYR-1 VSAPPPPSSAAATVGTVATGTAPAPG---APAAATASFVPYAVAGRDPGT
MAB_4783|M.abscessus_ATCC_1997 GGAPAPTASTAAPTPTTTSPATPGSAPAPTPPPAGAEGLGYAVRGDGPGF
Mb0939c|M.bovis_AF2122/97 GGAAPVSAGVGHAALVGALSVPHSWTTAAPEIQLAVQATPTFSSSAGADP
Rv0915c|M.tuberculosis_H37Rv GGAAPVSAGVGHAALVGALSVPHSWTTAAPEIQLAVQATPTFSSSAGADP
MMAR_2534|M.marinum_M GGAAPVTVGVGHAALVGSLSVPHGWTTAAPEIQLAVEAMRTGASSR-VDS
MUL_4463|M.ulcerans_Agy99 N-VVPTSAFVGHAALVGALSVPHSWAMAAPEIRLAVESLPSAGGLSAPAG
MAV_2906|M.avium_104 ----GVAGSMGRSTLVGSLSVPPGWTTAAPVLRTVASVLPAASSATAAAM
MLBr_01182|M.leprae_Br4923 SSGGHVTAQLGRAASIGSLRVPQTWTTASQPVTAATRALSPARVAVATES
. .
MSMEG_0619|M.smegmatis_MC2_155 GFTPTLGNKSQVAAPASGVPAAASGVAASLASRRKRRRKKGAQIEERGYA
TH_3569|M.thermoresistible__bu --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK GFSPTVRDSTGAKAPAGTIPAAASGIAASAAERRKRRRRQKEEIKGRGYA
Mvan_0415|M.vanbaalenii_PYR-1 GFSPTVRDSTSAKAPASGIPAAASGVAASAAERRKRRRRQKDEIAGRAYA
MAB_4783|M.abscessus_ATCC_1997 GFGPTIGASTGATAHAPSSAVSAAAALACNPATGKSRRRRRRTIDDRGYR
Mb0939c|M.bovis_AF2122/97 TALNGMP-----AGLLSGMALASLAARGTTGGGG-TRSGTSTDGQEDGRK
Rv0915c|M.tuberculosis_H37Rv TALNGMP-----AGLLSGMALASLAARGTTGGGG-TRSGTSTDGQEDGRK
MMAR_2534|M.marinum_M TALNGMS-----AGLLGGAALAGWAARGTIGGG---RS-SATD------K
MUL_4463|M.ulcerans_Agy99 PDMGGVAP----TGLLSGMALASLAGRGATGAGSRSPSESATNEDEQPQR
MAV_2906|M.avium_104 PASGGAVFGEMAAASLAGRALAGAGVR-TVGNG---TTGAATAAAADGAA
MLBr_01182|M.leprae_Br4923 ESAPLLG---------GGLPMAPMVPGGGSGTGGVNTALRLQPRAFVMPR
MSMEG_0619|M.smegmatis_MC2_155 DAYMDYEE-PDEDPAPQPEPRVRASERGSDAMGFTGTVTRH-DVTAAGLT
TH_3569|M.thermoresistible__bu --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK DAYADYEELPDDGPPEQPAPRVTASTRGAGPMGFAGTVSRG-DEQAGGLT
Mvan_0415|M.vanbaalenii_PYR-1 DAYADYEPEPDDEPPVRQEPRIAATERGAGPMGFAGTVSRD-AAQAGGLT
MAB_4783|M.abscessus_ATCC_1997 HEYATMDDHTPTGP--QDPVTAVASGTGAGRLGFAGVHTATTAVEATGLS
Mb0939c|M.bovis_AF2122/97 PPVVVIREQPPPGNPPR---------------------------------
Rv0915c|M.tuberculosis_H37Rv PPVVVIREQPPPGNPPR---------------------------------
MMAR_2534|M.marinum_M NPHPVW--------------------------------------------
MUL_4463|M.ulcerans_Agy99 KPTVVVIQKPPPAGGPPAARP-----------------------------
MAV_2906|M.avium_104 TTATIIVVPAD---------------------------------------
MLBr_01182|M.leprae_Br4923 NPAAG---------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155 TLTGDTFDDRPVTPMLPGTWDGDENPAPSPDDPEGGPRR------
TH_3569|M.thermoresistible__bu ---------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK TLAGDSFGGGPREPMLPGTWDPDATDDRHTDGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 TLPGDPFGGGPKAPMLPGTWDPDTEPD------ERHNHHDGKDSQ
MAB_4783|M.abscessus_ATCC_1997 TLDGDAEN--RTIPMLPGTWDVTDDDR------------------
Mb0939c|M.bovis_AF2122/97 ---------------------------------------------
Rv0915c|M.tuberculosis_H37Rv ---------------------------------------------
MMAR_2534|M.marinum_M ---------------------------------------------
MUL_4463|M.ulcerans_Agy99 ---------------------------------------------
MAV_2906|M.avium_104 ---------------------------------------------
MLBr_01182|M.leprae_Br4923 ---------------------------------------------