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MDFGGLPDFGGIPPEVNSGLMYAGPGPGSMLTSATAWDGLAAAMSTAAASYGSVIAGLKLESWLGPAAAS MATAAAPYAGWLSAAAAQAQQTATQARAAAAAFEEAFAATVPPPLIAANRNQLVSLAAANTLGQNSPAIE AAQAEYAEMWAQDAAAMYSYAGASEAASMLTPFNQPSQTVDPAGPLTQAAAAAATNAQTALAQLLALSTS ADLPTSGLPGLTSSPTGPLPAAPIQIPTPIGELDAIGLYIAVIASGSIALSITNTFRPWNLTESSGHGGG LGPTHGGLLGSTTAESGADSDGGAGAAPMSAAVGHAALVGALSVPHNWTLAAPEIKLAVEALPSTSVSSG PPDLGGVPTGLLSGMAVASLAGRGIGATGTPSVRDAAPEEGEGQPKRRPTVVKVPKPPPADGLPPH
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_1449 | - | - | 100% (416) | PPE family protein |
| M. marinum M | MMAR_4612 | - | e-126 | 58.03% (417) | PPE family protein |
| M. marinum M | MMAR_2534 | - | e-118 | 57.75% (400) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0939c | PPE14 | 1e-123 | 58.69% (426) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 6e-31 | 27.83% (406) | PPE protein |
| M. tuberculosis H37Rv | Rv0915c | PPE14 | 1e-123 | 58.69% (426) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 1e-40 | 32.85% (414) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_4783 | - | 2e-28 | 27.34% (428) | PPE family protein |
| M. avium 104 | MAV_3356 | - | 5e-77 | 43.96% (389) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 2e-29 | 34.78% (207) | PPE family protein |
| M. thermoresistible (build 8) | TH_3569 | - | 5e-31 | 36.19% (210) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_4463 | - | 1e-124 | 57.79% (417) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 5e-32 | 37.20% (207) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0939c|M.bovis_AF2122/97 ----------MDFG------LLPPEVNSSRMYSGPGPESMLAAAAAWDGV
Rv0915c|M.tuberculosis_H37Rv ----------MDFG------LLPPEVNSSRMYSGPGPESMLAAAAAWDGV
MMAR_1449|M.marinum_M ----------MDFGGLPDFGGIPPEVNSGLMYAGPGPGSMLTSATAWDGL
MUL_4463|M.ulcerans_Agy99 -------MLATDFG------ALPPEVNSGLLYAGPGAAPMLTAATAWDGL
MAV_3356|M.avium_104 ----------MDFG------SLPPEINSGRIYSGPGSAPLLAAAAAWHGL
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSP---VWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSL
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSP---VWMALPPEVHSALLSSGPGPGSMLAAAATWQSL
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAP---IWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSL
TH_3569|M.thermoresistible__bu ---------MMTAP---IWMALPPEVHSALLSSGPGPGSLLAAASAWHAL
MAB_4783|M.abscessus_ATCC_1997 ----------MTAP---VWMAAPPEVHSALLSSGPGPGSLFAAADAWRSL
MLBr_01182|M.leprae_Br4923 ---------MFDFA------ALSPETNSTRMYLGPGSSPILTAAAAWVVL
.** :* : ***. .::::. :* :
Mb0939c|M.bovis_AF2122/97 AAELTSAAVSYGSVVSTLIVEPWMGPAAAAMAAAATPYVGWLAATAALAK
Rv0915c|M.tuberculosis_H37Rv AAELTSAAVSYGSVVSTLIVEPWMGPAAAAMAAAATPYVGWLAATAALAK
MMAR_1449|M.marinum_M AAAMSTAAASYGSVIAGLKLESWLGPAAASMATAAAPYAGWLSAAAAQAQ
MUL_4463|M.ulcerans_Agy99 ATVLNSAAASYASVVSGLTLESRMGPASASMAAAAAPYATWLAVANEQAR
MAV_3356|M.avium_104 AAEMHSAAASYGSAIAELR-TLWHGPSSTAMAAAAAPFIAWLDGTAVQAE
Mflv_0325|M.gilvum_PYR-GCK SAEYASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSA
Mvan_0415|M.vanbaalenii_PYR-1 SAEYAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGA
MSMEG_0619|M.smegmatis_MC2_155 SAEYAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSA
TH_3569|M.thermoresistible__bu SAEYASAAAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSA
MAB_4783|M.abscessus_ATCC_1997 STEYSSAANELTTTLGSVRAGVWDGASAEQYQTAHVPYLSWLHETSAVSA
MLBr_01182|M.leprae_Br4923 AKELTAAAQGLQSAVEALL-TTFEGESAAALAERVTPYEKWLTQNAASAE
: :** : : : * :: .*: ** .
Mb0939c|M.bovis_AF2122/97 ETATQARAAAEAFGTAFAMTVPPSLVAANRSRLMSLVAANILGQNSAAIA
Rv0915c|M.tuberculosis_H37Rv ETATQARAAAEAFGTAFAMTVPPSLVAANRSRLMSLVAANILGQNSAAIA
MMAR_1449|M.marinum_M QTATQARAAAAAFEEAFAATVPPPLIAANRNQLVSLAAANTLGQNSPAIE
MUL_4463|M.ulcerans_Agy99 QTAAQARAAATAFETAFAVVVPPPLIAANRSQVASLVVANVLGQNTPAIE
MAV_3356|M.avium_104 QTAAQATAAAAAYDSVFAATVPPPVIAANRALLASLIATNVLGQNTPAIA
Mflv_0325|M.gilvum_PYR-GCK ATAVQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIA
Mvan_0415|M.vanbaalenii_PYR-1 AAAAQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIA
MSMEG_0619|M.smegmatis_MC2_155 AAAVQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIA
TH_3569|M.thermoresistible__bu ATAGRHETAAAAYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIPIA
MAB_4783|M.abscessus_ATCC_1997 GVAAQTETAATAYSEALATMPTLGELAANHATHGALVATNFFGINTIPIA
MLBr_01182|M.leprae_Br4923 LTATQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIA
.* : .** *: .:: . : *: * :* :* *: .*
Mb0939c|M.bovis_AF2122/97 ATQAEYAEMWAQDAAVMYSYEGASAAASALPPFTPPVQGTGPAGPAAAAA
Rv0915c|M.tuberculosis_H37Rv ATQAEYAEMWAQDAAVMYSYEGASAAASALPPFTPPVQGTGPAGPAAAAA
MMAR_1449|M.marinum_M AAQAEYAEMWAQDAAAMYSYAGASEAASMLTPFNQPSQTVDPAGPLTQAA
MUL_4463|M.ulcerans_Agy99 TLQAEYAEMWAQDAAVMYQYSAASEAASTLAAFTSPVQSTDPSRAQASTA
MAV_3356|M.avium_104 ATEAHYAEMWAQDAAAMYAYAGASAVATRLTPFGAPPQTADANAAADQSA
Mflv_0325|M.gilvum_PYR-GCK LNEADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGR
Mvan_0415|M.vanbaalenii_PYR-1 MTEADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGR
MSMEG_0619|M.smegmatis_MC2_155 LNEADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGS
TH_3569|M.thermoresistible__bu LNEADYVRMWIQAATSMSTYQAVAGTAVMSAPASSPAPLLLAPGVSEAAD
MAB_4783|M.abscessus_ATCC_1997 VNEADYIRMWIQAATVMSTYQAVSESSVSAAPPTSPAPPVLSPDSGAAAR
MLBr_01182|M.leprae_Br4923 EKEAEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEV
:*.* .** * *: * * . : . .
Mb0939c|M.bovis_AF2122/97 ATQAAGAGAVADAQATLAQLPP--GILSDILSALAANADPLTSGLLGIAS
Rv0915c|M.tuberculosis_H37Rv ATQAAGAGAVADAQATLAQLPP--GILSDILSALAANADPLTSGLLGIAS
MMAR_1449|M.marinum_M AAAAT------NAQTALAQLL-----------ALSTSADLPTSGLPGLTS
MUL_4463|M.ulcerans_Agy99 AGAAAAG---TTAQTTASQPT----------TAATDTAQGLAAEVPTIPA
MAV_3356|M.avium_104 AAASALQS--STASSVESALS------------QAVSQVPVAAQVNATAV
Mflv_0325|M.gilvum_PYR-GCK AAADMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLR
Mvan_0415|M.vanbaalenii_PYR-1 AAADVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLR
MSMEG_0619|M.smegmatis_MC2_155 ASASVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGGQ-AILDFLK
TH_3569|M.thermoresistible__bu AMATTQQIGSQATAADSGTALNLSDLIANLLQYYQDYLDQLFGPIVDFLR
MAB_4783|M.abscessus_ATCC_1997 TAA-------QDATKPPPIVPDPNDPIEMLLKNSQHFL-GMYRALKGLIT
MLBr_01182|M.leprae_Br4923 VEEVVEEVVEEVVEAEQ----------------AISQAALDQAVNEGMEA
.
Mb0939c|M.bovis_AF2122/97 TLNPQVGSAQPIVIPTPIGELDVIALYIASIATGSIALAITNTARPWHIG
Rv0915c|M.tuberculosis_H37Rv TLNPQVGSAQPIVIPTPIGELDVIALYIASIATGSIALAITNTARPWHIG
MMAR_1449|M.marinum_M SPTGPLP-AAPIQIPTPIGELDAIGLYIAVIASGSIALSITNTFRPWNLT
MUL_4463|M.ulcerans_Agy99 GS--DLAAPAAISIPTPVGELDLLAAYIAVAATASLSLSAVNTARPWSYS
MAV_3356|M.avium_104 TAAAQLP----LSLTDITGILKTFNSVMGTISGPYTPLGVANLAKNWYQI
Mflv_0325|M.gilvum_PYR-GCK DPIGNTFALITDFLTNPVQALITWGPFLLAVVYQAVSWVGASILYPSLFL
Mvan_0415|M.vanbaalenii_PYR-1 DPLGNTIKLITDFLTNPAQALITWGPFLAAVAYQAVSWVGASILYPSLLL
MSMEG_0619|M.smegmatis_MC2_155 DPLGNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNLVGWPTWGMIFA
TH_3569|M.thermoresistible__bu DPIGNLFQLIDDFLTNPAGALVTWWPLLFAVAYQVFTNLVGWPTWAMILA
MAB_4783|M.abscessus_ATCC_1997 DPVGTIVRIIIDFSTNPAAAIVTWTPLFYVFAYAATFAVMGTPIYAAIMG
MLBr_01182|M.leprae_Br4923 TVVPQVDQQVNVDVATPQTAVPDSSSAAAPQLWGGFAQHLSPINDTLSMI
. :
Mb0939c|M.bovis_AF2122/97 -----LYGNA-GGLGP------TQGHPLSSATDEPEPHWGPFGGAAPVSA
Rv0915c|M.tuberculosis_H37Rv -----LYGNA-GGLGP------TQGHPLSSATDEPEPHWGPFGGAAPVSA
MMAR_1449|M.marinum_M E----SSGHG-GGLGP------THGGLLGSTTAESGADSDGGAGAAPMSA
MUL_4463|M.ulcerans_Agy99 TNNDHAQPNG-GGVAP------TQGNTLGTERPDAEVLVSAPN-VVPTSA
MAV_3356|M.avium_104 ALSIPSVGTGIQGIGPLLHPKALTGVLAPLLRSDLLTGSTALSSAGTVSA
Mflv_0325|M.gilvum_PYR-GCK LPLLATTLAIVAGVGQH----LLSLLNTP-PAEEAAEEPAPAQSAPSRPD
Mvan_0415|M.vanbaalenii_PYR-1 LPLVATTLAIVLGVGAY----LLENLPAP-AEDAPAEEPAASSPAPTRAD
MSMEG_0619|M.smegmatis_MC2_155 SPFLIPALAALGITGLV----LLIDHVLNNPVDVPAEDEAPQEVAAAPRT
TH_3569|M.thermoresistible__bu SPVLIPLAITLGVAGLV----MIADQAQP-----PAEEAAPEEDVAAP--
MAB_4783|M.abscessus_ATCC_1997 PAAGISIPLAITLASLS----QMPEAPPV---------DAPAETVPARID
MLBr_01182|M.leprae_Br4923 NNHAGMANAGLSLVNGMG----SAMKSLAPTTTKAAESAFKAMGSAVQST
Mb0939c|M.bovis_AF2122/97 GVGHAALVGALSVPHSWTTAAPEIQLAVQATPTFSSSAGADPTALNG-MP
Rv0915c|M.tuberculosis_H37Rv GVGHAALVGALSVPHSWTTAAPEIQLAVQATPTFSSSAGADPTALNG-MP
MMAR_1449|M.marinum_M AVGHAALVGALSVPHNWTLAAPEIKLAVEALPSTSVSSG--PPDLGG-VP
MUL_4463|M.ulcerans_Agy99 FVGHAALVGALSVPHSWAMAAPEIRLAVESLPSAGGLSAPAGPDMGGVAP
MAV_3356|M.avium_104 SAGRAGLVGALSVPANWASAVPAVRTVAAELPETMLDAAP-AMAVNG--Q
Mflv_0325|M.gilvum_PYR-GCK QQSFPATMSAPPPPSGAPIAANTVSAGSPPAPG---APAAAAATFVPYVV
Mvan_0415|M.vanbaalenii_PYR-1 QPSPAIAVSAPPPPSSAAATVGTVATGTAPAPG---APAAATASFVPYAV
MSMEG_0619|M.smegmatis_MC2_155 DQPLAVGISPAGVPGSAATAAAPAPAPAGTTVA---APAPAAATFVPYAV
TH_3569|M.thermoresistible__bu -----------------VRAEPQNPLPLTXXX------------------
MAB_4783|M.abscessus_ATCC_1997 QPHAVAMGGAPAPTASTAAPTPTTTSPATPGSAPAPTPPPAGAEGLGYAV
MLBr_01182|M.leprae_Br4923 GRGLLGSSSGGHVTAQLGRAASIGSLRVPQTWTTASQPVTAATRALSPAR
.
Mb0939c|M.bovis_AF2122/97 AGLLSGMALASLAAR--GTTGGGG-TRSGTSTDGQEDGRKPPVVVIREQP
Rv0915c|M.tuberculosis_H37Rv AGLLSGMALASLAAR--GTTGGGG-TRSGTSTDGQEDGRKPPVVVIREQP
MMAR_1449|M.marinum_M TGLLSGMAVASLAGRGIGATGTPS-VRDAAPEEGEGQPKRRPTVVKVPKP
MUL_4463|M.ulcerans_Agy99 TGLLSGMALASLAGR--GATGAGSRSPSESATNEDEQPQRKPTVVVIQKP
MAV_3356|M.avium_104 QGMFGPTALSSLAGRAVGGTATRAVAGSTVRVPGAVAVDDLATTSTVIVI
Mflv_0325|M.gilvum_PYR-GCK AGRDPYEGFSPTVRDSTGAKAPAGTIPAAASGIAASAAERRKRRRRQKEE
Mvan_0415|M.vanbaalenii_PYR-1 AGRDPGTGFSPTVRDSTSAKAPASGIPAAASGVAASAAERRKRRRRQKDE
MSMEG_0619|M.smegmatis_MC2_155 ANRDPGEGFTPTLGNKSQVAAPASGVPAAASGVAASLASRRKRRRKKGAQ
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_4783|M.abscessus_ATCC_1997 RGDGPGFGFGPTIGASTGATAHAPSSAVSAAAALACNPATGKSRRRRRRT
MLBr_01182|M.leprae_Br4923 VAVATESESAPLLGGGLPMAPMVPGGGSGTGGVNTALRLQPRAFVMPRNP
Mb0939c|M.bovis_AF2122/97 PPGN--PPR-----------------------------------------
Rv0915c|M.tuberculosis_H37Rv PPGN--PPR-----------------------------------------
MMAR_1449|M.marinum_M PPADGLPPH-----------------------------------------
MUL_4463|M.ulcerans_Agy99 PPAGGPPAARP---------------------------------------
MAV_3356|M.avium_104 PPNAK---------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK IKGRGYADAYADYEELPDDGPPEQPAPRVTASTRGAGPMGFAGTVSRG-D
Mvan_0415|M.vanbaalenii_PYR-1 IAGRAYADAYADYEPEPDDEPPVRQEPRIAATERGAGPMGFAGTVSRD-A
MSMEG_0619|M.smegmatis_MC2_155 IEERGYADAYMDYEE-PDEDPAPQPEPRVRASERGSDAMGFTGTVTRH-D
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_4783|M.abscessus_ATCC_1997 IDDRGYRHEYATMDDHTPTGP--QDPVTAVASGTGAGRLGFAGVHTATTA
MLBr_01182|M.leprae_Br4923 AAG-----------------------------------------------
Mb0939c|M.bovis_AF2122/97 --------------------------------------------------
Rv0915c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1449|M.marinum_M --------------------------------------------------
MUL_4463|M.ulcerans_Agy99 --------------------------------------------------
MAV_3356|M.avium_104 --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK EQAGGLTTLAGDSFGGGPREPMLPGTWDPDATDDRHTDGRDGHDGHDGKE
Mvan_0415|M.vanbaalenii_PYR-1 AQAGGLTTLPGDPFGGGPKAPMLPGTWDPDTEPD------ERHNHHDGKD
MSMEG_0619|M.smegmatis_MC2_155 VTAAGLTTLTGDTFDDRPVTPMLPGTWDGDENPA------PSPDDPEGGP
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_4783|M.abscessus_ATCC_1997 VEATGLSTLDGDAEN--RTIPMLPGTWDVTDDDR----------------
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
Mb0939c|M.bovis_AF2122/97 --
Rv0915c|M.tuberculosis_H37Rv --
MMAR_1449|M.marinum_M --
MUL_4463|M.ulcerans_Agy99 --
MAV_3356|M.avium_104 --
Mflv_0325|M.gilvum_PYR-GCK KP
Mvan_0415|M.vanbaalenii_PYR-1 SQ
MSMEG_0619|M.smegmatis_MC2_155 RR
TH_3569|M.thermoresistible__bu --
MAB_4783|M.abscessus_ATCC_1997 --
MLBr_01182|M.leprae_Br4923 --