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AIDYNQGHIAEQYQQAKAQPWRERIETYSFLEHIGDVSGKKVLDVACGEGHFTRLLRRAGAGQVVGLDIS ERMIALARAQEKQQPLGIDYVVADARSTVAQQDYDVVVSAWLLVYAQNRAELAQMCRGLACRVKPGGRFV TVNTNPGVYSFRPDYRKYGFELQLADHVCDGAPIDITVNLADSRLRVRNYYLPIEAYARAFRHAGFHDFA VHIPDLEPAPEAGEEGDYWDYLLDNPFLVIMDCVKD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4425 | - | - | 100% (247) | methylase |
| M. marinum M | MMAR_3525 | - | 2e-89 | 60.98% (246) | methylase |
| M. marinum M | MMAR_3636 | - | 5e-18 | 37.80% (127) | methylase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0302 | tam | 4e-08 | 34.38% (96) | trans-aconitate methyltransferase tam |
| M. gilvum PYR-GCK | Mflv_0316 | - | 3e-06 | 32.29% (96) | trans-aconitate 2-methyltransferase |
| M. tuberculosis H37Rv | Rv0294 | tam | 4e-08 | 34.38% (96) | trans-aconitate methyltransferase tam |
| M. leprae Br4923 | MLBr_00130 | - | 3e-06 | 28.89% (135) | hypothetical protein MLBr_00130 |
| M. abscessus ATCC 19977 | MAB_0240 | - | 6e-07 | 27.40% (219) | hypothetical protein MAB_0240 |
| M. avium 104 | MAV_4859 | - | 4e-08 | 33.33% (96) | trans-aconitate 2-methyltransferase |
| M. smegmatis MC2 155 | MSMEG_3286 | - | 7e-09 | 27.84% (176) | methyltransferase |
| M. thermoresistible (build 8) | TH_1636 | - | 4e-07 | 30.40% (125) | POSSIBLE METHYLTRANSFERASE (METHYLASE) |
| M. ulcerans Agy99 | MUL_2739 | - | 1e-88 | 60.57% (246) | methylase |
| M. vanbaalenii PYR-1 | Mvan_4690 | - | 2e-08 | 35.85% (106) | methyltransferase type 11 |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4425|M.marinum_M --------------------------------------------------
MUL_2739|M.ulcerans_Agy99 MNVGVHHRRCAIRHVTTFAAALVSVSGIAEIWGRPVSVGFQPLTSSEHRL
Mb0302|M.bovis_AF2122/97 --------------------------------------------------
Rv0294|M.tuberculosis_H37Rv --------------------------------------------------
MAV_4859|M.avium_104 --------------------------------------------------
Mflv_0316|M.gilvum_PYR-GCK --------------------------------------------------
MLBr_00130|M.leprae_Br4923 ----------------------------MAFTRIHSFLASAGNTSMYKRV
TH_1636|M.thermoresistible__bu ----------------------------VRESRDQVFRKLNEKLTQHG--
MSMEG_3286|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_4690|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_0240|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_4425|M.marinum_M -------------------MAIDYNQGHIAEQYQQAKAQPWRERIETYSF
MUL_2739|M.ulcerans_Agy99 DSNPGEERGRTQRTGRGDRMVTDYNQGEIAEQYKKTKAIPVRTRIEAYSF
Mb0302|M.bovis_AF2122/97 -----------------------MWDPDVYLAFSGHRNRPF------YEL
Rv0294|M.tuberculosis_H37Rv -----------------------MWDPDVYLAFSGHRNRPF------YEL
MAV_4859|M.avium_104 -----------------------MWDPDVYLAFADHRARPF------YDL
Mflv_0316|M.gilvum_PYR-GCK -----------------------MWNPAVYLTYADHRGRPY------YDL
MLBr_00130|M.leprae_Br4923 WRFWYPLMTHKLGTDEIMFINWAYEEDPPMALPLEASDEPNRAHINLYHR
TH_1636|M.thermoresistible__bu QKFIYSYASRRLDDDDVVFLNYGYEEDPPMGLPLSETDEPNRYSIQLYHR
MSMEG_3286|M.smegmatis_MC2_155 ------MPDTVGPQPQYETFADEFLDHARDGFYNAHYDRPA--------C
Mvan_4690|M.vanbaalenii_PYR-1 ---------MVDRANVAQVQAWNGDSGRAWVTLQHVLDRTLKPFEDLIVD
MAB_0240|M.abscessus_ATCC_1997 -----------MRPDGPGFFAELMYAVNAAPWDIGGPQPVIR-------Q
MMAR_4425|M.marinum_M LEHIGDVSGKKVLDVACGEGHFTRLLRRAGAG-QVVG-LDISERMIALAR
MUL_2739|M.ulcerans_Agy99 LKHIGAVTGEKVVDIACGAGDYTRVMRRAGAA-RVVG-FDISEKMIGLAR
Mb0302|M.bovis_AF2122/97 VSRVGLERARRVVDLGCGPGHLTRYLARRWPG-AVIEALDSSPEMVAAAA
Rv0294|M.tuberculosis_H37Rv VSRVGLERARRVVDLGCGPGHLTRYLARRWPG-AVIEALDSSPEMVAAAA
MAV_4859|M.avium_104 LSRVGAERARRVVDLGCGPGHLTKYLGRRWPD-AVIEAMDSSPEMVAAAK
Mflv_0316|M.gilvum_PYR-GCK LSRVDAREPRRIVDLGCGPGNLTRTLTQRWPG-AVVEAWDSSEEMVTAAR
MLBr_00130|M.leprae_Br4923 TATQVNLSGKRILEVSCGHGGGASYLTRALHP-ASYTGLDLNPAGIKLCQ
TH_1636|M.thermoresistible__bu TAGQADLTGKRVLEVGCGHGGGASYLMRTLGP-MSYVGLDLNPAGIEFCR
MSMEG_3286|M.smegmatis_MC2_155 LALIGDVAGRTILDAACGPGLYAEELAKRG---ASLIGFDQSPRMVELAR
Mvan_4690|M.vanbaalenii_PYR-1 SVAAAAGPREQILDLGCGTGATTLALAERLGAHGGCTGIDISEPMIHAAR
MAB_0240|M.abscessus_ATCC_1997 LVALGAVRG-EVLDPGCGTGWHAIEYARAGCS---VTGVDLAPTAIARAR
::: .** * : . * : .
MMAR_4425|M.marinum_M AQEKQQPLGIDYVVADARSTVAQQD-YDVVVSAWLLVYAQNRAELAQ---
MUL_2739|M.ulcerans_Agy99 EQEAHEPLGIEYFVADASQEVAQQD-FDLAISAYLLVYARDRDELAR---
Mb0302|M.bovis_AF2122/97 ER------GIDATTGDLRDWKPKPD-TDVVVSNAALHWVPEHSDLLVRWV
Rv0294|M.tuberculosis_H37Rv ER------GIDATTGDLRDWKPKPD-TDVVVSNAALHWVPEHSDLLVRWV
MAV_4859|M.avium_104 ER------GIDAVTGDLRNWKPKPD-TDVVVSNAALHWVPEHSDLLLRWA
Mflv_0316|M.gilvum_PYR-GCK ER------GVDARVGDVRDWAPLPD-TDVVVSNATLHWVPEHPDLLLRWA
MLBr_00130|M.leprae_Br4923 KRHQLP--GLEFVRGDAENLPFDNESFDVVINIEASHCYPHFPRFLA---
TH_1636|M.thermoresistible__bu KKHRLP--GLEFVVGDAQDLPFGAESFDAVINIESSHLYPRFSRFLS---
MSMEG_3286|M.smegmatis_MC2_155 ARVPSGDFRVHDLAG-PLDWLPSQS-VDAVLLALALEYVDDRTAMLR---
Mvan_4690|M.vanbaalenii_PYR-1 TRARDRNLPVEFVVGDAQSFPFQPNTFDVMVSRFGVMFFDDPTTAFR---
MAB_0240|M.abscessus_ATCC_1997 NNTRTAGVEAQFVLGDATTLDYEAR-FDTVVDSKLLDNLDSAEARGR---
. . . * :
MMAR_4425|M.marinum_M --MCRGLACRVKPGGRFVTVNTNPGVYSFR--PDYRKYGFELQLADHVCD
MUL_2739|M.ulcerans_Agy99 --ICRGVACRVRPGGRFVTLTTNPGLYTFGRVPDYRKYGFQIKLADAAFE
Mb0302|M.bovis_AF2122/97 DELAPGSWIAVQIPGNFETP-SHAAVRALARREPYAKLMRDIPFRVGAVV
Rv0294|M.tuberculosis_H37Rv DELAPGSWIAVQIPGNFETP-SHAAVRALARREPYAKLMRDIPFRVGAVV
MAV_4859|M.avium_104 GQLAPGSWIGVQMPGNFESP-SYAAVRALARREPYAKLLRDIPFRVGAVV
Mflv_0316|M.gilvum_PYR-GCK GQLRAGSWIAFQVPGNFDAP-SHRAVRDLVSSARWAHLLRDFPFEKSEVV
MLBr_00130|M.leprae_Br4923 -----EVVRVLRPGGHLAYA-------DLRPSNKVGEWEVDFANSRLQQL
TH_1636|M.thermoresistible__bu -----EVARVLRPGGHFLYA-------DARQPHEFAEWEAALAAAPLDMV
MSMEG_3286|M.smegmatis_MC2_155 -----EFHRVLRPAGALVLS-------RMHPTGDWLRHGGNYFETRVVEE
Mvan_4690|M.vanbaalenii_PYR-1 -----NLRRATRPGGRLTFVCWRDPTDNPFMSTAERAAAQLLSDLKPGIA
MAB_0240|M.abscessus_ATCC_1997 --YLRSLYRAMKPQGRLFLY-----GFSDGHVNGFHNHELDGIDYEMALT
: * :
MMAR_4425|M.marinum_M GAP---IDITVNLADSRLRVRNYYLP-------------------IEAYA
MUL_2739|M.ulcerans_Agy99 GAP---IELTAFVDGAPLVIENYYLP-------------------IAAYE
Mb0302|M.bovis_AF2122/97 QSP---AYYAELLMDTGCKVDVWETTYLHQLTGEHPVLDWITGSALVPVR
Rv0294|M.tuberculosis_H37Rv QSP---AYYAELLMDTGCKVDVWETTYLHQLTGEHPVLDWITGSALVPVR
MAV_4859|M.avium_104 QPP---THYANMLLDAGCKVDVWETTYLHQLTGEHPVLEWITGTALVPVR
Mflv_0316|M.gilvum_PYR-GCK RPA---AGYAELLTDAGCTVDAWETTYVHELTGEKPVLEWIGGTALRPVR
MLBr_00130|M.leprae_Br4923 SQR---EINAEVLRGIASNSQKSRDL-------------------VDRHL
TH_1636|M.thermoresistible__bu SAR---VINAEVVRGMEQILPVWEDV-------------------IERVA
MSMEG_3286|M.smegmatis_MC2_155 TWS---RGWNVRYWLAPLERTCSELR------------------DAGFLI
Mvan_4690|M.vanbaalenii_PYR-1 GSPGPFAFADAHRTHSILRAGGWTAVDIRPVDVTCTMQE----SDLLPYL
MAB_0240|M.abscessus_ATCC_1997 AAG----FTITYLGETTYRLS------------------------IPSYR
MMAR_4425|M.marinum_M RAFRHAG--FHDF-AVHIPDLEPAPEAGEEGDYWDYLLDNPFLVIMDCVK
MUL_2739|M.ulcerans_Agy99 AALRQAG--FHDF-VVHVPELAAAPQGEDEGDFWDDYLNYPPAIVIECVR
Mb0302|M.bovis_AF2122/97 ERLSDES--WQQFRQELIPLLNDAYPPRADG---STIFPFRRLFMVAEVG
Rv0294|M.tuberculosis_H37Rv ERLSDES--WQQFRQELIPLLNDAYPPRADG---STIFPFRRLFMVAEVG
MAV_4859|M.avium_104 ERLDDDA--WEQFREELIPLLRDAYPPRADG---TTIFPFRRVFIVAEVG
Mflv_0316|M.gilvum_PYR-GCK AALPDHD--WQEFRAELIPLLDAAYPRRADG---ITFFPFRRIFVVARVK
MLBr_00130|M.leprae_Br4923 PAFLRFA--GREFIGVQGTQLSRYLEGGELSYR---MYSFAKD-------
TH_1636|M.thermoresistible__bu PAFLRRR--VREFAPARRAWEELRTEG-STEYR---MYCFTKPPEHADIP
MSMEG_3286|M.smegmatis_MC2_155 EELREPR--PTEEAARRDPQAYQRLAQAPEGFMTIRAVPDFRLRRPAAGR
Mvan_4690|M.vanbaalenii_PYR-1 TQMGPVGRTLRAVDARTRAQVITSLREAYTEFIVDGEVRYPAACWMVDAR
MAB_0240|M.abscessus_ATCC_1997 RICTDCPDQVPPDGQIHIPMIEIHAVRNGLWQA-----------------
.
MMAR_4425|M.marinum_M D------
MUL_2739|M.ulcerans_Agy99 D------
Mb0302|M.bovis_AF2122/97 GARRSGG
Rv0294|M.tuberculosis_H37Rv GARRSGG
MAV_4859|M.avium_104 SGRPAA-
Mflv_0316|M.gilvum_PYR-GCK N------
MLBr_00130|M.leprae_Br4923 -------
TH_1636|M.thermoresistible__bu -------
MSMEG_3286|M.smegmatis_MC2_155 -------
Mvan_4690|M.vanbaalenii_PYR-1 G------
MAB_0240|M.abscessus_ATCC_1997 -------