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MHADRQELTREKYNNIATQYAAGMINMALYHDLCQKPVIMDALTEAAGKSLLDLACGDGFYTRQFRTLVK AGPVSGSDLSAELISLAVSQENQKPLGIDYRVDDILNLQESRTFNTVTAIHLLHYMPDPVRLETAMRNVY RLLEPGGRFVSFSFNPDFRIELHDKKDSEEKFGYYVSKAEEKNGGLVHFHPARVEGLVFEVYRWHKSCIE DIASVVGFTDIEWRSPFVAKAGLDEFGADFFENHINNPQGKLLILTR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_3636 | - | - | 100% (257) | methylase |
| M. marinum M | MMAR_3525 | - | 4e-18 | 31.07% (206) | methylase |
| M. marinum M | MMAR_4425 | - | 5e-18 | 37.80% (127) | methylase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3064c | - | 8e-09 | 35.92% (103) | hypothetical protein Mb3064c |
| M. gilvum PYR-GCK | Mflv_4269 | - | 4e-10 | 32.39% (142) | methyltransferase type 11 |
| M. tuberculosis H37Rv | Rv3038c | - | 8e-09 | 35.92% (103) | hypothetical protein Rv3038c |
| M. leprae Br4923 | MLBr_01723 | - | 4e-10 | 33.61% (119) | hypothetical protein MLBr_01723 |
| M. abscessus ATCC 19977 | MAB_3381c | - | 1e-09 | 35.00% (100) | hypothetical protein MAB_3381c |
| M. avium 104 | MAV_3903 | - | 2e-09 | 37.00% (100) | methyltransferase, UbiE/COQ5 family protein |
| M. smegmatis MC2 155 | MSMEG_2329 | - | 2e-09 | 37.00% (100) | methyltransferase, UbiE/COQ5 family protein |
| M. thermoresistible (build 8) | TH_2189 | - | 2e-09 | 30.94% (139) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_2739 | - | 5e-19 | 32.51% (203) | methylase |
| M. vanbaalenii PYR-1 | Mvan_2090 | - | 5e-10 | 32.39% (142) | methyltransferase type 11 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4269|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2090|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2329|M.smegmatis_MC2_155 --------------------------------------------------
TH_2189|M.thermoresistible__bu VIRRLMATALTALTTAVLAGCGDAGSWVEAKPAEGWSAQYGDAANSSYTS
MAV_3903|M.avium_104 --------------------------------------------------
Mb3064c|M.bovis_AF2122/97 --------------------------------------------------
Rv3038c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_3381c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_01723|M.leprae_Br4923 --------------------------------------------------
MMAR_3636|M.marinum_M --------------------------------------------------
MUL_2739|M.ulcerans_Agy99 --------------------------------------------------
Mflv_4269|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2090|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2329|M.smegmatis_MC2_155 --------------------------------------------------
TH_2189|M.thermoresistible__bu AAGAEALTLEWSRSVKGELAAQVAVGASGYLAVNAQTPAGCSLMVWEYAN
MAV_3903|M.avium_104 --------------------------------------------------
Mb3064c|M.bovis_AF2122/97 --------------------------------------------------
Rv3038c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_3381c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_01723|M.leprae_Br4923 --------------------------------------------------
MMAR_3636|M.marinum_M --------------------------------------------------
MUL_2739|M.ulcerans_Agy99 --------------------------------------------------
Mflv_4269|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2090|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2329|M.smegmatis_MC2_155 --------------------------------------------------
TH_2189|M.thermoresistible__bu SARQRWCTRLVQGGGRTSPLLDGFDNVYIGQPGAILSFPPTQWIRWRKPV
MAV_3903|M.avium_104 --------------------------------------------------
Mb3064c|M.bovis_AF2122/97 --------------------------------------------------
Rv3038c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_3381c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_01723|M.leprae_Br4923 --------------------------------------------------
MMAR_3636|M.marinum_M --------------------------------------------------
MUL_2739|M.ulcerans_Agy99 --------------------------------------------------
Mflv_4269|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2090|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2329|M.smegmatis_MC2_155 --------------------------------------------------
TH_2189|M.thermoresistible__bu IGMPTTPRILAPGELLVVTHLGQVLLFDAHRGTVTGTPLDLVAGVDPTDS
MAV_3903|M.avium_104 --------------------------------------------------
Mb3064c|M.bovis_AF2122/97 --------------------------------------------------
Rv3038c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_3381c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_01723|M.leprae_Br4923 --------------------------------------------------
MMAR_3636|M.marinum_M --------------------------------------------------
MUL_2739|M.ulcerans_Agy99 --------------------------------------------------
Mflv_4269|M.gilvum_PYR-GCK ------------------------------------------MTETKEPG
Mvan_2090|M.vanbaalenii_PYR-1 ------------------------------------------MTETKEPG
MSMEG_2329|M.smegmatis_MC2_155 ------------------------------------------MTEIR---
TH_2189|M.thermoresistible__bu ERGLADCAGARXXXCWPPPRPPSTVTPRARDAARHPTARLPAMTETTEPG
MAV_3903|M.avium_104 ------------------------------------------MTRST---
Mb3064c|M.bovis_AF2122/97 ------------------------------------------MTRSSN--
Rv3038c|M.tuberculosis_H37Rv ------------------------------------------MTRSSN--
MAB_3381c|M.abscessus_ATCC_199 ------------------------------------------MTEITG--
MLBr_01723|M.leprae_Br4923 ------------------------------------------MTRSTEIS
MMAR_3636|M.marinum_M --------------------------------------------------
MUL_2739|M.ulcerans_Agy99 -------------------------MNVGVHHRRCAIRHVTTFAAALVSV
Mflv_4269|M.gilvum_PYR-GCK AYPDVAVPAPT---------PHATKEQVEAALHDTKLAQVLYHDWEAETY
Mvan_2090|M.vanbaalenii_PYR-1 TYPDVAVPAPTPDVAVPAPTPRATKEQVEAAMHDTKLAQVLYHDWEAETY
MSMEG_2329|M.smegmatis_MC2_155 ---DAADPAPN---------PHATAEEVEAAMHDSKLAQVLYHDWEAETY
TH_2189|M.thermoresistible__bu IGSEGAGDLPAPN-------PHATAEQVEAAMRDSKLAQILYHDWEAESY
MAV_3903|M.avium_104 ------DAVPT---------PHATAEQVEAARHDSKLAQVLYHDWEAETY
Mb3064c|M.bovis_AF2122/97 ---IPADATPN---------PHATAEQVAAARHDSKLAQVLYHDWEAENY
Rv3038c|M.tuberculosis_H37Rv ---IPADATPN---------PHATAEQVAAARHDSKLAQVLYHDWEAENY
MAB_3381c|M.abscessus_ATCC_199 -----LDGQPT---------TKATAEQVAAAFEDNKLAQILYHDWEAETY
MLBr_01723|M.leprae_Br4923 -----ANAVPN---------PHATAEQVAAARKDSKLAQVLYHDWEAENY
MMAR_3636|M.marinum_M --------------------MHADRQELTREKYNNIATQYAAGMINMALY
MUL_2739|M.ulcerans_Agy99 SGIAEIWGRPVSVGFQPLTSSEHRLDSNPGEERGRTQRTGRGDRMVTDYN
. :. .
Mflv_4269|M.gilvum_PYR-GCK DDKWSISYDQRCVDYARGRFDAAVPEEVQRELPYDRALELGCGTGFFLLN
Mvan_2090|M.vanbaalenii_PYR-1 DEKWSISYDQRCVDYARGRFDAAVPEEVQRELPYDRALELGCGTGFFLLN
MSMEG_2329|M.smegmatis_MC2_155 DEKWSISYDQRCIDYARGRFDAIVPEDEQRKLPYDRALELGCGTGFFLLN
TH_2189|M.thermoresistible__bu DDKWSISYDQRCVDYARGRFDAIVPDHVQRELPYDNALELGCGTGFFLLN
MAV_3903|M.avium_104 DEKWSISYDQRCIDYARGRFDAIVPEHVLRELPYDRALELGCGTGFFLLN
Mb3064c|M.bovis_AF2122/97 DEKWSISYDQRCVDYARGRFDAIVPDEVIAQLPYDRALELGCGTGFFLLN
Rv3038c|M.tuberculosis_H37Rv DEKWSISYDQRCVDYARGRFDAIVPDEVIAQLPYDRALELGCGTGFFLLN
MAB_3381c|M.abscessus_ATCC_199 DEKWSISYDQRCIDYARGRFDAIVPVEDQRELPYDRALELGCGTGFFLLN
MLBr_01723|M.leprae_Br4923 DEKWSISYDQRCVDYVRHCFDAIVPDELFTELPYDCALELGCGTGFFLLN
MMAR_3636|M.marinum_M HDLCQKPVIMDALTEAAG----------------KSLLDLACGDGFYTRQ
MUL_2739|M.ulcerans_Agy99 QGEIAEQYKKTKAIPVRTRIEAYSFLKHIGAVTGEKVVDIACGAGDYTRV
. . . :::.** * :
Mflv_4269|M.gilvum_PYR-GCK LIQAGVARRGSVTDLSPGMVKVATRNGQSLGLDIDGRVADAEGIPYEDNT
Mvan_2090|M.vanbaalenii_PYR-1 LIQAGVARRGSVTDLSPGMVKVATRNGQSLGLDIDGRVADAEGIPYEDNT
MSMEG_2329|M.smegmatis_MC2_155 LIQSGVARRGSVTDLSPGMVKVATRNGQSLGLDIDGRVADAEGIPYEDDT
TH_2189|M.thermoresistible__bu LIQSGVARRGSVTDLSPGMVRVATRNGRSLGLDVDGRVADAEGIPYDDNT
MAV_3903|M.avium_104 LIQSGVARRGSVTDLSPGMVKVATRNGQSLGLDIDGRVADAEGIPYEDDT
Mb3064c|M.bovis_AF2122/97 LIQAGVARRGSVTDLSPGMVKVATRNGQALGLDIDGRVADAEGIPYDDDA
Rv3038c|M.tuberculosis_H37Rv LIQAGVARRGSVTDLSPGMVKVATRNGQALGLDIDGRVADAEGIPYDDDA
MAB_3381c|M.abscessus_ATCC_199 LMQAGVARRGSVTDLSPGMVKVATRTGQELGLDVDGRVADAERIPYDDNT
MLBr_01723|M.leprae_Br4923 LIQSGVARRGSVTDLSPGMVKIATRNGQSLGLDINGRVADAEGIPYDDNT
MMAR_3636|M.marinum_M FRTLVKAGPVSGSDLSAELISLAVSQENQKPLGIDYRVDDILNLQ-ESRT
MUL_2739|M.ulcerans_Agy99 MRRAGAAR-VVGFDISEKMIGLAREQEAHEPLGIEYFVADAS-QEVAQQD
: * *:* :: :* *.:: * * .
Mflv_4269|M.gilvum_PYR-GCK FDLVVGHAVLHHIPD---VELSLREVVRVLKPGGRFV-FAGEPTTVGNRY
Mvan_2090|M.vanbaalenii_PYR-1 FDLVVGHAVLHHIPD---VELSLREVVRVLKPGGRFV-FAGEPTTVGNRY
MSMEG_2329|M.smegmatis_MC2_155 FDLVVGHAVLHHIPD---VELSLREVVRILKPGGRFV-FAGEPTTVGNRY
TH_2189|M.thermoresistible__bu FDLVVGHAVLHHIPD---VELSLREVVRVLRPGGRFV-FAGEPTTVGNSY
MAV_3903|M.avium_104 FDLVVGHAVLHHIPD---VELSLREVIRVLRPGGRFV-FAGEPTSAGDVY
Mb3064c|M.bovis_AF2122/97 FDLVVGHAVLHHIPD---VELSLREVVRVLKPGGRFV-FAGEPTTVGDGY
Rv3038c|M.tuberculosis_H37Rv FDLVVGHAVLHHIPD---VELSLREVVRVLKPGGRFV-FAGEPTTVGDGY
MAB_3381c|M.abscessus_ATCC_199 FDLVVGHAVLHHIPD---VELSLREVLRVLKPGGRFV-FAGEPTTVGNLY
MLBr_01723|M.leprae_Br4923 FDLVVGHAVLHHIPD---VELSLREVLRVLKPGGRFV-FAGEPTDVGNRY
MMAR_3636|M.marinum_M FNTVTAIHLLHYMPDPVRLETAMRNVYRLLEPGGRFVSFSFNPDFRIELH
MUL_2739|M.ulcerans_Agy99 FDLAISAYLLVYARDRDELARICRGVACRVRPGGRFVTLTTNPGLYTFGR
*: . . :* : * : * * :.****** :: :*
Mflv_4269|M.gilvum_PYR-GCK ARELSTLTWHAATNIMKLPMLSDWRRPQAELDESSRAAALEAVVDLHTFD
Mvan_2090|M.vanbaalenii_PYR-1 ARELSTLTWHAATTLTKLPWLDGWRRPQAELDESSRAAALEAVVDLHTFD
MSMEG_2329|M.smegmatis_MC2_155 ARELSTLTWHATTNLTKLPFLSGWRRPQEELDESSRAAALEAVVDLHTFD
TH_2189|M.thermoresistible__bu ARALSTLTWHVATTVTRLPGLQGWRRPQAELDESSRAAALEAVVDLHTFE
MAV_3903|M.avium_104 ARELSTLTWRIATNVTKLPGLGSWRRPQAELDESSRAAALEAIVDLHTFT
Mb3064c|M.bovis_AF2122/97 ARTLSTLTWRVVTNATKLPGLRGWRRPQGELDESSRAAALEALVDLHTFT
Rv3038c|M.tuberculosis_H37Rv ARTLSTLTWRVVTNATKLPGLRGWRRPQGELDESSRAAALEALVDLHTFT
MAB_3381c|M.abscessus_ATCC_199 ARALADLTWKATVQAMKLPGLESWRRPQEELDENSRAAALEWVVDLHTFD
MLBr_01723|M.leprae_Br4923 ARVFADLTWKVTIRVVQLPGLSAWRRTQVEIDENSRAAALEWVVDLHTFE
MMAR_3636|M.marinum_M DKKDSEEKFGYYVSKAEE--------KNGGLVHFHPARVEGLVFEVYRWH
MUL_2739|M.ulcerans_Agy99 VPDYRKYGFQIKLADAAFEG--------APIELTAFVDGAPLVIENYYLP
: : . :.: :
Mflv_4269|M.gilvum_PYR-GCK PADLERMAANAGAVEVRTASEEFTAAMLGWPVRTFEAAVPPGRLGWGWAK
Mvan_2090|M.vanbaalenii_PYR-1 PADLERMAVNAGAVEVRTASEEFTAAMLGWPIRTFEAAVPPGRLGWGWAK
MSMEG_2329|M.smegmatis_MC2_155 PADLERMATNAGAVEVRTASEEFTAAMLGWPVRTFEAAVPPGRLGWGWAK
TH_2189|M.thermoresistible__bu PSDLERMARNAGAVEVATASEEFTAAMLGWPVRTFEAAVPPGKLGWNWAK
MAV_3903|M.avium_104 PGDLERMAANAGATEVRTVSEEFTAAMFGWPVRTFEASVPPGRLGWGWAK
Mb3064c|M.bovis_AF2122/97 PQDLQRIAHNAGAVEVQTATEEFTAAMLGWPLRTFECTVPPGRLGWGWAR
Rv3038c|M.tuberculosis_H37Rv PQDLQRIAHNAGAVEVQTATEEFTAAMLGWPLRTFECTVPPGRLGWGWAR
MAB_3381c|M.abscessus_ATCC_199 PADLEKMAANAGAVAVRTASEEFTAAMLGWPVRTFESTVPPGKLGWGWAK
MLBr_01723|M.leprae_Br4923 PKVLETMATNAGAVQVKTVTEEFTAAMLGWPLRTFESTMPPSKLGWGWAR
MMAR_3636|M.marinum_M KSCIEDIASVVGFTDIEWR-------------------------------
MUL_2739|M.ulcerans_Agy99 IAAYEAALRQAGFHDFVVH-------------------------------
: .* .
Mflv_4269|M.gilvum_PYR-GCK FAFGSWTTLSWVDANVWRRIVPKGWFYNVMVTGVKPS
Mvan_2090|M.vanbaalenii_PYR-1 FAFGSWTTLSWVDANIWRRVVPKGWFYNVMVTGVKPS
MSMEG_2329|M.smegmatis_MC2_155 FAFNSWTTLSWVDANVWRKVVPKGWFYNVMVTGVKPS
TH_2189|M.thermoresistible__bu FAFGSWTALSWVDANVWRRVMPKGWFYNVMVTGVKPS
MAV_3903|M.avium_104 FAFNGWKTLSWVDANIWRRVVPKGWFYNVMVTGVKPT
Mb3064c|M.bovis_AF2122/97 FAFTSWKTLGWVDANVWRHVVPKGWFYNVMITGVKPS
Rv3038c|M.tuberculosis_H37Rv FAFTSWKTLGWVDANVWRHVVPKGWFYNVMITGVKPS
MAB_3381c|M.abscessus_ATCC_199 FAFNGWKALSWVDENVWRHVVPKGWYYNVMITGIKPS
MLBr_01723|M.leprae_Br4923 FAFTSWKTLSWVDANVWRRVIPKSWFYNIIITGVKPS
MMAR_3636|M.marinum_M SPFVAKAGLDEFGADFFENHINNPQGKLLILTR----
MUL_2739|M.ulcerans_Agy99 VPELAAAPQGEDEGDFWDDYLNYPPAIVIECVRD---
. . . :.: : : .