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VTDYNQGEIAERYKKTKAIPVRTRIEAYSFLKHIGDVTGEKVVDIACGAGDYARVMRRAGAARVVGFDIS EKMIGLAREQEAHEPLGIEYFVADASQEVAQQDYDLAISAYLLVYARDRDELARMCRGVACRVRPGGRFV TLTTNPGLYTFGRVPDYRKYGFQIKLADAAFEGAPIELTAFVDGAPLVIENYYLPIAAYEAALRQAGFHD FVVHVPELAAAPQGEDEGDFWDDYLNYPPAIVIECVRD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_3525 | - | - | 100% (249) | methylase |
| M. marinum M | MMAR_4425 | - | 2e-89 | 60.98% (246) | methylase |
| M. marinum M | MMAR_3636 | - | 4e-18 | 31.07% (206) | methylase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1440c | - | 2e-06 | 29.81% (104) | putative methyltransferase |
| M. gilvum PYR-GCK | Mflv_2768 | - | 2e-05 | 31.13% (106) | methyltransferase type 11 |
| M. tuberculosis H37Rv | Rv1405c | - | 2e-06 | 29.81% (104) | putative methyltransferase |
| M. leprae Br4923 | MLBr_00551 | - | 6e-05 | 27.66% (94) | putative methyltransferase |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. avium 104 | MAV_3373 | - | 4e-07 | 31.40% (121) | methyltransferase, UbiE/COQ5 family protein |
| M. smegmatis MC2 155 | MSMEG_3286 | - | 1e-09 | 29.15% (199) | methyltransferase |
| M. thermoresistible (build 8) | TH_1636 | - | 5e-07 | 28.92% (166) | POSSIBLE METHYLTRANSFERASE (METHYLASE) |
| M. ulcerans Agy99 | MUL_2739 | - | 1e-141 | 97.99% (249) | methylase |
| M. vanbaalenii PYR-1 | Mvan_2287 | - | 4e-06 | 29.66% (118) | methyltransferase type 11 |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3525|M.marinum_M --------------------------------------------------
MUL_2739|M.ulcerans_Agy99 MNVGVHHRRCAIRHVTTFAAALVSVSGIAEIWGRPVSVGFQPLTSSEHRL
Mb1440c|M.bovis_AF2122/97 --------------------------------------------------
Rv1405c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00551|M.leprae_Br4923 --------------------------------------------------
MAV_3373|M.avium_104 --------------------------------------------------
Mvan_2287|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3286|M.smegmatis_MC2_155 --------------------------------------------------
TH_1636|M.thermoresistible__bu --------------------------------VRESRDQVFRKLNEKLTQ
Mflv_2768|M.gilvum_PYR-GCK ----------------------MTTLAENSAPSSETTEEFAQRIVGALDA
MMAR_3525|M.marinum_M -------------------MVTDYNQGEIAERYKKTKAIPVRTRIEAYSF
MUL_2739|M.ulcerans_Agy99 DSNPGEERGRTQRTGRGDRMVTDYNQGEIAEQYKKTKAIPVRTRIEAYSF
Mb1440c|M.bovis_AF2122/97 --------MTIDTPAREDQTLAATHRAMWALGDYALMAEEVMAPLGP-IL
Rv1405c|M.tuberculosis_H37Rv --------MTIDTPAREDQTLAATHRAMWALGDYALMAEEVMAPLGP-IL
MLBr_00551|M.leprae_Br4923 --------MNLYTPIHEDQSLAAIHRAMWALGDYALMAEEVMAPLGP-IL
MAV_3373|M.avium_104 --------MTLDTTT-ADASVAARHRTVWALGDYALMAEEVMAPLGP-TL
Mvan_2287|M.vanbaalenii_PYR-1 ----MSTTATSASAHDADRQLKAKHRALWASGDYPAVAAELIAELGP-EL
MSMEG_3286|M.smegmatis_MC2_155 --------------MPDTVGPQPQYETFADEFLDHARDGFYNAHYDRPAC
TH_1636|M.thermoresistible__bu HGQKFIYSYASRRLDDDDVVFLNYGYEEDPPMGLPLSETDEPNRYSIQLY
Mflv_2768|M.gilvum_PYR-GCK ASLALLVSIGHQTHLFDTMANLPPSTSTQIADAAGLNERYVREWLGGVAA
MMAR_3525|M.marinum_M LKHIG--DVTGEKVVDIACGAGD-YARVMRRAGAARVVGFDISEKMIGLA
MUL_2739|M.ulcerans_Agy99 LKHIG--AVTGEKVVDIACGAGD-YTRVMRRAGAARVVGFDISEKMIGLA
Mb1440c|M.bovis_AF2122/97 VAAAG--IGPGVRVLDVAAGSGN-ISLPAAKTGAT-VISTDLTPELLQRS
Rv1405c|M.tuberculosis_H37Rv VAAAG--IGPGVRVLDVAAGSGN-ISLPAAKTGAT-VISTDLTPELLQRS
MLBr_00551|M.leprae_Br4923 VTATG--IRPGMQVLDVAAGSGN-ISLPAAKTGAT-IVSTDLTPELLQRS
MAV_3373|M.avium_104 VEAAG--IGPGVRVLDVAAGSGN-ITLPAAAAGAS-VVSTDLTPELLQRS
Mvan_2287|M.vanbaalenii_PYR-1 VRACG--IQAGDRVLDVAAGSGN-AAIPAAEVGAI-VTASDLTPELFGAG
MSMEG_3286|M.smegmatis_MC2_155 LALIG--DVAGRTILDAACGPGL-YAEELAKRGAS-LIGFDQSPRMVELA
TH_1636|M.thermoresistible__bu HRTAGQADLTGKRVLEVGCGHGGGASYLMRTLGPMSYVGLDLNPAGIEFC
Mflv_2768|M.gilvum_PYR-GCK GRIVD--YDPAAQTFSLPAHRAAVLTRTAGPDNLARVTQFIPLLSEVEQK
. .. .. . . : . .
MMAR_3525|M.marinum_M REQEAHEPLGIEYFVADAS-QEVAQQDYDLAISAYLLVYARDR----DEL
MUL_2739|M.ulcerans_Agy99 REQEAHEPLGIEYFVADAS-QEVAQQDFDLAISAYLLVYARDR----DEL
Mb1440c|M.bovis_AF2122/97 QARAAQQGLTLQYQEANAQALPFADDEFDTVISAIGVMFAPDHQAAADEL
Rv1405c|M.tuberculosis_H37Rv QARAAQQGLTLQYQEANAQALPFADDEFDTVISAIGVMFAPDHQAAADEL
MLBr_00551|M.leprae_Br4923 QARATELGLTLEYREADAQALPFGDGEFDVVMSAIGVMFAPDHRRAASEL
MAV_3373|M.avium_104 RDRAAGMGLTIDYREANAQALPFGDGEFDAVVSAIGVQFAPDHQRAADEL
Mvan_2287|M.vanbaalenii_PYR-1 RRIAAERGVDLEWVEADAESLPFADGSFDVVMSCVGAMFAPHHQATADEL
MSMEG_3286|M.smegmatis_MC2_155 RARVPSGDFRVHDLAGPLDWLPSQ--SVDAVLLALALEYVDDRTAMLREF
TH_1636|M.thermoresistible__bu RKKHRLP--GLEFVVGDAQDLPFGAESFDAVINIESSHLYPRFSRFLSEV
Mflv_2768|M.gilvum_PYR-GCK VIACFRDGGGLSYAEYPRFHTLMAEQSGEVFDAALVDGILPMAEGLTDRL
: . : ..
MMAR_3525|M.marinum_M ARMCRGVAC------------RVRPGGRFVTLTTNPGLYTFGRVPDYRKY
MUL_2739|M.ulcerans_Agy99 ARICRGVAC------------RVRPGGRFVTLTTNPGLYTFGRVPDYRKY
Mb1440c|M.bovis_AF2122/97 VRVCR-------------------PGGTIGVISWTCEGFFGRMLATIRPY
Rv1405c|M.tuberculosis_H37Rv VRVCR-------------------PGGTIGVISWTCEGFFGRMLATIRPY
MLBr_00551|M.leprae_Br4923 VRVCR-------------------PNGTIGVISWTQEGFFGRMLATIRPY
MAV_3373|M.avium_104 VRVCR-------------------PGGRIGLISWTPEGFFGRMLATIRPY
Mvan_2287|M.vanbaalenii_PYR-1 IRVCR-------------------PGGTIGMVNWTPGGFIGNLFATMKPY
MSMEG_3286|M.smegmatis_MC2_155 HRVLR-------------------PAGALVLSRMHPTG-------DWLRH
TH_1636|M.thermoresistible__bu ARVLR-------------------PGGHFLYADARQPHEFAEWEAALAAA
Mflv_2768|M.gilvum_PYR-GCK RQGVDVADFGCGSGHAVNVMAKAFPASRFTGIDFSEEGLAAGRDEARRLG
: * . :
MMAR_3525|M.marinum_M G--FQIKLADAAFEGAPI--ELTAFVDG--APLVIENYY-----------
MUL_2739|M.ulcerans_Agy99 G--FQIKLADAAFEGAPI--ELTAFVDG--APLVIENYY-----------
Mb1440c|M.bovis_AF2122/97 RPSVSADLPPSALWGREA--YVTGLLGDGVTGLKTARGL-----------
Rv1405c|M.tuberculosis_H37Rv RPSVSADLPPSALWGREA--YVTGLLGDGVTGLKTARGL-----------
MLBr_00551|M.leprae_Br4923 RPSLSAALPPAALWGREA--YIRGLLDDTVTNVKTERRQ-----------
MAV_3373|M.avium_104 RPSLSHPVPPAALWGRPG--YVRALLGERIGEITTARGM-----------
Mvan_2287|M.vanbaalenii_PYR-1 APPPPPGANPPPLWGDTD--HVTTLFGDRVGDLTTRRQT-----------
MSMEG_3286|M.smegmatis_MC2_155 GGNYFETRVVEETWSRGW--NVRYWLAPLERTCSELRDAG----------
TH_1636|M.thermoresistible__bu PLDMVSARVINAEVVRGM--EQILPVWEDVIERVAPAFLR----------
Mflv_2768|M.gilvum_PYR-GCK LTNASFNATDVATYDAAESFDVITAFDAIHDQAHPARVLANIHAALRPGG
.
MMAR_3525|M.marinum_M -LPIAAYEAALRQAGFHDFVVHVPELAAAPQGED-------EGDFWDDYL
MUL_2739|M.ulcerans_Agy99 -LPIAAYEAALRQAGFHDFVVHVPELAAAPQGED-------EGDFWDDYL
Mb1440c|M.bovis_AF2122/97 -LEVKRFDTAQAVHDYFKNNYGPTIEAYAHIGDNAVLAAELDRQLVELAA
Rv1405c|M.tuberculosis_H37Rv -LEVKRFDTAQAVHDYFKNNYGPTIEAYAHIGDNAVLAAELDRQLVELAA
MLBr_00551|M.leprae_Br4923 -LEVKRFNSAEGVHNYFKNHYGPTIEAYTNIGDNSVLAAELDAQLTELAQ
MAV_3373|M.avium_104 -LPVNRFGSAEDVHAYFKQHYGPTIEAYANIGHNRVLAAELDAQLVELAA
Mvan_2287|M.vanbaalenii_PYR-1 -VRMDHCADPAGFREYWKRNYGPTIAAYRFNAGHADRIGALDRDFLALLT
MSMEG_3286|M.smegmatis_MC2_155 -FLIEELREPRPTEEAARRDPQAYQRLAQAPEGFMTIRAVPDFRLRRPAA
TH_1636|M.thermoresistible__bu -RRVREFAPARRAWEELRTEGSTEYRMYCFTKPP---------EHADIP-
Mflv_2768|M.gilvum_PYR-GCK TFLMVDIKSSSRLENNIGVPFAPYLYTVSAMHCMSVSLGLDGDGLGTCWG
: .
MMAR_3525|M.marinum_M NYP-----------PAIVIECVRD----------
MUL_2739|M.ulcerans_Agy99 NYP-----------PAIVIECVRD----------
Mb1440c|M.bovis_AF2122/97 QY----LSDGVMEWEYLLLTAEKR----------
Rv1405c|M.tuberculosis_H37Rv QY----LSDGVMEWEYLLLTAEKR----------
MLBr_00551|M.leprae_Br4923 KY----LTNSTMGWEYLLLTAQKH----------
MAV_3373|M.avium_104 QH----LSDGTMGWEYLLVTAEKRSG--------
Mvan_2287|M.vanbaalenii_PYR-1 EWNRGDETNAFWEAEYLLVTMTRL----------
MSMEG_3286|M.smegmatis_MC2_155 GR--------------------------------
TH_1636|M.thermoresistible__bu ----------------------------------
Mflv_2768|M.gilvum_PYR-GCK REVATTMLADAGFGDVQVREIESDPINYYYIARK