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LDFGAYPPEYNSGRMYVGAGSGPLLAAAAAWDELAAELQSVGASYGSTVETLTTGPWTGPSSIAMAAAAA PYVAWLQATGAQAEQAGAQAKLAAAAYETAFAATVPPPVIAANRALLATLVATNILGQNTPAIAATEAHY MEMWAQDAAAMYAYAASSASAAQLTPFTEPPRTTNESAGPLQSAAVAQSAAQSGSNTAAHLSQLSATAQP AAQAAGNAASTTAASTQLTTPSFITNWNEFWSVVTGVYSPQSWTTIPGGPFLSFGQAYAWGQNGQGAAAY LAGPKAISGALAPLASGGNAVKPMLSSAVGAGQVSGSMGKAALVGSMSVPQGWTEAAPAIRTLAQVLPGN MAAAPAAMAGEEGVFSQMALSSLAGRAVAAAATRPVGGAASAASSLGGVAAEADPAAATIIVIPCIEE*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2910 | - | - | 100% (419) | PPE family protein |
| M. avium 104 | MAV_2906 | - | e-117 | 58.12% (425) | PPE family protein |
| M. avium 104 | MAV_3356 | - | e-100 | 51.18% (422) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1837 | PPE32 | 1e-120 | 58.47% (419) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 2e-31 | 30.25% (433) | PPE protein |
| M. tuberculosis H37Rv | Rv1808 | PPE32 | 1e-120 | 58.10% (420) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 9e-48 | 34.77% (417) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_4783 | - | 2e-28 | 28.81% (413) | PPE family protein |
| M. marinum M | MMAR_2684 | - | 1e-139 | 62.33% (430) | PPE family protein, PPE32 |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 3e-31 | 30.68% (427) | PPE family protein |
| M. thermoresistible (build 8) | TH_3569 | - | 2e-31 | 37.50% (208) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_3072 | - | 1e-139 | 62.09% (430) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 3e-34 | 32.25% (431) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
TH_3569|M.thermoresistible__bu ---------MMTAPIWMALPPEVHSALLSSGPGPGSLLAAASAWHALSAE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MAB_4783|M.abscessus_ATCC_1997 ----------MTAPVWMAAPPEVHSALLSSGPGPGSLFAAADAWRSLSTE
MMAR_2684|M.marinum_M ------------MIDFGALPPEINSGRMYVGPGAAPLIAAAAAWDELAAE
MUL_3072|M.ulcerans_Agy99 ------------MIDFGALPPEINSGRMYVGPGAAPLIAAAAAWDELAAE
MAV_2910|M.avium_104 ------------MLDFGAYPPEYNSGRMYVGAGSGPLLAAAAAWDELAAE
Mb1837|M.bovis_AF2122/97 -------------MDFGALPPEINSGRMYAGPGSGPLLAAAAAWDALAAE
Rv1808|M.tuberculosis_H37Rv -------------MDFGALPPEINSGRMYAGPGSGPLLAAAAAWDALAAE
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
: * .** :* : *.*...:::*. :* *: *
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
TH_3569|M.thermoresistible__bu YASAAAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSAATA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MAB_4783|M.abscessus_ATCC_1997 YSSAANELTTTLGSVRAGVWDGASAEQYQTAHVPYLSWLHETSAVSAGVA
MMAR_2684|M.marinum_M LQSMAASYGSTVQGLTVAPWTGASSITMAAAAAPYVTWINTTGVQAEQAA
MUL_3072|M.ulcerans_Agy99 LQSMAASYGSTVQGLTVAPWTGASSITMAAAAAPYVTWINTTGVQAEQAA
MAV_2910|M.avium_104 LQSVGASYGSTVETLTTGPWTGPSSIAMAAAAAPYVAWLQATGAQAEQAG
Mb1837|M.bovis_AF2122/97 LYSAAASYGSTIEGLTVAPWMGPSSITMAAAVAPYVAWISVTAGQAEQAG
Rv1808|M.tuberculosis_H37Rv LYSAAASYGSTIEGLTVAPWMGPSSITMAAAVAPYVAWISVTAGQAEQAG
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLT-TFEGESAAALAERVTPYEKWLTQNAASAELTA
: . : : : : * *: .** *: . . ..
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
TH_3569|M.thermoresistible__bu GRHETAAAAYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIPIALNE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MAB_4783|M.abscessus_ATCC_1997 AQTETAATAYSEALATMPTLGELAANHATHGALVATNFFGINTIPIAVNE
MMAR_2684|M.marinum_M TQAKLAAGAYETAFAATVPPPVIAANRALLMALIATNIFGQNTPAIAAAE
MUL_3072|M.ulcerans_Agy99 TQAKLAAGAYETASAATVPPPVIAANRALLMALIATNIFGQNTPAIAAAE
MAV_2910|M.avium_104 AQAKLAAAAYETAFAATVPPPVIAANRALLATLVATNILGQNTPAIAATE
Mb1837|M.bovis_AF2122/97 AQAKIAAGVYETAFAATVPPPVIEANRALLMSLVATNIFGQNTPAIAATE
Rv1808|M.tuberculosis_H37Rv AQAKIAAGVYETAFAATVPPPVIEANRALLMSLVATNIFGQNTPAIAATE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
: ** .* * : . : *:: *: :*::* *: .** *
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA
TH_3569|M.thermoresistible__bu ADYVRMWIQAATSMSTYQAVAGTAVMSAPASSPAPLLLAPGVSEAADAMA
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA
MAB_4783|M.abscessus_ATCC_1997 ADYIRMWIQAATVMSTYQAVSESSVSAAPPTSPAPPVLSPDSGAAARTAA
MMAR_2684|M.marinum_M AQYLEMWAQDAAAMYAYAGTAAAASALTPFTEPP---------QTTNPVA
MUL_3072|M.ulcerans_Agy99 AQYLEMWAQDAAAMYAYAGTAAAASALTPFTEPP---------QTTNPVA
MAV_2910|M.avium_104 AHYMEMWAQDAAAMYAYAASSASAAQLTPFTEPP---------RTTNESA
Mb1837|M.bovis_AF2122/97 AHYAEMWAQDAAAMYGYAGSSATASQLAPFSEPP---------QTTNPSA
Rv1808|M.tuberculosis_H37Rv AHYAEMWAQDAAAMYGYAGSSATASQLAPFSEPP---------QTTNPSA
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPP------LGVNEVGLA
*.* .** * *: * * . : : .. *
MSMEG_0619|M.smegmatis_MC2_155 SVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGGQ-AILDFLKDPL
TH_3569|M.thermoresistible__bu TTQQIGSQATAADSGTALNLSDLIANLLQYYQDYLDQLFGPIVDFLRDPI
Mflv_0325|M.gilvum_PYR-GCK DMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLRDPI
Mvan_0415|M.vanbaalenii_PYR-1 DVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLRDPL
MAB_4783|M.abscessus_ATCC_1997 -------QDATKPPPIVPDPNDPIEMLLKNSQHFL-GMYRALKGLITDPV
MMAR_2684|M.marinum_M GAAQSAAVAQASSTAASSDVVSQLAGLITSVPNALQTLATTSAAPTAASI
MUL_3072|M.ulcerans_Agy99 GAAQSAAVAQASSTAASSDVVSQLAGLITSVPNALQTLATTSAAPTAASI
MAV_2910|M.avium_104 GPLQSAAVAQSAAQSGS-NTAAHLSQLSATAQPAAQAAGNAASTTAASTQ
Mb1837|M.bovis_AF2122/97 TAAQSAVVAQAAGAAASSDITAQLSQLISLLPSTLQSLATTATATSASAG
Rv1808|M.tuberculosis_H37Rv TAAQSAVVAQAAGAAASSDITAQLSQLISLLPSTLQSLATTATATSASAG
MLBr_01182|M.leprae_Br4923 QEVVEEVVEEVVEEVVEAEQAISQAALDQAVNEGMEATVVPQVDQQVNVD
: : .
MSMEG_0619|M.smegmatis_MC2_155 GNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNLVGWPTWGMIFASPF
TH_3569|M.thermoresistible__bu GNLFQLIDDFLTNPAGALVTWWPLLFAVAYQVFTNLVGWPTWAMILASPV
Mflv_0325|M.gilvum_PYR-GCK GNTFALITDFLTNPVQALITWGPFLLAVVYQAVSWVGASILYPSLFLLPL
Mvan_0415|M.vanbaalenii_PYR-1 GNTIKLITDFLTNPAQALITWGPFLAAVAYQAVSWVGASILYPSLLLLPL
MAB_4783|M.abscessus_ATCC_1997 GTIVRIIIDFSTNPAAAIVTWTPLFYVFAYAATFAVMGTPIYAAIMGPAA
MMAR_2684|M.marinum_M LPEVSLPPWLATNLANWNTIMATLTGPFSLQGISSIPGGPFLSFGQVYAY
MUL_3072|M.ulcerans_Agy99 LPEVSLPPWLATNLANWNTIMATLTGPFSLQGISSIPGGPFLSFGQVYAY
MAV_2910|M.avium_104 LTTPSF-------ITNWNEFWSVVTGVYSPQSWTTIPGGPFLSFGQAYAW
Mb1837|M.bovis_AF2122/97 WDTVLQ---------SITTILANLTGPYSIIGLGAIPGGWWLTFGQILGL
Rv1808|M.tuberculosis_H37Rv WDTVLQ---------SITTILANLTGPYSIIGLGAIPGGWWLTFGQILGL
MLBr_01182|M.leprae_Br4923 VATPQTAVP-DSSSAAAPQLWGGFAQHLSPINDTLSMINNHAGMANAGLS
.
MSMEG_0619|M.smegmatis_MC2_155 LIPALAALGITGLVLLIDHVLNNPVDVPAEDEAPQEVAAAPRTDQPLAVG
TH_3569|M.thermoresistible__bu LIPLAITLGVAGLVMIADQAQP-----PAEEAAPEEDVAAP---------
Mflv_0325|M.gilvum_PYR-GCK LATTLAIVAGVGQHLLSLLNTP-PAEEAAEEPAPAQSAPSRPDQQSFPAT
Mvan_0415|M.vanbaalenii_PYR-1 VATTLAIVLGVGAYLLENLPAP-AEDAPAEEPAASSPAPTRADQPSPAIA
MAB_4783|M.abscessus_ATCC_1997 GISIPLAITLASLSQMPEAPPV---------DAPAETVPARIDQPHAVAM
MMAR_2684|M.marinum_M VQNAQGLNAFYS-PKAITGTLA----------------------------
MUL_3072|M.ulcerans_Agy99 VQNAQGLNAFYS-PKAITGTLA----------------------------
MAV_2910|M.avium_104 GQNGQGAAAYLAGPKAISGALA----------------------------
Mb1837|M.bovis_AF2122/97 AQNAPGVAALLG-PKAAAGALS----------------------------
Rv1808|M.tuberculosis_H37Rv AQNAPGVAALLG-PKAAAGALS----------------------------
MLBr_01182|M.leprae_Br4923 LVNGMGSAMKSLAPTTTKAAES---------------------------A
MSMEG_0619|M.smegmatis_MC2_155 ISPAGVPGSAATAAAPAPAPAGTTVA---APAPAAATFVPYAVANRDPGE
TH_3569|M.thermoresistible__bu ----------VRAEPQNPLPLTXXX-------------------------
Mflv_0325|M.gilvum_PYR-GCK MSAPPPPSGAPIAANTVSAGSPPAPG---APAAAAATFVPYVVAGRDPYE
Mvan_0415|M.vanbaalenii_PYR-1 VSAPPPPSSAAATVGTVATGTAPAPG---APAAATASFVPYAVAGRDPGT
MAB_4783|M.abscessus_ATCC_1997 GGAPAPTASTAAPTPTTTSPATPGSAPAPTPPPAGAEGLGYAVRGDGPGF
MMAR_2684|M.marinum_M --PLVPEISPGGVGLTSASVSNSVSGTMGRAALVGSMSVPQGWTQAAPAM
MUL_3072|M.ulcerans_Agy99 --PLVPEISPGGVGLTSASVSNSVSGTMGRAALVGSMSVPQGWTQAAPAM
MAV_2910|M.avium_104 --PLASGGNAVKPMLSSAVGAGQVSGSMGKAALVGSMSVPQGWTEAAPAI
Mb1837|M.bovis_AF2122/97 --PLAP--LRGGYIADITPLGGGATGGIARAIYVGSLSVPQGWAEAAPVM
Rv1808|M.tuberculosis_H37Rv --PLAP--LRGGYIGDITPLGGGATGGIARAIYVGSLSVPQGWAEAAPVM
MLBr_01182|M.leprae_Br4923 FKAMGSAVQSTGRGLLGSSSGGHVTAQLGRAASIGSLRVPQTWTTASQPV
.
MSMEG_0619|M.smegmatis_MC2_155 GFTPTLGNKSQVAAPASGVPAAASGVAASLASRRKRRRKKGAQIEERGYA
TH_3569|M.thermoresistible__bu --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK GFSPTVRDSTGAKAPAGTIPAAASGIAASAAERRKRRRRQKEEIKGRGYA
Mvan_0415|M.vanbaalenii_PYR-1 GFSPTVRDSTSAKAPASGIPAAASGVAASAAERRKRRRRQKDEIAGRAYA
MAB_4783|M.abscessus_ATCC_1997 GFGPTIGASTGATAHAPSSAVSAAAALACNPATGKSRRRRRRTIDDRGYR
MMAR_2684|M.marinum_M RLVSSVLSTNLAAAPTAGLPGEAGVFGQMALSSLAGRAMGASTFG-----
MUL_3072|M.ulcerans_Agy99 RLVSSVLSTNLAAAPTAGLPGEAGVFGQMALSSLAGRAMGASTFG-----
MAV_2910|M.avium_104 RTLAQVLPGNMAAAP-AAMAGEEGVFSQMALSSLAGRAVAAAATR-----
Mb1837|M.bovis_AF2122/97 RAVASVLPG-TGAAPALAAEAPGALFGEMALSSLAGRALAGTAVR-----
Rv1808|M.tuberculosis_H37Rv RAVASVLPG-TGAAPALAAEAPGALFGEMALSSLAGRALAGTAVR-----
MLBr_01182|M.leprae_Br4923 TAATRALSPARVAVATESESAPLLGGGLPMAPMVPGGGSG----------
MSMEG_0619|M.smegmatis_MC2_155 DAYMDYEE-PDEDPAPQPEPRVRASERGSDAMGFTGTVTRH-DVTAAGLT
TH_3569|M.thermoresistible__bu --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK DAYADYEELPDDGPPEQPAPRVTASTRGAGPMGFAGTVSRG-DEQAGGLT
Mvan_0415|M.vanbaalenii_PYR-1 DAYADYEPEPDDEPPVRQEPRIAATERGAGPMGFAGTVSRD-AAQAGGLT
MAB_4783|M.abscessus_ATCC_1997 HEYATMDDHTPTGP--QDPVTAVASGTGAGRLGFAGVHTATTAVEATGLS
MMAR_2684|M.marinum_M ----------------------SSSGGAVAN-SLGGVVAEADPAAATIIV
MUL_3072|M.ulcerans_Agy99 ----------------------SSSGGAVAN-SLGGVVAEADPAAATIIV
MAV_2910|M.avium_104 ----------------------PVGGAASAASSLGGVAAEADPAAATIIV
Mb1837|M.bovis_AF2122/97 ----------------------SGAGAARVA---GGSVTEDVASTTTIIV
Rv1808|M.tuberculosis_H37Rv ----------------------SGAGAARVA---GGSVTEDVASTTTIIV
MLBr_01182|M.leprae_Br4923 ----------------------------------TGGVNTALRLQPRAFV
MSMEG_0619|M.smegmatis_MC2_155 TLTGDTFDDRPVTPMLPGTWDGDENPAPSPDDPEGGPRR------
TH_3569|M.thermoresistible__bu ---------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK TLAGDSFGGGPREPMLPGTWDPDATDDRHTDGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 TLPGDPFGGGPKAPMLPGTWDPDTEPD------ERHNHHDGKDSQ
MAB_4783|M.abscessus_ATCC_1997 TLDGDAEN--RTIPMLPGTWDVTDDDR------------------
MMAR_2684|M.marinum_M IPALDE---------------------------------------
MUL_3072|M.ulcerans_Agy99 IPALDE---------------------------------------
MAV_2910|M.avium_104 IPCIEE---------------------------------------
Mb1837|M.bovis_AF2122/97 IPAD-----------------------------------------
Rv1808|M.tuberculosis_H37Rv IPAD-----------------------------------------
MLBr_01182|M.leprae_Br4923 MPRNPAAG-------------------------------------