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TASVWMASPPEVHSALLSAGPGPGPLHEAATAWTALSAEHASVAEELSTILGGAAAAWEGPSAQSYVDAH APYLAWLTTTSADYAATAAEHEAAAGAYTSALATMPTLAELAVNHTTHTALVATNFFGLNTIPITLNEAD YARMWVQAATTMSAYQVVSGTTLASMPHTTPVPPILNTQNGATPTPLKPVGPGLLSRFLIALEVLWWAPG AFLEAIVTGQYLLAAGVVLIALVVFALLPLFLVTDILAAFPILIPILIGLMALAAAFGALLASLASVLGP VASIAVPVALAGVERGLSAVFNIDIAQNLPLLLGFYAQPATLPIPPADAGLSTATPAPAPPNPIATAMVG EHHARIPGFPGTVHAESLQFPAGVGVLEPSHLGGGPQLPMLPATWV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_3379 | - | - | 100% (397) | PPE family protein |
| M. marinum M | MMAR_4266 | - | e-152 | 64.59% (449) | PPE family protein |
| M. marinum M | MMAR_3641 | - | e-128 | 57.14% (448) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3047c | PPE47 | 1e-79 | 44.10% (424) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 1e-66 | 42.86% (385) | PPE protein |
| M. tuberculosis H37Rv | Rv3018c | PPE46 | 1e-75 | 42.55% (423) | PPE family protein |
| M. leprae Br4923 | MLBr_01828 | PPE | 4e-51 | 35.80% (405) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_4783 | - | 3e-68 | 42.13% (394) | PPE family protein |
| M. avium 104 | MAV_4872 | - | 2e-69 | 43.86% (399) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 1e-63 | 64.61% (178) | PPE family protein |
| M. thermoresistible (build 8) | TH_3569 | - | 7e-66 | 67.42% (178) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_2686 | - | 9e-82 | 77.89% (190) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 2e-65 | 42.51% (407) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3047c|M.bovis_AF2122/97 ----------MTAPVWLASPPEVHSALLSAGPGPGSLQAAAAGWSALSAE
Rv3018c|M.tuberculosis_H37Rv ----------MTAPVWLASPPEVHSALLSAGPGPGSLQAAAAGWSALSAE
MMAR_3379|M.marinum_M ----------MTASVWMASPPEVHSALLSAGPGPGPLHEAATAWTALSAE
MUL_2686|M.ulcerans_Agy99 ----------MVGSAWMALPPEVHSAFLSAGPGPGLLREAAAAWTVLAAE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
TH_3569|M.thermoresistible__bu ---------MMTAPIWMALPPEVHSALLSSGPGPGSLLAAASAWHALSAE
MAB_4783|M.abscessus_ATCC_1997 ----------MTAPVWMAAPPEVHSALLSSGPGPGSLFAAADAWRSLSTE
MAV_4872|M.avium_104 ----------MTAPVWMAFAPEVHSTLLSSGPGPAGLLSAAASWTSLSET
MLBr_01828|M.leprae_Br4923 ----------MSAPIWMASPPEVHSALLSRGPGSGPLLVAAEAWRSLSSV
: .. *:* .*****::** ***.. : *. * *:
Mb3047c|M.bovis_AF2122/97 YAAVAQELSAVVAAVGAGVWQGPSAELFVAAYVPYVAWLVQASADSAAAA
Rv3018c|M.tuberculosis_H37Rv YAAVAQELSVVVAAVGAGVWQGPSAELFVAAYVPYVAWLVQASADSAAAA
MMAR_3379|M.marinum_M HASVAEELSTILGGAAA-AWEGPSAQSYVDAHAPYLAWLTTTSADYAATA
MUL_2686|M.ulcerans_Agy99 HASAAEELTSIVGGAAA-AWEGPSAQSYVDAHVPYLTWLATTSADYAATA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
TH_3569|M.thermoresistible__bu YASAAAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSAATA
MAB_4783|M.abscessus_ATCC_1997 YSSAANELTTTLGSVRAGVWDGASAEQYQTAHVPYLSWLHETSAVSAGVA
MAV_4872|M.avium_104 YASAAAELSATLAAAQSDAWQGPSAERYVAAHAPYLAWLERASANSAAVA
MLBr_01828|M.leprae_Br4923 YAEMADELVALLVVVPVSSWDGSAAEAYVIAYLPYLGWLRQASVDSAVMA
:: * ** : . *:*.::: : *: **: ** *. * *
Mb3047c|M.bovis_AF2122/97 GEHEAAAAGYVCALAEMPTLPELAANHLTHAVLVATNFFGINTIPIALNE
Rv3018c|M.tuberculosis_H37Rv GEHEAAAAGYVCALAEMPTLPELAANHLTHAVLVATNFFGINTIPIALNE
MMAR_3379|M.marinum_M AEHEAAAGAYTSALATMPTLAELAVNHTTHTALVATNFFGLNTIPITLNE
MUL_2686|M.ulcerans_Agy99 IEHEVAADAYAGALTAMPTLAELAANRTTHTALVATNFFGLNTVPITVNE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
TH_3569|M.thermoresistible__bu GRHETAAAAYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIPIALNE
MAB_4783|M.abscessus_ATCC_1997 AQTETAATAYSEALATMPTLGELAANHATHGALVATNFFGINTIPIAVNE
MAV_4872|M.avium_104 AQQETAAAAYTAALAAMPTLPELAGNHATHAALVATNFFGVNTIPIAVNE
MLBr_01828|M.leprae_Br4923 AHYETMATAYITTLAMMPTLAELAANRTAHTVLVTTNFFGINTIPIARNE
. :. * .* :*: ***: **: *: * .** ***:*:**:**: .*
Mb3047c|M.bovis_AF2122/97 ADYVRMWVQAATVMSAYEAVVGAALVATPHTGPAPVIVKPGANEASN---
Rv3018c|M.tuberculosis_H37Rv ADYVRMWVQAATVMSAYEAVVGAALVATPHTGPAPVIVKPGANEASN---
MMAR_3379|M.marinum_M ADYARMWVQAATTMSAYQVVSGTTLASMPHTTPVPPILNTQNGA------
MUL_2686|M.ulcerans_Agy99 ADYARMWVQAATTMGAYQVILGTALASMPHTTPAPLILNAE---------
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA
TH_3569|M.thermoresistible__bu ADYVRMWIQAATSMSTYQAVAGTAVMSAPASSPAPLLLAPGVSEAADAMA
MAB_4783|M.abscessus_ATCC_1997 ADYIRMWIQAATVMSTYQAVSESSVSAAPPTSPAPPVLSPDSGAAARTAA
MAV_4872|M.avium_104 ADYARMWVQAATTMSTYQAVAGTAVAAAPQTDPAPPIVNSTSSDGSDSDD
MLBr_01828|M.leprae_Br4923 IDYVRMWVEAAIAMGTYQEVSTVVVDSAPEAIAAPQIMASDALEASSDQP
** ***::** *.:*: : : : * : ..* :: .
Mb3047c|M.bovis_AF2122/97 ----------------------------AVAAATITPFPFGELAKFLEMA
Rv3018c|M.tuberculosis_H37Rv ----------------------------AVAAATITPFPWHEIVQFLEET
MMAR_3379|M.marinum_M -----------------------------------TPTPLKPVGPGLLSR
MUL_2686|M.ulcerans_Agy99 --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK DMSAFA--------------------AQPMAAQAGAAFDVSNIIADIIRL
Mvan_0415|M.vanbaalenii_PYR-1 DVTAFA--------------------AQAQAAEAGSALDLSNIIADLIRA
MSMEG_0619|M.smegmatis_MC2_155 SVQQMS--------------------AQATAAESGSSLDLSSIISDLLNQ
TH_3569|M.thermoresistible__bu TTQQIG--------------------SQATAADSGTALNLSDLIANLLQY
MAB_4783|M.abscessus_ATCC_1997 ---------------------------QDATKPPPIVPDPNDPIEMLLKN
MAV_4872|M.avium_104 SGDD----------------------GGIVDNDGGNPYQLSWWVNRFLEI
MLBr_01828|M.leprae_Br4923 SPTAPSQSPQVQNWLQWLQKIGYTDFYNTLVQPLITSLTNHPFFQGMFSG
Mb3047c|M.bovis_AF2122/97 AQAFTEVGELIMKSA--------------EAWAVGFVELITGLVNFEPWL
Rv3018c|M.tuberculosis_H37Rv FAAYDQYLSALLSEL--------------PAVAWVWFQLFVDILGFNIIG
MMAR_3379|M.marinum_M FLIALEVLWWAPGAF--------------L-EAIVTGQYLLAAGVVLIAL
MUL_2686|M.ulcerans_Agy99 --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK YGEVLRFLFEPIFNF--------------LRDPIGNTFALITDFLTNPVQ
Mvan_0415|M.vanbaalenii_PYR-1 YGELLRFLFEPIFDF--------------LRDPLGNTIKLITDFLTNPAQ
MSMEG_0619|M.smegmatis_MC2_155 YLQGVPGGQ-AILDF--------------LKDPLGNLGRLLTDFMTNPAG
TH_3569|M.thermoresistible__bu YQDYLDQLFGPIVDF--------------LRDPIGNLFQLIDDFLTNPAG
MAB_4783|M.abscessus_ATCC_1997 SQHFL-GMYRALKGL--------------ITDPVGTIVRIIIDFSTNPAA
MAV_4872|M.avium_104 FQTIG----RDLEEF--------------PENPSAALTQLLRDIWLLIVD
MLBr_01828|M.leprae_Br4923 FDPWLPSLGNPLSFLSPFNIAFALGTPMDIGSYVGYLSQTFAFIGADLAA
Mb3047c|M.bovis_AF2122/97 VLTGMIDMFFATVGFALGVFVLVPLLEFAVVLELAILSIGWIISNIFGAI
Rv3018c|M.tuberculosis_H37Rv FIITLASNAQLLTEFAINASYVAVGLLYAIAGVIDIV-VEWVIGNLFGVV
MMAR_3379|M.marinum_M VVFALLPLFLVTDILAAFPILIPILIGLMALAAAFGALLASLASV-LGPV
MUL_2686|M.ulcerans_Agy99 ------PLILEPEIEIAKFITDPVGSAVMGIWEMFCCFWII---------
Mflv_0325|M.gilvum_PYR-GCK ALITWGPFLLAVVYQAVSWVGASILYPSLFLLPLLATTLAIVAGVGQHLL
Mvan_0415|M.vanbaalenii_PYR-1 ALITWGPFLAAVAYQAVSWVGASILYPSLLLLPLVATTLAIVLGVGAYLL
MSMEG_0619|M.smegmatis_MC2_155 ALATWWPFLFGVAYQVFFNLVGWPTWGMIFASPFLIPALAALGITGLVLL
TH_3569|M.thermoresistible__bu ALVTWWPLLFAVAYQVFTNLVGWPTWAMILASPVLIPLAITLGVAGLVMI
MAB_4783|M.abscessus_ATCC_1997 AIVTWTPLFYVFAYAATFAVMGTPIYAAIMGP---AAGISIPLAITLASL
MAV_4872|M.avium_104 EIGHAIEAFQAFAPQIAAFSLALPAGAAAGLAG-LSGLAAIQKAAPLPAL
MLBr_01828|M.leprae_Br4923 AFASGNPVTIGFTLLFTTIEAIGTIITDTIALVKTMIEQSFVLLPMILPL
Mb3047c|M.bovis_AF2122/97 PVLAGPLLGALAAAVVPGVAGVTGLAG------------------LAAVP
Rv3018c|M.tuberculosis_H37Rv PLLGGPLLGALAAAVVPGVAGLAGVAG------------------LAALP
MMAR_3379|M.marinum_M ASIAVPVALAGVERGLSAVFNIDIAQN-----------------LPLLLG
MUL_2686|M.ulcerans_Agy99 --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK SLLNTP-PAEEAAEEPAPAQSAPSRPDQQSFPATMSAPPPPSGAPIAANT
Mvan_0415|M.vanbaalenii_PYR-1 ENLPAP-AEDAPAEEPAASSPAPTRADQPSPAIAVSAPPPPSSAAATVGT
MSMEG_0619|M.smegmatis_MC2_155 IDHVLNNPVDVPAEDEAPQEVAAAPRTDQPLAVGISPAGVPGSAATAAAP
TH_3569|M.thermoresistible__bu ADQAQP-----PAEEAAPEEDVAAP-------------------VRAEPQ
MAB_4783|M.abscessus_ATCC_1997 SQMPEAPPVDAPAETVPARIDQPHAVAMGGAPAPTASTAAP--TPTTTSP
MAV_4872|M.avium_104 PAAPPPQPSSMPAVVAGPAMGAAAVAAPAPASAG---------APAPASA
MLBr_01828|M.leprae_Br4923 LTAPLAVATAGAAGSFAGLSELAGLVGVAPPGLPSAPPVAAVAPVVPPSM
Mb3047c|M.bovis_AF2122/97 AVGAAAGAPAALVGSVAP-----------------------------VSG
Rv3018c|M.tuberculosis_H37Rv AVGAAAGAPAALVGSVAP-----------------------------VSG
MMAR_3379|M.marinum_M FYAQPATLPIPPADAG-------------------------------LST
MUL_2686|M.ulcerans_Agy99 --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK VSAGSPPAPGAPAAAAATFVPYVVAGRDPYEGFSPTVR---------DST
Mvan_0415|M.vanbaalenii_PYR-1 VATGTAPAPGAPAAATASFVPYAVAGRDPGTGFSPTVR---------DST
MSMEG_0619|M.smegmatis_MC2_155 APAPAGTTVAAPAPAAATFVPYAVANRDPGEGFTPTLG---------NKS
TH_3569|M.thermoresistible__bu NPLPLTXXX-----------------------------------------
MAB_4783|M.abscessus_ATCC_1997 ATPGSAPAP-TPPPAGAEGLGYAVRGDGPGFGFGPTIG---------AST
MAV_4872|M.avium_104 TVTASGAAPPPPSGIGGTAYPYLIGG--PTIGSGTGMG---------SGA
MLBr_01828|M.leprae_Br4923 PTLASIPTPTPMPAPAASTAPVVTPPGPPPVTAPPSVTGAGVESFGYLVG
Mb3047c|M.bovis_AF2122/97 GVVSPQARLVSAVEPAPAST------------------------------
Rv3018c|M.tuberculosis_H37Rv GVVSPQARLVSAVEPAPAST------------------------------
MMAR_3379|M.marinum_M ATPAPAPPNPIATAMVGEHHARIP--------------------------
MUL_2686|M.ulcerans_Agy99 --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK GAKAPAGTIPAAASGIAASAAERRKRRRRQKEEIKGRGYADAYADYEELP
Mvan_0415|M.vanbaalenii_PYR-1 SAKAPASGIPAAASGVAASAAERRKRRRRQKDEIAGRAYADAYADYEPEP
MSMEG_0619|M.smegmatis_MC2_155 QVAAPASGVPAAASGVAASLASRRKRRRKKGAQIEERGYADAYMDYEE-P
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_4783|M.abscessus_ATCC_1997 GATAHAPSSAVSAAAALACNPATGKSRRRRRRTIDDRGYRHEYATMDDHT
MAV_4872|M.avium_104 QRKASEPDPAAAAAPAGASASERARARRRRRAAMKDRYRGYEFMDVEPDA
MLBr_01828|M.leprae_Br4923 RLPSTARGVVGTSVRQQSSAPDRIEAPDAAATPQEQARSRWRRRAKVTPF
Mb3047c|M.bovis_AF2122/97 --------SVSVLASDRGAGALGFVGTAGKESVGQPAGLTVLA-DEFGDG
Rv3018c|M.tuberculosis_H37Rv --------SVSVLASDRGAGALGFVGTAGKESVGQPAGLTVLA-DEFGDG
MMAR_3379|M.marinum_M ----------------------GFPGTVHAESLQFPAGVGVLEPSHLGGG
MUL_2686|M.ulcerans_Agy99 --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK DDGPPEQPAPRVTASTRGAGPMGFAGT-VSRGDEQAGGLTTLAGDSFGGG
Mvan_0415|M.vanbaalenii_PYR-1 DDEPPVRQEPRIAATERGAGPMGFAGT-VSRDAAQAGGLTTLPGDPFGGG
MSMEG_0619|M.smegmatis_MC2_155 DEDPAPQPEPRVRASERGSDAMGFTGT-VTRHDVTAAGLTTLTGDTFDDR
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_4783|M.abscessus_ATCC_1997 PTGP--QDPVTAVASGTGAGRLGFAGVHTATTAVEATGLSTLDGDAEN--
MAV_4872|M.avium_104 GPEP---ETDSVTASDRGAGPLGFAGT-APSAPAQATGLATLAGDEFGTG
MLBr_01828|M.leprae_Br4923 DSSGSPNPKAAPTASDQGAGTLGLAGTARQASSGPATGLVTLSNGTFSDS
Mb3047c|M.bovis_AF2122/97 APVPMLPGSWGPDLVGVAGDGGLVSV---------
Rv3018c|M.tuberculosis_H37Rv APVPMLPGSWGPDLVGVAGDGGLVSV---------
MMAR_3379|M.marinum_M PQLPMLPATWV------------------------
MUL_2686|M.ulcerans_Agy99 -----------------------------------
Mflv_0325|M.gilvum_PYR-GCK PREPMLPGTWDPDATDDRHTDGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 PKAPMLPGTWDPDTEPD------ERHNHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 PVTPMLPGTWDGDENPA------PSPDDPEGGPRR
TH_3569|M.thermoresistible__bu -----------------------------------
MAB_4783|M.abscessus_ATCC_1997 RTIPMLPGTWDVTDDDR------------------
MAV_4872|M.avium_104 PSMPMVPGNWTGE----------------------
MLBr_01828|M.leprae_Br4923 PRAPMLPRTWGADPTFCYNAADIGPAGGWDDE---