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VLADELLEFFLQFGLLLLAATILGRVAIRLGMPAIAGELCAGVLLGPSILGQVAPGLSSWLLPEQVSERL GLDAVGTFGVLLLMGLTGMQVDLNLLKSNRLAITKISAACLLVPVVFGLGIGFLMPSVLTGGSNRLVFAL FLAVALSVSAIAVIVKTLSDLGLMHRDIAQLILATAVIDNVIAWVLLSVVCAMALAHLSLGTVLLTVFLI ISVVAATIIGRKIVEVFVNSRQQPAAAEHSAGPRPILAYAVGLVMLAAAATHALKLEPVLGAFAAGIMLA ALPPDRRSGLDSLHPVVNNVLAPLYFATAGLQADLTGLADRTTLAAALVVLAAAVASKFLGAYIGAKSSG RSGAEAVALGAGLNARGVIQIIIADTAYDLGIFNDSFYTIVLLTAIATSVMAAPILRIAAARIAIDPDDE IRRQDALPEAH
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_3635 | - | - | 100% (431) | integral membrane ion antiporter |
| M. marinum M | MMAR_4262 | - | 1e-34 | 28.25% (400) | hypothetical protein MMAR_4262 |
| M. marinum M | MMAR_1309 | - | 2e-09 | 22.28% (404) | membrane transporter |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3264c | - | 4e-11 | 25.62% (406) | integral membrane transport protein |
| M. gilvum PYR-GCK | Mflv_0160 | - | 1e-06 | 23.46% (422) | potassium/proton antiporter |
| M. tuberculosis H37Rv | Rv3236c | - | 4e-11 | 25.62% (406) | integral membrane transport protein |
| M. leprae Br4923 | MLBr_00782 | - | 8e-09 | 20.70% (401) | putative transmembrane transport protein |
| M. abscessus ATCC 19977 | MAB_2285 | - | 4e-70 | 39.80% (407) | Na+/H+ antiporter |
| M. avium 104 | MAV_4198 | - | 8e-12 | 23.13% (402) | transporter, monovalent cation:proton antiporter-2 (CPA2) |
| M. smegmatis MC2 155 | MSMEG_6769 | - | 3e-43 | 28.60% (437) | transporter, monovalent cation:proton antiporter-2 (CPA2) |
| M. thermoresistible (build 8) | TH_3766 | - | 8e-07 | 25.36% (280) | PUTATIVE Na+/H+ antiporter NhaA |
| M. ulcerans Agy99 | MUL_2572 | - | 1e-09 | 22.28% (404) | membrane transporter |
| M. vanbaalenii PYR-1 | Mvan_1424 | - | 1e-13 | 25.44% (397) | sodium/hydrogen exchanger |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3635|M.marinum_M -----------MLADELLEFFLQFGLLLLAATILGRVAIR-LGMPAIAGE
MAB_2285|M.abscessus_ATCC_1997 MSNTAVTAAAALSKDVSLIFFADLVILLVAALACGAVAGK-IGLPKMVGE
Mb3264c|M.bovis_AF2122/97 -------------MEVSRALLFELGVLLAVLAVLGAVARR-FALSPIPVY
Rv3236c|M.tuberculosis_H37Rv -------------MEVSRALLFELGVLLAVLAVLGAVARR-FALSPIPVY
MUL_2572|M.ulcerans_Agy99 -------------MEVSRALLFEVGALLTTLALLGAIARR-FALSPIPVY
MLBr_00782|M.leprae_Br4923 -------------MEISGALLSQVGALLTTLAVLGAGARR-YSLSPIPVY
MAV_4198|M.avium_104 -------------MQISGTLLLQLGALLATLAVLGAAARR-FALSPIPVY
MSMEG_6769|M.smegmatis_MC2_155 -----------MPADTAIHFFLQLAVILMACRLAGLVARR-IGQAQVVGE
Mvan_1424|M.vanbaalenii_PYR-1 ---------------MDGHLFPTIAIILALATAAGVVATR-LRQPLIVAF
Mflv_0160|M.gilvum_PYR-GCK -----------MTLHQLYVALFLGGLVLLASIAATRLATG-VGLPSLLLF
TH_3766|M.thermoresistible__bu --------VIARPLRRPPRRLLTRGSWAETSRITAILRRETVGGGVLLVV
: :
MMAR_3635|M.marinum_M LCAGVLLGPSILGQVAPGLSSWLLPEQVSERLGLDAVGTFGVLLLMGLTG
MAB_2285|M.abscessus_ATCC_1997 IAAGVLLGPTVFGRLFPETKDALFPSAGTGSEIISGLCLLAVVLLVGVAG
Mb3264c|M.bovis_AF2122/97 LLAGLSLG-----------NGGILGVAAAG-EFIATGAPIGVVLLLLALG
Rv3236c|M.tuberculosis_H37Rv LLAGLSLG-----------NGGILGVAAAG-EFIATGAPIGVVLLLLALG
MUL_2572|M.ulcerans_Agy99 LLAGLSLG-----------KGGVLPVAAAD-DFVATGAPIGIVLLLLTLG
MLBr_00782|M.leprae_Br4923 LMAGLSLG-----------KGGIMPVSAAD-EFITTGAPIGIVLLLLTLG
MAV_4198|M.avium_104 LLAGLALG-----------KGGLLPLATGG-QFITTSAPIGVVLLLLTLG
MSMEG_6769|M.smegmatis_MC2_155 MIAGVILGPSLLGRIAPDLQGLLFPPGITN-VVLYTTAQIGLVLYMFIIG
Mvan_1424|M.vanbaalenii_PYR-1 IMVGVAVG-------------PVGAGWVSADSTMELLARLGLAVLLFLVG
Mflv_0160|M.gilvum_PYR-GCK LGVGVLVG------------EGGLGLQFDNAQLGQDLGTAALAVILVEGG
TH_3766|M.thermoresistible__bu AAAALLWANSPWSAGYFGLRDATVGGEPLGLHLNLTVGTWAADGLLAIFF
..: . . :
MMAR_3635|M.marinum_M MQVDLNLLKSNRLAITKISAACLLVPVVFG--LGIGFLMPSVLT-GGSNR
MAB_2285|M.abscessus_ATCC_1997 MHVDVDKLKQRLAGIATISVLGLAVPLAGG--MAVGYLVPEPLRPAAVDR
Mb3264c|M.bovis_AF2122/97 LEFSATEFASSLRHHLPSAGVDIVLNATPG--AVAGWLLG--------LD
Rv3236c|M.tuberculosis_H37Rv LEFSATEFASSLRHHLPSAGVDIVLNATPG--AVAGWLLG--------LD
MUL_2572|M.ulcerans_Agy99 LEFSATEFASSLRHHMPSAMVDIVLNATPG--AVAGWLLG--------LD
MLBr_00782|M.leprae_Br4923 LEFSATEFASSLRRHLPSAGVDIILNATPG--AVAGWLLG--------LD
MAV_4198|M.avium_104 CEFSVAEFSSSMRHHLPSAAVDVVLNAAPG--AIAGWLLG--------LD
MSMEG_6769|M.smegmatis_MC2_155 LNFDVNHVKQRAGTAAAVSATGTLAPLALGGVAAIPLLAHGGFFGDGVNV
Mvan_1424|M.vanbaalenii_PYR-1 LRLDLHMIRNTGPVAVITGLGQVLVTFALG--LLIALALG--------MD
Mflv_0160|M.gilvum_PYR-GCK LTTRFSDIRKVLAPAAVLATLGVAVSTLVT-AAAVHWLLG--------MN
TH_3766|M.thermoresistible__bu LVVGLELKREFVAGDLRDPARAVLPIVAAVGGMVAPALIFVVVAAGGGEG
.
MMAR_3635|M.marinum_M LVFALFLAVALSVSAIAVIVKTLSDLGLMHRDIAQLILATAVIDNVIAWV
MAB_2285|M.abscessus_ATCC_1997 TVFALFLGTAVAVSAIPVIARILMDLGLASHEIAQVILAAAIVDDVAGWL
Mb3264c|M.bovis_AF2122/97 GVAILGLAGVTYISSSGVIARLLEDLRRLGNRETPAVLSVLVLEDFAMAA
Rv3236c|M.tuberculosis_H37Rv GVAILGLAGVTYISSSGVIARLLEDLRRLGNRETPAVLSVLVLEDFAMAA
MUL_2572|M.ulcerans_Agy99 GVAILALAGVTYISSSGVVARLLEDLRRLGNRETPAVLSVLVLEDFAMAG
MLBr_00782|M.leprae_Br4923 GVAVLALAGVTYISSSGVIARLLADLRRLGNRETPAVLSVLVLEDFAMAA
MAV_4198|M.avium_104 GVAILCLAGVTYISSSGVVARLLEDLRRLGNRETPAVLSVLVLEDFAMAA
MSMEG_6769|M.smegmatis_MC2_155 GMAMMFLGASVAITAFPMLARIIFEKRLSGTSLGTLALACGATSDAISWC
Mvan_1424|M.vanbaalenii_PYR-1 NVTALYVAVALTFSSTIIIVKLLSDKRELEQLHGRIALGILIVQDIVVVV
Mflv_0160|M.gilvum_PYR-GCK WQLALLLGAVISSTDAAAVFSVLR-VVPLPRRLSGLLEAESGFNDAPAVI
TH_3766|M.thermoresistible__bu ALRGWAIPTATDIAFAVAVLAVLS--THLPAALRTFLLTLAVVDDLLAVT
: : : : .:
MMAR_3635|M.marinum_M LLSVVCAMALA-HLS--LGTVLLTVFLIISVVAATIIGRKIVEVFVNSRQ
MAB_2285|M.abscessus_ATCC_1997 LLSAVTGMASD-SGTGGVAVLKMAVAAIVAVVALTALTRPALRNRLARRC
Mb3264c|M.bovis_AF2122/97 YLPLFAVLATDGSWLEAVVGMTVAIAALLGAFAASYRWGHHVGRLVTHPD
Rv3236c|M.tuberculosis_H37Rv YLPLFAVLATDGSWLEAVVGMTVAIAALLGAFAASYRWGHHVGRLVTHPD
MUL_2572|M.ulcerans_Agy99 YLPLFTVLALHGDWLHALGGTLAAIAALLGAFAASFYWGHHFGRLFAHPD
MLBr_00782|M.leprae_Br4923 YLPLFAVLAAGGSWLDAVVGMIVAVCALFAAFAASYHWGHHVGRLVAHPD
MAV_4198|M.avium_104 YLPLFAVLASGGGWLHAVVGMVVAVSALVAAFAASYRWGHHVQRLVEHPD
MSMEG_6769|M.smegmatis_MC2_155 ILAVVLAVYRNSPVMAVVAIVGGLVYTLVLLTLGRRAFAKLGDAAEARQA
Mvan_1424|M.vanbaalenii_PYR-1 VMIALTASGRGGEGSVGAGIAAVALKGIGLLATLWVLMRFVLPWLMPQIA
Mflv_0160|M.gilvum_PYR-GCK LVMLFSVVPMELNAVDIVGTLVYELGIGTVLGLGFGVLGAMTLRRIALPA
TH_3766|M.thermoresistible__bu VIAVFYTEEINTTALGLTLVPLAAFTVCVQRRIRAWWLLIPLGVATWVLM
: . .
MMAR_3635|M.marinum_M QPAAAEHSAGPRPILAYAVGLVMLAAAATHALKLEPVLGAFAAGIMLAAL
MAB_2285|M.abscessus_ATCC_1997 SRWSAPTST------TVTVATIIVCATAGQLLGFEPVIGAFFAGILVIAA
Mb3264c|M.bovis_AF2122/97 SEQ----------LLLRVLGITLIVAAVAESLHASAAVGAFLVGLTLTGE
Rv3236c|M.tuberculosis_H37Rv SEQ----------LLLRVLGITLIVAAVAESLHASAAVGAFLVGLTLTGE
MUL_2572|M.ulcerans_Agy99 SEQ----------LLLRVLGITLMVAALAETLHASAAVGAFLVGLTLTGE
MLBr_00782|M.leprae_Br4923 SEQ----------LLLRVLGVTLIVAAVAESLHASAAVGAFLVGLTLTGD
MAV_4198|M.avium_104 SEQ----------LMLRVLGITLIVAAMAESLHASAAVGAFLVGLTLTGE
MSMEG_6769|M.smegmatis_MC2_155 ITAP---------MLSTVLIVLMACAWLTDTIGIYAIFGAFILGAAMPSG
Mvan_1424|M.vanbaalenii_PYR-1 RSQE--------LLVLFGVAYAVSVASFSEWLGFSSEVGAFLAGVSLAGT
Mflv_0160|M.gilvum_PYR-GCK AGLYP----------LATFGLGMLAFAAAGTAHGSGFLAAYLASVVLANS
TH_3766|M.thermoresistible__bu HESG------------VHATVAGVLLGFAVPVRRSAAAGGPAAGPGMAEH
.. . :
MMAR_3635|M.marinum_M PPDRRSGLDSLHPVVNNVLAPLYFATAGLQADLTGLADRTTLAAALVVLA
MAB_2285|M.abscessus_ATCC_1997 TPAGSRVHKPLHAMAVAFFGPIFFATIGLQLDLGRLLSGPVLALTASICV
Mb3264c|M.bovis_AF2122/97 TADRAR---MVLTPLRDLFATIFFLGIGLSVDPGKLVS--MLPVALALAA
Rv3236c|M.tuberculosis_H37Rv TADRAR---MVLTPLRDLFATIFFLGIGLSVDPGKLVS--MLPVALALAA
MUL_2572|M.ulcerans_Agy99 TAERAR---RVLGPLRDLFAAIFFLGIGLSVAPKELIP--ALPVAILLAV
MLBr_00782|M.leprae_Br4923 TAERAR---KVLGPLRDLFAAIFFLAIGISVDPHKLLP--MFPTALILAT
MAV_4198|M.avium_104 TATRTR---QVLAPLRDLFAAIFFLAIGYSVDPHELIP--MLPAALILAA
MSMEG_6769|M.smegmatis_MC2_155 FFAERLTG-RLEPLTTTFLLPLFFVYSGLNTEIGLVNTPFLWAVTAGLLV
Mvan_1424|M.vanbaalenii_PYR-1 QFRDALG--ARLVSLRDFLLFFFFLNLGAGLDFSEAAG--QITAAIILSV
Mflv_0160|M.gilvum_PYR-GCK GLPHRSATRSFAEGAGWLAQIGVFVILGLLVSPDQLLD-EVVPAIVAGLA
TH_3766|M.thermoresistible__bu FEHRLR---PLSAGLAVPVFAFFAAGVDFGG-LSGLGDALRDPVTLGIIG
. .
MMAR_3635|M.marinum_M AAVASKFLGAYIGAKSSGRSGAEAVALGAGLNARG----------VIQII
MAB_2285|M.abscessus_ATCC_1997 VAVFSKFLGAGMGARISGFSWPESVAVGAGLNTRG----------VIQIV
Mb3264c|M.bovis_AF2122/97 VTAATKVATGMFAARREGVARRGQLRAGTALVARG----------EFSLI
Rv3236c|M.tuberculosis_H37Rv VTAATKVATGMFAARREGVARRGQLRAGTALVARG----------EFSLI
MUL_2572|M.ulcerans_Agy99 VTAATKVLTGMFAARRDGVARRGQLRAGTALIARG----------EFSLI
MLBr_00782|M.leprae_Br4923 VTAVTKVATGILAARYDGVARRGQLRAGTALVARG----------EFSLI
MAV_4198|M.avium_104 ATAATKVATGIFAARHDGVARRGQLRAGTALIARG----------EFSLI
MSMEG_6769|M.smegmatis_MC2_155 VAVVGKGVACAVAARLSRVPVRDSLALGSLMNARG----------LIELI
Mvan_1424|M.vanbaalenii_PYR-1 FVLVAKPAIVIAIMSVMRYPVRVGFLVGLPLAQIS----------EFSLI
Mflv_0160|M.gilvum_PYR-GCK LLLLARPISVFLSLIGFRVPWREKMFLSWAGLRGA----------VPIVL
TH_3766|M.thermoresistible__bu GLVVGKPVGIWLTTRLLAAFTRARLDATLRWVDVFGVSLLAGIGFTVSLL
: . ::
MMAR_3635|M.marinum_M IADTAYDLGIFNDSFYTIVLLTAIATSVMAAPILRIAAARIAIDPDDEIR
MAB_2285|M.abscessus_ATCC_1997 IAMVGVRCGVFSPEVFTALVVTTIATTAIAGPVLKRTLTPRRQLP-AVIS
Mb3264c|M.bovis_AF2122/97 IIGLAG----ASIPGVAALATAYVFVMAIVGPILARYTGGGLPAAAVASN
Rv3236c|M.tuberculosis_H37Rv IIGLAG----ASIPGVAALATAYVFVMAIVGPILARYTGGGLPAAAVASN
MUL_2572|M.ulcerans_Agy99 IIGLVG----ASIPAVAALATAYVFIMAVAGPVLARYTGG--PVATTA--
MLBr_00782|M.leprae_Br4923 IIGLVG----TSTPAVAALATAYVFIMAIAGPVLARYTPGSLPTSSGSAN
MAV_4198|M.avium_104 IIGLAG----SSLPAVAALATSYVFIMAIAGPVLARYTGPR-PAAPAT--
MSMEG_6769|M.smegmatis_MC2_155 LLNIGLEAGVITPTLFTILVLVAIVTTLMASPIFEFVYGRHRTDETGDTT
Mvan_1424|M.vanbaalenii_PYR-1 LAALGLSLGHISNATVSLITVVGLITIAASTYMTMYSDGIFARSQRWLSH
Mflv_0160|M.gilvum_PYR-GCK CTYPIVAGVPDSWRLLHIVFILVVLYTAIQGPSLRRVAEWLNLIPRDTTR
TH_3766|M.thermoresistible__bu IGDLAYGTGSIRDDHVKVGVLLGSVTAAALAAAVLRMRNRYYRILHQQET
MMAR_3635|M.marinum_M RQDALPEAH-----------------------------------------
MAB_2285|M.abscessus_ATCC_1997 KPPQEPALNR----------------------------------------
Mb3264c|M.bovis_AF2122/97 --------------------------------------------------
Rv3236c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_2572|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00782|M.leprae_Br4923 --------------------------------------------------
MAV_4198|M.avium_104 --------------------------------------------------
MSMEG_6769|M.smegmatis_MC2_155 QERVPQPSA-----------------------------------------
Mvan_1424|M.vanbaalenii_PYR-1 LERKHQRDHEVAGLSDGDFDIILFGLGRFGSHLADRLSGAGHRVLGVDFD
Mflv_0160|M.gilvum_PYR-GCK EIQVDAAPLDVLGAELLTMTVLPGSRLHNVTVLELRLPDPSVITLIIRDG
TH_3766|M.thermoresistible__bu EDADRDGVPDIYQSPNT---------------------------------
MMAR_3635|M.marinum_M --------------------------------------------------
MAB_2285|M.abscessus_ATCC_1997 --------------------------------------------------
Mb3264c|M.bovis_AF2122/97 --------------------------------------------------
Rv3236c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_2572|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00782|M.leprae_Br4923 --------------------------------------------------
MAV_4198|M.avium_104 --------------------------------------------------
MSMEG_6769|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_1424|M.vanbaalenii_PYR-1 PHGVRAHRRDGVTTTFGSAEDLDLLEALPLDRAKYVISAIPVLQTNLALL
Mflv_0160|M.gilvum_PYR-GCK ----QSFVPQPVTRLQIGDELLIVTTSVTRDQAERRLRAVSRRGKLAYWF
TH_3766|M.thermoresistible__bu --------------------------------------------------
MMAR_3635|M.marinum_M --------------------------------------------------
MAB_2285|M.abscessus_ATCC_1997 --------------------------------------------------
Mb3264c|M.bovis_AF2122/97 --------------------------------------------------
Rv3236c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_2572|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00782|M.leprae_Br4923 --------------------------------------------------
MAV_4198|M.avium_104 --------------------------------------------------
MSMEG_6769|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_1424|M.vanbaalenii_PYR-1 HGLRQHQFSGAVALTAHTRHDAERLRATGVEIVIEPFSSAAHTTSNTLHD
Mflv_0160|M.gilvum_PYR-GCK DEYGDPA-------------------------------------------
TH_3766|M.thermoresistible__bu --------------------------------------------------
MMAR_3635|M.marinum_M ---------------------------
MAB_2285|M.abscessus_ATCC_1997 ---------------------------
Mb3264c|M.bovis_AF2122/97 ---------------------------
Rv3236c|M.tuberculosis_H37Rv ---------------------------
MUL_2572|M.ulcerans_Agy99 ---------------------------
MLBr_00782|M.leprae_Br4923 ---------------------------
MAV_4198|M.avium_104 ---------------------------
MSMEG_6769|M.smegmatis_MC2_155 ---------------------------
Mvan_1424|M.vanbaalenii_PYR-1 LLTTEFEDTDDEGYSDDEGGAQPRPSR
Mflv_0160|M.gilvum_PYR-GCK ---------------------------
TH_3766|M.thermoresistible__bu ---------------------------