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QISGTLLLQLGALLATLAVLGAAARRFALSPIPVYLLAGLALGKGGLLPLATGGQFITTSAPIGVVLLLL TLGCEFSVAEFSSSMRHHLPSAAVDVVLNAAPGAIAGWLLGLDGVAILCLAGVTYISSSGVVARLLEDLR RLGNRETPAVLSVLVLEDFAMAAYLPLFAVLASGGGWLHAVVGMVVAVSALVAAFAASYRWGHHVQRLVE HPDSEQLMLRVLGITLIVAAMAESLHASAAVGAFLVGLTLTGETATRTRQVLAPLRDLFAAIFFLAIGYS VDPHELIPMLPAALILAAATAATKVATGIFAARHDGVARRGQLRAGTALIARGEFSLIIIGLAGSSLPAV AALATSYVFIMAIAGPVLARYTGPRPAAPAT*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_4198 | - | - | 100% (382) | transporter, monovalent cation:proton antiporter-2 (CPA2) family protein |
| M. avium 104 | MAV_4118 | - | 2e-13 | 24.55% (391) | transporter, monovalent cation:proton antiporter-2 (CPA2) |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3264c | - | 1e-169 | 81.55% (374) | integral membrane transport protein |
| M. gilvum PYR-GCK | - | - | - | - | - |
| M. tuberculosis H37Rv | Rv3236c | - | 1e-169 | 81.55% (374) | integral membrane transport protein |
| M. leprae Br4923 | MLBr_00782 | - | 1e-172 | 81.77% (373) | putative transmembrane transport protein |
| M. abscessus ATCC 19977 | MAB_2285 | - | 3e-17 | 26.86% (417) | Na+/H+ antiporter |
| M. marinum M | MMAR_1309 | - | 1e-165 | 78.22% (381) | membrane transporter |
| M. smegmatis MC2 155 | MSMEG_3664 | - | 1e-155 | 74.27% (377) | transporter, monovalent cation:proton antiporter-2 (CPA2) |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_2572 | - | 1e-165 | 78.22% (381) | membrane transporter |
| M. vanbaalenii PYR-1 | Mvan_1424 | - | 4e-19 | 25.88% (371) | sodium/hydrogen exchanger |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3264c|M.bovis_AF2122/97 -------------MEVSRALLFELGVLLAVLAVLGAVARRFALSPIPVYL
Rv3236c|M.tuberculosis_H37Rv -------------MEVSRALLFELGVLLAVLAVLGAVARRFALSPIPVYL
MMAR_1309|M.marinum_M -------------MEVSRALLFEVGALLTTLALLGAIARRFALSPIPVYL
MUL_2572|M.ulcerans_Agy99 -------------MEVSRALLFEVGALLTTLALLGAIARRFALSPIPVYL
MLBr_00782|M.leprae_Br4923 -------------MEISGALLSQVGALLTTLAVLGAGARRYSLSPIPVYL
MAV_4198|M.avium_104 -------------MQISGTLLLQLGALLATLAVLGAAARRFALSPIPVYL
MSMEG_3664|M.smegmatis_MC2_155 -------------MEVSGALLLELGVILVALTVLGTAARRFALSPIPLYL
Mvan_1424|M.vanbaalenii_PYR-1 ---------------MDGHLFPTIAIILALATAAGVVATRLRQPLIVAFI
MAB_2285|M.abscessus_ATCC_1997 MSNTAVTAAAALSKDVSLIFFADLVILLVAALACGAVAGKIGLPKMVGEI
:. :: : :*. *. * : . : :
Mb3264c|M.bovis_AF2122/97 LAGLSLG------------NGGILGVAAAGEFIATGAPIGVVLLLLALGL
Rv3236c|M.tuberculosis_H37Rv LAGLSLG------------NGGILGVAAAGEFIATGAPIGVVLLLLALGL
MMAR_1309|M.marinum_M LAGLSLG------------KGGVLPVAAADDFVATGAPIGIVLLLLTLGL
MUL_2572|M.ulcerans_Agy99 LAGLSLG------------KGGVLPVAAADDFVATGAPIGIVLLLLTLGL
MLBr_00782|M.leprae_Br4923 MAGLSLG------------KGGIMPVSAADEFITTGAPIGIVLLLLTLGL
MAV_4198|M.avium_104 LAGLALG------------KGGLLPLATGGQFITTSAPIGVVLLLLTLGC
MSMEG_3664|M.smegmatis_MC2_155 VAGLALG------------EGGLAPVPATVEFVNTGASIGVVLLLLTLGL
Mvan_1424|M.vanbaalenii_PYR-1 MVGVAVG------------PVGAG-WVSADSTMELLARLGLAVLLFLVGL
MAB_2285|M.abscessus_ATCC_1997 AAGVLLGPTVFGRLFPETKDALFPSAGTGSEIISGLCLLAVVLLVGVAGM
.*: :* : . : . :.:.:*: *
Mb3264c|M.bovis_AF2122/97 EFSATEFASSLRHHLPSAGVDIVLNATPGAVAGWLLGLDG--------VA
Rv3236c|M.tuberculosis_H37Rv EFSATEFASSLRHHLPSAGVDIVLNATPGAVAGWLLGLDG--------VA
MMAR_1309|M.marinum_M EFSATEFASSLRHHMPSAMVDIVLNATPGAVAGWLLGLDG--------VA
MUL_2572|M.ulcerans_Agy99 EFSATEFASSLRHHMPSAMVDIVLNATPGAVAGWLLGLDG--------VA
MLBr_00782|M.leprae_Br4923 EFSATEFASSLRRHLPSAGVDIILNATPGAVAGWLLGLDG--------VA
MAV_4198|M.avium_104 EFSVAEFSSSMRHHLPSAAVDVVLNAAPGAIAGWLLGLDG--------VA
MSMEG_3664|M.smegmatis_MC2_155 EFSIGEFASSLRRHLPSAWIDLVLNALPGAIAGWLLDLGA--------VG
Mvan_1424|M.vanbaalenii_PYR-1 RLDLHMIRNTGPVAVITGLGQVLVTFALGLLIALALGMDN--------VT
MAB_2285|M.abscessus_ATCC_1997 HVDVDKLKQRLAGIATISVLGLAVPLAGGMAVGYLVPEPLRPAAVDRTVF
... : . . : : * . : *
Mb3264c|M.bovis_AF2122/97 ILGLAGVTYISSSGVIARLLEDLRRLGNRETPAVLSVLVLEDFAMAAYLP
Rv3236c|M.tuberculosis_H37Rv ILGLAGVTYISSSGVIARLLEDLRRLGNRETPAVLSVLVLEDFAMAAYLP
MMAR_1309|M.marinum_M ILALAGVTYISSSGVVARLLEDLRRLGNRETPAVLSVLVLEDFAMAGYLP
MUL_2572|M.ulcerans_Agy99 ILALAGVTYISSSGVVARLLEDLRRLGNRETPAVLSVLVLEDFAMAGYLP
MLBr_00782|M.leprae_Br4923 VLALAGVTYISSSGVIARLLADLRRLGNRETPAVLSVLVLEDFAMAAYLP
MAV_4198|M.avium_104 ILCLAGVTYISSSGVVARLLEDLRRLGNRETPAVLSVLVLEDFAMAAYLP
MSMEG_3664|M.smegmatis_MC2_155 ILALAGVTYISSSGVIARLLGDLRRLGNRETPAVLSILVLEDFAMAAYLP
Mvan_1424|M.vanbaalenii_PYR-1 ALYVAVALTFSSTIIIVKLLSDKRELEQLHGRIALGILIVQDIVVVVVMI
MAB_2285|M.abscessus_ATCC_1997 ALFLGTAVAVSAIPVIARILMDLGLASHEIAQVILAAAIVDDVAGWLLLS
* :. . .*: ::.::* * : *. :::*.. :
Mb3264c|M.bovis_AF2122/97 LFAVLATDG--SWLEAVVGMTVAIAALLGAFAASYR--WGHHVGRLVTHP
Rv3236c|M.tuberculosis_H37Rv LFAVLATDG--SWLEAVVGMTVAIAALLGAFAASYR--WGHHVGRLVTHP
MMAR_1309|M.marinum_M LFTVLALHG--DWLHALGGTLAAIAALLGAFAASFY--WGHHFGRLFAHP
MUL_2572|M.ulcerans_Agy99 LFTVLALHG--DWLHALGGTLAAIAALLGAFAASFY--WGHHFGRLFAHP
MLBr_00782|M.leprae_Br4923 LFAVLAAGG--SWLDAVVGMIVAVCALFAAFAASYH--WGHHVGRLVAHP
MAV_4198|M.avium_104 LFAVLASGG--GWLHAVVGMVVAVSALVAAFAASYR--WGHHVQRLVEHP
MSMEG_3664|M.smegmatis_MC2_155 LLAVLAAGG--TLLHALLGMAVAIAALVVAFVVSYR--WGHHVTRFVSHP
Mvan_1424|M.vanbaalenii_PYR-1 ALTASGRGGEGSVGAGIAAVALKGIGLLATLWVLMR--FVLPWLMPQIAR
MAB_2285|M.abscessus_ATCC_1997 AVTGMASDS-GTGGVAVLKMAVAAIVAVVALTALTRPALRNRLARRCSRW
.: . . .: . :: .
Mb3264c|M.bovis_AF2122/97 DSEQLLLRVLGITLIVAAVAESLHASAAVGAFLVGLTLTGETADRAR---
Rv3236c|M.tuberculosis_H37Rv DSEQLLLRVLGITLIVAAVAESLHASAAVGAFLVGLTLTGETADRAR---
MMAR_1309|M.marinum_M DSEQLLLRVLGITLMVAALAETLHASAAVGAFLVGLTLTGETAERAR---
MUL_2572|M.ulcerans_Agy99 DSEQLLLRVLGITLMVAALAETLHASAAVGAFLVGLTLTGETAERAR---
MLBr_00782|M.leprae_Br4923 DSEQLLLRVLGVTLIVAAVAESLHASAAVGAFLVGLTLTGDTAERAR---
MAV_4198|M.avium_104 DSEQLMLRVLGITLIVAAMAESLHASAAVGAFLVGLTLTGETATRTR---
MSMEG_3664|M.smegmatis_MC2_155 DNEQLLLRVLGLTLIVAALAEFIHASAAVGAFLVGLTLTGDSAHRAR---
Mvan_1424|M.vanbaalenii_PYR-1 SQELLVLFGVAYAVSVASFSEWLGFSSEVGAFLAGVSLAGTQFRDALG--
MAB_2285|M.abscessus_ATCC_1997 SAPTSTTVTVATIIVCATAGQLLGFEPVIGAFFAGILVIAATPAGSRVHK
. :. : *: .: : .. :***:.*: : . :
Mb3264c|M.bovis_AF2122/97 MVLTPLRDLFATIFFLGIGLSVDPGKLVS--MLPVALALAAVTAATKVAT
Rv3236c|M.tuberculosis_H37Rv MVLTPLRDLFATIFFLGIGLSVDPGKLVS--MLPVALALAAVTAATKVAT
MMAR_1309|M.marinum_M RVLGPLRDLFAAIFFLGIGLSVAPKELIP--ALPVAMVLAVVTAATKVLT
MUL_2572|M.ulcerans_Agy99 RVLGPLRDLFAAIFFLGIGLSVAPKELIP--ALPVAILLAVVTAATKVLT
MLBr_00782|M.leprae_Br4923 KVLGPLRDLFAAIFFLAIGISVDPHKLLP--MFPTALILATVTAVTKVAT
MAV_4198|M.avium_104 QVLAPLRDLFAAIFFLAIGYSVDPHELIP--MLPAALILAAATAATKVAT
MSMEG_3664|M.smegmatis_MC2_155 LVLSPLRDLFAAIFFLAIGLSVHPSDLIP--MLPAAFVLAVVTAGTKVLT
Mvan_1424|M.vanbaalenii_PYR-1 ARLVSLRDFLLFFFFLNLGAGLDFSEAAG--QITAAIILSVFVLVAKPAI
MAB_2285|M.abscessus_ATCC_1997 PLHAMAVAFFGPIFFATIGLQLDLGRLLSGPVLALTASICVVAVFSKFLG
:: :** :* : :. : :.. . :*
Mb3264c|M.bovis_AF2122/97 GMFAARREGVARRGQLRAGTALVARGEFSLIIIGL---AGASIPGVA-AL
Rv3236c|M.tuberculosis_H37Rv GMFAARREGVARRGQLRAGTALVARGEFSLIIIGL---AGASIPGVA-AL
MMAR_1309|M.marinum_M GMFAARRDGVARRGQLRAGTALIARGEFSLIIIGL---VGASIPAVA-AL
MUL_2572|M.ulcerans_Agy99 GMFAARRDGVARRGQLRAGTALIARGEFSLIIIGL---VGASIPAVA-AL
MLBr_00782|M.leprae_Br4923 GILAARYDGVARRGQLRAGTALVARGEFSLIIIGL---VGTSTPAVA-AL
MAV_4198|M.avium_104 GIFAARHDGVARRGQLRAGTALIARGEFSLIIIGL---AGSSLPAVA-AL
MSMEG_3664|M.smegmatis_MC2_155 GQFAARRDGVARAGQLRAGTALIARGEFSLVIIGL---VGQTYERLE-AI
Mvan_1424|M.vanbaalenii_PYR-1 VIAIMSVMRYPVRVGFLVGLPLAQISEFSLILAALGLSLGHISNATV-SL
MAB_2285|M.abscessus_ATCC_1997 AGMGARISGFSWPESVAVGAGLNTRGVIQIVIAMVGVRCGVFSPEVFTAL
. . .* * . :.::: : * ::
Mb3264c|M.bovis_AF2122/97 ATAYVFVMAIVGPILARYTGGGLPAAAVASN-------------------
Rv3236c|M.tuberculosis_H37Rv ATAYVFVMAIVGPILARYTGGGLPAAAVASN-------------------
MMAR_1309|M.marinum_M ATAYVFIMAVAGPVLARYTGG--PVATTA---------------------
MUL_2572|M.ulcerans_Agy99 ATAYVFIMAVAGPVLARYTGG--PVATTA---------------------
MLBr_00782|M.leprae_Br4923 ATAYVFIMAIAGPVLARYTPGSLPTSSGSAN-------------------
MAV_4198|M.avium_104 ATSYVFIMAIAGPVLARYTGPR-PAAPAT---------------------
MSMEG_3664|M.smegmatis_MC2_155 ATPYVFILAIAGPVLTRYLGAR-PVVRT----------------------
Mvan_1424|M.vanbaalenii_PYR-1 ITVVGLITIAASTYMTMYSDGIFARSQRWLSHLERKHQRDHEVAGLSDGD
MAB_2285|M.abscessus_ATCC_1997 VVTTIATTAIAGPVLKRTLTPRRQLPAVISKPPQEPALNR----------
. ... :
Mb3264c|M.bovis_AF2122/97 --------------------------------------------------
Rv3236c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1309|M.marinum_M --------------------------------------------------
MUL_2572|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00782|M.leprae_Br4923 --------------------------------------------------
MAV_4198|M.avium_104 --------------------------------------------------
MSMEG_3664|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_1424|M.vanbaalenii_PYR-1 FDIILFGLGRFGSHLADRLSGAGHRVLGVDFDPHGVRAHRRDGVTTTFGS
MAB_2285|M.abscessus_ATCC_1997 --------------------------------------------------
Mb3264c|M.bovis_AF2122/97 --------------------------------------------------
Rv3236c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1309|M.marinum_M --------------------------------------------------
MUL_2572|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00782|M.leprae_Br4923 --------------------------------------------------
MAV_4198|M.avium_104 --------------------------------------------------
MSMEG_3664|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_1424|M.vanbaalenii_PYR-1 AEDLDLLEALPLDRAKYVISAIPVLQTNLALLHGLRQHQFSGAVALTAHT
MAB_2285|M.abscessus_ATCC_1997 --------------------------------------------------
Mb3264c|M.bovis_AF2122/97 --------------------------------------------------
Rv3236c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1309|M.marinum_M --------------------------------------------------
MUL_2572|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00782|M.leprae_Br4923 --------------------------------------------------
MAV_4198|M.avium_104 --------------------------------------------------
MSMEG_3664|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_1424|M.vanbaalenii_PYR-1 RHDAERLRATGVEIVIEPFSSAAHTTSNTLHDLLTTEFEDTDDEGYSDDE
MAB_2285|M.abscessus_ATCC_1997 --------------------------------------------------
Mb3264c|M.bovis_AF2122/97 ---------
Rv3236c|M.tuberculosis_H37Rv ---------
MMAR_1309|M.marinum_M ---------
MUL_2572|M.ulcerans_Agy99 ---------
MLBr_00782|M.leprae_Br4923 ---------
MAV_4198|M.avium_104 ---------
MSMEG_3664|M.smegmatis_MC2_155 ---------
Mvan_1424|M.vanbaalenii_PYR-1 GGAQPRPSR
MAB_2285|M.abscessus_ATCC_1997 ---------