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DGHLFPTIAIILALATAAGVVATRLRQPLIVAFIMVGVAVGPVGAGWVSADSTMELLARLGLAVLLFLVG LRLDLHMIRNTGPVAVITGLGQVLVTFALGLLIALALGMDNVTALYVAVALTFSSTIIIVKLLSDKRELE QLHGRIALGILIVQDIVVVVVMIALTASGRGGEGSVGAGIAAVALKGIGLLATLWVLMRFVLPWLMPQIA RSQELLVLFGVAYAVSVASFSEWLGFSSEVGAFLAGVSLAGTQFRDALGARLVSLRDFLLFFFFLNLGAG LDFSEAAGQITAAIILSVFVLVAKPAIVIAIMSVMRYPVRVGFLVGLPLAQISEFSLILAALGLSLGHIS NATVSLITVVGLITIAASTYMTMYSDGIFARSQRWLSHLERKHQRDHEVAGLSDGDFDIILFGLGRFGSH LADRLSGAGHRVLGVDFDPHGVRAHRRDGVTTTFGSAEDLDLLEALPLDRAKYVISAIPVLQTNLALLHG LRQHQFSGAVALTAHTRHDAERLRATGVEIVIEPFSSAAHTTSNTLHDLLTTEFEDTDDEGYSDDEGGAQ PRPSR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1424 | - | - | 100% (566) | sodium/hydrogen exchanger |
| M. vanbaalenii PYR-1 | Mvan_0746 | - | 2e-07 | 26.61% (327) | potassium/proton antiporter |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3264c | - | 4e-20 | 25.48% (365) | integral membrane transport protein |
| M. gilvum PYR-GCK | Mflv_0160 | - | 8e-08 | 25.54% (325) | potassium/proton antiporter |
| M. tuberculosis H37Rv | Rv3236c | - | 4e-20 | 25.48% (365) | integral membrane transport protein |
| M. leprae Br4923 | MLBr_00782 | - | 1e-20 | 26.44% (382) | putative transmembrane transport protein |
| M. abscessus ATCC 19977 | MAB_0385 | - | 3e-16 | 25.65% (386) | hypothetical protein MAB_0385 |
| M. marinum M | MMAR_1309 | - | 7e-19 | 25.33% (379) | membrane transporter |
| M. avium 104 | MAV_4198 | - | 5e-19 | 25.88% (371) | transporter, monovalent cation:proton antiporter-2 (CPA2) |
| M. smegmatis MC2 155 | MSMEG_3664 | - | 3e-18 | 28.06% (392) | transporter, monovalent cation:proton antiporter-2 (CPA2) |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_2572 | - | 3e-19 | 25.59% (379) | membrane transporter |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3264c|M.bovis_AF2122/97 --MEVSRALLFELGVLLAVLAVLGAVARRFALSPIPVYLLAGLSLGNGGI
Rv3236c|M.tuberculosis_H37Rv --MEVSRALLFELGVLLAVLAVLGAVARRFALSPIPVYLLAGLSLGNGGI
MMAR_1309|M.marinum_M --MEVSRALLFEVGALLTTLALLGAIARRFALSPIPVYLLAGLSLGKGGV
MUL_2572|M.ulcerans_Agy99 --MEVSRALLFEVGALLTTLALLGAIARRFALSPIPVYLLAGLSLGKGGV
MLBr_00782|M.leprae_Br4923 --MEISGALLSQVGALLTTLAVLGAGARRYSLSPIPVYLMAGLSLGKGGI
MAV_4198|M.avium_104 --MQISGTLLLQLGALLATLAVLGAAARRFALSPIPVYLLAGLALGKGGL
MSMEG_3664|M.smegmatis_MC2_155 --MEVSGALLLELGVILVALTVLGTAARRFALSPIPLYLVAGLALGEGGL
Mvan_1424|M.vanbaalenii_PYR-1 ----MDGHLFPTIAIILALATAAGVVATRLRQPLIVAFIMVGVAVGPVGA
Mflv_0160|M.gilvum_PYR-GCK MTLHQLYVALFLGGLVLLASIAATRLATGVGLPSLLLFLGVGVLVGEGGL
MAB_0385|M.abscessus_ATCC_1997 --MSGFGFPTLAIVVIVGMIGPLLALNTRLRIPVVIGELLAGIVIGRTGF
:: . : : .*: :* *
Mb3264c|M.bovis_AF2122/97 LGVAAAGEFIATGAPIGVVLLLLALGLEFSATEFASSLR-HHLPSAGVDI
Rv3236c|M.tuberculosis_H37Rv LGVAAAGEFIATGAPIGVVLLLLALGLEFSATEFASSLR-HHLPSAGVDI
MMAR_1309|M.marinum_M LPVAAADDFVATGAPIGIVLLLLTLGLEFSATEFASSLR-HHMPSAMVDI
MUL_2572|M.ulcerans_Agy99 LPVAAADDFVATGAPIGIVLLLLTLGLEFSATEFASSLR-HHMPSAMVDI
MLBr_00782|M.leprae_Br4923 MPVSAADEFITTGAPIGIVLLLLTLGLEFSATEFASSLR-RHLPSAGVDI
MAV_4198|M.avium_104 LPLATGGQFITTSAPIGVVLLLLTLGCEFSVAEFSSSMR-HHLPSAAVDV
MSMEG_3664|M.smegmatis_MC2_155 APVPATVEFVNTGASIGVVLLLLTLGLEFSIGEFASSLR-RHLPSAWIDL
Mvan_1424|M.vanbaalenii_PYR-1 G-WVSADSTMELLARLGLAVLLFLVGLRLDLHMIRNTGP-VAVITGLGQV
Mflv_0160|M.gilvum_PYR-GCK GLQFDNAQLGQDLGTAALAVILVEGGLTTRFSDIRKVLAPAAVLATLGVA
MAB_0385|M.abscessus_ATCC_1997 GWIDAFDPTFKMFADVGFALVMFVAGTHVPVRDKTMRAS--LPQAALRAI
. ...:::. * :
Mb3264c|M.bovis_AF2122/97 VLNATPGAVAGWLLGLDGVAILGLAGVTYISSSGVIARLLEDLRRLGNRE
Rv3236c|M.tuberculosis_H37Rv VLNATPGAVAGWLLGLDGVAILGLAGVTYISSSGVIARLLEDLRRLGNRE
MMAR_1309|M.marinum_M VLNATPGAVAGWLLGLDGVAILALAGVTYISSSGVVARLLEDLRRLGNRE
MUL_2572|M.ulcerans_Agy99 VLNATPGAVAGWLLGLDGVAILALAGVTYISSSGVVARLLEDLRRLGNRE
MLBr_00782|M.leprae_Br4923 ILNATPGAVAGWLLGLDGVAVLALAGVTYISSSGVIARLLADLRRLGNRE
MAV_4198|M.avium_104 VLNAAPGAIAGWLLGLDGVAILCLAGVTYISSSGVVARLLEDLRRLGNRE
MSMEG_3664|M.smegmatis_MC2_155 VLNALPGAIAGWLLDLGAVGILALAGVTYISSSGVIARLLGDLRRLGNRE
Mvan_1424|M.vanbaalenii_PYR-1 LVTFALGLLIALALGMDNVTALYVAVALTFSSTIIIVKLLSDKRELEQLH
Mflv_0160|M.gilvum_PYR-GCK VSTLVTAAAVHWLLGMNWQLALLLGAVISSTDAAAVFSVLR-VVPLPRRL
MAB_0385|M.abscessus_ATCC_1997 VVGAVAAVLGVLLANVFHTGHAPLYAVLIASSSAALVLPVIDSLGLGGPK
: . .: : . :.: : : *
Mb3264c|M.bovis_AF2122/97 TPAVLSVLVLEDFAMAAYLPLFAVLATDG--SWLEAVVGMTVAIAALLGA
Rv3236c|M.tuberculosis_H37Rv TPAVLSVLVLEDFAMAAYLPLFAVLATDG--SWLEAVVGMTVAIAALLGA
MMAR_1309|M.marinum_M TPAVLSVLVLEDFAMAGYLPLFTVLALHG--DWLHALGGTLAAIAALLGA
MUL_2572|M.ulcerans_Agy99 TPAVLSVLVLEDFAMAGYLPLFTVLALHG--DWLHALGGTLAAIAALLGA
MLBr_00782|M.leprae_Br4923 TPAVLSVLVLEDFAMAAYLPLFAVLAAGG--SWLDAVVGMIVAVCALFAA
MAV_4198|M.avium_104 TPAVLSVLVLEDFAMAAYLPLFAVLASGG--GWLHAVVGMVVAVSALVAA
MSMEG_3664|M.smegmatis_MC2_155 TPAVLSILVLEDFAMAAYLPLLAVLAAGG--TLLHALLGMAVAIAALVVA
Mvan_1424|M.vanbaalenii_PYR-1 GRIALGILIVQDIVVVVVMIALTASGRGGEGSVGAGIAAVALKGIGLLAT
Mflv_0160|M.gilvum_PYR-GCK SGLLEAESGFNDAPAVILVMLFSVVPMELN---AVDIVGTLVYELGIGTV
MAB_0385|M.abscessus_ATCC_1997 VLITTAQVAIADTASIILLPLVIDLKHAPR-AAVGAVAVAACAGIVFVIL
. . * : . : :
Mb3264c|M.bovis_AF2122/97 FAASY-RWGHHVGRLVTHPDSEQLLLRVLGITLIVAAVAESLHASAAVGA
Rv3236c|M.tuberculosis_H37Rv FAASY-RWGHHVGRLVTHPDSEQLLLRVLGITLIVAAVAESLHASAAVGA
MMAR_1309|M.marinum_M FAASF-YWGHHFGRLFAHPDSEQLLLRVLGITLMVAALAETLHASAAVGA
MUL_2572|M.ulcerans_Agy99 FAASF-YWGHHFGRLFAHPDSEQLLLRVLGITLMVAALAETLHASAAVGA
MLBr_00782|M.leprae_Br4923 FAASY-HWGHHVGRLVAHPDSEQLLLRVLGVTLIVAAVAESLHASAAVGA
MAV_4198|M.avium_104 FAASY-RWGHHVQRLVEHPDSEQLMLRVLGITLIVAAMAESLHASAAVGA
MSMEG_3664|M.smegmatis_MC2_155 FVVSY-RWGHHVTRFVSHPDNEQLLLRVLGLTLIVAALAEFIHASAAVGA
Mvan_1424|M.vanbaalenii_PYR-1 LWVLM-RFVLPWLMPQIARSQELLVLFGVAYAVSVASFSEWLGFSSEVGA
Mflv_0160|M.gilvum_PYR-GCK LGLGFGVLGAMTLRRIALPAAGLYPLATFGLGMLAFAAAGTAHGSGFLAA
MAB_0385|M.abscessus_ATCC_1997 HALDQAGKLDRFHDYSKQRRVAMELRISLAIVFGLAALAVETHVSIMLAG
.. . : : * :..
Mb3264c|M.bovis_AF2122/97 FLVGLTLT--GETADRAR-MVLTPLRDLFATIFFLGIGLSVDPGKLVSML
Rv3236c|M.tuberculosis_H37Rv FLVGLTLT--GETADRAR-MVLTPLRDLFATIFFLGIGLSVDPGKLVSML
MMAR_1309|M.marinum_M FLVGLTLT--GETAERAR-RVLGPLRDLFAAIFFLGIGLSVAPKELIPAL
MUL_2572|M.ulcerans_Agy99 FLVGLTLT--GETAERAR-RVLGPLRDLFAAIFFLGIGLSVAPKELIPAL
MLBr_00782|M.leprae_Br4923 FLVGLTLT--GDTAERAR-KVLGPLRDLFAAIFFLAIGISVDPHKLLPMF
MAV_4198|M.avium_104 FLVGLTLT--GETATRTR-QVLAPLRDLFAAIFFLAIGYSVDPHELIPML
MSMEG_3664|M.smegmatis_MC2_155 FLVGLTLT--GDSAHRAR-LVLSPLRDLFAAIFFLAIGLSVHPSDLIPML
Mvan_1424|M.vanbaalenii_PYR-1 FLAGVSLA--GTQFRDALGARLVSLRDFLLFFFFLNLGAGLDFSEAAGQI
Mflv_0160|M.gilvum_PYR-GCK YLASVVLANSGLPHRSATRSFAEGAGWLAQIGVFVILGLLVSPDQLLDEV
MAB_0385|M.abscessus_ATCC_1997 FALGLVVAGIGEPRRLAK-QLFGFTEGFFSPLFFVWLGASLHVRELG-EN
: .: :: * : : .*: :* : .
Mb3264c|M.bovis_AF2122/97 PVALALAAVTAATKVATGMFAARR-EGVARRGQLRAGTA-LVARGEFSLI
Rv3236c|M.tuberculosis_H37Rv PVALALAAVTAATKVATGMFAARR-EGVARRGQLRAGTA-LVARGEFSLI
MMAR_1309|M.marinum_M PVAMVLAVVTAATKVLTGMFAARR-DGVARRGQLRAGTA-LIARGEFSLI
MUL_2572|M.ulcerans_Agy99 PVAILLAVVTAATKVLTGMFAARR-DGVARRGQLRAGTA-LIARGEFSLI
MLBr_00782|M.leprae_Br4923 PTALILATVTAVTKVATGILAARY-DGVARRGQLRAGTA-LVARGEFSLI
MAV_4198|M.avium_104 PAALILAAATAATKVATGIFAARH-DGVARRGQLRAGTA-LIARGEFSLI
MSMEG_3664|M.smegmatis_MC2_155 PAAFVLAVVTAGTKVLTGQFAARR-DGVARAGQLRAGTA-LIARGEFSLV
Mvan_1424|M.vanbaalenii_PYR-1 TAAIILSVFVLVAKPAIVIAIMSV-MRYPVRVGFLVGLP-LAQISEFSLI
Mflv_0160|M.gilvum_PYR-GCK VPAIVAGLALLLLARPISVFLSLIGFRVPWREKMFLSWAGLRGAVPIVLC
MAB_0385|M.abscessus_ATCC_1997 PKLILLGVGLGVAAVLAHLVVRIFGQPLPLGALAAAQLGVPIAAAAIGEQ
: . . :
Mb3264c|M.bovis_AF2122/97 IIGL---AGASIPGVAALATAYVFVMAIVGPILARYTGGGLPAAAVASN-
Rv3236c|M.tuberculosis_H37Rv IIGL---AGASIPGVAALATAYVFVMAIVGPILARYTGGGLPAAAVASN-
MMAR_1309|M.marinum_M IIGL---VGASIPAVAALATAYVFIMAVAGPVLARYTGG--PVATTA---
MUL_2572|M.ulcerans_Agy99 IIGL---VGASIPAVAALATAYVFIMAVAGPVLARYTGG--PVATTA---
MLBr_00782|M.leprae_Br4923 IIGL---VGTSTPAVAALATAYVFIMAIAGPVLARYTPGSLPTSSGSAN-
MAV_4198|M.avium_104 IIGL---AGSSLPAVAALATSYVFIMAIAGPVLARYTGPR-PAAPAT---
MSMEG_3664|M.smegmatis_MC2_155 IIGL---VGQTYERLEAIATPYVFILAIAGPVLTRYLGAR-PVVRT----
Mvan_1424|M.vanbaalenii_PYR-1 LAALGLSLGHISNATVSLITVVGLITIAASTYMTMYSDGIFARSQRWLSH
Mflv_0160|M.gilvum_PYR-GCK TYPIVAGVPDSWRLLHIVFILVVLYTAIQGPSLRRVAEWLNLIPRDTTRE
MAB_0385|M.abscessus_ATCC_1997 QQSL---IHGEASALILGALVTIAAATVGGSLYAKTSQGNQPGVAKPERP
: ..
Mb3264c|M.bovis_AF2122/97 --------------------------------------------------
Rv3236c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1309|M.marinum_M --------------------------------------------------
MUL_2572|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00782|M.leprae_Br4923 --------------------------------------------------
MAV_4198|M.avium_104 --------------------------------------------------
MSMEG_3664|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_1424|M.vanbaalenii_PYR-1 LERKHQRDHEVAGLSDGDFDIILFGLGRFGSHLADRLSGAGHRVLGVDFD
Mflv_0160|M.gilvum_PYR-GCK IQVDAAP-----------------------------LDVLGAELLTMTVL
MAB_0385|M.abscessus_ATCC_1997 VDDSEG-------------------------------SGAGGGAEGAGGG
Mb3264c|M.bovis_AF2122/97 --------------------------------------------------
Rv3236c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1309|M.marinum_M --------------------------------------------------
MUL_2572|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00782|M.leprae_Br4923 --------------------------------------------------
MAV_4198|M.avium_104 --------------------------------------------------
MSMEG_3664|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_1424|M.vanbaalenii_PYR-1 PHGVRAHRRDGVTTTFGSAEDLDLLEALPLDRAKYVISAIPVLQTNLALL
Mflv_0160|M.gilvum_PYR-GCK P-GSRLHNVTVLELRLPDPSVITLIIRDGQSFVPQPVTRLQIGDELLIVT
MAB_0385|M.abscessus_ATCC_1997 VAG-----------------------------------------------
Mb3264c|M.bovis_AF2122/97 --------------------------------------------------
Rv3236c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1309|M.marinum_M --------------------------------------------------
MUL_2572|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00782|M.leprae_Br4923 --------------------------------------------------
MAV_4198|M.avium_104 --------------------------------------------------
MSMEG_3664|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_1424|M.vanbaalenii_PYR-1 HGLRQHQFSGAVALTAHTRHDAERLRATGVEIVIEPFSSAAHTTSNTLHD
Mflv_0160|M.gilvum_PYR-GCK TSVTRDQAERRLRAVSRRGKLAYWFDEYGDPA------------------
MAB_0385|M.abscessus_ATCC_1997 --------------------------------------------------
Mb3264c|M.bovis_AF2122/97 ---------------------------
Rv3236c|M.tuberculosis_H37Rv ---------------------------
MMAR_1309|M.marinum_M ---------------------------
MUL_2572|M.ulcerans_Agy99 ---------------------------
MLBr_00782|M.leprae_Br4923 ---------------------------
MAV_4198|M.avium_104 ---------------------------
MSMEG_3664|M.smegmatis_MC2_155 ---------------------------
Mvan_1424|M.vanbaalenii_PYR-1 LLTTEFEDTDDEGYSDDEGGAQPRPSR
Mflv_0160|M.gilvum_PYR-GCK ---------------------------
MAB_0385|M.abscessus_ATCC_1997 ---------------------------