For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
EVSRALLFELGVLLAVLAVLGAVARRFALSPIPVYLLAGLSLGNGGILGVAAAGEFIATGAPIGVVLLLL ALGLEFSATEFASSLRHHLPSAGVDIVLNATPGAVAGWLLGLDGVAILGLAGVTYISSSGVIARLLEDLR RLGNRETPAVLSVLVLEDFAMAAYLPLFAVLATDGSWLEAVVGMTVAIAALLGAFAASYRWGHHVGRLVT HPDSEQLLLRVLGITLIVAAVAESLHASAAVGAFLVGLTLTGETADRARMVLTPLRDLFATIFFLGIGLS VDPGKLVSMLPVALALAAVTAATKVATGMFAARREGVARRGQLRAGTALVARGEFSLIIIGLAGASIPGV AALATAYVFVMAIVGPILARYTGGGLPAAAVASN*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3236c | - | - | 100% (385) | PROBABLE CONSERVED INTEGRAL MEMBRANE TRANSPORT PROTEIN |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3264c | - | 0.0 | 100.00% (385) | integral membrane transport protein |
| M. gilvum PYR-GCK | - | - | - | - | - |
| M. leprae Br4923 | MLBr_00782 | - | 1e-173 | 81.56% (385) | putative transmembrane transport protein |
| M. abscessus ATCC 19977 | MAB_2285 | - | 1e-15 | 24.81% (403) | Na+/H+ antiporter |
| M. marinum M | MMAR_1309 | - | 1e-174 | 83.20% (381) | membrane transporter |
| M. avium 104 | MAV_4198 | - | 1e-169 | 81.55% (374) | transporter, monovalent cation:proton antiporter-2 (CPA2) |
| M. smegmatis MC2 155 | MSMEG_3664 | - | 1e-150 | 74.06% (374) | transporter, monovalent cation:proton antiporter-2 (CPA2) |
| M. thermoresistible (build 8) | TH_2104 | - | 7e-05 | 24.42% (303) | sulfate permease |
| M. ulcerans Agy99 | MUL_2572 | - | 1e-174 | 83.20% (381) | membrane transporter |
| M. vanbaalenii PYR-1 | Mvan_1424 | - | 4e-20 | 25.48% (365) | sodium/hydrogen exchanger |
CLUSTAL 2.0.9 multiple sequence alignment
Rv3236c|M.tuberculosis_H37Rv -------------MEVSRALLFELGVLLAVLAVLGAVARRFALSPIPVYL
Mb3264c|M.bovis_AF2122/97 -------------MEVSRALLFELGVLLAVLAVLGAVARRFALSPIPVYL
MMAR_1309|M.marinum_M -------------MEVSRALLFEVGALLTTLALLGAIARRFALSPIPVYL
MUL_2572|M.ulcerans_Agy99 -------------MEVSRALLFEVGALLTTLALLGAIARRFALSPIPVYL
MLBr_00782|M.leprae_Br4923 -------------MEISGALLSQVGALLTTLAVLGAGARRYSLSPIPVYL
MAV_4198|M.avium_104 -------------MQISGTLLLQLGALLATLAVLGAAARRFALSPIPVYL
MSMEG_3664|M.smegmatis_MC2_155 -------------MEVSGALLLELGVILVALTVLGTAARRFALSPIPLYL
MAB_2285|M.abscessus_ATCC_1997 MSNTAVTAAAALSKDVSLIFFADLVILLVAALACGAVAGKIGLPKMVGEI
Mvan_1424|M.vanbaalenii_PYR-1 ---------------MDGHLFPTIAIILALATAAGVVATRLRQPLIVAFI
TH_2104|M.thermoresistible__bu --VIATAKENLIRLLPSRRDYAELPRSWRRDILAGITVGVVALPLALAFG
. : * . .
Rv3236c|M.tuberculosis_H37Rv LAG-----LSLGN---GGILGVAAAGEFIATGAP---------IGVVLLL
Mb3264c|M.bovis_AF2122/97 LAG-----LSLGN---GGILGVAAAGEFIATGAP---------IGVVLLL
MMAR_1309|M.marinum_M LAG-----LSLGK---GGVLPVAAADDFVATGAP---------IGIVLLL
MUL_2572|M.ulcerans_Agy99 LAG-----LSLGK---GGVLPVAAADDFVATGAP---------IGIVLLL
MLBr_00782|M.leprae_Br4923 MAG-----LSLGK---GGIMPVSAADEFITTGAP---------IGIVLLL
MAV_4198|M.avium_104 LAG-----LALGK---GGLLPLATGGQFITTSAP---------IGVVLLL
MSMEG_3664|M.smegmatis_MC2_155 VAG-----LALGE---GGLAPVPATVEFVNTGAS---------IGVVLLL
MAB_2285|M.abscessus_ATCC_1997 AAG-----VLLGPTVFGRLFPETKDALFPSAGTGSEIISGLCLLAVVLLV
Mvan_1424|M.vanbaalenii_PYR-1 MVG-----VAVGPVG-AGWVSADSTMELLAR------------LGLAVLL
TH_2104|M.thermoresistible__bu ISSGVGAAAGLITAVVAGLVAAVFGGSHIQVSGPTG------AMAVILAP
. : . :.: :
Rv3236c|M.tuberculosis_H37Rv LALGLEFSATEFASSLRHHLPSAG----VDIVLNATPG-AVAGWLLGLDG
Mb3264c|M.bovis_AF2122/97 LALGLEFSATEFASSLRHHLPSAG----VDIVLNATPG-AVAGWLLGLDG
MMAR_1309|M.marinum_M LTLGLEFSATEFASSLRHHMPSAM----VDIVLNATPG-AVAGWLLGLDG
MUL_2572|M.ulcerans_Agy99 LTLGLEFSATEFASSLRHHMPSAM----VDIVLNATPG-AVAGWLLGLDG
MLBr_00782|M.leprae_Br4923 LTLGLEFSATEFASSLRRHLPSAG----VDIILNATPG-AVAGWLLGLDG
MAV_4198|M.avium_104 LTLGCEFSVAEFSSSMRHHLPSAA----VDVVLNAAPG-AIAGWLLGLDG
MSMEG_3664|M.smegmatis_MC2_155 LTLGLEFSIGEFASSLRRHLPSAW----IDLVLNALPG-AIAGWLLDLGA
MAB_2285|M.abscessus_ATCC_1997 GVAGMHVDVDKLKQRLAGIATISV----LGLAVPLAGG-MAVGYLVPEPL
Mvan_1424|M.vanbaalenii_PYR-1 FLVGLRLDLHMIRNTGPVAVITGL----GQVLVTFALG-LLIALALGMDN
TH_2104|M.thermoresistible__bu IVAQHGLTSIALVTVLAGLIVLAAGITGLGRAVTFIPWPVIEGFTLGIAA
. : . : . :
Rv3236c|M.tuberculosis_H37Rv --------VAILGLAGVTYISSSGVIARLLEDLRRLGNRETPAVLSVLVL
Mb3264c|M.bovis_AF2122/97 --------VAILGLAGVTYISSSGVIARLLEDLRRLGNRETPAVLSVLVL
MMAR_1309|M.marinum_M --------VAILALAGVTYISSSGVVARLLEDLRRLGNRETPAVLSVLVL
MUL_2572|M.ulcerans_Agy99 --------VAILALAGVTYISSSGVVARLLEDLRRLGNRETPAVLSVLVL
MLBr_00782|M.leprae_Br4923 --------VAVLALAGVTYISSSGVIARLLADLRRLGNRETPAVLSVLVL
MAV_4198|M.avium_104 --------VAILCLAGVTYISSSGVVARLLEDLRRLGNRETPAVLSVLVL
MSMEG_3664|M.smegmatis_MC2_155 --------VGILALAGVTYISSSGVIARLLGDLRRLGNRETPAVLSILVL
MAB_2285|M.abscessus_ATCC_1997 RPAAVDRTVFALFLGTAVAVSAIPVIARILMDLGLASHEIAQVILAAAIV
Mvan_1424|M.vanbaalenii_PYR-1 --------VTALYVAVALTFSSTIIIVKLLSDKRELEQLHGRIALGILIV
TH_2104|M.thermoresistible__bu -------IIFLQQVPAAFATEAPAGQRTLVAAWHVVTHADWTAAVKTLSV
: : . .: :: : : :
Rv3236c|M.tuberculosis_H37Rv EDFAMAAYLPLFAVLATD--GSWLEAVVGMTVAIAALLGAFAASYR--WG
Mb3264c|M.bovis_AF2122/97 EDFAMAAYLPLFAVLATD--GSWLEAVVGMTVAIAALLGAFAASYR--WG
MMAR_1309|M.marinum_M EDFAMAGYLPLFTVLALH--GDWLHALGGTLAAIAALLGAFAASFY--WG
MUL_2572|M.ulcerans_Agy99 EDFAMAGYLPLFTVLALH--GDWLHALGGTLAAIAALLGAFAASFY--WG
MLBr_00782|M.leprae_Br4923 EDFAMAAYLPLFAVLAAG--GSWLDAVVGMIVAVCALFAAFAASYH--WG
MAV_4198|M.avium_104 EDFAMAAYLPLFAVLASG--GGWLHAVVGMVVAVSALVAAFAASYR--WG
MSMEG_3664|M.smegmatis_MC2_155 EDFAMAAYLPLLAVLAAG--GTLLHALLGMAVAIAALVVAFVVSYR--WG
MAB_2285|M.abscessus_ATCC_1997 DDVAGWLLLSAVTGMASDS-GTGGVAVLKMAVAAIVAVVALTALTRPALR
Mvan_1424|M.vanbaalenii_PYR-1 QDIVVVVVMIALTASGRGGEGSVGAGIAAVALKGIGLLATLWVLMR--FV
TH_2104|M.thermoresistible__bu VSLVALLMVVLPRLHRSIPESLTAVVAATVIVTVFGISVATIGELPSQLP
... : . :
Rv3236c|M.tuberculosis_H37Rv HHVGRLVTHPDSEQLLLRVLGITLIVAAVAES----LHASAAVGAFLVGL
Mb3264c|M.bovis_AF2122/97 HHVGRLVTHPDSEQLLLRVLGITLIVAAVAES----LHASAAVGAFLVGL
MMAR_1309|M.marinum_M HHFGRLFAHPDSEQLLLRVLGITLMVAALAET----LHASAAVGAFLVGL
MUL_2572|M.ulcerans_Agy99 HHFGRLFAHPDSEQLLLRVLGITLMVAALAET----LHASAAVGAFLVGL
MLBr_00782|M.leprae_Br4923 HHVGRLVAHPDSEQLLLRVLGVTLIVAAVAES----LHASAAVGAFLVGL
MAV_4198|M.avium_104 HHVQRLVEHPDSEQLMLRVLGITLIVAAMAES----LHASAAVGAFLVGL
MSMEG_3664|M.smegmatis_MC2_155 HHVTRFVSHPDNEQLLLRVLGLTLIVAALAEF----IHASAAVGAFLVGL
MAB_2285|M.abscessus_ATCC_1997 NRLARRCSRWSAPTSTTVTVATIIVCATAGQL----LGFEPVIGAFFAGI
Mvan_1424|M.vanbaalenii_PYR-1 LPWLMPQIARSQELLVLFGVAYAVSVASFSEW----LGFSSEVGAFLAGV
TH_2104|M.thermoresistible__bu TPVLPQADMGAMQTLLGAALAIAALAAIESLLSARVAATMSATGPYHPDR
:. * . . *.: .
Rv3236c|M.tuberculosis_H37Rv TLTGETADR----ARMVLTPLRDLFATIFFLGIGLSVDPGKLVS--MLPV
Mb3264c|M.bovis_AF2122/97 TLTGETADR----ARMVLTPLRDLFATIFFLGIGLSVDPGKLVS--MLPV
MMAR_1309|M.marinum_M TLTGETAER----ARRVLGPLRDLFAAIFFLGIGLSVAPKELIP--ALPV
MUL_2572|M.ulcerans_Agy99 TLTGETAER----ARRVLGPLRDLFAAIFFLGIGLSVAPKELIP--ALPV
MLBr_00782|M.leprae_Br4923 TLTGDTAER----ARKVLGPLRDLFAAIFFLAIGISVDPHKLLP--MFPT
MAV_4198|M.avium_104 TLTGETATR----TRQVLAPLRDLFAAIFFLAIGYSVDPHELIP--MLPA
MSMEG_3664|M.smegmatis_MC2_155 TLTGDSAHR----ARLVLSPLRDLFAAIFFLAIGLSVHPSDLIP--MLPA
MAB_2285|M.abscessus_ATCC_1997 LVIAATPAGSRV-HKPLHAMAVAFFGPIFFATIGLQLDLGRLLSGPVLAL
Mvan_1424|M.vanbaalenii_PYR-1 SLAGTQFRD--A-LGARLVSLRDFLLFFFFLNLGAGLDFSEAAG--QITA
TH_2104|M.thermoresistible__bu ELVGQGMASVASGLFGGMPATGAIARTAVNVRSGARTRLAAIVHSLVLLA
: . : . * :
Rv3236c|M.tuberculosis_H37Rv ALALAAVTAATKVATGMFAARREGVARRGQLRAGTALVARG---EFSLII
Mb3264c|M.bovis_AF2122/97 ALALAAVTAATKVATGMFAARREGVARRGQLRAGTALVARG---EFSLII
MMAR_1309|M.marinum_M AMVLAVVTAATKVLTGMFAARRDGVARRGQLRAGTALIARG---EFSLII
MUL_2572|M.ulcerans_Agy99 AILLAVVTAATKVLTGMFAARRDGVARRGQLRAGTALIARG---EFSLII
MLBr_00782|M.leprae_Br4923 ALILATVTAVTKVATGILAARYDGVARRGQLRAGTALVARG---EFSLII
MAV_4198|M.avium_104 ALILAAATAATKVATGIFAARHDGVARRGQLRAGTALIARG---EFSLII
MSMEG_3664|M.smegmatis_MC2_155 AFVLAVVTAGTKVLTGQFAARRDGVARAGQLRAGTALIARG---EFSLVI
MAB_2285|M.abscessus_ATCC_1997 TASICVVAVFSKFLGAGMGARISGFSWPESVAVGAGLNTRG---VIQIVI
Mvan_1424|M.vanbaalenii_PYR-1 AIILSVFVLVAKPAIVIAIMSVMRYPVRVGFLVGLPLAQIS---EFSLIL
TH_2104|M.thermoresistible__bu VVYLATGPVSAIPLSALAGVLMVTSFRMVSLHTARRILRSTRSDALTFVL
. :.. : . .. : : :::
Rv3236c|M.tuberculosis_H37Rv IGLAG----ASIPGVAALATAYVFVMAIVG--------------------
Mb3264c|M.bovis_AF2122/97 IGLAG----ASIPGVAALATAYVFVMAIVG--------------------
MMAR_1309|M.marinum_M IGLVG----ASIPAVAALATAYVFIMAVAG--------------------
MUL_2572|M.ulcerans_Agy99 IGLVG----ASIPAVAALATAYVFIMAVAG--------------------
MLBr_00782|M.leprae_Br4923 IGLVG----TSTPAVAALATAYVFIMAIAG--------------------
MAV_4198|M.avium_104 IGLAG----SSLPAVAALATSYVFIMAIAG--------------------
MSMEG_3664|M.smegmatis_MC2_155 IGLVG----QTYERLEAIATPYVFILAIAG--------------------
MAB_2285|M.abscessus_ATCC_1997 AMVGVRCGVFSPEVFTALVVTTIATTAIAG--------------------
Mvan_1424|M.vanbaalenii_PYR-1 AALGLSLGHISNATVSLITVVGLITIAASTYMTMYSDGIFARSQRWLSHL
TH_2104|M.thermoresistible__bu TALVT----ITFDLIEAVQIGVLVAAFFALR-------------------
: : . : :
Rv3236c|M.tuberculosis_H37Rv ------------------------------PILARYTGGGLPAAAVASN-
Mb3264c|M.bovis_AF2122/97 ------------------------------PILARYTGGGLPAAAVASN-
MMAR_1309|M.marinum_M ------------------------------PVLARYTGG--PVATTA---
MUL_2572|M.ulcerans_Agy99 ------------------------------PVLARYTGG--PVATTA---
MLBr_00782|M.leprae_Br4923 ------------------------------PVLARYTPGSLPTSSGSAN-
MAV_4198|M.avium_104 ------------------------------PVLARYTGPR-PAAPAT---
MSMEG_3664|M.smegmatis_MC2_155 ------------------------------PVLTRYLGAR-PVVRT----
MAB_2285|M.abscessus_ATCC_1997 ------------------------------PVLKRTLTPRRQLPAVISKP
Mvan_1424|M.vanbaalenii_PYR-1 ERKHQRDHEVAGLSDGDFDIILFGLGRFGSHLADRLSGAGHRVLGVDFDP
TH_2104|M.thermoresistible__bu ------------------------------NVARRSGVTREELPGEPQPG
: *
Rv3236c|M.tuberculosis_H37Rv --------------------------------------------------
Mb3264c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_1309|M.marinum_M --------------------------------------------------
MUL_2572|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00782|M.leprae_Br4923 --------------------------------------------------
MAV_4198|M.avium_104 --------------------------------------------------
MSMEG_3664|M.smegmatis_MC2_155 --------------------------------------------------
MAB_2285|M.abscessus_ATCC_1997 PQEPALNR------------------------------------------
Mvan_1424|M.vanbaalenii_PYR-1 HGVRAHRRDGVTTTFGSAEDLDLLEALPLDRAKYVISAIPVLQTNLALLH
TH_2104|M.thermoresistible__bu DERIALLRLEGSMFFG------VAERMSSTISEIEADDISVVIIRLSQLG
Rv3236c|M.tuberculosis_H37Rv --------------------------------------------------
Mb3264c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_1309|M.marinum_M --------------------------------------------------
MUL_2572|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00782|M.leprae_Br4923 --------------------------------------------------
MAV_4198|M.avium_104 --------------------------------------------------
MSMEG_3664|M.smegmatis_MC2_155 --------------------------------------------------
MAB_2285|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_1424|M.vanbaalenii_PYR-1 GLRQHQFSGAVALTAHTRHDAERLRATGVEIVIEPFSSAAHTTSNTLHDL
TH_2104|M.thermoresistible__bu TLDATGANSLAQIATELERRGITVIIKGVQPEHSKLLSNVGVFESLRHEK
Rv3236c|M.tuberculosis_H37Rv ---------------------------
Mb3264c|M.bovis_AF2122/97 ---------------------------
MMAR_1309|M.marinum_M ---------------------------
MUL_2572|M.ulcerans_Agy99 ---------------------------
MLBr_00782|M.leprae_Br4923 ---------------------------
MAV_4198|M.avium_104 ---------------------------
MSMEG_3664|M.smegmatis_MC2_155 ---------------------------
MAB_2285|M.abscessus_ATCC_1997 ---------------------------
Mvan_1424|M.vanbaalenii_PYR-1 LTTEFEDTDDEGYSDDEGGAQPRPSR-
TH_2104|M.thermoresistible__bu HLIDSLEDAIEHARSHVARQQTARTTS