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PADTAIHFFLQLAVILMACRLAGLVARRIGQAQVVGEMIAGVILGPSLLGRIAPDLQGLLFPPGITNVVL YTTAQIGLVLYMFIIGLNFDVNHVKQRAGTAAAVSATGTLAPLALGGVAAIPLLAHGGFFGDGVNVGMAM MFLGASVAITAFPMLARIIFEKRLSGTSLGTLALACGATSDAISWCILAVVLAVYRNSPVMAVVAIVGGL VYTLVLLTLGRRAFAKLGDAAEARQAITAPMLSTVLIVLMACAWLTDTIGIYAIFGAFILGAAMPSGFFA ERLTGRLEPLTTTFLLPLFFVYSGLNTEIGLVNTPFLWAVTAGLLVVAVVGKGVACAVAARLSRVPVRDS LALGSLMNARGLIELILLNIGLEAGVITPTLFTILVLVAIVTTLMASPIFEFVYGRHRTDETGDTTQERV PQPSA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6769 | - | - | 100% (426) | transporter, monovalent cation:proton antiporter-2 (CPA2) family protein |
| M. smegmatis MC2 155 | MSMEG_3664 | - | 3e-11 | 25.12% (406) | transporter, monovalent cation:proton antiporter-2 (CPA2) |
| M. smegmatis MC2 155 | MSMEG_2775 | nhaA | 1e-07 | 25.27% (277) | Na+/H+ antiporter NhaA |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3264c | - | 2e-11 | 25.06% (407) | integral membrane transport protein |
| M. gilvum PYR-GCK | - | - | - | - | - |
| M. tuberculosis H37Rv | Rv3236c | - | 3e-11 | 25.06% (407) | integral membrane transport protein |
| M. leprae Br4923 | MLBr_00782 | - | 1e-10 | 23.56% (399) | putative transmembrane transport protein |
| M. abscessus ATCC 19977 | MAB_2285 | - | 6e-51 | 30.88% (408) | Na+/H+ antiporter |
| M. marinum M | MMAR_3635 | - | 3e-43 | 28.60% (437) | integral membrane ion antiporter |
| M. avium 104 | MAV_4118 | - | 2e-14 | 25.67% (413) | transporter, monovalent cation:proton antiporter-2 (CPA2) |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_2572 | - | 4e-10 | 23.69% (401) | membrane transporter |
| M. vanbaalenii PYR-1 | Mvan_1424 | - | 9e-18 | 24.05% (395) | sodium/hydrogen exchanger |
CLUSTAL 2.0.9 multiple sequence alignment
MAB_2285|M.abscessus_ATCC_1997 MSNTAVTAAAALSKDVSLIFFADLVILLVAALACG---AVAGKIGLPKMV
MMAR_3635|M.marinum_M -----------MLADELLEFFLQFGLLLLAATILG---RVAIRLGMPAIA
Mb3264c|M.bovis_AF2122/97 -------------MEVSRALLFELGVLLAVLAVLG---AVARRFALSPIP
Rv3236c|M.tuberculosis_H37Rv -------------MEVSRALLFELGVLLAVLAVLG---AVARRFALSPIP
MUL_2572|M.ulcerans_Agy99 -------------MEVSRALLFEVGALLTTLALLG---AIARRFALSPIP
MLBr_00782|M.leprae_Br4923 -------------MEISGALLSQVGALLTTLAVLG---AGARRYSLSPIP
MSMEG_6769|M.smegmatis_MC2_155 -----------MPADTAIHFFLQLAVILMACRLAG---LVARRIGQAQVV
Mvan_1424|M.vanbaalenii_PYR-1 ---------------MDGHLFPTIAIILALATAAG---VVATRLRQPLIV
MAV_4118|M.avium_104 -----------MQNERVQGFGFHTLALLTAVGFAGPLLASAKRFRIPVVI
: :* * * : . :
MAB_2285|M.abscessus_ATCC_1997 GEIAAGVLLGPTVFGRLFPETKDALFPSAGTGSEIISGLCLLAVVLLVGV
MMAR_3635|M.marinum_M GELCAGVLLGPSILGQVAPGLSSWLLPEQVSERLGLDAVGTFGVLLLMGL
Mb3264c|M.bovis_AF2122/97 VYLLAGLSLG-----------NGGILGVAAAGEFIATG-APIGVVLLLLA
Rv3236c|M.tuberculosis_H37Rv VYLLAGLSLG-----------NGGILGVAAAGEFIATG-APIGVVLLLLA
MUL_2572|M.ulcerans_Agy99 VYLLAGLSLG-----------KGGVLPVAAADDFVATG-APIGIVLLLLT
MLBr_00782|M.leprae_Br4923 VYLMAGLSLG-----------KGGIMPVSAADEFITTG-APIGIVLLLLT
MSMEG_6769|M.smegmatis_MC2_155 GEMIAGVILGPSLLGRIAPDLQGLLFPPGITNVVLYTT-AQIGLVLYMFI
Mvan_1424|M.vanbaalenii_PYR-1 AFIMVGVAVG-------------PVGAGWVSADSTMELLARLGLAVLLFL
MAV_4118|M.avium_104 GELIAGLAIG------------RTGFGVVDVADPTFQLLANIGFALVMFV
: .*: :* :.. : :
MAB_2285|M.abscessus_ATCC_1997 AG--MHVDVDKLKQRLAGIATISVLGLAVPLAGG--MAVGYLVPEPLRPA
MMAR_3635|M.marinum_M TG--MQVDLNLLKSNRLAITKISAACLLVPVVFG--LGIGFLMPSVLT-G
Mb3264c|M.bovis_AF2122/97 LG--LEFSATEFASSLRHHLPSAGVDIVLNATPG--AVAGWLLG------
Rv3236c|M.tuberculosis_H37Rv LG--LEFSATEFASSLRHHLPSAGVDIVLNATPG--AVAGWLLG------
MUL_2572|M.ulcerans_Agy99 LG--LEFSATEFASSLRHHMPSAMVDIVLNATPG--AVAGWLLG------
MLBr_00782|M.leprae_Br4923 LG--LEFSATEFASSLRRHLPSAGVDIILNATPG--AVAGWLLG------
MSMEG_6769|M.smegmatis_MC2_155 IG--LNFDVNHVKQRAGTAAAVSATGTLAPLALGGVAAIPLLAHGGFFGD
Mvan_1424|M.vanbaalenii_PYR-1 VG--LRLDLHMIRNTGPVAVITGLGQVLVTFALG--LLIALALG------
MAV_4118|M.avium_104 VGTHVPLRARLMRSALPAALARAALAGGIAAVLGVALAVQFDTG------
* : . . . . . *
MAB_2285|M.abscessus_ATCC_1997 AVDRTVFALFLGTAVAVSAIPVIARILMDLGLASHEIAQVILAAAIVDDV
MMAR_3635|M.marinum_M GSNRLVFALFLAVALSVSAIAVIVKTLSDLGLMHRDIAQLILATAVIDNV
Mb3264c|M.bovis_AF2122/97 --LDGVAILGLAGVTYISSSGVIARLLEDLRRLGNRETPAVLSVLVLEDF
Rv3236c|M.tuberculosis_H37Rv --LDGVAILGLAGVTYISSSGVIARLLEDLRRLGNRETPAVLSVLVLEDF
MUL_2572|M.ulcerans_Agy99 --LDGVAILALAGVTYISSSGVVARLLEDLRRLGNRETPAVLSVLVLEDF
MLBr_00782|M.leprae_Br4923 --LDGVAVLALAGVTYISSSGVIARLLADLRRLGNRETPAVLSVLVLEDF
MSMEG_6769|M.smegmatis_MC2_155 GVNVGMAMMFLGASVAITAFPMLARIIFEKRLSGTSLGTLALACGATSDA
Mvan_1424|M.vanbaalenii_PYR-1 --MDNVTALYVAVALTFSSTIIIVKLLSDKRELEQLHGRIALGILIVQDI
MAV_4118|M.avium_104 ------HAALYAVLMASSSAALALPVIDSLRLRGPR-VLSVTTQIAIADA
. :: : : . :
MAB_2285|M.abscessus_ATCC_1997 AGWLLLSAVTGMASD-SGTGGVAVLKMAVAAIVAVVALTALTRPALRNRL
MMAR_3635|M.marinum_M IAWVLLSVVCAMALA-HLS--LGTVLLTVFLIISVVAATIIGRKIVEVFV
Mb3264c|M.bovis_AF2122/97 AMAAYLPLFAVLATDGSWLEAVVGMTVAIAALLGAFAASYRWGHHVGRLV
Rv3236c|M.tuberculosis_H37Rv AMAAYLPLFAVLATDGSWLEAVVGMTVAIAALLGAFAASYRWGHHVGRLV
MUL_2572|M.ulcerans_Agy99 AMAGYLPLFTVLALHGDWLHALGGTLAAIAALLGAFAASFYWGHHFGRLF
MLBr_00782|M.leprae_Br4923 AMAAYLPLFAVLAAGGSWLDAVVGMIVAVCALFAAFAASYHWGHHVGRLV
MSMEG_6769|M.smegmatis_MC2_155 ISWCILAVVLAVYRN----SPVMAVVAIVGGLVYTLVLLTLGRRAFAKLG
Mvan_1424|M.vanbaalenii_PYR-1 VVVVVMIALTASGRGGEGSVGAGIAAVALKGIGLLATLWVLMRFVLPWLM
MAV_4118|M.avium_104 ACIVLLPLVIDIRRAPTAALGALAVAGCAAALFVLLRAADRKGWRRRLHA
: . :
MAB_2285|M.abscessus_ATCC_1997 ARRCSRWSAPTST------TVTVATIIVCATAGQLLGFEPVIGAFFAGIL
MMAR_3635|M.marinum_M NSRQQPAAAEHSAGPRPILAYAVGLVMLAAAATHALKLEPVLGAFAAGIM
Mb3264c|M.bovis_AF2122/97 THPDSEQ----------LLLRVLGITLIVAAVAESLHASAAVGAFLVGLT
Rv3236c|M.tuberculosis_H37Rv THPDSEQ----------LLLRVLGITLIVAAVAESLHASAAVGAFLVGLT
MUL_2572|M.ulcerans_Agy99 AHPDSEQ----------LLLRVLGITLMVAALAETLHASAAVGAFLVGLT
MLBr_00782|M.leprae_Br4923 AHPDSEQ----------LLLRVLGVTLIVAAVAESLHASAAVGAFLVGLT
MSMEG_6769|M.smegmatis_MC2_155 DAAEARQAITAP-----MLSTVLIVLMACAWLTDTIGIYAIFGAFILGAA
Mvan_1424|M.vanbaalenii_PYR-1 PQIARSQE--------LLVLFGVAYAVSVASFSEWLGFSSEVGAFLAGVS
MAV_4118|M.avium_104 YSEQHRFA--------LELRTSLLVLFALAALAVATQVSIMLAGFAVGLV
: . * ...* *
MAB_2285|M.abscessus_ATCC_1997 VIAATPAGSRVHKPLHAMAVAFFGPIFFATIGLQLDLGRLLSGPVLALTA
MMAR_3635|M.marinum_M LAALPPDRRSGLDSLHPVVNNVLAPLYFATAGLQADLTGLADRTTLAAAL
Mb3264c|M.bovis_AF2122/97 LTGETADRAR---MVLTPLRDLFATIFFLGIGLSVDPGKLVS--MLPVAL
Rv3236c|M.tuberculosis_H37Rv LTGETADRAR---MVLTPLRDLFATIFFLGIGLSVDPGKLVS--MLPVAL
MUL_2572|M.ulcerans_Agy99 LTGETAERAR---RVLGPLRDLFAAIFFLGIGLSVAPKELIP--ALPVAI
MLBr_00782|M.leprae_Br4923 LTGDTAERAR---KVLGPLRDLFAAIFFLAIGISVDPHKLLP--MFPTAL
MSMEG_6769|M.smegmatis_MC2_155 MPSGFFAERLTG-RLEPLTTTFLLPLFFVYSGLNTEIGLVNTPFLWAVTA
Mvan_1424|M.vanbaalenii_PYR-1 LAGTQFRDALG--ARLVSLRDFLLFFFFLNLGAGLDFSEAAG--QITAAI
MAV_4118|M.avium_104 VGAVGEPHRLAR-QLFGITEGFFSPLFFVWLGASLQVRELGA----HPQL
: . .: ::* *
MAB_2285|M.abscessus_ATCC_1997 SICVVAVFSKFLGAGMGARISGFSWPESVAVGAGLNTRGVIQIVIAMVGV
MMAR_3635|M.marinum_M VVLAAAVASKFLGAYIGAKSSGRSGAEAVALGAGLNARGVIQIIIADTAY
Mb3264c|M.bovis_AF2122/97 ALAAVTAATKVATGMFAARREGVARRGQLRAGTALVARGEFSLIIIGLAG
Rv3236c|M.tuberculosis_H37Rv ALAAVTAATKVATGMFAARREGVARRGQLRAGTALVARGEFSLIIIGLAG
MUL_2572|M.ulcerans_Agy99 LLAVVTAATKVLTGMFAARRDGVARRGQLRAGTALIARGEFSLIIIGLVG
MLBr_00782|M.leprae_Br4923 ILATVTAVTKVATGILAARYDGVARRGQLRAGTALVARGEFSLIIIGLVG
MSMEG_6769|M.smegmatis_MC2_155 GLLVVAVVGKGVACAVAARLSRVPVRDSLALGSLMNARGLIELILLNIGL
Mvan_1424|M.vanbaalenii_PYR-1 ILSVFVLVAKPAIVIAIMSVMRYPVRVGFLVGLPLAQISEFSLILAALGL
MAV_4118|M.avium_104 ILLGAGLGCGAVLAHCAGRLLGQPLTLAVLSAAQLGVP----VAAATIGT
: . . . : :
MAB_2285|M.abscessus_ATCC_1997 RCGVFSPEVFTALVVTTIATTAIAGPVLKRTLTPRRQLP-AVISKPPQEP
MMAR_3635|M.marinum_M DLGIFNDSFYTIVLLTAIATSVMAAPILRIAAARIAIDPDDEIRRQDALP
Mb3264c|M.bovis_AF2122/97 ----ASIPGVAALATAYVFVMAIVGPILARYTGGGLPAAAVASN------
Rv3236c|M.tuberculosis_H37Rv ----ASIPGVAALATAYVFVMAIVGPILARYTGGGLPAAAVASN------
MUL_2572|M.ulcerans_Agy99 ----ASIPAVAALATAYVFIMAVAGPVLARYTGG--PVATTA--------
MLBr_00782|M.leprae_Br4923 ----TSTPAVAALATAYVFIMAIAGPVLARYTPGSLPTSSGSAN------
MSMEG_6769|M.smegmatis_MC2_155 EAGVITPTLFTILVLVAIVTTLMASPIFEFVYGRHRTDETGDTTQERVPQ
Mvan_1424|M.vanbaalenii_PYR-1 SLGHISNATVSLITVVGLITIAASTYMTMYSDGIFARSQRWLSHLERKHQ
MAV_4118|M.avium_104 QQHLLAPGEASALMFGALLTIAAASIAAGLAARRQGAPEPGEPAR-----
: : :
MAB_2285|M.abscessus_ATCC_1997 ALNR----------------------------------------------
MMAR_3635|M.marinum_M EAH-----------------------------------------------
Mb3264c|M.bovis_AF2122/97 --------------------------------------------------
Rv3236c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_2572|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00782|M.leprae_Br4923 --------------------------------------------------
MSMEG_6769|M.smegmatis_MC2_155 PSA-----------------------------------------------
Mvan_1424|M.vanbaalenii_PYR-1 RDHEVAGLSDGDFDIILFGLGRFGSHLADRLSGAGHRVLGVDFDPHGVRA
MAV_4118|M.avium_104 --------------------------------------------------
MAB_2285|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_3635|M.marinum_M --------------------------------------------------
Mb3264c|M.bovis_AF2122/97 --------------------------------------------------
Rv3236c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_2572|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00782|M.leprae_Br4923 --------------------------------------------------
MSMEG_6769|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_1424|M.vanbaalenii_PYR-1 HRRDGVTTTFGSAEDLDLLEALPLDRAKYVISAIPVLQTNLALLHGLRQH
MAV_4118|M.avium_104 --------------------------------------------------
MAB_2285|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_3635|M.marinum_M --------------------------------------------------
Mb3264c|M.bovis_AF2122/97 --------------------------------------------------
Rv3236c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_2572|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00782|M.leprae_Br4923 --------------------------------------------------
MSMEG_6769|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_1424|M.vanbaalenii_PYR-1 QFSGAVALTAHTRHDAERLRATGVEIVIEPFSSAAHTTSNTLHDLLTTEF
MAV_4118|M.avium_104 --------------------------------------------------
MAB_2285|M.abscessus_ATCC_1997 ---------------------
MMAR_3635|M.marinum_M ---------------------
Mb3264c|M.bovis_AF2122/97 ---------------------
Rv3236c|M.tuberculosis_H37Rv ---------------------
MUL_2572|M.ulcerans_Agy99 ---------------------
MLBr_00782|M.leprae_Br4923 ---------------------
MSMEG_6769|M.smegmatis_MC2_155 ---------------------
Mvan_1424|M.vanbaalenii_PYR-1 EDTDDEGYSDDEGGAQPRPSR
MAV_4118|M.avium_104 ---------------------