For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
TLHQLYVALFLGGLVLLASIAATRLATGVGLPSLLLFLGVGVLVGEGGLGLQFDNAQLGQDLGTAALAVI LVEGGLTTRFSDIRKVLAPAAVLATLGVAVSTLVTAAAVHWLLGMNWQLALLLGAVISSTDAAAVFSVLR VVPLPRRLSGLLEAESGFNDAPAVILVMLFSVVPMELNAVDIVGTLVYELGIGTVLGLGFGVLGAMTLRR IALPAAGLYPLATFGLGMLAFAAAGTAHGSGFLAAYLASVVLANSGLPHRSATRSFAEGAGWLAQIGVFV ILGLLVSPDQLLDEVVPAIVAGLALLLLARPISVFLSLIGFRVPWREKMFLSWAGLRGAVPIVLCTYPIV AGVPDSWRLLHIVFILVVLYTAIQGPSLRRVAEWLNLIPRDTTREIQVDAAPLDVLGAELLTMTVLPGSR LHNVTVLELRLPDPSVITLIIRDGQSFVPQPVTRLQIGDELLIVTTSVTRDQAERRLRAVSRRGKLAYWF DEYGDPA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0160 | - | - | 100% (498) | potassium/proton antiporter |
| M. gilvum PYR-GCK | Mflv_2583 | - | 1e-17 | 24.60% (443) | sodium/hydrogen exchanger |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2309 | yjcE | 2e-21 | 27.71% (433) | integral membrane transport protein YjcE |
| M. tuberculosis H37Rv | Rv2287 | yjcE | 2e-21 | 27.71% (433) | integral membrane transport protein YjcE |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4717c | - | 0.0 | 72.78% (496) | potassium/proton antiporter |
| M. marinum M | MMAR_2583 | - | 0.0 | 72.84% (497) | sodium/hydrogen exchanger (antiporter) |
| M. avium 104 | MAV_2145 | - | 1e-24 | 31.03% (435) | Na+/H+ antiporter |
| M. smegmatis MC2 155 | MSMEG_4682 | - | 8e-19 | 24.44% (491) | Na+/H+ antiporter |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_3177 | - | 0.0 | 72.64% (497) | potassium/proton antiporter |
| M. vanbaalenii PYR-1 | Mvan_0746 | - | 0.0 | 90.96% (498) | potassium/proton antiporter |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0160|M.gilvum_PYR-GCK ------MTLHQLYVALFLGGLVLLASIAATRLATGVGLPSLLLFLGVGVL
Mvan_0746|M.vanbaalenii_PYR-1 ------MTLHQLYVALMIGGVVLLASIAATRLATGIGLPSLLLFLGVGVL
MMAR_2583|M.marinum_M ------MSLQQLYLAMLIGGFVLLASIVGTRLATRVGFPSMLLFLLVGVI
MUL_3177|M.ulcerans_Agy99 ------MSLQQLYLAMLIGGFVLLASIVGTRLATRVGFPSMLLFLLVGVI
MAB_4717c|M.abscessus_ATCC_199 ------MSLHQLYLDLLIGGLVLLASIVGTRVATRIGFPSLLFFLLVGVV
Mb2309|M.bovis_AF2122/97 MNGRRTIGEDGLVFGLVVIVALVAAVVVGTVLGHRYRVGPPVLLILSGSL
Rv2287|M.tuberculosis_H37Rv MNGRRTIGEDGLVFGLVVIVALVAAVVVGTVLGHRYRVGPPVLLILSGSL
MAV_2145|M.avium_104 ------------MFGLVLIVALVSTVIVGTVIGRRYRVGPPVLLIVLGVL
MSMEG_4682|M.smegmatis_MC2_155 ----------------MELLLVVVGAILVTAIAHHRGFEPALMIVVVGSA
. :: : * :. . . :::: *
Mflv_0160|M.gilvum_PYR-GCK VGEGGLGLQFDNAQLG-QDLGTAALAVILVEGGLTTRFSDIRKVLAPAAV
Mvan_0746|M.vanbaalenii_PYR-1 VGEDGLGLPFDNAQLA-QDLGTAALAVILVEGGLTTRFSDIRKVLAPAGV
MMAR_2583|M.marinum_M VGEDGFGLRFDDVELA-RNMGTAALAVILVEGGLTTRFSDIRKVLAPAAT
MUL_3177|M.ulcerans_Agy99 VGEDGFGLRFDDVELA-RNMGTAALAVILVEGGLTTRFSDIRKVLAPAAT
MAB_4717c|M.abscessus_ATCC_199 LGEDGLGLEFDNVELA-RNVCTAALAVILVEGGLTTRFADIRKVLAPAGA
Mb2309|M.bovis_AF2122/97 LG---LIPRFGDVQIDGEVVLLLFLPAILYWESMNTSFREIRWNLR-VIV
Rv2287|M.tuberculosis_H37Rv LG---LIPRFGDVQIDGEVVLLLFLPAILYWESMNTSFREIRWNLR-VIV
MAV_2145|M.avium_104 LG---LVPQFGHVRIDGEIVLLLFLPAILYWEGLNISFREIRANAR-IIV
MSMEG_4682|M.smegmatis_MC2_155 VS---FLPDFEPPELDSHILLSVVLPPLLYSAALNFSFPTFLRHIRPILG
:. : * .: . : *. :* .:. * :
Mflv_0160|M.gilvum_PYR-GCK LATLGVAVSTLVTAAAVH---WLLGMNWQLALLLGAVISSTDAAAVFSVL
Mvan_0746|M.vanbaalenii_PYR-1 LATVGVAVSTAVTAAAVH---WILGMDWQLALLLGAVVSSTDAAAVFSVL
MMAR_2583|M.marinum_M LATVGVMVSMVVTAVGVH---LVLGVSWQAALLLGAIVSSTDAAAVFSVL
MUL_3177|M.ulcerans_Agy99 LATVGVMVSMVVTAVGVH---LVLGVSWQPALLLGAIVSSTDAAAVFSVL
MAB_4717c|M.abscessus_ATCC_199 LATVGVVVSTVVTAFGAH---VLLRMDWQLALLLGAIVSSTDAAAVFSVL
Mb2309|M.bovis_AF2122/97 MFSIGLVIATAVAVSWTA---RALGMESHAAAVLGAVLSPTDAAAVAGLA
Rv2287|M.tuberculosis_H37Rv MFSIGLVIATAVAVSWTA---RALGMESHAAAVLGAVLSPTDAAAVAGLA
MAV_2145|M.avium_104 FLSVALVIATAVAVSWTA---RALGMDPHAAGVLGAVLSPTDAAAVAGLA
MSMEG_4682|M.smegmatis_MC2_155 LG-VGLVVVSAFAVAAVSSWLVIVPLTFGTALVLGAIVAPPDAVTAVAVG
: :.: : .:. . : : * :***:::..**.:. .:
Mflv_0160|M.gilvum_PYR-GCK RVVPLPRRLSGLLEAESGFNDAPAVILVMLFSVVPMELN---AVDIVGTL
Mvan_0746|M.vanbaalenii_PYR-1 RVVPLPRRLSGLLEAESGFNDAPAVILVTLFSVVPLDLD---PVTIVGTL
MMAR_2583|M.marinum_M RVLPLPRRVAGLLEAESGFNDAPAVILVLMFSEVPFAFR---PAAALEAL
MUL_3177|M.ulcerans_Agy99 RVLPLPRRVAGLLEAESGFNDAPAVILVLMFSEVPFAFR---PAAALEAL
MAB_4717c|M.abscessus_ATCC_199 RVLPLPRRLAGLLEAESGFNDAPAVILVLMFSIVPFVFE---PKSTAVQI
Mb2309|M.bovis_AF2122/97 KRLP--RRALTVLRGESLINDGTALVLFAVTVAVAEGAAGIGPAALVGRF
Rv2287|M.tuberculosis_H37Rv KRLP--RRALTVLRGESLINDGTALVLFAVTVAVAEGAAGIGPAALVGRF
MAV_2145|M.avium_104 KKLP--RRSLTVLKAESLINDGTALVLFAVSVHVAIGAPAISPPEVTLRF
MSMEG_4682|M.smegmatis_MC2_155 RKLGLPKRMMAILTGESLINDAAALTLFSIAVTQVAGGH-IFIENPLLLF
: : :* :* .** :**..*: *. : :
Mflv_0160|M.gilvum_PYR-GCK VYELGIGTVLGLGFGVLGAMTLRRIALP-AAGLYPLATFGLGMLAFAAAG
Mvan_0746|M.vanbaalenii_PYR-1 AYELAIGTVLGLAAGVLGAMALRRIALP-ATGLYPLATFGLGMLAFAAAG
MMAR_2583|M.marinum_M VFELLVGAAIGLAIGYLGAFTLRRIALP-ASGLYPIATFGLGLVAFAAAG
MUL_3177|M.ulcerans_Agy99 VFELLVGAAIGLAIGYLGAFTLRRIALP-ASGLYPIATFGLGLVAFAAAG
MAB_4717c|M.abscessus_ATCC_199 VYELLAGSAIGLLCGFLGAMALRRVALP-ASGLYPIATFGIGLVAFAASG
Mb2309|M.bovis_AF2122/97 VVSYLGGIMAGLLVGGLVTLLRRRIDAPLEEGALSLLTP---FAAFLLAQ
Rv2287|M.tuberculosis_H37Rv VVSYLGGIMAGLLVGGLVTLLRRRIDAPLEEGALSLLTP---FAAFLLAQ
MAV_2145|M.avium_104 IGSYLGGIAAGLLVGGAVTLVRKRIDAPQEEGALSLVTP---FAAFLLAQ
MSMEG_4682|M.smegmatis_MC2_155 GYSATVGPLVGAVLGYVTLWIRKRLANPGLETVQGLVVP---FAAFITAE
. * * * :*: * : . : ** :
Mflv_0160|M.gilvum_PYR-GCK TAHGSGFLAAYLASVVLANSG-----LPHRSATRSFAEGAGWLAQIGVFV
Mvan_0746|M.vanbaalenii_PYR-1 SAHGSGFLAAYLAGVVLANSG-----LPHRSATRSFAEGAGWLAQIGVFV
MMAR_2583|M.marinum_M ESHASGFIAAYLAAVVLANTG-----LPHRAATRSFAEGVGWLAQIGLFV
MUL_3177|M.ulcerans_Agy99 ESHASGFIAAYLAAVVLANTG-----LPHRAATRSFAEGVGWLAQIGLFV
MAB_4717c|M.abscessus_ATCC_199 TVHASGFIAAYLAAVVLANSG-----LPHRSATRSFAEGLGWLAQIGLFV
Mb2309|M.bovis_AF2122/97 SLKCSGVVAVLVSALVLTYVGPTVIRARSRLQAHAFWDIATFLINGSLWV
Rv2287|M.tuberculosis_H37Rv SLKCSGVVAVLVSALVLTYVGPTVIRARSRLQAHAFWDIATFLINGSLWV
MAV_2145|M.avium_104 SVECSGVVAVVVSALVLAYSGPVVIRARSRLQSYAFWDIATFLLNGSLWV
MSMEG_4682|M.smegmatis_MC2_155 ELHASGVLAVVVAGFVVGNGNLG-AGYQTRLQERYVWNSVDVLLEAFVFA
. **.:*. ::..*: . * . : * : ::.
Mflv_0160|M.gilvum_PYR-GCK ILGLLVS--------------PDQLLDEVVPAIVAG---------LALLL
Mvan_0746|M.vanbaalenii_PYR-1 ILGLLVS--------------PDELLDEVVPAIVAG---------LVLLL
MMAR_2583|M.marinum_M LLGLLVE--------------PIEVIHDLIAAIVVG---------LLLLL
MUL_3177|M.ulcerans_Agy99 LLGLLVE--------------PIEVIHDLIAAIVVG---------LLLLL
MAB_4717c|M.abscessus_ATCC_199 LLGLLVN--------------PSELMDDLLPAILVG---------LVLLL
Mb2309|M.bovis_AF2122/97 FVGVQIPGAIDHIAGEDGGLPRATVLALAVTGVVIATR---IAWVQATTV
Rv2287|M.tuberculosis_H37Rv FVGVQIPGAIDHIAGEDGGLPRATVLALAVTGVVIATR---IAWVQATTV
MAV_2145|M.avium_104 FVGVQIPGALRGIAGVDGGVRHALFVALVITGVVIVSR---IFWGEFTTM
MSMEG_4682|M.smegmatis_MC2_155 YIGLHLRFVLEHLNEAHESLTEVITASAVVLLIVLVIRPLSVFAIFGRNK
:*: : : ::
Mflv_0160|M.gilvum_PYR-GCK LARPISVFLSLIG------------------------------FRVPWRE
Mvan_0746|M.vanbaalenii_PYR-1 LARPLSVVLSLIG------------------------------FRVPWRE
MMAR_2583|M.marinum_M VARPLSVVLSLSG------------------------------FRIPWRD
MUL_3177|M.ulcerans_Agy99 VARPLSVVLSLSG------------------------------FRIPWRD
MAB_4717c|M.abscessus_ATCC_199 VARPLSVVVSLIG------------------------------FGVPWRE
Mb2309|M.bovis_AF2122/97 LGHTVDRVLKKPT------------------------------RHVGFRQ
Rv2287|M.tuberculosis_H37Rv LGHTVDRVLKKPT------------------------------RHVGFRQ
MAV_2145|M.avium_104 LIRLIDRRAVQRE------------------------------RRVGWRQ
MSMEG_4682|M.smegmatis_MC2_155 LSRHVEKKLSVPAPDGSRSSLGAAVRKQRKKKRRANWRTMVDRRTLSWQE
: : :. : :::
Mflv_0160|M.gilvum_PYR-GCK KMFLSWAGLRGAVPIVLCTYPIVAG-----VPDSWRLLHIVFILVVLYTA
Mvan_0746|M.vanbaalenii_PYR-1 QLFLSWAGLRGAVPIVLCTYPIVAG-----VPDSWRLLNIVFILVVLFTV
MMAR_2583|M.marinum_M QVFLSWAGLRGAVPIVLATFPIVAG-----VPDSYRLLNIVFMLVVVFTL
MUL_3177|M.ulcerans_Agy99 QVFLSWAGLRGAVPIVLATFPIVAG-----VPDSYRLLNIVFMLVVVFTL
MAB_4717c|M.abscessus_ATCC_199 QAFLSWAGLRGAVPVVLATFPIVAG-----VPDSYRLLNIVFVLVVVFTL
Mb2309|M.bovis_AF2122/97 RCVTSWAGFRGAVSLAAALAVPMTTNSGAPFPDRNLIIFVVSVVILVTVL
Rv2287|M.tuberculosis_H37Rv RCVTSWAGFRGAVSLAAALAVPMTTNSGAPFPDRNLIIFVVSVVILVTVL
MAV_2145|M.avium_104 RFVTAWAGFRGAVSLAAAVAVPMTTLSGAPFPDRSLLIFIVTVVILVTVL
MSMEG_4682|M.smegmatis_MC2_155 NVVLSWTGMRGVVTLAAAAAIPAYTESGEPFPERATIQAIAFVVAVGTLL
. . :*:*:**.*.:. . .*: : :. :: :
Mflv_0160|M.gilvum_PYR-GCK IQGPSLRRVAEWLNL--IPRDTTREIQVDAAPLDVLGAELLTMTVLPGSR
Mvan_0746|M.vanbaalenii_PYR-1 IQGPSLRPVAEWLHL--IPRDTTREIQVDAAPLDVLGAELLTMTVSPGSR
MMAR_2583|M.marinum_M VQGPSLRPIAHLLGL--ISREATREIQVEAAPLDVLDAELVTMTVQPPSR
MUL_3177|M.ulcerans_Agy99 VQGPSLRPIAHLLGL--ISREATREIQVEAAPLDVLDAELVTMTVQPPSR
MAB_4717c|M.abscessus_ATCC_199 VQGPSLRPVAHLLGL--ITREATREIQVEAAPLDVLDAELLTMKVQPASR
Mb2309|M.bovis_AF2122/97 VQGTSLPTVVRWAR---MPEDVAHANELQLARTRSAQAALDALPTVADEL
Rv2287|M.tuberculosis_H37Rv VQGTSLPTVVRWAR---MPEDVAHANELQLARTRSAQAALDALPTVADEL
MAV_2145|M.avium_104 VQGSTLPAVVRWAR---LPADVAHAEELQLARTRAARAALDALPAVADEV
MSMEG_4682|M.smegmatis_MC2_155 LQGSTLPWLIRKLHISRFNDDHEADRAEEVKAERVAHDAAEKILVEFQAN
:**.:* : . : : : : .
Mflv_0160|M.gilvum_PYR-GCK ---LHNVTVLELRLPDPSVITLIIRDGQSFVPQPVTRLQIGDELLIVTTS
Mvan_0746|M.vanbaalenii_PYR-1 ---LHNVTVLELRLPDPSVITLIIRAGQPFVPQPVTRLRVGDELLIVTTS
MMAR_2583|M.marinum_M ---LHNVTVLELRLPDPAVITLIIRKGHTFVPMPDTRIQRGDELLIVTTS
MUL_3177|M.ulcerans_Agy99 ---LHNVTMLELRLPDPAVITLIIRKGHTFVPMPDTRIQRGDELLIVTTS
MAB_4717c|M.abscessus_ATCC_199 ---LRNVTILELRLPDPAVVTLIIRQGNTFVPLPDTRIEPGDELMIVTTS
Mb2309|M.bovis_AF2122/97 GVAPDLVKHLEKEYEERAVLVMADGADSATSDLAERNDLVRRVRLGVLQH
Rv2287|M.tuberculosis_H37Rv GVAPDLVKHLEKEYEERAVLVMADGADSATSDLAERNDLVRRVRLGVLQH
MAV_2145|M.avium_104 GVSDELRRRLHKEYEEKAALVLATENGSPDNRILKTREKVRQVRLGVLEH
MSMEG_4682|M.smegmatis_MC2_155 PPANLNPALVEEIYIRIARHTQDVDEMPDPEAPIKRAAAFTTLYREVLAA
:. : . *
Mflv_0160|M.gilvum_PYR-GCK VTRDQAERRLR-----AVSRRGKLAYWFDEYGDPA-----------
Mvan_0746|M.vanbaalenii_PYR-1 VTRDLAERRLR-----AVSRRGKLAYWFDEYGDQA-----------
MMAR_2583|M.marinum_M TTRAAAESRLR-----AVSRRGKLAYWFDEYGEPD-----------
MUL_3177|M.ulcerans_Agy99 TTRAAAESRLR-----AVSRRGKLAYWFDEYGEPD-----------
MAB_4717c|M.abscessus_ATCC_199 KTRALTESRLR-----AVSRRGKLAYWFDEYGDVG-----------
Mb2309|M.bovis_AF2122/97 QRQAVTTLRNQNLIDDIVLRELQAAMDLEEVQLLDPADAE------
Rv2287|M.tuberculosis_H37Rv QRQAVTTLRNQNLIDDIVLRELQAAMDLEEVQLLDPADAE------
MAV_2145|M.avium_104 KRREVTALRNQNRIDDTVLRELQNEMDLEEVQLLAAAADEDDGDTE
MSMEG_4682|M.smegmatis_MC2_155 QRAALIDQRDAGHIEDEAVRAMLERLDLQEAGVTARLESRL-----
* . * ::*