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VGSAWMALPPEVHSALLSAGPGPGPLREAAAAWTVLAAEHASAAEELTSIVGGAAAAWEGPSAQSYVDAH VPYLTWLATTSADYAATAIEHEVAADAYAGALTAMPTLAELAANRTTHTALVATNFFGLNTVPITVNEAD YARMWVQAATTMGAYQVISGTALASMPHTTPAPLILNAEPLILEPEIEIAKFIADPVGSAVMGIWEMFLL LLDNIVQLLVLIVAGQFLIAFLQLIWTLAIFVLLLVEIIKEFAFFLVVAGLAALGAWHVLLGLELCIVSA PLGACVLSCVERGLSAAFNIDIAQSLSFLPSLYGQPAPLGMLRADGGAASATLASAHNGELRMPNDASPV ESTDNGRPSTVSQVQLLTTTAPGYSSTTAPALPPLRTSC*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_3378 | - | - | 100% (390) | PPE family protein |
| M. marinum M | MMAR_3641 | - | e-109 | 56.20% (395) | PPE family protein |
| M. marinum M | MMAR_4266 | - | e-107 | 53.40% (412) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3047c | PPE47 | 6e-63 | 41.16% (362) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 2e-61 | 49.25% (266) | PPE protein |
| M. tuberculosis H37Rv | Rv0286 | PPE4 | 8e-62 | 63.13% (179) | PPE family protein |
| M. leprae Br4923 | MLBr_01828 | PPE | 3e-49 | 53.37% (178) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_2254c | - | 1e-57 | 56.44% (202) | PPE family protein |
| M. avium 104 | MAV_4867 | - | 6e-64 | 57.14% (217) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 9e-62 | 50.42% (238) | PPE family protein |
| M. thermoresistible (build 8) | TH_3569 | - | 1e-61 | 62.36% (178) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_2686 | - | 1e-114 | 98.09% (209) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 1e-60 | 62.92% (178) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3378|M.marinum_M ----------MVG---SAWMALPPEVHSALLSAGPGPGPLREAAAAWTVL
MUL_2686|M.ulcerans_Agy99 ----------MVG---SAWMALPPEVHSAFLSAGPGPGLLREAAAAWTVL
Rv0286|M.tuberculosis_H37Rv ----------MAA---PIWMASPPEVHSALLSNGPGPGSLVAAATAWSQL
MAV_4867|M.avium_104 ----------MTSPFGPIWMASPPEVHSALLSAGPGPGPLLAAAGAWTSL
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTS---PVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSL
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSS---PVWMALPPEVHSALLSSGPGPGSMLAAAATWQSL
MSMEG_0619|M.smegmatis_MC2_155 ----------MTA---PIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSL
TH_3569|M.thermoresistible__bu ---------MMTA---PIWMALPPEVHSALLSSGPGPGSLLAAASAWHAL
MAB_2254c|M.abscessus_ATCC_199 ----------MSA---PIWMAFPPEVHSALLGAGPGPGPLLAAAAQWHAL
Mb3047c|M.bovis_AF2122/97 ----------MTA---PVWLASPPEVHSALLSAGPGPGSLQAAAAGWSAL
MLBr_01828|M.leprae_Br4923 ----------MSA---PIWMASPPEVHSALLSRGPGSGPLLVAAEAWRSL
: . . *:* ******::*. ***.* : *. * *
MMAR_3378|M.marinum_M AAEHASAAEELTSIVGGAAA-AWEGPSAQSYVDAHVPYLTWLATTSADYA
MUL_2686|M.ulcerans_Agy99 AAEHASAAEELTSIVGGAAA-AWEGPSAQSYVDAHVPYLTWLATTSADYA
Rv0286|M.tuberculosis_H37Rv SAEYASTAAELSGLLGAVPGWAWQGPSAEWYVAAHLPYVAWLTQASADAA
MAV_4867|M.avium_104 SAQYATAAAELSALLGEAQAGSWEGESAAQYAAAHLPYLAWLQQASADSA
Mflv_0325|M.gilvum_PYR-GCK SAEYASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSA
Mvan_0415|M.vanbaalenii_PYR-1 SAEYAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGA
MSMEG_0619|M.smegmatis_MC2_155 SAEYAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSA
TH_3569|M.thermoresistible__bu SAEYASAAAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSA
MAB_2254c|M.abscessus_ATCC_199 SYEYSMAATELTQLLGVTAAGVWQGSSATQYVASHTPYLAWLTQQSATSA
Mb3047c|M.bovis_AF2122/97 SAEYAAVAQELSAVVAAVGAGVWQGPSAELFVAAYVPYVAWLVQASADSA
MLBr_01828|M.leprae_Br4923 SSVYAEMADELVALLVVVPVSSWDGSAAEAYVIAYLPYLGWLRQASVDSA
: :: * ** :: . *:* :: :. :: **: ** *. *
MMAR_3378|M.marinum_M ATAIEHEVAADAYAGALTAMPTLAELAANRTTHTALVATNFFGLNTVPIT
MUL_2686|M.ulcerans_Agy99 ATAIEHEVAADAYAGALTAMPTLAELAANRTTHTALVATNFFGLNTVPIT
Rv0286|M.tuberculosis_H37Rv GAAAQHEAAAAAYTTALAAMPTLAELAANHVIHTVLVATNFFGINTIPIT
MAV_4867|M.avium_104 GAAAQQEVAATAYTTALAAMPTLAELAANHTIHGVLLATNFFGINTIPIA
Mflv_0325|M.gilvum_PYR-GCK ATAVQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIA
Mvan_0415|M.vanbaalenii_PYR-1 AAAAQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIA
MSMEG_0619|M.smegmatis_MC2_155 AAAVQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIA
TH_3569|M.thermoresistible__bu ATAGRHETAAAAYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIPIA
MAB_2254c|M.abscessus_ATCC_199 ANAALHETSAAAYTTALAAMPTLPELATNHTVHGILVGTNFFGINTIPIA
Mb3047c|M.bovis_AF2122/97 AAAGEHEAAAAGYVCALAEMPTLPELAANHLTHAVLVATNFFGINTIPIA
MLBr_01828|M.leprae_Br4923 VMAAHYETMATAYITTLAMMPTLAELAANRTAHTVLVTTNFFGINTIPIA
* :. * .* :*: ***:.**: *: * *: ***:*:**:**:
MMAR_3378|M.marinum_M VNEADYARMWVQAATTMGAYQVISGTALASMPHTTPAPLILNAEPLILEP
MUL_2686|M.ulcerans_Agy99 VNEADYARMWVQAATTMGAYQVILGTALASMPHTTPAPLILNAEPLILEP
Rv0286|M.tuberculosis_H37Rv LNEADYVRMWLQAAAVMGLYQAASGAALASAPRTVPAPTVMNPGGGAAST
MAV_4867|M.avium_104 VNEADYARMWVQAATTMGTYQAVAGSALAAAPRTAPAPSIVKPGGEANNL
Mflv_0325|M.gilvum_PYR-GCK LNEADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGR
Mvan_0415|M.vanbaalenii_PYR-1 MTEADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGR
MSMEG_0619|M.smegmatis_MC2_155 LNEADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGS
TH_3569|M.thermoresistible__bu LNEADYVRMWIQAATSMSTYQAVAGTAVMSAPASSPAPLLLAPGVSEAAD
MAB_2254c|M.abscessus_ATCC_199 LNEADYVRMWVQAATTMGVYQGVSSTAVAAAAPTTTSPLIMPPGS-ELSR
Mb3047c|M.bovis_AF2122/97 LNEADYVRMWVQAATVMSAYEAVVGAALVATPHTGPAPVIVKPGANEASN
MLBr_01828|M.leprae_Br4923 RNEIDYVRMWVEAAIAMGTYQEVSTVVVDSAPEAIAAPQIMASDALEASS
.* **.***::** *. *: .: : . : .:* :: .
MMAR_3378|M.marinum_M EIEIAK--------------------------------------------
MUL_2686|M.ulcerans_Agy99 EIEIAK--------------------------------------------
Rv0286|M.tuberculosis_H37Rv VGAVNPW-----QWLLALLQQLWNAYTGFYGWMLQLIW------------
MAV_4867|M.avium_104 AAN-----------------AAQNSSGDWWQNFIQQLS------------
Mflv_0325|M.gilvum_PYR-GCK AAADMS------AFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLF--
Mvan_0415|M.vanbaalenii_PYR-1 AAADVT------AFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLF--
MSMEG_0619|M.smegmatis_MC2_155 ASASVQ------QMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGGQ--
TH_3569|M.thermoresistible__bu AMATTQ------QIGSQATAADSGTALNLSDLIANLLQYYQDYLDQLF--
MAB_2254c|M.abscessus_ATCC_199 MAADMS------GFAAQAQATESGSALDSSNSVIDQL-------------
Mb3047c|M.bovis_AF2122/97 AVAAAT-----------ITPFPFGELAKFLEMAAQAFT------------
MLBr_01828|M.leprae_Br4923 DQPSPTAPSQSPQVQNWLQWLQKIGYTDFYNTLVQPLITSLTNHPFFQGM
MMAR_3378|M.marinum_M ---------FIADPVGSAVMGIWEMFLLLLDNIVQLL-------------
MUL_2686|M.ulcerans_Agy99 ---------FITDPVGSAVMGIWEMF------------------------
Rv0286|M.tuberculosis_H37Rv --------QFLQDPIGNSIKIIIAFLTNPIQALITYG-------------
MAV_4867|M.avium_104 --------QFFQN----IQKMLQDFWANLPAFLAANG-------------
Mflv_0325|M.gilvum_PYR-GCK ----EPIFNFLRDPIGNTFALITDFLTNPVQALITWG-------------
Mvan_0415|M.vanbaalenii_PYR-1 ----EPIFDFLRDPLGNTIKLITDFLTNPAQALITWG-------------
MSMEG_0619|M.smegmatis_MC2_155 -----AILDFLKDPLGNLGRLLTDFMTNPAGALATWW-------------
TH_3569|M.thermoresistible__bu ----GPIVDFLRDPIGNLFQLIDDFLTNPAGALVTWW-------------
MAB_2254c|M.abscessus_ATCC_199 -------LNFFRDPLGTLRQIIEDFIRNPGAALATWL-------------
Mb3047c|M.bovis_AF2122/97 ---------EVGELIMKSAEAWAVGFVELITGLVNFE-------------
MLBr_01828|M.leprae_Br4923 FSGFDPWLPSLGNPLSFLSPFNIAFALGTPMDIGSYVGYLSQTFAFIGAD
. :
MMAR_3378|M.marinum_M ---------------VLIVAGQFLI-AFLQLIWTLAIFVLLLVEIIKEFA
MUL_2686|M.ulcerans_Agy99 ------------------------------------------------CC
Rv0286|M.tuberculosis_H37Rv ---------------PLLFALGYQ--IFFNLVGWPTWGMILSSPFLLPAG
MAV_4867|M.avium_104 ---------------PLLFFVAYQ--VFFNAVGWPTWGAILTAPFLLPLL
Mflv_0325|M.gilvum_PYR-GCK ---------------PFLLAVVYQ--AVSWVGASILYPSLFLLPLLATTL
Mvan_0415|M.vanbaalenii_PYR-1 ---------------PFLAAVAYQ--AVSWVGASILYPSLLLLPLVATTL
MSMEG_0619|M.smegmatis_MC2_155 ---------------PFLFGVAYQ--VFFNLVGWPTWGMIFASPFLIPAL
TH_3569|M.thermoresistible__bu ---------------PLLFAVAYQ--VFTNLVGWPTWAMILASPVLIPLA
MAB_2254c|M.abscessus_ATCC_199 ---------------PFLLVLASMTYVLFAQVFWLFWAALLSAPLWLPLL
Mb3047c|M.bovis_AF2122/97 ---------------PWLVLTGMID-MFFATVGFALGVFVLVPLLEFAVV
MLBr_01828|M.leprae_Br4923 LAAAFASGNPVTIGFTLLFTTIEAIGTIITDTIALVKTMIEQSFVLLPMI
MMAR_3378|M.marinum_M FFLVVAGLAALGAWHVL-----LGLELCIVSA------------------
MUL_2686|M.ulcerans_Agy99 FWII----------------------------------------------
Rv0286|M.tuberculosis_H37Rv LGLGLAAIAFLPIVLAP---AVIPPASTPLAAAAVAAGSVWPAVSMAVTG
MAV_4867|M.avium_104 LGIGLSSLLAAPAEIAP---VAAPAAITPVLASNKPP-TLPAAVALAPSV
Mflv_0325|M.gilvum_PYR-GCK AIVAGVGQHLLSLLNTP-PAEEAAEEPAPAQSAPSRPDQQSFPATMSAPP
Mvan_0415|M.vanbaalenii_PYR-1 AIVLGVGAYLLENLPAP-AEDAPAEEPAASSPAPTRADQPSPAIAVSAPP
MSMEG_0619|M.smegmatis_MC2_155 AALGITGLVLLIDHVLNNPVDVPAEDEAPQEVAAAPRTDQPLAVGISPAG
TH_3569|M.thermoresistible__bu ITLGVAGLVMIADQAQP-----PAEEAAPEEDVAAP--------------
MAB_2254c|M.abscessus_ATCC_199 ILAAWQYLQPPAVDAAP--ADEIRPELGSTVNGQREHIEPLPAIALAPTA
Mb3047c|M.bovis_AF2122/97 LELAILSIGWIISNIFGAIPVLAGPLLGALAAAVVPG-------------
MLBr_01828|M.leprae_Br4923 LPLLTAPLAVATAGAAG--SFAGLSELAGLVGVAPPGLPSAPPVAAVAPV
MMAR_3378|M.marinum_M --PLGACVLSCVERGLSAAFNIDIAQSLSFLP--SLYG------------
MUL_2686|M.ulcerans_Agy99 --------------------------------------------------
Rv0286|M.tuberculosis_H37Rv AGTAGAATPAAGAAPSAGAAPAPAAPATASFA--YAVGGSGDWGPSLGPT
MAV_4867|M.avium_104 ATPAGAPASTVAAGSGAAAAPGPAA-AAGNFA--YLVAFGGDPDTGVGPT
Mflv_0325|M.gilvum_PYR-GCK PPSGAPIAANTVSAGSPPAPGAPAAAAATFVP--YVVA-GRDPYEGFSPT
Mvan_0415|M.vanbaalenii_PYR-1 PPSSAAATVGTVATGTAPAPGAPAAATASFVP--YAVA-GRDPGTGFSPT
MSMEG_0619|M.smegmatis_MC2_155 VPGSAATAAAPAPAPAGTTVAAPAPAAATFVP--YAVA-NRDPGEGFTPT
TH_3569|M.thermoresistible__bu -----VRAEPQNPLPLTXXX------------------------------
MAB_2254c|M.abscessus_ATCC_199 TPVPTASASAPSAPAPAPAPTAAGAGFAPYLV--GAIP-DEPPAIQFGPT
Mb3047c|M.bovis_AF2122/97 ----VAGVTGLAGLAAVPAVGAAAGAPAALVG--SVAP------------
MLBr_01828|M.leprae_Br4923 VPPSMPTLASIPTPTPMPAPAASTAPVVTPPGPPPVTAPPSVTGAGVESF
MMAR_3378|M.marinum_M ------QPAPLGMLRADGGAASATLASAHNGELRMPN-------------
MUL_2686|M.ulcerans_Agy99 --------------------------------------------------
Rv0286|M.tuberculosis_H37Rv VGGRGGIKAPAATVPAAAAAAATRGQSRARRRRRSELRDYGDEFLDMDSD
MAV_4867|M.avium_104 LSGRGGAKAPAATIPAAGAAAPARAEARARRRRRAALHDYSDEFLDMDSG
Mflv_0325|M.gilvum_PYR-GCK VRDSTGAKAPAGTIPAAASGIAASAAERRKRRRRQKEEIKGRGYADAYAD
Mvan_0415|M.vanbaalenii_PYR-1 VRDSTSAKAPASGIPAAASGVAASAAERRKRRRRQKDEIAGRAYADAYAD
MSMEG_0619|M.smegmatis_MC2_155 LGNKSQVAAPASGVPAAASGVAASLASRRKRRRKKGAQIEERGYADAYMD
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_2254c|M.abscessus_ATCC_199 LNEGNKAQAPASGISAAAA-AAASARSRARRKRGARVKDPAPQYMDMNVT
Mb3047c|M.bovis_AF2122/97 --VSGGVVSPQARLVSAVEPAPASTSVS----------------------
MLBr_01828|M.leprae_Br4923 GYLVGRLPSTARGVVGTSVRQQSSAPDRIEAPDAAATPQEQARSRWRRRA
MMAR_3378|M.marinum_M -----------------DASPVESTDNGRPSTVSQVQLLTTT--------
MUL_2686|M.ulcerans_Agy99 --------------------------------------------------
Rv0286|M.tuberculosis_H37Rv SGFGPSTG-DHG----AQASERGAGTLGFAGTATKERRVRAVGLTA----
MAV_4867|M.avium_104 FGVPPDYG-AEEELAAAVASGQGAGTLGFAGTQQRRKAFQAAGLTK----
Mflv_0325|M.gilvum_PYR-GCK YEELPDDGPPEQPAPRVTASTRGAGPMGFAGTVSRG-DEQAGGLTT----
Mvan_0415|M.vanbaalenii_PYR-1 YEPEPDDEPPVRQEPRIAATERGAGPMGFAGTVSRD-AAQAGGLTT----
MSMEG_0619|M.smegmatis_MC2_155 YEE-PDEDPAPQPEPRVRASERGSDAMGFTGTVTRH-DVTAAGLTT----
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_2254c|M.abscessus_ATCC_199 VDADYGEPPGSAQR-QSTASARGAGHLGLAGTSPKT-TATAAGLVARGSA
Mb3047c|M.bovis_AF2122/97 ----------------VLASDRGAGALGFVGTAGKESVGQPAGLTV----
MLBr_01828|M.leprae_Br4923 KVTPFDSSGSPNPKAAPTASDQGAGTLGLAGTARQASSGPATGLVT----
MMAR_3378|M.marinum_M -APGYSSTTAPALPPLRTSC--------------------------
MUL_2686|M.ulcerans_Agy99 ----------------------------------------------
Rv0286|M.tuberculosis_H37Rv -LAGDEFGNGPRMPMVPGTWEQGSNEPEAPDGSGRGGGDGLPHDSK
MAV_4867|M.avium_104 -LADDDFGGSPRMPMVPGTWEQDTQNGAHPTEPGKGG---------
Mflv_0325|M.gilvum_PYR-GCK -LAGDSFGGGPREPMLPGTWDPDATDDRHTDGRDGHDGHDGKEKP-
Mvan_0415|M.vanbaalenii_PYR-1 -LPGDPFGGGPKAPMLPGTWDPDTEPD------ERHNHHDGKDSQ-
MSMEG_0619|M.smegmatis_MC2_155 -LTGDTFDDRPVTPMLPGTWDGDENPA------PSPDDPEGGPRR-
TH_3569|M.thermoresistible__bu ----------------------------------------------
MAB_2254c|M.abscessus_ATCC_199 GSDTDVPETARIVPMIPTTWSTDSDEAID-----------------
Mb3047c|M.bovis_AF2122/97 --LADEFGDGAPVPMLPGSWGPDLVGVAGDGGLVSV----------
MLBr_01828|M.leprae_Br4923 -LSNGTFSDSPRAPMLPRTWGADPTFCYNAADIGPAGGWDDE----