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MVLPAMDFGALPPEVNSLRMYSGPGSAPMLAAMAAWDDVSAEMLLTAAAYESVLSALLSDGWLGPASAAM AAAAAPYVTWLSATGLQAAQTAGQAAAAAAAFEAAFAMTVPPSVVAANRVQLLTLVATNFLGINTPAIAA TEAEYAEMWAQDATAMYGYAAGSAVASTLEPFSEPAHTASRSGLAGQTAAVAQAASTAMGGLTQTELPQL MSAVPASLQGLAAPAAAPLDTIAGSGLLADILNFLDGNDGNAFGIFLNSSLANGVISAGYTAPGIVVPAV TSAMADVNALALDGLPGIALPITGSDSGDAVWTRMTVPQSGLGGVAAGTNQATMVGRLSVPPSWAGTTEV TDHVATALPGAGTATAPEASAAMPGVPGVPAPGAYARSYGTGPRYGFRLTIMPRPLSGG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_2682 | - | - | 100% (409) | PPE family protein |
| M. marinum M | MMAR_2681 | - | e-145 | 62.41% (423) | PPE family protein, PPE31_1 |
| M. marinum M | MMAR_4452 | - | 7e-89 | 47.17% (407) | PPE family protein, PPE15 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1068c | PPE15 | 2e-90 | 47.65% (405) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 3e-34 | 31.04% (393) | PPE protein |
| M. tuberculosis H37Rv | Rv1039c | PPE15 | 2e-90 | 47.65% (405) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 3e-44 | 32.64% (435) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0809c | - | 1e-32 | 30.19% (414) | PPE family protein |
| M. avium 104 | MAV_2914 | - | 2e-82 | 42.82% (411) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 1e-34 | 39.45% (256) | PPE family protein |
| M. thermoresistible (build 8) | TH_3113 | - | 3e-35 | 33.08% (393) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_3076 | - | 1e-126 | 64.61% (356) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 3e-35 | 32.92% (404) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_2682|M.marinum_M --------MVLPAMDFGALPPEVNSLRMYSGPGSAPMLAAMAAWDDVSAE
MUL_3076|M.ulcerans_Agy99 -------------MDFAALPPEINPIRMYSGPGSAPMLAAVTAWDGLAAE
Mb1068c|M.bovis_AF2122/97 -------------MDFGALPPEINSARMYAGAGAGPMMAAGAAWNGLAAE
Rv1039c|M.tuberculosis_H37Rv -------------MDFGALPPEINSARMYAGAGAGPMMAAGAAWNGLAAE
MAV_2914|M.avium_104 ------------MIDFAALPPEINSARIYAGPGSAPMMSAAAAWNTMAAE
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
MAB_0809c|M.abscessus_ATCC_199 ---------MLAAPVWMASPPEVHSALLSSGPGPGPLLAAAAEWSSLGAH
TH_3113|M.thermoresistible__bu ----------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDE
* .** :. : *.*...: :* * :. .
MMAR_2682|M.marinum_M MLLTAAAYESVLSALLSDGWLGPASAAMAAAAAPYVTWLSATGLQAAQTA
MUL_3076|M.ulcerans_Agy99 LRSTAAAYETVIAVLTGDGWLGPASESMEAAVFPYLAWMNITGMQAEQTA
Mb1068c|M.bovis_AF2122/97 LGTTAASYESVITRLTTESWMGPASMAMVAAAQPYLAWLTYTAEAAAHAG
Rv1039c|M.tuberculosis_H37Rv LGTTAASYESVITRLTTESWMGPASMAMVAAAQPYLAWLTYTAEAAAHAG
MAV_2914|M.avium_104 MRSAAASYGAVISELTSADWFGPSSMSMLAAVTPYLTWLTDTATRAEEAA
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLTT-FEGESAAALAERVTPYEKWLTQNAASAELTA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
MAB_0809c|M.abscessus_ATCC_199 YSATAQELRAILAATHASAWHGPSAETYVAAHTPYLEWLNQGALESNARA
TH_3113|M.thermoresistible__bu YRAAAVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAG
:* : : : * .: ** *: . . .
MMAR_2682|M.marinum_M GQAAAAAAAFEAAFAMTVPPSVVAANRVQLLTLVATNFLGINTPAIAATE
MUL_3076|M.ulcerans_Agy99 RQAAAAAGAFEAAFAMTVPPAQVAANRTQLQTLVATNLLGQNTPAIAATE
Mb1068c|M.bovis_AF2122/97 SQAMASAAAYEAAYAMTVPPEVVAANRALLAALVATNVLGINTPAIMATE
Rv1039c|M.tuberculosis_H37Rv SQAMASAAAYEAAYAMTVPPEVVAANRALLAALVATNVLGINTPAIMATE
MAV_2914|M.avium_104 AQANSAATAYEAAFAMTVPPAVVAANRAQLATLVATNVFGQNTPAIAATE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
MAB_0809c|M.abscessus_ATCC_199 VQHGAAAGAYSTALAVMPTLAELAANHATHAALVATNFFGINTIPILATE
TH_3113|M.thermoresistible__bu AQLEAAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNE
* :* *. :* : . : *:. *: :*.:* *: .* .*
MMAR_2682|M.marinum_M AEYAEMWAQDATAMYGYAAGSAVAS-TLEPFSEPAHTASRSGLAGQT--A
MUL_3076|M.ulcerans_Agy99 AAYGEMWAQDAAAMYGYAVGSAAAS-TLTQFTQPAQTTDPSGLASQS--A
Mb1068c|M.bovis_AF2122/97 ALYAEMWAQDALAMYGYAAASGAAG-MLQPLSPPSQTTNPGGLAAQS--A
Rv1039c|M.tuberculosis_H37Rv ALYAEMWAQDALAMYGYAAASGAAG-MLQPLSPPSQTTNPGGLAAQS--A
MAV_2914|M.avium_104 AEYGQMWAQDAAAMNGYAVASTAAT-RLTPMTAPRSNTSPEGVAAQA--T
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEVVEE
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA
MAB_0809c|M.abscessus_ATCC_199 ADYVRMWVQAATTMATYQTASEVALASAPPSTPPPSILHD----------
TH_3113|M.thermoresistible__bu ADYARMWIQAATTMATYEAVASAAVSATPRTVAPPPILGAGTGESATAAI
* * .** * * :* * * .
MMAR_2682|M.marinum_M AVAQAASTAMGGLTQT----------------------------------
MUL_3076|M.ulcerans_Agy99 AVTQAVGSTVGNLTQT----------------------------------
Mb1068c|M.bovis_AF2122/97 AVGSAAATAA--VNQV----------------------------------
Rv1039c|M.tuberculosis_H37Rv AVGSAAATAA--VNQV----------------------------------
MAV_2914|M.avium_104 SVTNAAQAPAG---------------------------------------
MLBr_01182|M.leprae_Br4923 VVEEVVEEVVEAEQAI----------------------------------
Mflv_0325|M.gilvum_PYR-GCK DMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLR---
Mvan_0415|M.vanbaalenii_PYR-1 DVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLR---
MSMEG_0619|M.smegmatis_MC2_155 SVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGG-QAILDFLK---
MAB_0809c|M.abscessus_ATCC_199 --HDHGHDDHDHEHGHDDDHG---------HGDLDPTDPEWWVHVAG---
TH_3113|M.thermoresistible__bu TGAHVTAELRAAESRTLLDEINELIDRLFAPLFPPGFADALPDGLLGTLL
MMAR_2682|M.marinum_M ------------ELPQLMSAVPASLQGLAAPAAA-PLDTIAGSGLLADIL
MUL_3076|M.ulcerans_Agy99 ------------ELPQLMSAVPASLQGLASPAAASPIDAIPGSGLLAALL
Mb1068c|M.bovis_AF2122/97 ------------SVADLISSLPNAVSGLASPVTS-VLDSTGLSGIIADID
Rv1039c|M.tuberculosis_H37Rv ------------SVADLISSLPNAVSGLASPVTS-VLDSTGLSGIIADID
MAV_2914|M.avium_104 ------------TVQSTVSSS--GLAGLLSGSDNSAFGTFTN--------
MLBr_01182|M.leprae_Br4923 ------------SQAALDQAVNEGMEATVVPQVDQQVNVDVATPQTAVPD
Mflv_0325|M.gilvum_PYR-GCK -----------DPIGNTFALITDFLTNPVQALITWGPFLLAVVYQA----
Mvan_0415|M.vanbaalenii_PYR-1 -----------DPLGNTIKLITDFLTNPAQALITWGPFLAAVAYQA----
MSMEG_0619|M.smegmatis_MC2_155 -----------DPLGNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNL
MAB_0809c|M.abscessus_ATCC_199 -----------EMVEHFELLLNNLLTDPAALLTNLPMVLADVAFHA----
TH_3113|M.thermoresistible__bu APLLPGATGDGPPMATIMSFLLMGLSNPAYLFPVLVYLLFTGVVHTTVAV
:
MMAR_2682|M.marinum_M NFLDGNDGNAFGIFLNSSLANGVISAGYTAPGIVVPAVTSAMADVNALAL
MUL_3076|M.ulcerans_Agy99 NFLDGNDGNPYGVFLNSSLVNGFVSAGYVSPAVVGPAIWAAMADINAVAL
Mb1068c|M.bovis_AF2122/97 ALL----ATPFVANIINSAVN--TAAWYVN-----AAIPTAIFLANALNS
Rv1039c|M.tuberculosis_H37Rv ALL----ATPFVANIINSAVN--TAAWYVN-----AAIPTAIFLANALNS
MAV_2914|M.avium_104 -----------GNFFSTAVVNGSLAGGPFNPQFIISSVQGVLAAQHATTL
MLBr_01182|M.leprae_Br4923 SSSAAAPQLWGGFAQHLSPINDTLSMINNHAGMANAGLSLVNGMGSAMKS
Mflv_0325|M.gilvum_PYR-GCK VSWVGASILYPSLFLLPLLATT---LAIVAGVG--QHLLSLLNTPPAEEA
Mvan_0415|M.vanbaalenii_PYR-1 VSWVGASILYPSLLLLPLVATT---LAIVLGVG--AYLLENLPAPAEDAP
MSMEG_0619|M.smegmatis_MC2_155 VGWPTWGMIFASPFLIPALAALGI-TGLVLLID--HVLNNPVDVPAEDEA
MAB_0809c|M.abscessus_ATCC_199 AQLASTIGQFAPALIQPALALAIANLGWAAGFAGLAGIQPSPEILAVEPG
TH_3113|M.thermoresistible__bu SGMLAQLVPLMPALLPVAVAALGGLAGVWAGLSGLAGLAGLTAVPAADGG
:
MMAR_2682|M.marinum_M DGLPGIALPITGSDSGDAVWTRMTVPQS---------------GLGGVAA
MUL_3076|M.ulcerans_Agy99 GAQESAAVPPMGSGEGNPSWIPAASPASPESLPVLGEETAATLGTGGISA
Mb1068c|M.bovis_AF2122/97 GAPVAIAEGAIEAAEGAASAAAAGLADS--------------VTPAGLGA
Rv1039c|M.tuberculosis_H37Rv GAPVAIAEGAIEAAEGAASAAAAGLADS--------------VTPAGLGA
MAV_2914|M.avium_104 GGLGDFAADAEGAATADLAASTG--------------------GSAPVAA
MLBr_01182|M.leprae_Br4923 LAPTTTKAAESAFKAMGSAVQSTGRGLLG------------SSSGGHVTA
Mflv_0325|M.gilvum_PYR-GCK AEEPAPAQSAPSRPDQQSFPATMSAPPPPSGAPIAANTVSAGSPPAPGAP
Mvan_0415|M.vanbaalenii_PYR-1 AEEPAASSPAPTRADQPSPAIAVSAPPPPSSAAATVGTVATGTAPAPGAP
MSMEG_0619|M.smegmatis_MC2_155 PQEVAAAP----RTDQP-LAVGISPAGVPGSAATAAAPAPAPAGTTVAAP
MAB_0809c|M.abscessus_ATCC_199 SVEDAPMAASAGTALAPSPPASAAAPAAPASAPAPTASGTAPAPPSP-PP
TH_3113|M.thermoresistible__bu ASAAPVPAGGPSLPSGSSAPPAPTGSAAPTTGTAPGGAGSPPPAGHSVPP
.
MMAR_2682|M.marinum_M GTNQATMVGRLSVPPSWAG-----TTEVTDHVATALPG--------AGTA
MUL_3076|M.ulcerans_Agy99 GMNQAELVGRMSVPQSWAWQQRWPITPVRQPRAAAGPVRPLSPKRQSGCP
Mb1068c|M.bovis_AF2122/97 SLGEATLVGRLSVPAAWST-----AAPATTAGATALEG--------SGWT
Rv1039c|M.tuberculosis_H37Rv SLGEATLVGRLSVPAAWST-----AAPATTAGATALEG--------SGWT
MAV_2914|M.avium_104 GMGRAQLVGSLSVPQGWAN------AATINPGQAAVPA--------TGVT
MLBr_01182|M.leprae_Br4923 QLGRAASIGSLRVPQTWTT----ASQPVTAATRALSPAR-------VAVA
Mflv_0325|M.gilvum_PYR-GCK AAAAATFVPYVVAGRD-PYEGFSPTVRDSTGAKAPAGTIPAAASGIAASA
Mvan_0415|M.vanbaalenii_PYR-1 AAATASFVPYAVAGRD-PGTGFSPTVRDSTSAKAPASGIPAAASGVAASA
MSMEG_0619|M.smegmatis_MC2_155 APAAATFVPYAVANRD-PGEGFTPTLGNKSQVAAPASGVPAAASGVAASL
MAB_0809c|M.abscessus_ATCC_199 VGDPGFSFPYAVGGGPRLGTGLALAAQVRRGTSAAARSSAREQAAAAETA
TH_3113|M.thermoresistible__bu APHSAPPVGTSGPPYLIAAQPAPGVARRSAGARRAASIVEPAGSAAAAAA
. .
MMAR_2682|M.marinum_M TAPEASA----------------------AMPGVPGVPAPG--AYARSYG
MUL_3076|M.ulcerans_Agy99 AFQVCPR----------------------AFTGTASAMPPGTDSAQRSWG
Mb1068c|M.bovis_AF2122/97 VAAEEAG----------------------PVTG----MMPGMASAAKGTG
Rv1039c|M.tuberculosis_H37Rv VAAEEAG----------------------PVTG----MMPGMASAAKGTG
MAV_2914|M.avium_104 GLTDAAS----------------------AAGGPGGVAGPVGGTGRRLRR
MLBr_01182|M.leprae_Br4923 TESESAP----------------------LLGGGLPMAPMVPGGGSGTGG
Mflv_0325|M.gilvum_PYR-GCK AERRKRRRRQKEEIKGRGYADAYADYEELPDDGPPEQPAPRVTASTRGAG
Mvan_0415|M.vanbaalenii_PYR-1 AERRKRRRRQKDEIAGRAYADAYADYEPEPDDEPPVRQEPRIAATERGAG
MSMEG_0619|M.smegmatis_MC2_155 ASRRKRRRKKGAQIEERGYADAYMDYEE-PDEDPAPQPEPRVRASERGSD
MAB_0809c|M.abscessus_ATCC_199 AARQARRRRDKGKQQGRG-----IEYMDMNATARCEEPAPDTTASHRGAG
TH_3113|M.thermoresistible__bu ARESAPIRRRRGQKDGLHG--------HRHEHQQPASMSAATAPSAAGIR
MMAR_2682|M.marinum_M TGPRYG--FRLTIMPRPLSGG-----------------------------
MUL_3076|M.ulcerans_Agy99 ARQLLDDETEVTVTSTIGSGTAAATESASMTPSR----------------
Mb1068c|M.bovis_AF2122/97 AYAGPRYGFKPTVMPKQVVV------------------------------
Rv1039c|M.tuberculosis_H37Rv AYAGPRYGFKPTVMPKQVVV------------------------------
MAV_2914|M.avium_104 AIPKYG--FRPVVMPRPPAAG-----------------------------
MLBr_01182|M.leprae_Br4923 VNTALRLQPRAFVMPRNPAAG-----------------------------
Mflv_0325|M.gilvum_PYR-GCK PMGFAGTVSRGDEQAGGLTTLA-GDSFGGGPREPMLPGTWDPDATDDRHT
Mvan_0415|M.vanbaalenii_PYR-1 PMGFAGTVSRDAAQAGGLTTLP-GDPFGGGPKAPMLPGTWDPDTEPD---
MSMEG_0619|M.smegmatis_MC2_155 AMGFTGTVTRHDVTAAGLTTLT-GDTFDDRPVTPMLPGTWDGDENPAP--
MAB_0809c|M.abscessus_ATCC_199 TMGFAGTVIKTGATASGLAMLSRDDDLFEGVRAPMVPNTWDP--------
TH_3113|M.thermoresistible__bu VLGGAGRISRTRGSVPHAEITP-GDPTEPSSPTDRAHRPAEPN-------
.
MMAR_2682|M.marinum_M ---------------
MUL_3076|M.ulcerans_Agy99 ---------------
Mb1068c|M.bovis_AF2122/97 ---------------
Rv1039c|M.tuberculosis_H37Rv ---------------
MAV_2914|M.avium_104 ---------------
MLBr_01182|M.leprae_Br4923 ---------------
Mflv_0325|M.gilvum_PYR-GCK DGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 ---ERHNHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 ----SPDDPEGGPRR
MAB_0809c|M.abscessus_ATCC_199 ----EHGRQD-----
TH_3113|M.thermoresistible__bu ---------------