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DFAALPPEINPIRMYSGPGSAPMLAAVTAWDGLAAELRSTAAAYETVIAVLTGDGWLGPASESMEAAVFP YLAWMNITGMQAEQTARQAAAAAGAFEAAFAMTVPPAQVAANRTQLQTLVATNLLGQNTPAIAATEAAYG EMWAQDAAAMYGYAVGSAAASTLTQFTQPAQTTDPSGLASQSAAVTQAVGSTVGNLTQTELPQLMSAVPA SLQGLASPAAASPIDAIPGSGLLAALLNFLDGNDGNPYGVFLNSSLVNGFVSAGYVSPAVVGPAIWAAMA DINAVALGAQESAAVPPMGSGEGNPSWIPAASPASPESLPVLGEETAATLGTGGISAGMNQAELVGRMSV PQSWAWQQRWPITPVRQPRAAAGPVRPLSPKRQSGCPAFQVCPRAFTGTASAMPPGTDSAQRSWGARQLL DDETEVTVTSTIGSGTAAATESASMTPSR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_3076 | - | - | 100% (450) | PPE family protein |
| M. ulcerans Agy99 | MUL_3074 | - | 5e-76 | 45.07% (426) | PPE family protein |
| M. ulcerans Agy99 | MUL_4621 | - | 2e-75 | 47.06% (357) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1836 | PPE31 | 4e-81 | 44.84% (417) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 1e-26 | 39.34% (183) | PPE protein |
| M. tuberculosis H37Rv | Rv1807 | PPE31 | 3e-81 | 44.66% (421) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 7e-40 | 32.56% (430) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0809c | - | 4e-28 | 39.31% (173) | PPE family protein |
| M. marinum M | MMAR_2681 | - | 0.0 | 99.72% (355) | PPE family protein, PPE31_1 |
| M. avium 104 | MAV_2914 | - | 1e-75 | 44.60% (361) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 3e-27 | 33.33% (243) | PPE family protein |
| M. thermoresistible (build 8) | TH_3113 | - | 5e-31 | 30.83% (412) | PUTATIVE PPE protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 2e-29 | 31.01% (358) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_3076|M.ulcerans_Agy99 -------------MDFAALPPEINPIRMYSGPGSAPMLAAVTAWDGLAAE
MMAR_2681|M.marinum_M -------------MDFAALPPEINSIRMYSGPGSAPMLAAVTAWDGLAAE
Mb1836|M.bovis_AF2122/97 -------------MDFATLPPEINSARMYSGAGSAPMLAAASAWHGLSAE
Rv1807|M.tuberculosis_H37Rv -------------LDFATLPPEINSARMYSGAGSAPMLAAASAWHGLSAE
MAV_2914|M.avium_104 ------------MIDFAALPPEINSARIYAGPGSAPMMSAAAAWNTMAAE
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
MAB_0809c|M.abscessus_ATCC_199 ---------MLAAPVWMASPPEVHSALLSSGPGPGPLLAAAAEWSSLGAH
TH_3113|M.thermoresistible__bu ----------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDE
: .** :. : *.*...: :* * :. .
MUL_3076|M.ulcerans_Agy99 LRSTAAAYETVIAVLTGDGWLGPASESMEAAVFPYLAWMNITGMQAEQTA
MMAR_2681|M.marinum_M LRSTAAAYETVIAVLTGDGWLGPASESMEAAVFPYLAWMNITGMQAEQTA
Mb1836|M.bovis_AF2122/97 LRASALSYSSVLSTLTGEEWHGPASASMTAAAAPYVAWMSVTAVRAEQAG
Rv1807|M.tuberculosis_H37Rv LRASALSYSSVLSTLTGEEWHGPASASMTAAAAPYVAWMSVTAVRAEQAG
MAV_2914|M.avium_104 MRSAAASYGAVISELTSADWFGPSSMSMLAAVTPYLTWLTDTATRAEEAA
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLTT-FEGESAAALAERVTPYEKWLTQNAASAELTA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
MAB_0809c|M.abscessus_ATCC_199 YSATAQELRAILAATHASAWHGPSAETYVAAHTPYLEWLNQGALESNARA
TH_3113|M.thermoresistible__bu YRAAAVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAG
::* : : : * .: ** *: . . .
MUL_3076|M.ulcerans_Agy99 RQAAAAAGAFEAAFAMTVPPAQVAANRTQLQTLVATNLLGQNTPAIAATE
MMAR_2681|M.marinum_M RQAAAAAGAFEAAFAMTVPPAQVAANRTQLQTLVATNLLGQNTPAIAATE
Mb1836|M.bovis_AF2122/97 AQAEAAAAAYEAAFAATVPPPVIEANRAQLMALIATNVLGQNAPAIAATE
Rv1807|M.tuberculosis_H37Rv AQAEAAAAAYEAAFAATVPPPVIEANRAQLMALIATNVLGQNAPAIAATE
MAV_2914|M.avium_104 AQANSAATAYEAAFAMTVPPAVVAANRAQLATLVATNVFGQNTPAIAATE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
MAB_0809c|M.abscessus_ATCC_199 VQHGAAAGAYSTALAVMPTLAELAANHATHAALVATNFFGINTIPILATE
TH_3113|M.thermoresistible__bu AQLEAAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNE
* ** *. :*:: . : *:: *: :*.:* *: .* .*
MUL_3076|M.ulcerans_Agy99 AAYGEMWAQDAAAMYGYAVGSAAAS-TLTQFTQPA---------------
MMAR_2681|M.marinum_M AAYGEMWAQDAAAMYGYAVGSAAAS-TLTQFTQPA---------------
Mb1836|M.bovis_AF2122/97 AQYAEMWSQDAMAMYGYAGASAAAT-QLTPFTEPV---------------
Rv1807|M.tuberculosis_H37Rv AQYAEMWSQDAMAMYGYAGASAAAT-QLTPFTEPV---------------
MAV_2914|M.avium_104 AEYGQMWAQDAAAMNGYAVASTAAT-RLTPMTAPR---------------
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPP---------------
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA
MAB_0809c|M.abscessus_ATCC_199 ADYVRMWVQAATTMATYQTASEVALASAPPSTPPPSILHD----------
TH_3113|M.thermoresistible__bu ADYARMWIQAATTMATYEAVASAAVSATPRTVAPPPILGAGTGESATAAI
* * .** * * :* * * . .
MUL_3076|M.ulcerans_Agy99 --QTTDPSGLASQS------------------------------------
MMAR_2681|M.marinum_M --QTTDPSGLASQS------------------------------------
Mb1836|M.bovis_AF2122/97 --QTTNASGLAAQS------------------------------------
Rv1807|M.tuberculosis_H37Rv --QTTNASGLAAQS------------------------------------
MAV_2914|M.avium_104 --SNTSPEGVAAQA------------------------------------
MLBr_01182|M.leprae_Br4923 --LGVNEVGLAQEVVE----------------------------------
Mflv_0325|M.gilvum_PYR-GCK DMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLR---
Mvan_0415|M.vanbaalenii_PYR-1 DVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLR---
MSMEG_0619|M.smegmatis_MC2_155 SVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGG-QAILDFLK---
MAB_0809c|M.abscessus_ATCC_199 --HDHGHDDHDHEHGHDDDHG---------HGDLDPTDPEWWVHVAG---
TH_3113|M.thermoresistible__bu TGAHVTAELRAAESRTLLDEINELIDRLFAPLFPPGFADALPDGLLGTLL
:
MUL_3076|M.ulcerans_Agy99 ------------------AAVTQAVGSTVGNLTQTELPQLMSAVPASLQG
MMAR_2681|M.marinum_M ------------------AAVTQAVGSTVGNLTQTELPQLMSAVPASLQG
Mb1836|M.bovis_AF2122/97 ------------------AAIAHATGASAG-AQQTTLSQLIAAIPSVLQG
Rv1807|M.tuberculosis_H37Rv ------------------AAIAHATGASAG-AQQTTLSQLIAAIPSVLQG
MAV_2914|M.avium_104 ------------------TSVTNAAQAPAGTVQSTVS-------SSGLAG
MLBr_01182|M.leprae_Br4923 ------------------EVVEEVVEEVVEAEQAISQAALDQAVNEGMEA
Mflv_0325|M.gilvum_PYR-GCK -----------DPIGNTFALITDFLTNPVQALITWGPFLLAVVYQA----
Mvan_0415|M.vanbaalenii_PYR-1 -----------DPLGNTIKLITDFLTNPAQALITWGPFLAAVAYQA----
MSMEG_0619|M.smegmatis_MC2_155 -----------DPLGNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNL
MAB_0809c|M.abscessus_ATCC_199 -----------EMVEHFELLLNNLLTDPAALLTNLPMVLADVAFHA----
TH_3113|M.thermoresistible__bu APLLPGATGDGPPMATIMSFLLMGLSNPAYLFPVLVYLLFTGVVHTTVAV
: .
MUL_3076|M.ulcerans_Agy99 LASPAAASPIDAIPGSGLLAALLNFLDGNDGNPYGVFLNSSLVNGFVSAG
MMAR_2681|M.marinum_M LASPAAASPIDAIPGSGLLAALLNFLDGNDGNPYGVFLNSSLVNGFVSAG
Mb1836|M.bovis_AF2122/97 LSSSTAATSASGP--SGLLGILGSGSSWLDKLWALLDPNSNFWNTIASSG
Rv1807|M.tuberculosis_H37Rv LSSSTAATFASGP--SGLLGIVGSGSSWLDKLWALLDPNSNFWNTIASSG
MAV_2914|M.avium_104 LLSGSDNS------------AFGTFTNGN-------FFSTAVVNGSLAGG
MLBr_01182|M.leprae_Br4923 TVVPQVDQQVNVDVATPQTAVPDSSSAAAPQLWGGFAQHLSPINDTLSMI
Mflv_0325|M.gilvum_PYR-GCK VSWVGASILYPSLFLLPLLATT---LAIVAGVG--QHLLSLLNTPPAEEA
Mvan_0415|M.vanbaalenii_PYR-1 VSWVGASILYPSLLLLPLVATT---LAIVLGVG--AYLLENLPAPAEDAP
MSMEG_0619|M.smegmatis_MC2_155 VGWPTWGMIFASPFLIPALAALGI-TGLVLLID--HVLNNPVDVPAEDEA
MAB_0809c|M.abscessus_ATCC_199 AQLASTIGQFAPALIQPALALAIANLGWAAGFAGLAGIQPSPEILAVEPG
TH_3113|M.thermoresistible__bu SGMLAQLVPLMPALLPVAVAALGGLAGVWAGLSGLAGLAGLTAVPAADGG
MUL_3076|M.ulcerans_Agy99 YVSPAVVGPAIWAAMADINAVALGAQESAAVPPMGSGEGNPSWIPAASPA
MMAR_2681|M.marinum_M YVSPAVVGPAIWAAMADINAVALGAQESAAVPPMGSGEGNPSWIPAASPA
Mb1836|M.bovis_AF2122/97 LFLPSNTIAPFLGLLGGVAAADAAGDVLGEATSGGLG---------GALV
Rv1807|M.tuberculosis_H37Rv LFLPSNTIAPFLGLLGGVAAADAAGDVLGEATSGGLG---------GALV
MAV_2914|M.avium_104 PFNPQFIISSVQGVLAAQHATTLGGLGDFAADAEG-----------AATA
MLBr_01182|M.leprae_Br4923 NNHAGMANAGLSLVNGMGSAMKSLAPTTTKAAESAFKAMG------SAVQ
Mflv_0325|M.gilvum_PYR-GCK AEEPAPAQSAPSRPDQQSFPATMSAPPPPSGAPIAANTVSAGSPPAPGAP
Mvan_0415|M.vanbaalenii_PYR-1 AEEPAASSPAPTRADQPSPAIAVSAPPPPSSAAATVGTVATGTAPAPGAP
MSMEG_0619|M.smegmatis_MC2_155 PQEVAAAP----RTDQP-LAVGISPAGVPGSAATAAAPAPAPAGTTVAAP
MAB_0809c|M.abscessus_ATCC_199 SVEDAPMAASAGTALAPSPPASAAAPAAPASAPAPTASGTAPAPPSP-PP
TH_3113|M.thermoresistible__bu ASAAPVPAGGPSLPSGSSAPPAPTGSAAPTTGTAPGGAGSPPPAGHSVPP
.
MUL_3076|M.ulcerans_Agy99 SPESLPVLGEETAATLGTGGISAGMNQAELVGRMSVPQSWAWQQRWPITP
MMAR_2681|M.marinum_M SPESLPVLGEETAATLGTGGISAGMNQAELVGRMSVPQSWG-----VATA
Mb1836|M.bovis_AF2122/97 AP-----LG--SAGGLG-GTVAAGLGNAATVGTLSVPPSWT-----AAAP
Rv1807|M.tuberculosis_H37Rv AP-----LG--SAGGLG-GTVAAGLGNAATVGTLSVPPSWT-----AAAP
MAV_2914|M.avium_104 DL---------AASTGGSAPVAAGMGRAQLVGSLSVPQGWAN----AATI
MLBr_01182|M.leprae_Br4923 ST------GRGLLGSSSGGHVTAQLGRAASIGSLRVPQTWTT----ASQP
Mflv_0325|M.gilvum_PYR-GCK AAAAATFVPYVVAGRD-PYEGFSPTVRDSTGAKAPAGTIPAAASGIAASA
Mvan_0415|M.vanbaalenii_PYR-1 AAATASFVPYAVAGRD-PGTGFSPTVRDSTSAKAPASGIPAAASGVAASA
MSMEG_0619|M.smegmatis_MC2_155 APAAATFVPYAVANRD-PGEGFTPTLGNKSQVAAPASGVPAAASGVAASL
MAB_0809c|M.abscessus_ATCC_199 VGDPGFSFPYAVGGGPRLGTGLALAAQVRRGTSAAARSSAREQAAAAETA
TH_3113|M.thermoresistible__bu APHSAPPVGTSGPPYLIAAQPAPGVARRSAGARRAASIVEPAGSAAAAAA
. .
MUL_3076|M.ulcerans_Agy99 VRQPRAAAGPVRPL-----------SPKRQSGCPAFQVCPRAFTGTASAM
MMAR_2681|M.marinum_M VANHAGAAAPG-------------------GGWTSTAVVPEAAVG----M
Mb1836|M.bovis_AF2122/97 LASPLGSALGG---------------------TPMVAPPPAVAAG----M
Rv1807|M.tuberculosis_H37Rv LASPLGSALGG---------------------TPMVAPPPAVAAG----M
MAV_2914|M.avium_104 NPGQAAVPATG---------------------VTGLTDAASAAGG-----
MLBr_01182|M.leprae_Br4923 VTAATRALSPAR-----------------VAVATESESAPLLGGG----L
Mflv_0325|M.gilvum_PYR-GCK AERRKRRRRQKEEIKGRGYADAYADYEELPDDGPPEQPAPRVTASTRGAG
Mvan_0415|M.vanbaalenii_PYR-1 AERRKRRRRQKDEIAGRAYADAYADYEPEPDDEPPVRQEPRIAATERGAG
MSMEG_0619|M.smegmatis_MC2_155 ASRRKRRRKKGAQIEERGYADAYMDYEE-PDEDPAPQPEPRVRASERGSD
MAB_0809c|M.abscessus_ATCC_199 AARQARRRRDKGKQQGRG-----IEYMDMNATARCEEPAPDTTASHRGAG
TH_3113|M.thermoresistible__bu ARESAPIRRRRGQKDGLHG--------HRHEHQQPASMSAATAPSAAGIR
.
MUL_3076|M.ulcerans_Agy99 PPGTDSAQRSWGARQLLDDETEVTVTSTIGSGTAAATESASMTPSR----
MMAR_2681|M.marinum_M PGIPGMPAGIYGHN--LGNAPRYGFRPTIMGRPPAAG-------------
Mb1836|M.bovis_AF2122/97 PGMPFGTMGGQGFG---RAVPQYGFRPNFVARPPAAG-------------
Rv1807|M.tuberculosis_H37Rv PGMPFGTMGGQGFG---RAVPQYGFRPNFVARPPAAG-------------
MAV_2914|M.avium_104 PGGVAGPVGGTGRR-LRRAIPKYGFRPVVMPRPPAAG-------------
MLBr_01182|M.leprae_Br4923 PMAPMVPGGGSGTG-GVNTALRLQPRAFVMPRNPAAG-------------
Mflv_0325|M.gilvum_PYR-GCK PMGFAGTVSRGDEQAGGLTTLA-GDSFGGGPREPMLPGTWDPDATDDRHT
Mvan_0415|M.vanbaalenii_PYR-1 PMGFAGTVSRDAAQAGGLTTLP-GDPFGGGPKAPMLPGTWDPDTEPD---
MSMEG_0619|M.smegmatis_MC2_155 AMGFTGTVTRHDVTAAGLTTLT-GDTFDDRPVTPMLPGTWDGDENPAP--
MAB_0809c|M.abscessus_ATCC_199 TMGFAGTVIKTGATASGLAMLSRDDDLFEGVRAPMVPNTWDP--------
TH_3113|M.thermoresistible__bu VLGGAGRISRTRGSVPHAEITP-GDPTEPSSPTDRAHRPAEPN-------
MUL_3076|M.ulcerans_Agy99 ---------------
MMAR_2681|M.marinum_M ---------------
Mb1836|M.bovis_AF2122/97 ---------------
Rv1807|M.tuberculosis_H37Rv ---------------
MAV_2914|M.avium_104 ---------------
MLBr_01182|M.leprae_Br4923 ---------------
Mflv_0325|M.gilvum_PYR-GCK DGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 ---ERHNHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 ----SPDDPEGGPRR
MAB_0809c|M.abscessus_ATCC_199 ----EHGRQD-----
TH_3113|M.thermoresistible__bu ---------------