For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
SQEAALTAVEEDLVVVDTSPVDAGGYVSVPVLLSDFGSLSPEINSGRIYAGPGSGPVLAAAGAWDALATE LGATACGYSCVITQLTSLPWSGPAAAAMLTAVTPYVSWLTTMATRAEQTAMQARAAAAAYEAAFAMTVPP PAIAVNRVRLLALIATNFFGQNTPSIAATEAEYAEFWAQDATAMYCYASTSTSFLALPAFPGPPRTTDPA GLAGQAAATSQSAASATSSSAIQALTQVSSSLAAAGHWLPILSTAEWNTLVNTWGLAYFGAGIFQLGTLF AQQLLPDAAAAPSAAAAAESTAVAAQLAAPVAATPVSAVFARADTIGPMSVPPSWTTAAPAPTAGGAAIS GIDVAPGRPQAPNALLPNLRDNSRATTFARRRYGIRLTVMLRPPEAG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_1095 | - | - | 100% (398) | PPE family protein |
| M. marinum M | MMAR_2517 | - | 9e-81 | 46.32% (421) | PPE family protein, PPE23 |
| M. marinum M | MMAR_2669 | - | 1e-78 | 43.06% (418) | PPE family protein, PPE25 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2916c | PPE45 | 4e-84 | 46.44% (407) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 8e-33 | 31.15% (382) | PPE protein |
| M. tuberculosis H37Rv | Rv2892c | PPE45 | 5e-84 | 46.44% (407) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 5e-47 | 36.10% (421) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_4783 | - | 1e-31 | 31.14% (350) | PPE family protein |
| M. avium 104 | MAV_4015 | - | 4e-81 | 47.64% (382) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 2e-33 | 29.04% (365) | PPE family protein |
| M. thermoresistible (build 8) | TH_3113 | - | 5e-30 | 37.25% (204) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_3089 | - | 2e-79 | 43.30% (418) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 3e-35 | 30.96% (365) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2916c|M.bovis_AF2122/97 ----------------------------------MDFGVLPPEINSGRMY
Rv2892c|M.tuberculosis_H37Rv ----------------------------------MDFGVLPPEINSGRMY
MUL_3089|M.ulcerans_Agy99 ---------------------------------MFDFGALPPEINSGRMY
MMAR_1095|M.marinum_M MSQEAALTAVEEDLVVVDTSPVDAGGYVSVPVLLSDFGSLSPEINSGRIY
MAV_4015|M.avium_104 ----------------------------------MDFGFLPPEVNSARMY
MLBr_01182|M.leprae_Br4923 ---------------------------------MFDFAALSPETNSTRMY
Mflv_0325|M.gilvum_PYR-GCK ---------------------MTSPVASLAPVTSPVWMALPPEVHSTMLS
Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------MSSPVWMALPPEVHSALLS
MSMEG_0619|M.smegmatis_MC2_155 -------------------------------MTAPIWMALPPEVHSSLLS
MAB_4783|M.abscessus_ATCC_1997 -------------------------------MTAPVWMAAPPEVHSALLS
TH_3113|M.thermoresistible__bu -------------------------------------MALPPEVHSTLLR
.** :* :
Mb2916c|M.bovis_AF2122/97 AGPGSGPMMAAAAAWDSLAAELGLAAGGYRLAISELTGAYWAGPAAASMV
Rv2892c|M.tuberculosis_H37Rv AGPGSGPMMAAAAAWDSLAAELGLAAGGYRLAISELTGAYWAGPAAASMV
MUL_3089|M.ulcerans_Agy99 TGPGSGPMMAAASAWDALAAELSSAASGYSLVIAELTSSPWLGPASRSMM
MMAR_1095|M.marinum_M AGPGSGPVLAAAGAWDALATELGATACGYSCVITQLTSLPWSGPAAAAML
MAV_4015|M.avium_104 AGPGSGSLLAAAGSWDSLAAELSITAAVYESVLAGLTGLYWHGPASRAMA
MLBr_01182|M.leprae_Br4923 LGPGSSPILTAAAAWVVLAKELTAAAQGLQSAVEALLTT-FEGESAAALA
Mflv_0325|M.gilvum_PYR-GCK SGPGPGSLLAAGVAWQSLSAEYASAAAELTSILAGVQSGAWEGPSSQQYV
Mvan_0415|M.vanbaalenii_PYR-1 SGPGPGSMLAAAATWQSLSAEYAAAAAELSSILADVQAGAWEGPSSEQYV
MSMEG_0619|M.smegmatis_MC2_155 SGPGPGSLLAAAGAWQSLSAEYAAAAAELTSVLSAVQAGSWEGPSSEQYV
MAB_4783|M.abscessus_ATCC_1997 SGPGPGSLFAAADAWRSLSTEYSSAANELTTTLGSVRAGVWDGASAEQYQ
TH_3113|M.thermoresistible__bu TGPGPGALSAAADAWRMLSDEYRAAAVELAAVVSQTCATAWEGVGADAYA
***...: :*. :* *: * :* : : * .:
Mb2916c|M.bovis_AF2122/97 AAVTPYVAWLSATAGQAEQAGMQARAAAAAYELAFAMTVPPPVVVANRAL
Rv2892c|M.tuberculosis_H37Rv AAVTPYVAWLSATAGQAEQAGMQARAAAAAYELAFAMTVPPPVVVANRAL
MUL_3089|M.ulcerans_Agy99 SAVAPYVTWLSAAAAQTETAASQARAAAAAYETAFVMTVPPPVIAANRVL
MMAR_1095|M.marinum_M TAVTPYVSWLTTMATRAEQTAMQARAAAAAYEAAFAMTVPPPAIAVNRVR
MAV_4015|M.avium_104 AGAAPYVGWLHTTAERAQQTATQARAAAAAYELAHAMTVPPAAVAANRTQ
MLBr_01182|M.leprae_Br4923 ERVTPYEKWLTQNAASAELTATQLTVAANAYETAFTMTVPPLMVFVNRAQ
Mflv_0325|M.gilvum_PYR-GCK AAHTPYLAWLAQQSAVSAATAVQHDTAAAAYTTALATMPTLPELALNHTT
Mvan_0415|M.vanbaalenii_PYR-1 AAHTPYLAWLAQQSAAGAAAAAQHEAAAAAYSTALATMPTLPELALNHTT
MSMEG_0619|M.smegmatis_MC2_155 AAHAPYLQWLAQQSANSAAAAVQHETAAAAYSTALATMPTMAELALNHTM
MAB_4783|M.abscessus_ATCC_1997 TAHVPYLSWLHETSAVSAGVAAQTETAATAYSEALATMPTLGELAANHAT
TH_3113|M.thermoresistible__bu AAHGPYLFWLTDTAAAAAAAGAQLEAAAAAHASALAAMPTMAELTANRTT
** ** : .. * .** *: * . . : *:.
Mb2916c|M.bovis_AF2122/97 LVALVATNFFGQNTPAIAATEAQYAEMWAQDAAAMYAYAGSAAIAT-ELT
Rv2892c|M.tuberculosis_H37Rv LVALVATNFFGQNTPAIAATEAQYAEMWAQDAAAMYAYAGSAAIAT-ELT
MUL_3089|M.ulcerans_Agy99 LMALVATNFFGQNTPAIAATEAQYMEMWAQDAAAMYSYAGSSAPAT-ELP
MMAR_1095|M.marinum_M LLALIATNFFGQNTPSIAATEAEYAEFWAQDATAMYCYASTSTSFL-ALP
MAV_4015|M.avium_104 LAALVATNFFGQNTAAIAATEAQYAEYWAQDAAAMYAYSASSAAAA-QFS
MLBr_01182|M.leprae_Br4923 ACLLIMSNIFGQNSTAIAEKEAEYTEMWIQDAAAMTSYQASVLEAVGATK
Mflv_0325|M.gilvum_PYR-GCK HAVLVGTNFLGINTIPIALNEADYVRMWIQAATTMATYQSVSGAALAATP
Mvan_0415|M.vanbaalenii_PYR-1 HAVLVATNFLGINTIPIAMTEADYVRMWIQAATTMATYQAVSGAALAATP
MSMEG_0619|M.smegmatis_MC2_155 HGVLVATNFFGINTIPIALNEADYVRMWIQAATTMSTYQAVSGAAVAAAP
MAB_4783|M.abscessus_ATCC_1997 HGALVATNFFGINTIPIAVNEADYIRMWIQAATVMSTYQAVSESSVSAAP
TH_3113|M.thermoresistible__bu HAALVATNFFGVNTIPIAVNEADYARMWIQAATTMATYEAVASAAVSATP
*: :*::* *: .** .**:* . * * *:.* * .
Mb2916c|M.bovis_AF2122/97 PFTAAPVTTSPAALAGQAAATVSSTVPPLATTAA---VPQLLQQLSS---
Rv2892c|M.tuberculosis_H37Rv PFTAAPVTTSPAALAGQAAATVSSTVPPLATTAA---VPQLLQQLSS---
MUL_3089|M.ulcerans_Agy99 RFAPPPDTTSVNAAGGQSAVVAQAAATPAGDSAQT--ITATIPQLLS---
MMAR_1095|M.marinum_M AFPGPPRTTDPAGLAGQAAATSQSAASATSSSAI----QALTQVSSS---
MAV_4015|M.avium_104 PFASPRRTTDPGGVTAQQAAVAAAETGSTGTDSG----TQVIPPTAG---
MLBr_01182|M.leprae_Br4923 AFTAPPLGVNEVGLAQEVVEEVVEEVVEEVVEAEQAISQAALDQAVN---
Mflv_0325|M.gilvum_PYR-GCK TSAPAPSVLLPGVGEAGRAAADMSAFAAQPMAAQAGAAFDVSNIIADIIR
Mvan_0415|M.vanbaalenii_PYR-1 TATPAPFVLAPGVGEAGRAAADVTAFAAQAQAAEAGSALDLSNIIADLIR
MSMEG_0619|M.smegmatis_MC2_155 VSAPAPFLLKPGVGEAGSASASVQQMSAQATAAESGSSLDLSSIISDLLN
MAB_4783|M.abscessus_ATCC_1997 PTSPAPPVLSPDSGAAART-------AAQDATKPPPIVPDPNDPIEMLLK
TH_3113|M.thermoresistible__bu RTVAPPPILGAGTGESATAAITGAHVTAELRAAESRTLLDEINELIDRLF
. .
Mb2916c|M.bovis_AF2122/97 -------------TSLIPWYSALQQWLAENLLGLTPDNRMTIVRLLGISY
Rv2892c|M.tuberculosis_H37Rv -------------TSLIPWYSALQQWLAENLLGLTPDNRMTIVRLLGISY
MUL_3089|M.ulcerans_Agy99 -------------SAGVP---GLQQRSLSSVSSMSPSAASSPTVWQIIQT
MMAR_1095|M.marinum_M -------------LAAAG----HWLPILST------AEWNTLVNTWGLAY
MAV_4015|M.avium_104 -------------ASEIP----LDFRILDTIL----GAQTTFRSIFTTEG
MLBr_01182|M.leprae_Br4923 -------------EGMEATVVPQVDQQVNVDVATPQTAVPDSSSAAAPQL
Mflv_0325|M.gilvum_PYR-GCK LYGEVLRFLFEPIFNFLRDPIGNTFALITDFLTNPVQALITWGPFLLAVV
Mvan_0415|M.vanbaalenii_PYR-1 AYGELLRFLFEPIFDFLRDPLGNTIKLITDFLTNPAQALITWGPFLAAVA
MSMEG_0619|M.smegmatis_MC2_155 QYLQGVPGG-QAILDFLKDPLGNLGRLLTDFMTNPAGALATWWPFLFGVA
MAB_4783|M.abscessus_ATCC_1997 NS-QHFLGMYRALKGLITDPVGTIVRIIIDFSTNPAAAIVTWTPLFYVFA
TH_3113|M.thermoresistible__bu AP----LFPPGFADALPDGLLGTLLAPLLPGATGDGPPMATIMSFLLMGL
Mb2916c|M.bovis_AF2122/97 FDEG----------LLQFEASLAQQAIPGTPGGAGDSGSSVLDS-WGPTI
Rv2892c|M.tuberculosis_H37Rv FDEG----------LLQFEASLAQQAIPGTPGGAGDSGSSVLDS-WGPTI
MUL_3089|M.ulcerans_Agy99 QVQN----------FLTYGLPTPDNNYAGLYPGMYNALRQTLQAYFGVGI
MMAR_1095|M.marinum_M FGAG----------IFQLGTLFAQQLLPDAAAAPSAAAAAESTA------
MAV_4015|M.avium_104 IPAG----------IIQADKNLG--ILPNLATIPAALPRTP---------
MLBr_01182|M.leprae_Br4923 WGGF----------AQHLSPINDTLSMINNHAGMANAGLSLVNG------
Mflv_0325|M.gilvum_PYR-GCK YQA----VSWVGASILYPSLFLLPLLATT--LAIVAGVGQHLLSLLNTPP
Mvan_0415|M.vanbaalenii_PYR-1 YQA----VSWVGASILYPSLLLLPLVATT--LAIVLGVGAYLLENLPAPA
MSMEG_0619|M.smegmatis_MC2_155 YQVFFNLVGWPTWGMIFASPFLIPALAALGITGLVLLIDHVLNNPVDVPA
MAB_4783|M.abscessus_ATCC_1997 YAA-----TFAVMGTPIYAAIMGPAAGISIPLAITLAS---LSQMPEAPP
TH_3113|M.thermoresistible__bu SNP---AYLFPVLVYLLFTGVVHTTVAVSGMLAQLVPLMPALLPVAVAAL
Mb2916c|M.bovis_AF2122/97 --FAGPRASPSVAGGG----AVGGVQTPQPYWYWALDRESIGGSVSAALG
Rv2892c|M.tuberculosis_H37Rv --FAGPRASPSVAGGG----AVGGVQTPQPYWYWALDRESIGGSVSAALG
MUL_3089|M.ulcerans_Agy99 GNFGWSIAQQLTLGPGGTTAGAGGAWYPTP-EFAALGADTWHWHPMASFA
MMAR_1095|M.marinum_M --VAAQLAAPVA-----------------------------ATPVSAVFA
MAV_4015|M.avium_104 ----ALSASPTG-----------------------------LGRIDAVLA
MLBr_01182|M.leprae_Br4923 --MGSAMKSLAPTTTKAAESAFKAMGSAVQSTGRGLLGSSSGGHVTAQLG
Mflv_0325|M.gilvum_PYR-GCK AEEAAEEPAPAQSAPSRPDQQSFPATMSAPPPPSGAPIAANTVSAGSPPA
Mvan_0415|M.vanbaalenii_PYR-1 EDAPAEEPAASSPAPTRADQPSPAIAVSAPPPPSSAAATVGTVATGTAPA
MSMEG_0619|M.smegmatis_MC2_155 EDEAPQEVAAAP----RTDQP-LAVGISPAGVPGSAATAAAPAPAPAGTT
MAB_4783|M.abscessus_ATCC_1997 VDAPAETVPARIDQPHAVAMGGAPAPTASTAAP--TPTTTSPATPGSAPA
TH_3113|M.thermoresistible__bu GGLAGVWAGLSGLAGLAGLTAVPAADGGASAAPVPAGGPSLPSGSSAPPA
:
Mb2916c|M.bovis_AF2122/97 KGSSAGSLSVPPDWAARARWANPAAWRLPGDDVTALRGTAE-----NALL
Rv2892c|M.tuberculosis_H37Rv KGSSAGSLSVPPDWAARARWANPAAWRLPGDDVTALRGTAE-----NALL
MUL_3089|M.ulcerans_Agy99 SSSKVGGLSVPASWGTTPGAVEQASTKLVSTNFTTSPGEANPANGLNAAL
MMAR_1095|M.marinum_M RADTIGPMSVPPSWTTAAPAPTAGG--AAISGIDVAPGRPQ---APNALL
MAV_4015|M.avium_104 RAARIGPMSVPAGWTAATGNPVAAAPVTGWSEPSAADARPG---VTAPGL
MLBr_01182|M.leprae_Br4923 RAASIGSLRVPQTWTTASQPVTAATRALSPARVAVATESES-APLLGGGL
Mflv_0325|M.gilvum_PYR-GCK PGAPAAAAATFVPYVVAGRDPYEGFSPTVRDSTGAKAPAGTIPAAASGIA
Mvan_0415|M.vanbaalenii_PYR-1 PGAPAAATASFVPYAVAGRDPGTGFSPTVRDSTSAKAPASGIPAAASGVA
MSMEG_0619|M.smegmatis_MC2_155 VAAPAPAAATFVPYAVANRDPGEGFTPTLGNKSQVAAPASGVPAAASGVA
MAB_4783|M.abscessus_ATCC_1997 P-TPPPAGAEGLGYAVRGDGPGFGFGPTIGASTGATAHAPSSAVSAAAAL
TH_3113|M.thermoresistible__bu PTGSAAPTTGTAPGGAGSPPPAGHSVPPAPHSAPPVGTSGPPYLIAAQPA
.
Mb2916c|M.bovis_AF2122/97 RGFPMASAGQSTGG--GFVHKYGFRLAVMQRPPFAG--------------
Rv2892c|M.tuberculosis_H37Rv RGFPMASAGQSTGG--GFVHKYGFRLAVMQRPPFAG--------------
MUL_3089|M.ulcerans_Agy99 RGFPVGSRGAQRTG--NLGVRYGFRYPVLTRPPSAG--------------
MMAR_1095|M.marinum_M PNLR---DNSRATT--FARRRYGIRLTVMLRPPEAG--------------
MAV_4015|M.avium_104 PGIPG--ATLRRAA--LVVPRYGVRITVMARPPAAG--------------
MLBr_01182|M.leprae_Br4923 PMAPMVPGGGSGTGGVNTALRLQPRAFVMPRNPAAG--------------
Mflv_0325|M.gilvum_PYR-GCK ASAAERRKRRRRQKEEIKGRGYADAYADYEELPDDGPPEQPAPRVTASTR
Mvan_0415|M.vanbaalenii_PYR-1 ASAAERRKRRRRQKDEIAGRAYADAYADYEPEPDDEPPVRQEPRIAATER
MSMEG_0619|M.smegmatis_MC2_155 ASLASRRKRRRKKGAQIEERGYADAYMDYEE-PDEDPAPQPEPRVRASER
MAB_4783|M.abscessus_ATCC_1997 ACNPATGKSRRRRRRTIDDRGYRHEYATMDDHTPTGP--QDPVTAVASGT
TH_3113|M.thermoresistible__bu PGVARRSAGARRAASIVEPAGSAAAAAAARESAPIRRRRGQKDGLHGHRH
.
Mb2916c|M.bovis_AF2122/97 --------------------------------------------------
Rv2892c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3089|M.ulcerans_Agy99 --------------------------------------------------
MMAR_1095|M.marinum_M --------------------------------------------------
MAV_4015|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK GAGPMGFAGTVSRG-DEQAGGLTTLAGDSFGGGPREPMLPGTWDPDATDD
Mvan_0415|M.vanbaalenii_PYR-1 GAGPMGFAGTVSRD-AAQAGGLTTLPGDPFGGGPKAPMLPGTWDPDTEPD
MSMEG_0619|M.smegmatis_MC2_155 GSDAMGFTGTVTRH-DVTAAGLTTLTGDTFDDRPVTPMLPGTWDGDENPA
MAB_4783|M.abscessus_ATCC_1997 GAGRLGFAGVHTATTAVEATGLSTLDGDAEN--RTIPMLPGTWDVTDDDR
TH_3113|M.thermoresistible__bu EHQQPASMSAATAP---SAAGIRVLGGAGRISRTRGSVPHAEITPGDPTE
Mb2916c|M.bovis_AF2122/97 ------------------
Rv2892c|M.tuberculosis_H37Rv ------------------
MUL_3089|M.ulcerans_Agy99 ------------------
MMAR_1095|M.marinum_M ------------------
MAV_4015|M.avium_104 ------------------
MLBr_01182|M.leprae_Br4923 ------------------
Mflv_0325|M.gilvum_PYR-GCK RHTDGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 ------ERHNHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 P------SPDDPEGGPRR
MAB_4783|M.abscessus_ATCC_1997 ------------------
TH_3113|M.thermoresistible__bu PSSPTDRAHRPAEPN---