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MAHADYGARPPEINSALMYFGPGSRSMLAAAAAWDAVAFELGVLASGYTSVISELTSGPWVGPAAASMVG ASAPYVAWLRASAIRAERTASQARSAAAAYEAAFVMTVPPPVVAANRVLLTTLIVTNFFGQNTPAIAVTE AQYAEMWAQDAAAMYGYAASSATATRLTPFVPPPATTNLPGPLWQASAMGKAATTTAVAGGSTLLAATRR PVALPRLAALAQWLEAHLPGITPAERTTVVRLLGQSYFALGMVQFSTSIALQAIPGTASGAGASGSSVVD NWGSMLHGAHGGATAEFEEDLGTLTRPVSAAMGKARLTGSLSTPSSWGAGVREFANAAADEQLDLAGSVA SAKSNAYLQGMPMTAAGRNTAVAEQKYGFRYRVMQRTPAGG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_1905 | - | - | 100% (391) | PPE family protein |
| M. marinum M | MMAR_2669 | - | 2e-79 | 44.05% (420) | PPE family protein, PPE25 |
| M. marinum M | MMAR_1095 | - | 1e-75 | 44.99% (389) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2916c | PPE45 | 1e-103 | 52.77% (415) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 5e-30 | 39.08% (174) | PPE protein |
| M. tuberculosis H37Rv | Rv2892c | PPE45 | 1e-103 | 52.77% (415) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 2e-39 | 33.41% (437) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_2230c | - | 2e-30 | 37.50% (200) | PPE family protein |
| M. avium 104 | MAV_2928 | - | 2e-86 | 45.77% (437) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 1e-31 | 38.31% (201) | PPE family protein |
| M. thermoresistible (build 8) | TH_3569 | - | 5e-32 | 38.78% (196) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_2129 | - | 0.0 | 99.49% (391) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 2e-32 | 38.95% (190) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
TH_3569|M.thermoresistible__bu ---------MMTAPIWMALPPEVHSALLSSGPGPGSLLAAASAWHALSAE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MAB_2230c|M.abscessus_ATCC_199 ----------MSAPIWMASPPEVHSALLSAGPGPGALLAAAAQWQALSVQ
MMAR_1905|M.marinum_M ----------MAHADYGARPPEINSALMYFGPGSRSMLAAAAAWDAVAFE
MUL_2129|M.ulcerans_Agy99 ----------MAHADYGARPPEINSALMYFGPGSRSMLAAAAAWDAVAFE
Mb2916c|M.bovis_AF2122/97 -------------MDFGVLPPEINSGRMYAGPGSGPMMAAAAAWDSLAAE
Rv2892c|M.tuberculosis_H37Rv -------------MDFGVLPPEINSGRMYAGPGSGPMMAAAAAWDSLAAE
MAV_2928|M.avium_104 ------------MFDFGALPPEINSGRMYAGPGSGPLMAAAAAWDEVAAE
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
: . .** :* : ***. .:::*. * :: :
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
TH_3569|M.thermoresistible__bu YASAAAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSAATA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MAB_2230c|M.abscessus_ATCC_199 YTTAATELTQLLAATGSGSWQGPSAAQYVASHAPYLAWLTQQSAMSATNA
MMAR_1905|M.marinum_M LGVLASGYTSVISELTSGPWVGPAAASMVGASAPYVAWLRASAIRAERTA
MUL_2129|M.ulcerans_Agy99 LGVLASGYTSVISELTSGPWVGPAAASMVGASAPYVAWLRASAIRAERTA
Mb2916c|M.bovis_AF2122/97 LGLAAGGYRLAISELTGAYWAGPAAASMVAAVTPYVAWLSATAGQAEQAG
Rv2892c|M.tuberculosis_H37Rv LGLAAGGYRLAISELTGAYWAGPAAASMVAAVTPYVAWLSATAGQAEQAG
MAV_2928|M.avium_104 LGIAASGYHSVIAELTSGPWVGPASLSMVSAITPYVGWLSAVAAQAEETA
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLT-TFEGESAAALAERVTPYEKWLTQNAASAELTA
* : : * :: . :** ** : . .
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
TH_3569|M.thermoresistible__bu GRHETAAAAYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIPIALNE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MAB_2230c|M.abscessus_ATCC_199 VLHETSAAAYTTALAAMPTLAELAANHMIHGVLLATNFFGINTIPIALNE
MMAR_1905|M.marinum_M SQARSAAAAYEAAFVMTVPPPVVAANRVLLTTLIVTNFFGQNTPAIAVTE
MUL_2129|M.ulcerans_Agy99 SQARSAAAAYEAAFVMTVPPPVVAANRVLLTTLIVTNFFGQNTPAIAVTE
Mb2916c|M.bovis_AF2122/97 MQARAAAAAYELAFAMTVPPPVVVANRALLVALVATNFFGQNTPAIAATE
Rv2892c|M.tuberculosis_H37Rv MQARAAAAAYELAFAMTVPPPVVVANRALLVALVATNFFGQNTPAIAATE
MAV_2928|M.avium_104 SQGRAAAAAFEAAFAMTVPPPVIAANRVLLATLVATNFFGQNTPAIAATE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
:* *: *:. . : *: *: :*::* *: .** .*
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA
TH_3569|M.thermoresistible__bu ADYVRMWIQAATSMSTYQAVAGTAVMSAPASSPAPLLLAPGVSEAADAMA
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA
MAB_2230c|M.abscessus_ATCC_199 ADYIRMWIQAATTMGVYQGVSTAAVTSVAPTPPAPTIMAPG-GEMSRMSA
MMAR_1905|M.marinum_M AQYAEMWAQDAAAMYGYAASSATAT-RLTPFVPPPATTNLPGPLWQASAM
MUL_2129|M.ulcerans_Agy99 AQYAEMWAQDAAAMYGYAASSATAT-RLTPFVPPPATTNLPGPLWQASAM
Mb2916c|M.bovis_AF2122/97 AQYAEMWAQDAAAMYAYAGSAAIAT-ELTPFTAAPVTTSPAALAGQAAAT
Rv2892c|M.tuberculosis_H37Rv AQYAEMWAQDAAAMYAYAGSAAIAT-ELTPFTAAPVTTSPAALAGQAAAT
MAV_2928|M.avium_104 AQYMEMWAQDAAAMYGYAAASQTAS-TLSPFAAPPNTTAPEGESDQAAAV
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEVVEE
*:* .** * *::* * . * ..*
MSMEG_0619|M.smegmatis_MC2_155 SVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGGQ-AILDFLKDPL
TH_3569|M.thermoresistible__bu TTQQIGSQATAADSGTALNLSDLIANLLQYYQDYLDQLFGPIVDFLRDPI
Mflv_0325|M.gilvum_PYR-GCK DMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLRDPI
Mvan_0415|M.vanbaalenii_PYR-1 DVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLRDPL
MAB_2230c|M.abscessus_ATCC_199 DMSGMAAQAQAAESGMALDDS----------ESFFDKLMRQIQEFFSDPL
MMAR_1905|M.marinum_M GKAATT-----TAVAGGSTLLAATR----------------RPVALPRLA
MUL_2129|M.ulcerans_Agy99 GKAATT-----TAVAGGSTLLAATR----------------RPVALPRLA
Mb2916c|M.bovis_AF2122/97 VSSTVPPL---ATTAAVPQLLQQLS----------------STSLIPWYS
Rv2892c|M.tuberculosis_H37Rv VSSTVPPL---ATTAAVPQLLQQLS----------------STSLIPWYS
MAV_2928|M.avium_104 SQAMAQPAGSTAQTAANTSSQLATP----------------QALSAGTSQ
MLBr_01182|M.leprae_Br4923 VVEEVVEEVVEAEQAISQAALDQAVN------------EGMEATVVPQVD
: .
MSMEG_0619|M.smegmatis_MC2_155 GNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNLVGWPTWGMIFASPF
TH_3569|M.thermoresistible__bu GNLFQLIDDFLTNPAGALVTWWPLLFAVAYQVFTNLVGWPTWAMILASPV
Mflv_0325|M.gilvum_PYR-GCK GNTFALITDFLTNPVQALITWGPFLLAVVYQAVSWVGASILYPSLFLLPL
Mvan_0415|M.vanbaalenii_PYR-1 GNTIKLITDFLTNPAQALITWGPFLAAVAYQAVSWVGASILYPSLLLLPL
MAB_2230c|M.abscessus_ATCC_199 GTLQKILQDFMRNPLEALVAWGPLLFFIAYEAFFIPFGFTFWGVMLSAPL
MMAR_1905|M.marinum_M ALAQWLEAHLPGITPAERTT-VVRLLGQSYFALGMVQFS--TSIALQAIP
MUL_2129|M.ulcerans_Agy99 ALAQWLEAHLPGITPAERTT-VVRLLGQSYFALGMVQFS--TSIALQAIP
Mb2916c|M.bovis_AF2122/97 ALQQWLAENLLGLTPDNRMT-IVRLLGISYFDEGLLQFE--ASLAQQAIP
Rv2892c|M.tuberculosis_H37Rv ALQQWLAENLLGLTPDNRMT-IVRLLGISYFDEGLLQFE--ASLAQQAIP
MAV_2928|M.avium_104 AATQASSSSASQTGPFTWLTSALQNLQQSGLPTPTNNYLGLSPTFYTVML
MLBr_01182|M.leprae_Br4923 QQVNVDVATPQTAVPDSSSAAAPQLWGGFAQHLSPIN-------DTLSMI
:
MSMEG_0619|M.smegmatis_MC2_155 LIPALAALGITGLVLLIDHVLNNPVDVPAEDEAPQEVAAAPRTDQPLAVG
TH_3569|M.thermoresistible__bu LIPLAITLGVAGLVMIADQAQP-----PAEEAAPEEDVAAP---------
Mflv_0325|M.gilvum_PYR-GCK LATTLAIVAGVGQHLLSLLNTP-PAEEAAEEPAPAQSAPSRPDQQSFPAT
Mvan_0415|M.vanbaalenii_PYR-1 VATTLAIVLGVGAYLLENLPAP-AEDAPAEEPAASSPAPTRADQPSPAIA
MAB_2230c|M.abscessus_ATCC_199 WLP----LLLVGLAQLVN-PVPVEADAPADEPAPQQARVERSSPQQQPFA
MMAR_1905|M.marinum_M GTASGAGASGSSVVDNWGSMLHG--------AHGGATAEFEE--------
MUL_2129|M.ulcerans_Agy99 GTASGAGGSGSSVVDNWGSMLHG--------AHGGAAAEFEE--------
Mb2916c|M.bovis_AF2122/97 GTPGGAGDSGSSVLDSWGPTIFAGPRASPSVAGGGAVGGVQTPQPYWYWA
Rv2892c|M.tuberculosis_H37Rv GTPGGAGDSGSSVLDSWGPTIFAGPRASPSVAGGGAVGGVQTPQPYWYWA
MAV_2928|M.avium_104 KQTSGLGYFSNGITAFWSQLAQQLVSGPGGSTAGAGGAWYPTPQFASLGL
MLBr_01182|M.leprae_Br4923 NNHAGMANAGLSLVNGMGSAMKSLAPTTTKAAESAFKAMGSAVQSTGRG-
.
MSMEG_0619|M.smegmatis_MC2_155 ISPAGVPGSAATAAAPAPAPAGTTVAAPAPAAAT--FVPYAVANRDPGEG
TH_3569|M.thermoresistible__bu ----------VRAEPQNPLPLTXXX-------------------------
Mflv_0325|M.gilvum_PYR-GCK MSAPPPPSGAPIAANTVSAGSPPAPGAPAAAAAT--FVPYVVAGRDPYEG
Mvan_0415|M.vanbaalenii_PYR-1 VSAPPPPSSAAATVGTVATGTAPAPGAPAAATAS--FVPYAVAGRDPGTG
MAB_2230c|M.abscessus_ATCC_199 MGGMPGGGGAPATPANAPATPANAPASPAAAAATPAYMVYAVQEDPPAAR
MMAR_1905|M.marinum_M -DLGTLTRP--VSAAMGKARLTGSLSTPSSWGAGVREFANAAADEQ---L
MUL_2129|M.ulcerans_Agy99 -DLGTLTRP--VSAAMGKARLTGSLSTPSSWGAGVREFANAAADEQ---L
Mb2916c|M.bovis_AF2122/97 LDRESIGGS--VSAALGKGSSAGSLSVPPDWAARARWANPAAWRLP---G
Rv2892c|M.tuberculosis_H37Rv LDRESIGGS--VSAALGKGSSAGSLSVPPDWAARARWANPAAWRLP---G
MAV_2928|M.avium_104 GNLGSVGGASHVSAISAGAGRAGALSVPQQWATLTSAVSPAVSEEGSAVQ
MLBr_01182|M.leprae_Br4923 -LLGSSSGG-HVTAQLGRAASIGSLRVPQTWTTASQPVTAATRALS---P
:
MSMEG_0619|M.smegmatis_MC2_155 FTPTLGNKSQVAAPASG----VPAAASGVAASLASRRKRRRKKGAQIEER
TH_3569|M.thermoresistible__bu --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK FSPTVRDSTGAKAPAGT----IPAAASGIAASAAERRKRRRRQKEEIKGR
Mvan_0415|M.vanbaalenii_PYR-1 FSPTVRDSTSAKAPASG----IPAAASGVAASAAERRKRRRRQKDEIAGR
MAB_2230c|M.abscessus_ATCC_199 FGPTLNEGSGAKAPAAG----ISAAAA-AAASARSRARRKRGARIKDPAP
MMAR_1905|M.marinum_M DLAGSVASAKSNAYLQG----MPMTAAG-RNT--AVAEQKYGFRYRVMQR
MUL_2129|M.ulcerans_Agy99 DLAGSVASAKSNAYLQG----MPMTAAG-RNT--AVAEQKYGFRYRVMQR
Mb2916c|M.bovis_AF2122/97 DDVTALRGTAENALLRG----FPMASAG-QSTG-GGFVHKYGFRLAVMQR
Rv2892c|M.tuberculosis_H37Rv DDVTALRGTAENALLRG----FPMASAG-QSTG-GGFVHKYGFRLAVMQR
MAV_2928|M.avium_104 AAAGGAPGGAANGLLRG----MPVGALGRRGAA-AGYVNKYGFRYSVLTR
MLBr_01182|M.leprae_Br4923 ARVAVATESESAPLLGGGLPMAPMVPGGGSGTGGVNTALRLQPRAFVMPR
MSMEG_0619|M.smegmatis_MC2_155 GYADAYMDYEE-PDEDPAPQPEPRVRASERGSDAMGFTGTVTRHDVT---
TH_3569|M.thermoresistible__bu --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK GYADAYADYEELPDDGPPEQPAPRVTASTRGAGPMGFAGTVSRGDEQ---
Mvan_0415|M.vanbaalenii_PYR-1 AYADAYADYEPEPDDEPPVRQEPRIAATERGAGPMGFAGTVSRDAAQ---
MAB_2230c|M.abscessus_ATCC_199 QFMDMNSPVDP-DFSEPATRHTAGVGASGRGAGQLGFAGTLPRTTSTTSA
MMAR_1905|M.marinum_M TPAGG---------------------------------------------
MUL_2129|M.ulcerans_Agy99 TPAGG---------------------------------------------
Mb2916c|M.bovis_AF2122/97 PPFAG---------------------------------------------
Rv2892c|M.tuberculosis_H37Rv PPFAG---------------------------------------------
MAV_2928|M.avium_104 PPSAG---------------------------------------------
MLBr_01182|M.leprae_Br4923 NPAAG---------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155 AAGLTTLTGDTFDDRPVTPMLPGTWDGDENPAPSPDDPEGGPRR------
TH_3569|M.thermoresistible__bu --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK AGGLTTLAGDSFGGGPREPMLPGTWDPDATDDRHTDGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 AGGLTTLPGDPFGGGPKAPMLPGTWDPDTEPD------ERHNHHDGKDSQ
MAB_2230c|M.abscessus_ATCC_199 AGLIEREAASEMDGTRTVPMLPTSWGTDPEPDPDRAPSVPAPDEDWPPGE
MMAR_1905|M.marinum_M --------------------------------------------------
MUL_2129|M.ulcerans_Agy99 --------------------------------------------------
Mb2916c|M.bovis_AF2122/97 --------------------------------------------------
Rv2892c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2928|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155 -----
TH_3569|M.thermoresistible__bu -----
Mflv_0325|M.gilvum_PYR-GCK -----
Mvan_0415|M.vanbaalenii_PYR-1 -----
MAB_2230c|M.abscessus_ATCC_199 RGAST
MMAR_1905|M.marinum_M -----
MUL_2129|M.ulcerans_Agy99 -----
Mb2916c|M.bovis_AF2122/97 -----
Rv2892c|M.tuberculosis_H37Rv -----
MAV_2928|M.avium_104 -----
MLBr_01182|M.leprae_Br4923 -----