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STYRTVPYRPGEALLALYRRRGAFIDAGVGRHGFVYLLGPEANRFVFANADAFSWRETFESLVPVDGPTA LIVSDGEDHRRRRSIVAPGLRHRSVQDYVATMVSTIDNVIDSWRPGQPLDIYQEFRCAVRRSTTESLFGP RLASHSDYLGRQLQPLIDLTHRLPQVMQLQQRLNSPGWRRAMAARTRIDELIDAEIANARAEPSPDDRML TALINGRSEEGCALSDNEIRDSIVSLIAAGYETTSGALAWATYSLLTLPGAWETAAREVARVLGGTAPSA ETLGALTYLNGVVHETLRLYSPGVVSARRLIRDLWFDGHRINSGRLLIFSAYVTHRIPEVWPNPTQFLPQ RWDPAAPDYRKPAPHEFIPFSGGLHRCIGAVMATTELVVLLARLVARTRLRLPAQRIRAANFAALAPKPG LRVEFVDSVPAQ*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_2475 | cyp139A3 | - | 100% (433) | cytochrome P450 139A3 Cyp139A3 |
| M. marinum M | MMAR_0281 | cyp183B1 | 6e-42 | 32.24% (366) | cytochrome P450 183B1 Cyp183B1 |
| M. marinum M | MMAR_0283 | cyp274A1 | 1e-39 | 31.13% (363) | cytochrome P450 274A1 Cyp274A1 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1694c | cyp139 | 0.0 | 79.07% (430) | cytochrome P450 139 CYP139 |
| M. gilvum PYR-GCK | Mflv_0056 | - | 2e-37 | 29.81% (369) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv1666c | cyp139 | 0.0 | 79.07% (430) | cytochrome P450 139 CYP139 |
| M. leprae Br4923 | MLBr_02088 | - | 6e-16 | 23.92% (347) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_2078 | - | 5e-32 | 25.30% (411) | cytochrome P450 |
| M. avium 104 | MAV_3106 | - | 0.0 | 74.00% (427) | P450 heme-thiolate protein |
| M. smegmatis MC2 155 | MSMEG_0822 | - | 4e-35 | 30.06% (316) | cytochrome P450 |
| M. thermoresistible (build 8) | TH_0136 | - | 9e-38 | 28.84% (423) | PROBABLE CYTOCHROME P450 137 CYP137 |
| M. ulcerans Agy99 | MUL_0473 | cyp51B1 | 9e-30 | 26.01% (373) | cytochrome P450 51B1 Cyp51B1 |
| M. vanbaalenii PYR-1 | Mvan_0245 | - | 3e-37 | 29.94% (354) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0056|M.gilvum_PYR-GCK -----------------------------------------MVAGTEPG-
Mvan_0245|M.vanbaalenii_PYR-1 -----------------------------------------MVGTVERED
MSMEG_0822|M.smegmatis_MC2_155 -----------------------------------------MVETASPP-
Mb1694c|M.bovis_AF2122/97 --------------------------------------------------
Rv1666c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2475|M.marinum_M --------------------------------------------------
MAV_3106|M.avium_104 --------------------------------------------------
TH_0136|M.thermoresistible__bu ---------------------------------------VRPPSLPAPAP
MUL_0473|M.ulcerans_Agy99 -----------------------------------------MTTAIVPRV
MAB_2078|M.abscessus_ATCC_1997 MTNHLLAPAHHVKERLSSVIMVPAPHAVDDRWRRWSRDWPVRELAPAPAG
MLBr_02088|M.leprae_Br4923 ---------------------------------MRTCVPTRTCVYAFIEY
Mflv_0056|M.gilvum_PYR-GCK VGHLPLAPKNPLPYR-RLLTLVRALDTGQ----LQVRAAGGPITRVQVAP
Mvan_0245|M.vanbaalenii_PYR-1 LGALPLAPRNPLPYR-QQVRAIRTFHTGL----ETLRDAGGPVTRLKLAP
MSMEG_0822|M.smegmatis_MC2_155 LTELPLAPRNTLPCR-EQIRCLRSFIDGM----QRLRDVGGPVTRIVLGP
Mb1694c|M.bovis_AF2122/97 -----------MRYP-LGEALLALYRW------------RGPLINAGVGG
Rv1666c|M.tuberculosis_H37Rv -----------MRYP-LGEALLALYRW------------RGPLINAGVGG
MMAR_2475|M.marinum_M -----MSTYRTVPYR-PGEALLALYRR------------RGAFIDAGVGR
MAV_3106|M.avium_104 -----------MRYR-PGEALLALYRR------------RGPVIDAGAGR
TH_0136|M.thermoresistible__bu LSAVFGAGYAAAYAV-GGNRMVARMLKR-----------YGPVVALPVLG
MUL_0473|M.ulcerans_Agy99 SGGEEEHGHLEEFRT-DPIGLMQRVRD-----------ECGDVGWFQLAN
MAB_2078|M.abscessus_ATCC_1997 SGLKAVRGDAGLPFVGHTLDYIRFGSDFS----RERYDRLGSVSWMGAFG
MLBr_02088|M.leprae_Br4923 LSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADPFPVYRALIDYGPMQLPG
:
Mflv_0056|M.gilvum_PYR-GCK RWLFPPFVAVFSPRGVRDVLGRNDAFSER--CIVHEEVRD--MAGDSLFV
Mvan_0245|M.vanbaalenii_PYR-1 KWLMPPMVVATSPQGARDILARGGGHIDK--TRVHHEMRR--LLGANLFD
MSMEG_0822|M.smegmatis_MC2_155 RWLVPPALLVTSPQGAHDVLSLPDAVADRGGSRNMRQLQR--LMGGNLLD
Mb1694c|M.bovis_AF2122/97 ----HGYTYLLGAEANRFVFANADAFSWS---QTFESLVP--VDGPTALI
Rv1666c|M.tuberculosis_H37Rv ----HGYTYLLGAEANRFVFANADAFSWS---QTFESLVP--VDGPTALI
MMAR_2475|M.marinum_M ----HGFVYLLGPEANRFVFANADAFSWR---ETFESLVP--VDGPTALI
MAV_3106|M.avium_104 ----RGYTLLLGAEANKFVFANADAFSWR---ATFENLAL--VDGPTALI
TH_0136|M.thermoresistible__bu ---YGTVVAVADPALARQVFAEKPDVLLG--GDGVGPAAA--IYGPRSMF
MUL_0473|M.ulcerans_Agy99 ----KHVVLLSGAKANEFFFRSSDEELDQ--AEAYPFMTP--IFGKG--V
MAB_2078|M.abscessus_ATCC_1997 ----TKMVVIAGPDATREAFTSEAKAFSQ---DGWSFLID--AFFHRGLM
MLBr_02088|M.leprae_Br4923 MPLTVFSSFSDCDEALRHPLSASDRLKATLAQQAIAAGAEPRPFYASSFM
. :
Mflv_0056|M.gilvum_PYR-GCK LPN-EPWRPRKRALQPVFTPQNVRRFGGHMSRAAEVFVDAWRDGGDVDLD
Mvan_0245|M.vanbaalenii_PYR-1 LTH-EPWLPRRRALQPIFTKQHVREFAGHMATAAQTVADSWADGTELDLD
MSMEG_0822|M.smegmatis_MC2_155 LPH-DRWLPRRRTLQPLFTKKHVPRFAGHMAAAAQSVAVSWADGATVDLD
Mb1694c|M.bovis_AF2122/97 VSDGADHRRRRSVVAPGLRHHHVQRYVATMVSNIDTVIDGWQPGQRLDIY
Rv1666c|M.tuberculosis_H37Rv VSDGADHRRRRSVVAPGLRHHHVQRYVATMVSNIDTVIDGWQPGQRLDIY
MMAR_2475|M.marinum_M VSDGEDHRRRRSIVAPGLRHRSVQDYVATMVSTIDNVIDSWRPGQPLDIY
MAV_3106|M.avium_104 VSDGDDHRRRRSVVAPGLRHRQIQDYVTTMVSCIDRVIDGWRPGQRLDVY
TH_0136|M.thermoresistible__bu VQEEPEHLRRRRLLIPPLHGAALAGHVPVIEAATRSAMASWPVGRPMRML
MUL_0473|M.ulcerans_Agy99 VFDASPERRKEMLHNSALRGEHMKGHATTIEREVHRMIENWGQEGEIDLL
MAB_2078|M.abscessus_ATCC_1997 LMSFDEHLMHRRIMQEAFTRPRLTGYVEQVTPCVRSAVPAWPVGPSVRIY
MLBr_02088|M.leprae_Br4923 FLDPPDHTRLRKLVSKAFAPKVVQALEGDIAALVDSLLDKGAAAGQFDVI
. . : : : . :
Mflv_0056|M.gilvum_PYR-GCK LECRRITMQSLGRSVLGVDLNESADVIAEHMHVASSYTADRALRPVRAPR
Mvan_0245|M.vanbaalenii_PYR-1 TECRKLTLRALGRSVLGLDLDEHSDAIAEPLRTALEYIADRALQPISAPR
MSMEG_0822|M.smegmatis_MC2_155 RACRALTLRALGRSVFGVDLDQRAEDVGPALRTSLSWVADRASRPVNLPQ
Mb1694c|M.bovis_AF2122/97 QELRSAVRRSTAESLFGQRLAVHSDFLGEQLQPLLDLTR-RPPQVMRLQQ
Rv1666c|M.tuberculosis_H37Rv QELRSAVRRSTAESLFGQRLAVHSDFLGEQLQPLLDLTR-RPPQVMRLQQ
MMAR_2475|M.marinum_M QEFRCAVRRSTTESLFGPRLASHSDYLGRQLQPLIDLTH-RLPQVMQLQQ
MAV_3106|M.avium_104 QHCRAAVRRSTAESLFGRRLAVHSDALGEYLQPLLDLTH-QPPQLVGLQR
TH_0136|M.thermoresistible__bu DAARDLTLDVIIRVIFGVHDPAEVARLAAPFETLLALAVSVQTPVRYALR
MUL_0473|M.ulcerans_Agy99 EFFAELTSYTSTSCLIGTKFRNQLDSRFAHFCHELERGT---DPLCYVDP
MAB_2078|M.abscessus_ATCC_1997 PLLKELTLDIATDVFMGGRGKDESDAVNKAFVATVRAAS------SLVRA
MLBr_02088|M.leprae_Br4923 ADLAFPLAVAVICRLLGVPYEDAPEFGRVSALLVQSVDP-------FITI
.:*
Mflv_0056|M.gilvum_PYR-GCK WLPTP-ARRRAAHAVAEMRQVAADMLQVCRD---DPDRDAPLVRALMDAR
Mvan_0245|M.vanbaalenii_PYR-1 WLPTP-ARRRARAASSTLHKLADKILQACRT---DPTRDAPLVQALIAAS
MSMEG_0822|M.smegmatis_MC2_155 WVPTR-GQRKARAGNATLHRLAAEILADVRA---DPDRDAPLVRALLEAR
Mb1694c|M.bovis_AF2122/97 RVNSP-GWRRAMAARKRIDDLIDAQIADART---APRPDDHMLTTLISGC
Rv1666c|M.tuberculosis_H37Rv RVNSP-GWRRAMAARKRIDDLIDAQIADART---APRPDDHMLTTLISGC
MMAR_2475|M.marinum_M RLNSP-GWRRAMAARTRIDELIDAEIANARA---EPSPDDRMLTALINGR
MAV_3106|M.avium_104 RINAP-AWRRAMAARQRINNLVDTLIAEARA---APNPDDHMLTMLIDGR
TH_0136|M.thermoresistible__bu RAGALRFWHAYRDANRRIDELVRPLIAARRVP--DAGPRDDILSMLVAAR
MUL_0473|M.ulcerans_Agy99 YLPIE-SFRRRDEARKGLVALVQDIMHQRVANPPTDKRDRDMLDVLVSIT
MAB_2078|M.abscessus_ATCC_1997 PLPGT-RFRAGVQGRRVLEDYFFRHLPAARAG-----ETEDLFAALCQAT
MLBr_02088|M.leprae_Br4923 TGEPPEATEERLRAGVWLRDYLEQLVKCRRG-----TPGEDLISRLIELD
. . : : :. *
Mflv_0056|M.gilvum_PYR-GCK DPETGMALSDDDICNDLLIFMLAGHDTTATALTYALWVLGHHPDVQDRVA
Mvan_0245|M.vanbaalenii_PYR-1 DPATGRPLSDDEIRDELIVFMLAGHDTTATTLTYAMWALGHHHDVQDRVR
MSMEG_0822|M.smegmatis_MC2_155 DPETGRGLTDDQICDELVLFMLAGHDTTSTTLCYSLWALGHHPDIQERVY
Mb1694c|M.bovis_AF2122/97 S-EEGTTLSDNEIRDSIVSLITAGYETTSGALAWAIYALLTVPGTWESAA
Rv1666c|M.tuberculosis_H37Rv S-EEGTTLSDNEIRDSIVSLITAGYETTSGALAWAIYALLTVPGTWESAA
MMAR_2475|M.marinum_M S-EEGCALSDNEIRDSIVSLIAAGYETTSGALAWATYSLLTLPGAWETAA
MAV_3106|M.avium_104 G-DEGYALNDNEIRDAIVSLVTAGYETTSGALAWAVYLLLSQPGAWATAA
TH_0136|M.thermoresistible__bu T-EDGDRLTDDEIRDDLITLVLAGHETTATTLAWLIDYLVHHPAALDRVR
MUL_0473|M.ulcerans_Agy99 DEQGNPRFCTDEVTGMFISLMFAGHHTSSGTSAWTLIELLRHPDAYAAVI
MAB_2078|M.abscessus_ATCC_1997 T-EDGERFSDEDVVNHMIFLMMAAHDTSTITTTAVTYFLAKYPQWQEAAA
MLBr_02088|M.leprae_Br4923 E--SGDQLTEEEIIATCGLLLVAGHETTVNLIANAVLAMLRNPSQWKALS
. : ::: :: *.:.*: :
Mflv_0056|M.gilvum_PYR-GCK AEAA-ALGR-RELEPGDVPHLKYTTQVLLEALRLCPPAAGVGRMAVRDID
Mvan_0245|M.vanbaalenii_PYR-1 AEVV-GIGD-RELTPEDVPALGYTIQVLHEALRLCPPAAATARMAMRDVE
MSMEG_0822|M.smegmatis_MC2_155 AEVA-ALGD-RELTTDDVPQLTYTMRVLHEALRLCPPGSGTMRMLNEEMT
Mb1694c|M.bovis_AF2122/97 SEVARVLGG-RVPAADDLSALTYLNGVVHETLRLYSPGVISARRVLRDLW
Rv1666c|M.tuberculosis_H37Rv SEVARVLGG-RVPAADDLSALTYLNGVVHETLRLYSPGVISARRVLRDLW
MMAR_2475|M.marinum_M REVARVLGG-TAPSAETLGALTYLNGVVHETLRLYSPGVVSARRLIRDLW
MAV_3106|M.avium_104 GEVRRVLAG-RLPAAADLSGLTYLNGVVHETLRLYPPGVISARRVMRDLR
TH_0136|M.thermoresistible__bu AEAAPGGAQ-RGAGP-------YTEAVINETLRLRPPGPVTGRTTAGHYR
MUL_0473|M.ulcerans_Agy99 DELDELYADGQLVSFHALRQIPRLENVLKETLRLHPPLIILMRVAKGEFQ
MAB_2078|M.abscessus_ATCC_1997 AEAAAIGDG--LPDIEALEKMTVIDRVIKEALRLLAPVPLVMRKTVRDVA
MLBr_02088|M.leprae_Br4923 SNPQ------------------RAPLVVEETLRYDPAIHLIGRVAAKDMT
: *: *:** .. * .
Mflv_0056|M.gilvum_PYR-GCK VDGHRVQAGTLVAVGIYALHRDPEIWPDPDRFDPDRFSPEQTAQRD--RW
Mvan_0245|M.vanbaalenii_PYR-1 VDGYRIEAGSMMAVGIYALHRDPALWERPLVFDPDRFSAQNSGGRD--RW
MSMEG_0822|M.smegmatis_MC2_155 VDGYRVEAGTVAIVNFYAMHRSPTLWDAPERFDPDRFSPERSAGRN--RW
Mb1694c|M.bovis_AF2122/97 FDGHRIRAGRLLIFSAYVTHRLPEIWPEPTEFRPLRWDPNAADYRKPAPH
Rv1666c|M.tuberculosis_H37Rv FDGHRIRAGRLLIFSAYVTHRLPEIWPEPTEFRPLRWDPNAADYRKPAPH
MMAR_2475|M.marinum_M FDGHRINSGRLLIFSAYVTHRIPEVWPNPTQFLPQRWDPAAPDYRKPAPH
MAV_3106|M.avium_104 FEGRRIRSGRLLIFSPYVTHRLPEIWPEPMRFAPERWNPDAPGYRRPAPH
TH_0136|M.thermoresistible__bu LGDYTLAPRTRIVLLLGVINRDPNSYPDPHDFRPDRFLHTRP-----DPY
MUL_0473|M.ulcerans_Agy99 VEGYPIHEGELVAASPAISNRIAEDFPDPDEFVPERYQEPRQEDLIN-RW
MAB_2078|M.abscessus_ATCC_1997 IDGYHIPSNTLCAITPAVNHFDRTIWNDPERFDPSRFDEPRREDQHH-RF
MLBr_02088|M.leprae_Br4923 IGQTTLTEGDTMVLLLAAANRDPAVYSRPDEFDPDRPS-----------S
. : : : * * * *
Mflv_0056|M.gilvum_PYR-GCK HFLPFAGGARSCIGEHFARLETTLALATIVRSMRVTSSDNDFPVDVPFTT
Mvan_0245|M.vanbaalenii_PYR-1 QYLPFGAGPRSCIGDHFAMLEATLALATIIRSAEIRSSDPHFPMIVPFTT
MSMEG_0822|M.smegmatis_MC2_155 QYLPFGGGPRSCIGDHFAMLEATLALATVIRAVSVESQNTDLPVETPFTV
Mb1694c|M.bovis_AF2122/97 EFIPFSGGLHRCIGAVMATTEMTVILARLVARAMLQLPAQRTHRIRAANF
Rv1666c|M.tuberculosis_H37Rv EFIPFSGGLHRCIGAVMATTEMTVILARLVARAMLQLPAQRTHRIRAANF
MMAR_2475|M.marinum_M EFIPFSGGLHRCIGAVMATTELVVLLARLVARTRLRLPAQR---IRAANF
MAV_3106|M.avium_104 EFIPFSAGLHRCVGAAMATTEMTVMLARLLARTRLRLPAQR---LRAANV
TH_0136|M.thermoresistible__bu AWVPFGGGVKRCLGAAFAMRELTTILRILLTEADLRPVNARPESAAGRAA
MUL_0473|M.ulcerans_Agy99 TWIPFGAGRHRCVGAAFATMQIKAIFSVLLREYEFEMAQPADSYRNDHSK
MAB_2078|M.abscessus_ATCC_1997 AWVPFGGGAHKCIGMQFGTLEVKAILHRMLRSFTWKVPENY--HVRWDNT
MLBr_02088|M.leprae_Br4923 RHLAFAVGSHFCLGAALARLEATVTLSAISARFPQVQLAGELVYKPNVAM
:.*. * : *:* :. : : :
Mflv_0056|M.gilvum_PYR-GCK VAHGPIPAHLTPR------------------
Mvan_0245|M.vanbaalenii_PYR-1 VAAEPIRARVKSVNRIPAADSGGR-------
MSMEG_0822|M.smegmatis_MC2_155 IAAAPVPARVTRR------------------
Mb1694c|M.bovis_AF2122/97 AALRPWPGLTVEIRKSAPAQ-----------
Rv1666c|M.tuberculosis_H37Rv AALRPWPGLTVEIRKSAPAQ-----------
MMAR_2475|M.marinum_M AALAPKPGLRVEFVDSVPAQ-----------
MAV_3106|M.avium_104 AALRPTPGLTVEVIDSVPAQ-----------
TH_0136|M.thermoresistible__bu AVVVPRHGTPVYFRPTAPAASPRCAGRTSTV
MUL_0473|M.ulcerans_Agy99 MVVQLARPARVRYRRRKLSDNRGH-------
MAB_2078|M.abscessus_ATCC_1997 SLPIPVDGLPLEMKRR---------------
MLBr_02088|M.leprae_Br4923 RGMSALPVQV---------------------