For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
TTAIVPRVSGGEEEHGHLEEFRTDPIGLMQRVRDECGDVGWFQLANKHVVLLSGAKANEFFFRSSDEELD QAEAYPFMTPIFGKGVVFDASPERRKEMLHNSALRGEHMKGHATTIEREVHRMIENWGQEGEIDLLEFFA ELTSYTSTSCLIGTKFRNQLDSRFAHFCHELERGTDPLCYVDPYLPIESFRRRDEARKGLVALVQDIMHQ RVANPPTDKRDRDMLDVLVSITDEQGNPRFCTDEVTGMFISLMFAGHHTSSGTSAWTLIELLRHPDAYAA VIDELDELYADGQLVSFHALRQIPRLENVLKETLRLHPPLIILMRVAKGEFQVEGYPIHEGELVAASPAI SNRIAEDFPDPDEFVPERYQEPRQEDLINRWTWIPFGAGRHRCVGAAFATMQIKAIFSVLLREYEFEMAQ PADSYRNDHSKMVVQLARPARVRYRRRKLSDNRGH*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_0473 | cyp51B1 | - | 100% (456) | cytochrome P450 51B1 Cyp51B1 |
| M. ulcerans Agy99 | MUL_3402 | cyp136A2 | 9e-31 | 37.19% (199) | cytochrome P450 136A2 Cyp136A2 |
| M. ulcerans Agy99 | MUL_0604 | cyp185A4 | 4e-14 | 24.68% (235) | cytochrome P450 185A4 Cyp185A4 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0787c | cyp51 | 0.0 | 81.92% (448) | cytochrome P450 sterol 14-alpha demethylase |
| M. gilvum PYR-GCK | Mflv_1596 | - | 0.0 | 82.41% (449) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv0764c | cyp51 | 0.0 | 81.92% (448) | cytochrome P450 sterol 14-alpha demethylase |
| M. leprae Br4923 | MLBr_02088 | - | 7e-11 | 22.12% (339) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_1214c | - | 0.0 | 80.04% (451) | cytochrome P450 |
| M. marinum M | MMAR_4932 | cyp51B1 | 0.0 | 98.68% (456) | cytochrome P450 51B1 Cyp51B1 |
| M. avium 104 | MAV_0708 | - | 0.0 | 84.12% (447) | cytochrome P450 51 |
| M. smegmatis MC2 155 | MSMEG_5863 | - | 0.0 | 82.39% (443) | cytochrome P450 51 |
| M. thermoresistible (build 8) | TH_4391 | - | 0.0 | 82.17% (443) | PUTATIVE cytochrome P450 |
| M. vanbaalenii PYR-1 | Mvan_5161 | - | 0.0 | 84.20% (443) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0787c|M.bovis_AF2122/97 ------MSAV---ALPRVSGGHD---EHGHLEEFRTDPIGLMQR------
Rv0764c|M.tuberculosis_H37Rv ------MSAV---ALPRVSGGHD---EHGHLEEFRTDPIGLMQR------
MAB_1214c|M.abscessus_ATCC_199 ------MTTP---TVPRVSGGED---QYGHLEEFRTDPIALMKR------
MUL_0473|M.ulcerans_Agy99 ------MTTA---IVPRVSGGEE---EHGHLEEFRTDPIGLMQR------
MMAR_4932|M.marinum_M ------MTTA---IVPRVSGGEE---EHGHLEEFRTDPIGLMQR------
MAV_0708|M.avium_104 ------MTTS--TVVPRVSGGEE---EHGHLEEFRTDPIGLMQR------
TH_4391|M.thermoresistible__bu ------MTSQQLKEVPRVSGGEE---EHGHLEEFRTDPIGLMQR------
MSMEG_5863|M.smegmatis_MC2_155 ------MTTL--HDVPRVSGGEE---EHGHLEEFRTDPIGLMKR------
Mvan_5161|M.vanbaalenii_PYR-1 ------MTAV--KEVPRVSGGEE---EHGHLEEFRTDPIGLMKR------
Mflv_1596|M.gilvum_PYR-GCK -------MTT--AIVPRVSGGEDD--EHGHLEEFRTDPIGLMKR------
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
: : :* .. : * * : : *:.
Mb0787c|M.bovis_AF2122/97 --VRDECGDVGTFQLAGKQVVLLSGSHANEFFFRAGDDDLDQAKAYPFMT
Rv0764c|M.tuberculosis_H37Rv --VRDECGDVGTFQLAGKQVVLLSGSHANEFFFRAGDDDLDQAKAYPFMT
MAB_1214c|M.abscessus_ATCC_199 --IRAECGNVGTFQLADKQVVFLSGAEANEFFFRSSDEDLDQAEAYPFMT
MUL_0473|M.ulcerans_Agy99 --VRDECGDVGWFQLANKHVVLLSGAKANEFFFRSSDEELDQAEAYPFMT
MMAR_4932|M.marinum_M --VRDECGDVGWFQLANKHVVLLSGAKANEFFFRSSDEELDQAEAYPFMT
MAV_0708|M.avium_104 --VRDECGDVGWFQLVDKHVILLSGAQANEFFFRSADEDLDQAEAYPFMT
TH_4391|M.thermoresistible__bu --VRDECGDVGYFQLVDKPVILLTGAEANEFFFRAADEDLDQAAAYPFMT
MSMEG_5863|M.smegmatis_MC2_155 --VRSECGDVGWFQLADKQVVLLSGAEANEFFFRSSDSELNQAEAYPFMT
Mvan_5161|M.vanbaalenii_PYR-1 --VREECGDVGWFQLADKQVILLSGAEANEFFFRSSDSELNQAEAYPFMT
Mflv_1596|M.gilvum_PYR-GCK --IREECGDVGWFQLADKQVVMLSGAEANEFFFRSTDSELNQAEAYPFMT
MLBr_02088|M.leprae_Br4923 FPVYRALIDYGPMQLPGMPLTVFSSFSDCDEALRHPLSASDRLKATLAQQ
: : * :** . : .::. : :* . :: *
Mb0787c|M.bovis_AF2122/97 PIFGEG----------VVFDASPERRKEMLHNAALRGEQMKGHAATIEDQ
Rv0764c|M.tuberculosis_H37Rv PIFGEG----------VVFDASPERRKEMLHNAALRGEQMKGHAATIEDQ
MAB_1214c|M.abscessus_ATCC_199 PIFGKG----------VVFDADPERRKEMLHNAALRGEQMKGHAATIENE
MUL_0473|M.ulcerans_Agy99 PIFGKG----------VVFDASPERRKEMLHNSALRGEHMKGHATTIERE
MMAR_4932|M.marinum_M PIFGKG----------VVFDASPERRKEMLHNSALRGEHMKGHATTIERE
MAV_0708|M.avium_104 PIFGKG----------VVFDASPERRKEMLHNSALRGEQMKGHASTIEGE
TH_4391|M.thermoresistible__bu PIFGKG----------VVFDASPERRKEMLHNSALRGEHMKSHATTIEGE
MSMEG_5863|M.smegmatis_MC2_155 PIFGEG----------VVFDADPERRAEMLHNTALRGEQMKGHAATIENE
Mvan_5161|M.vanbaalenii_PYR-1 PIFGEG----------VVFDADPERRAEMLHNTALRGEHMKGHATTIEAE
Mflv_1596|M.gilvum_PYR-GCK PIFGEG----------VVFDADPERRAEMLHNTALRGEQMKGHAATIENE
MLBr_02088|M.leprae_Br4923 AIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKVVQALEGDIAAL
.* . . :.:*. . * . * . *: : ::. *
Mb0787c|M.bovis_AF2122/97 VRRMIADWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYH
Rv0764c|M.tuberculosis_H37Rv VRRMIADWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYH
MAB_1214c|M.abscessus_ATCC_199 VRQMISRWGESGEVDLLDFFAELTIYTSSACLIGKKFRDELDGRFAHLYH
MUL_0473|M.ulcerans_Agy99 VHRMIENWGQEGEIDLLEFFAELTSYTSTSCLIGTKFRNQLDSRFAHFCH
MMAR_4932|M.marinum_M VHRMIENWGQEGEIDLLEFFAELTIYTSTSCLIGTKFRNQLDSRFAHFYH
MAV_0708|M.avium_104 VKKMIADWGDEGEIELLDFFAELTIYTSTACLIGLKFREQLDHRFAEYYH
TH_4391|M.thermoresistible__bu VRKMIADWGDEGEIDLLDFFAELTIYTSTACLIGLKFRNQLDKRFAEYYH
MSMEG_5863|M.smegmatis_MC2_155 VRRMVESWGDEGEIDLLEFFAELTIYTSTACLIGVKFRNQLDKRFADYYH
Mvan_5161|M.vanbaalenii_PYR-1 VRKMIEGWGESGEIDLLEFFAELTIYTSTACLIGLKFRNQLDSRFANYYH
Mflv_1596|M.gilvum_PYR-GCK VRRMIENWGEQGEIELLDFFSELTIYTSTACLIGLKFRNQLDSRFAEYYH
MLBr_02088|M.leprae_Br4923 VDSLLDKGAAAGQFDVIADLAFPLAVAVICRLLGVPYEDAP--EFGRVSA
* :: . *:.::: :: : . *:* :.: .*.
Mb0787c|M.bovis_AF2122/97 ELERGTDPLAYVDPYLPIESFRRRDEARNGLVALVADIMNG---RIANPP
Rv0764c|M.tuberculosis_H37Rv ELERGTDPLAYVDPYLPIESFRRRDEARNGLVALVADIMNG---RIANPP
MAB_1214c|M.abscessus_ATCC_199 QLEQGTDPLCYVDPYLEIESFRQRDEARTGLVALVQEIINGRVQRSADSP
MUL_0473|M.ulcerans_Agy99 ELERGTDPLCYVDPYLPIESFRRRDEARKGLVALVQDIMHQ---RVANPP
MMAR_4932|M.marinum_M ELERGTDPLCYVDPYLPIESFRRRDEARKGLVALVQDIMHQ---RVANPP
MAV_0708|M.avium_104 DLERGTDPLCYVDPYLPIESFKRRDEARVKLVALVQEIMDQ---RLANPP
TH_4391|M.thermoresistible__bu LLERGTDPLCYVDPYLPIESFRLRDEARAKLVELVQEIIDQ---RLANPP
MSMEG_5863|M.smegmatis_MC2_155 LLERGTDPLCYVDPYLPIESFRIRDEARANLVELVQEVMNG---RIANPP
Mvan_5161|M.vanbaalenii_PYR-1 LLERGTDPLCYVDPYLPIESFRIRDEARAGLVELVQDVMHG---RIANPP
Mflv_1596|M.gilvum_PYR-GCK LLERGTDPLCYVDPYLPIESFRIRDEARASLVELVQEVMNG---RIANPP
MLBr_02088|M.leprae_Br4923 LLVQSVDPFITITG-EPPEATEERLRAGVWLRDYLEQLVKCR--------
* :..**: : *: . * .* * : :::.
Mb0787c|M.bovis_AF2122/97 TDKSDRDMLDVLIAVKAETGTPRFSADEITGMFISMMFAGHHTSSGTASW
Rv0764c|M.tuberculosis_H37Rv TDKSDRDMLDVLIAVKAETGTPRFSADEITGMFISMMFAGHHTSSGTASW
MAB_1214c|M.abscessus_ATCC_199 TDKSQRDMLDVLIMIKDEHGNPRFTADEITGMFISMMFAGHHTSSGTASW
MUL_0473|M.ulcerans_Agy99 TDKRDRDMLDVLVSITDEQGNPRFCTDEVTGMFISLMFAGHHTSSGTSAW
MMAR_4932|M.marinum_M TDKRDRDMLDVLVSITDEQGNPRFCADEVTGMFISLMFAGHHTSSGTSAW
MAV_0708|M.avium_104 KDKADRDMLDVLVSIKDEDGKPRFSADEITGMFISLMFAGHHTSSGTSAW
TH_4391|M.thermoresistible__bu RSKADRDMLDVLVSIKDENGDPRFSADEITGMFISLMFAGHHTSSGTSAW
MSMEG_5863|M.smegmatis_MC2_155 KDKSDRDLLDVLVSIKDEDGTPRFSANEVTGMFISLMFAGHHTSSGTASW
Mvan_5161|M.vanbaalenii_PYR-1 KDKSDRDMLDVLVSIKDEDGNPRFTANEITGMFISLMFAGHHTSSGTSSW
Mflv_1596|M.gilvum_PYR-GCK TDKSDRDLLDVLVSIKDEDGNPRFSANEVTGMFISLMFAGHHTSSGTSSW
MLBr_02088|M.leprae_Br4923 RGTPGEDLISRLIELDESGD--QLTEEEIIATCGLLLVAGHETTVNLIAN
.. .*::. *: : . . :: :*: . ::.***.*: . :
Mb0787c|M.bovis_AF2122/97 TLIELMRHRDAYAAVIDELDELYGDGRSVSFHALRQIPQLENVLKETLRL
Rv0764c|M.tuberculosis_H37Rv TLIELMRHRDAYAAVIDELDELYGDGRSVSFHALRQIPQLENVLKETLRL
MAB_1214c|M.abscessus_ATCC_199 VLIELLRHPDIQSQVIDELDELYADGSEVSFHALRQIPKLENVLKETLRL
MUL_0473|M.ulcerans_Agy99 TLIELLRHPDAYAAVIDELDELYADGQLVSFHALRQIPRLENVLKETLRL
MMAR_4932|M.marinum_M TLIELLRHPDAYAAVIDELDELYADGQPVSFHALRQIPRLENVLKETLRL
MAV_0708|M.avium_104 TLIELIRHPDVYAEVLAELEELYADGQEVSFHALRSIPKLDNVVKETLRL
TH_4391|M.thermoresistible__bu TLIELIRHPEIYAEVQAELDELYSDGQAVNFHALRQIPKLDNVVKETLRL
MSMEG_5863|M.smegmatis_MC2_155 TLIELLRHPEFYAKVQAELDDLYADGQEISFHALRQIPNLDNALKETLRL
Mvan_5161|M.vanbaalenii_PYR-1 TLIELLRHPEFYAKVQQELDDLYADGQEVSFHALRQIPSLDNALKETLRL
Mflv_1596|M.gilvum_PYR-GCK TLIELLRHPEYYAQVQQELDDLYADGQEVSFHALRQIPKIDNALKETLRL
MLBr_02088|M.leprae_Br4923 AVLAMLRNPSQWKALSSNP------------------QRAPLVVEETLRY
.:: ::*: . : : .::****
Mb0787c|M.bovis_AF2122/97 HPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPEDFPDPHDFVP
Rv0764c|M.tuberculosis_H37Rv HPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPEDFPDPHDFVP
MAB_1214c|M.abscessus_ATCC_199 HPPLIILMRVAKGEFEVGGFPIHDGDMVAASPAVSNRIAEDFPNPDGFVP
MUL_0473|M.ulcerans_Agy99 HPPLIILMRVAKGEFQVEGYPIHEGELVAASPAISNRIAEDFPDPDEFVP
MMAR_4932|M.marinum_M HPPLIILMRVAKGEFQVEGYPIHEGELVAASPAISNRIAEDFPDPDEFVP
MAV_0708|M.avium_104 HPPLIILMRVAKGEFEVEGFPIHEGDYVAASPAISNRIPEDFPDPDAFKP
TH_4391|M.thermoresistible__bu HPPLIILMRVAQGEFEVCGFPIHKGDYVAASPAISNRIPEDFPDPDAFRP
MSMEG_5863|M.smegmatis_MC2_155 HPPLIILMRVAQDEFEVAGRPIHKGQMVAASPAISNRIPEDFPDPDTFDP
Mvan_5161|M.vanbaalenii_PYR-1 HPPLIILMRVAQDEFEVAGYPIHKGQMVAASPAISNRIPEDFPNPDDFDP
Mflv_1596|M.gilvum_PYR-GCK HPPLIILMRVAQDEFEVAGYPIHKGQMVAASPAISNRIPEDFPYPDAFDP
MLBr_02088|M.leprae_Br4923 DPAIHLIGRVAAKDMTIGQTTLTEGDTMVLLLAAANRDPAVYSRPDEFDP
.*.: :: *** :: : : .*: :. * :** . :. *. * *
Mb0787c|M.bovis_AF2122/97 ARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEF
Rv0764c|M.tuberculosis_H37Rv ARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEF
MAB_1214c|M.abscessus_ATCC_199 DRYEKPRQEDIVNRWTWIPFGAGRHRCVGAAFATMQIKAIFSVLLREYEF
MUL_0473|M.ulcerans_Agy99 ERYQEPRQEDLINRWTWIPFGAGRHRCVGAAFATMQIKAIFSVLLREYEF
MMAR_4932|M.marinum_M ERYQEPRQEDLINRWTWIPFGAGRHRCVGAAFATMQIKAIFSVLLREYEF
MAV_0708|M.avium_104 DRYNKPEQADIVNRWTWIPFGAGRHRCVGAAFAQMQIKAIFSVLLREYDF
TH_4391|M.thermoresistible__bu DRYDKPEQADIVNRWTWIPFGAGRHRCVGAAFAQMQIKAIFSVLLREYEF
MSMEG_5863|M.smegmatis_MC2_155 DRYDKPRQEDLINRWTWIPFGAGKHRCVGAAFAQMQIKAIFSVLLRDFEF
Mvan_5161|M.vanbaalenii_PYR-1 DRYEKPRQEDLINRWTWIPFGAGKHRCVGAAFAQMQIKAIFSVLLREYEF
Mflv_1596|M.gilvum_PYR-GCK DRYEKPRQEDLINRWTWIPFGAGKHRCVGAAFAQMQIKAIFSVLLREYEF
MLBr_02088|M.leprae_Br4923 DRPSS----------RHLAFAVGSHFCLGAALARLEATVTLSAISARFP-
* .. :.*..* * *:***:* :: .. :*.: :
Mb0787c|M.bovis_AF2122/97 EMAQPPESYRNDHSKMVVQLAQPACVRYRRRTGV------
Rv0764c|M.tuberculosis_H37Rv EMAQPPESYRNDHSKMVVQLAQPACVRYRRRTGV------
MAB_1214c|M.abscessus_ATCC_199 EMAQPADSYHNDHSKMVVQLAQPAKVRYRKRSA-------
MUL_0473|M.ulcerans_Agy99 EMAQPADSYRNDHSKMVVQLARPARVRYRRRKLSDNRGH-
MMAR_4932|M.marinum_M EMAQPADSYRNDHSKMVVQLARPARVRYRRRKMSDNRGH-
MAV_0708|M.avium_104 EMAQPADSYRNDHSKMVVQLARPAKVRYRKRNA-------
TH_4391|M.thermoresistible__bu EMAQPPESYRNDHSKMVVQLQQPARARYRRRAKAAKAAKE
MSMEG_5863|M.smegmatis_MC2_155 EMAQPSESYRNDHSKMVVQLARPAKVRYRRRVR-------
Mvan_5161|M.vanbaalenii_PYR-1 EMAQPPESYQNDHSKMVVQLARPAKVRYRRRVRD------
Mflv_1596|M.gilvum_PYR-GCK EMAQPAESYQNDHSKMVVQLARPAKVRYRRRVKD------
MLBr_02088|M.leprae_Br4923 QVQLAGELVYKPNVAMRGMSALPVQV--------------
:: . : : : * *. .