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MTVAGSPTLRTPPVAPGRLPGLGHLSALARDPLGYLARLRSVADVVTIYLGPRPSYLVTSHDLVRDMLVS QSECFTRGAVFERAGKALGQGLLVSDGEFHRCQRRLLQPAFHHRQTPRYAEVMADAAQTLSRAWRPGVPI EVTHEIHTMALAVVCRGLFHTDLGGSAVSRVERALTGINQGVIWQTLYPFDWLARLPIPVNRRFRSAITD VRDLVTQLISACRTTGEGREGVLAMLLQARDEETGRPMSDDQVRDEVLTLLLAATETSSTTLSWLFYELD RHPEIERGVARELDDKLANQSITHDNLRDLDLMKRVVDETLRLHTPNSILTRRAVREVQLGQFRIPAGAE VAFSPTAIHRDPTVYDDPLSFKPDRWLSENSAHVPRHMFIPFGMGKHKCIGDSFAITEMHVTAATVLRDW RLSLAPNAHVRERPWAIVQPHGLRMIPFPRR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_0283 | cyp274A1 | - | 100% (451) | cytochrome P450 274A1 Cyp274A1 |
| M. marinum M | MMAR_0281 | cyp183B1 | 7e-74 | 36.78% (435) | cytochrome P450 183B1 Cyp183B1 |
| M. marinum M | MMAR_0852 | cyp185A4 | 2e-50 | 29.74% (427) | cytochrome P450 185A4 Cyp185A4 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1694c | cyp139 | 7e-38 | 29.64% (388) | cytochrome P450 139 CYP139 |
| M. gilvum PYR-GCK | Mflv_0056 | - | 2e-47 | 29.53% (447) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv1666c | cyp139 | 7e-38 | 29.64% (388) | cytochrome P450 139 CYP139 |
| M. leprae Br4923 | MLBr_02088 | - | 1e-11 | 24.25% (268) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_1426 | - | 2e-44 | 29.35% (443) | putative cytochrome P450 |
| M. avium 104 | MAV_3106 | - | 1e-40 | 30.77% (377) | P450 heme-thiolate protein |
| M. smegmatis MC2 155 | MSMEG_0822 | - | 3e-49 | 32.17% (429) | cytochrome P450 |
| M. thermoresistible (build 8) | TH_3255 | - | 2e-45 | 28.18% (433) | PUTATIVE cytochrome P450 |
| M. ulcerans Agy99 | MUL_0604 | cyp185A4 | 5e-48 | 28.57% (427) | cytochrome P450 185A4 Cyp185A4 |
| M. vanbaalenii PYR-1 | Mvan_0245 | - | 1e-51 | 29.66% (445) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1694c|M.bovis_AF2122/97 -----------------------------------------------MRY
Rv1666c|M.tuberculosis_H37Rv -----------------------------------------------MRY
MAV_3106|M.avium_104 -----------------------------------------------MRY
Mflv_0056|M.gilvum_PYR-GCK --------------------------MVAGTEPG-VGHLPLAPKNPLPYR
TH_3255|M.thermoresistible__bu --------------------------MVVTTERADVATLPPAPRNPLPYW
Mvan_0245|M.vanbaalenii_PYR-1 --------------------------MVGTVEREDLGALPLAPRNPLPYR
MUL_0604|M.ulcerans_Agy99 -----------------------------MVDPPDIRSLPLAPRNPLPYW
MSMEG_0822|M.smegmatis_MC2_155 --------------------------MVETASPP-LTELPLAPRNTLPCR
MMAR_0283|M.marinum_M ---------------------------MTVAGSPTLRTPPVAPGRLPGLG
MAB_1426|M.abscessus_ATCC_1997 MSASALQPEPLSAPVEVAAGECPVNHDLYPGGPTFLRWHHTRVGYLKSWR
MLBr_02088|M.leprae_Br4923 -----------------MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVE
Mb1694c|M.bovis_AF2122/97 PLGEALLALYRWRGPLINAG-----------VGGHGYTYLLGAEANRFVF
Rv1666c|M.tuberculosis_H37Rv PLGEALLALYRWRGPLINAG-----------VGGHGYTYLLGAEANRFVF
MAV_3106|M.avium_104 RPGEALLALYRRRGPVIDAG-----------AGRRGYTLLLGAEANKFVF
Mflv_0056|M.gilvum_PYR-GCK RLLTLVRALDTGQLQVRAAGGPITRVQVAPRWLFPPFVAVFSPRGVRDVL
TH_3255|M.thermoresistible__bu RQVRAVRSFHTGQELLRDAGGPVK-------WAIPPIVLVTSPAGIRDVL
Mvan_0245|M.vanbaalenii_PYR-1 QQVRAIRTFHTGLETLRDAGGPVTRLKLAPKWLMPPMVVATSPQGARDIL
MUL_0604|M.ulcerans_Agy99 QQLKALKTLHVGSEALRDAGGSVTRIWLGPKRLVPPMVMVTSPQGARDVL
MSMEG_0822|M.smegmatis_MC2_155 EQIRCLRSFIDGMQRLRDVGGPVTRIVLGPRWLVPPALLVTSPQGAHDVL
MMAR_0283|M.marinum_M HLSALARDPLGYLARLRSVADVVT-----IYLGPRPSYLVTSHDLVRDML
MAB_1426|M.abscessus_ATCC_1997 LALGAVWSTYRHTISEYLADLPGQDDVIVARAPMRKAVIVRNPELARHVL
MLBr_02088|M.leprae_Br4923 AQMLLLRLIDPGTRADPFPVYRALIDYGPMQLPGMPLTVFSSFSDCDEAL
. :
Mb1694c|M.bovis_AF2122/97 ANADAFSWS---QTFESLVPVDGP------TALIVSDGADHRRRRSVVAP
Rv1666c|M.tuberculosis_H37Rv ANADAFSWS---QTFESLVPVDGP------TALIVSDGADHRRRRSVVAP
MAV_3106|M.avium_104 ANADAFSWR---ATFENLALVDGP------TALIVSDGDDHRRRRSVVAP
Mflv_0056|M.gilvum_PYR-GCK GRNDAFSER--CIVHEEVRDMAGD------SLFVLPN-EPWRPRKRALQP
TH_3255|M.thermoresistible__bu NRRDALSER--CQVHHEVRHLGGD------SLFVLPT-DPWRARRRALAP
Mvan_0245|M.vanbaalenii_PYR-1 ARGGGHIDK--TRVHHEMRRLLGA------NLFDLTH-EPWLPRRRALQP
MUL_0604|M.ulcerans_Agy99 GRSGALSDRGTLPLLKDLRRAIGE------SVLNLPH-DTWLPRRRTLQP
MSMEG_0822|M.smegmatis_MC2_155 SLPDAVADRGGSRNMRQLQRLMGG------NLLDLPH-DRWLPRRRTLQP
MMAR_0283|M.marinum_M VSQSECFTRG--AVFERAGKALGQ------GLLVSDG-EFHRCQRRLLQP
MAB_1426|M.abscessus_ATCC_1997 VANQDNYIKS--AEYDLLAVGFGR------GLVTDLNEGLWNRNRRLVQP
MLBr_02088|M.leprae_Br4923 RHPLSASDRLKATLAQQAIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSK
. . : :
Mb1694c|M.bovis_AF2122/97 GLRHHHVQRYVATMVSNIDTVIDGWQP----GQRLDIYQELRSAVRRSTA
Rv1666c|M.tuberculosis_H37Rv GLRHHHVQRYVATMVSNIDTVIDGWQP----GQRLDIYQELRSAVRRSTA
MAV_3106|M.avium_104 GLRHRQIQDYVTTMVSCIDRVIDGWRP----GQRLDVYQHCRAAVRRSTA
Mflv_0056|M.gilvum_PYR-GCK VFTPQNVRRFGGHMSRAAEVFVDAWRD----GGDVDLDLECRRITMQSLG
TH_3255|M.thermoresistible__bu VFTPTAVRSYGGYMSEAAQRVADGWQA----AREVDLDAECRRLTMRSLG
Mvan_0245|M.vanbaalenii_PYR-1 IFTKQHVREFAGHMATAAQTVADSWAD----GTELDLDTECRKLTLRALG
MUL_0604|M.ulcerans_Agy99 IFTKQRVAGFAGHMSEAANHILLGWPD----GAEVDLNAASHALVLRVVG
MSMEG_0822|M.smegmatis_MC2_155 LFTKKHVPRFAGHMAAAAQSVAVSWAD----GATVDLDRACRALTLRALG
MMAR_0283|M.marinum_M AFHHRQTPRYAEVMADAAQTLSRAWRP----GVPIEVTHEIHTMALAVVC
MAB_1426|M.abscessus_ATCC_1997 IFAKRQVDLFAPQMAEAAARTISRWDELYAEGKPVDITAEMNYLTMDIVA
MLBr_02088|M.leprae_Br4923 AFAPKVVQALEGDIAALVDSLLDKGAA----AGQFDVIADLAFPLAVAVI
: : . .::
Mb1694c|M.bovis_AF2122/97 ESLFGQRLA-VHSDFLGEQLQPLLDLTR----------------------
Rv1666c|M.tuberculosis_H37Rv ESLFGQRLA-VHSDFLGEQLQPLLDLTR----------------------
MAV_3106|M.avium_104 ESLFGRRLA-VHSDALGEYLQPLLDLTH----------------------
Mflv_0056|M.gilvum_PYR-GCK RSVLGVDLN-ESADVIAEHMHVASSYTAD---------------------
TH_3255|M.thermoresistible__bu RSVLGLDIN-ERADAISEPMHIASSYTAD---------------------
Mvan_0245|M.vanbaalenii_PYR-1 RSVLGLDLD-EHSDAIAEPLRTALEYIAD---------------------
MUL_0604|M.ulcerans_Agy99 HSVFGLDLQ-DKADVITTGVTLAAKWAAD---------------------
MSMEG_0822|M.smegmatis_MC2_155 RSVFGVDLD-QRAEDVGPALRTSLSWVAD---------------------
MMAR_0283|M.marinum_M RGLFHTDLGGSAVSRVERALTGINQGVIW---------------------
MAB_1426|M.abscessus_ATCC_1997 QTMFGIDLSGDMAERMRIYFARLLKLFGVGFIVGAAPPLRWVVDKLAAHG
MLBr_02088|M.leprae_Br4923 CRLLGVPYE--DAPEFGRVSALLVQSVDP---------------------
:: . .
Mb1694c|M.bovis_AF2122/97 -------RPPQVMRLQQRVNSPGWRRAMAARKRIDDLIDAQIADARTA-P
Rv1666c|M.tuberculosis_H37Rv -------RPPQVMRLQQRVNSPGWRRAMAARKRIDDLIDAQIADARTA-P
MAV_3106|M.avium_104 -------QPPQLVGLQRRINAPAWRRAMAARQRINNLVDTLIAEARAA-P
Mflv_0056|M.gilvum_PYR-GCK -------RALRPVRAPRWLPTPARRRAAHAVAEMRQVAADMLQVCRDD-P
TH_3255|M.thermoresistible__bu -------RALRPVRAPRWLPTPARRRARAAVATMRRITDEMLQACRAD-P
Mvan_0245|M.vanbaalenii_PYR-1 -------RALQPISAPRWLPTPARRRARAASSTLHKLADKILQACRTD-P
MUL_0604|M.ulcerans_Agy99 -------RSARPVRAPHWLPTPARPRARGAYDAMYKIAADMLAACRAD-P
MSMEG_0822|M.smegmatis_MC2_155 -------RASRPVNLPQWVPTRGQRKARAGNATLHRLAAEILADVRAD-P
MMAR_0283|M.marinum_M -------QTLYPFDWLARLPIPVNRRFRSAITDVRDLVTQLISACRTT-G
MAB_1426|M.abscessus_ATCC_1997 PDELSSHTPRLAIRALRIGASVAAPRTMKGLRWVERTIDQLIADHRSGRI
MLBr_02088|M.leprae_Br4923 ------------FITITGEPPEATEERLRAGVWLRDYLEQLVKCRRGT--
. . . : : *
Mb1694c|M.bovis_AF2122/97 RPDDHMLTTLISGCS-EEGTTLSDNEIRDSIVSLITAGYETTSGALAWAI
Rv1666c|M.tuberculosis_H37Rv RPDDHMLTTLISGCS-EEGTTLSDNEIRDSIVSLITAGYETTSGALAWAI
MAV_3106|M.avium_104 NPDDHMLTMLIDGRG-DEGYALNDNEIRDAIVSLVTAGYETTSGALAWAV
Mflv_0056|M.gilvum_PYR-GCK DRDAPLVRALMDARDPETGMALSDDDICNDLLIFMLAGHDTTATALTYAL
TH_3255|M.thermoresistible__bu DRDAPLVHALIRATDPETGRGLSDEDICNDLLIFMLAGHDTTATALTYAL
Mvan_0245|M.vanbaalenii_PYR-1 TRDAPLVQALIAASDPATGRPLSDDEIRDELIVFMLAGHDTTATTLTYAM
MUL_0604|M.ulcerans_Agy99 SREAPLITALIDATGPNTGESLSDQQICDEMVYFMILGEDTTSTVLTYAL
MSMEG_0822|M.smegmatis_MC2_155 DRDAPLVRALLEARDPETGRGLTDDQICDELVLFMLAGHDTTSTTLCYSL
MMAR_0283|M.marinum_M EGREGVLAMLLQARDEETGRPMSDDQVRDEVLTLLLAATETSSTTLSWLF
MAB_1426|M.abscessus_ATCC_1997 ARQDNLLALLMAAEDPETGAKYTDLEIRDELMTFLGAGFETTAAALAWTW
MLBr_02088|M.leprae_Br4923 -PGEDLISRLIELDE--SGDQLTEEEIIATCGLLLVAGHETTVNLIANAV
:: *: * .: :: :: . :*: :
Mb1694c|M.bovis_AF2122/97 YALLTVPGTWESAASEVARVLGGRVPAADDLSALTYLNGVVHETLRLYSP
Rv1666c|M.tuberculosis_H37Rv YALLTVPGTWESAASEVARVLGGRVPAADDLSALTYLNGVVHETLRLYSP
MAV_3106|M.avium_104 YLLLSQPGAWATAAGEVRRVLAGRLPAAADLSGLTYLNGVVHETLRLYPP
Mflv_0056|M.gilvum_PYR-GCK WVLGHHPDVQDRVAAEAA-ALGRRELEPGDVPHLKYTTQVLLEALRLCPP
TH_3255|M.thermoresistible__bu WALGHHPEIQDRVAAEVA-ELPDREITPHDVPRLGYTVQVLRESLRLCPP
Mvan_0245|M.vanbaalenii_PYR-1 WALGHHHDVQDRVRAEVV-GIGDRELTPEDVPALGYTIQVLHEALRLCPP
MUL_0604|M.ulcerans_Agy99 WALGQHCQLQDRLAAEAA-ELGDRPLTPADVPRLGYTIQVLQEAMRLRPP
MSMEG_0822|M.smegmatis_MC2_155 WALGHHPDIQERVYAEVA-ALGDRELTTDDVPQLTYTMRVLHEALRLCPP
MMAR_0283|M.marinum_M YELDRHPEIERGVARELDDKLANQSITHDNLRDLDLMKRVVDETLRLHTP
MAB_1426|M.abscessus_ATCC_1997 YLLSRNPDARAKLGQEVDRVLGGRQPTAADVDNLPWTAAVLNEAMRVYPP
MLBr_02088|M.leprae_Br4923 LAMLRNPSQWKALSSNPQ-----------------RAPLVVEETLRYDPA
: : *: *::* ..
Mb1694c|M.bovis_AF2122/97 GVISARRVLRDLWFDGHRIRAGRLLIFSAYVTHRLPEIWPEPTEFRPLRW
Rv1666c|M.tuberculosis_H37Rv GVISARRVLRDLWFDGHRIRAGRLLIFSAYVTHRLPEIWPEPTEFRPLRW
MAV_3106|M.avium_104 GVISARRVMRDLRFEGRRIRSGRLLIFSPYVTHRLPEIWPEPMRFAPERW
Mflv_0056|M.gilvum_PYR-GCK AAGVGRMAVRDIDVDGHRVQAGTLVAVGIYALHRDPEIWPDPDRFDPDRF
TH_3255|M.thermoresistible__bu AAGVGRLAMSDLAVDGYRVEAGTLLAVGIQAIHRDPSLWPDPMVFDPDRF
Mvan_0245|M.vanbaalenii_PYR-1 AAATARMAMRDVEVDGYRIEAGSMMAVGIYALHRDPALWERPLVFDPDRF
MUL_0604|M.ulcerans_Agy99 GPTVARRAMQDIEVDGYRVQAGTYCLVGVYAMHRDPALWDDPLAFDPDRF
MSMEG_0822|M.smegmatis_MC2_155 GSGTMRMLNEEMTVDGYRVEAGTVAIVNFYAMHRSPTLWDAPERFDPDRF
MMAR_0283|M.marinum_M NSILTRRAVREVQLGQFRIPAGAEVAFSPTAIHRDPTVYDDPLSFKPDRW
MAB_1426|M.abscessus_ATCC_1997 ILGLARTAKADDVLGDYPISAGTTVMVLIDSIHHNERVWDDAKTFDPARF
MLBr_02088|M.leprae_Br4923 IHLIGRVAAKDMTIGQTTLTEGDTMVLLLAAANRDPAVYSRPDEFDPDRP
* : . : * . :: :: . * * *
Mb1694c|M.bovis_AF2122/97 DPNAADYRKPAPHEFIPFSGGLHRCIGAVMATTEMTVILARLVARAMLQL
Rv1666c|M.tuberculosis_H37Rv DPNAADYRKPAPHEFIPFSGGLHRCIGAVMATTEMTVILARLVARAMLQL
MAV_3106|M.avium_104 NPDAPGYRRPAPHEFIPFSAGLHRCVGAAMATTEMTVMLARLLARTRLRL
Mflv_0056|M.gilvum_PYR-GCK SPEQTAQRD--RWHFLPFAGGARSCIGEHFARLETTLALATIVRSMRVTS
TH_3255|M.thermoresistible__bu APERFKAMD--RWQFVPFIGGPRSCIGEHFAMLESTLAIATLIRSVRIRS
Mvan_0245|M.vanbaalenii_PYR-1 SAQNSGGRD--RWQYLPFGAGPRSCIGDHFAMLEATLALATIIRSAEIRS
MUL_0604|M.ulcerans_Agy99 APKKSKGRD--RWQYLPFGGGGRSCLGDHFAMLEASLALATIIREAEIHS
MSMEG_0822|M.smegmatis_MC2_155 SPERSAGRN--RWQYLPFGGGPRSCIGDHFAMLEATLALATVIRAVSVES
MMAR_0283|M.marinum_M LSENSAHVP--RHMFIPFGMGKHKCIGDSFAITEMHVTAATVLRDWRLSL
MAB_1426|M.abscessus_ATCC_1997 LKENLQPEQ--RKAHMPFGAGKRMCVASGFANLEAIIGIAALAQNYELDL
MLBr_02088|M.leprae_Br4923 SSR-----------HLAFAVGSHFCLGAALARLEATVTLSAISARFPQVQ
.:.* * : *:. :* * : : :
Mb1694c|M.bovis_AF2122/97 PAQRTHR-IRAANFAALRPWPGLTVEIRKSAPAQ-----------
Rv1666c|M.tuberculosis_H37Rv PAQRTHR-IRAANFAALRPWPGLTVEIRKSAPAQ-----------
MAV_3106|M.avium_104 PAQR----LRAANVAALRPTPGLTVEVIDSVPAQ-----------
Mflv_0056|M.gilvum_PYR-GCK SDNDFPV-DVPFTTVAHGPIPAHLTPR------------------
TH_3255|M.thermoresistible__bu LDDDFPV-EVPFTTVARGPIRAVVSARR-----------------
Mvan_0245|M.vanbaalenii_PYR-1 SDPHFPM-IVPFTTVAAEPIRARVKSVNR------IPAADSGGR-
MUL_0604|M.ulcerans_Agy99 LDGDFPV-AIPLPIVPAGPIRARVNQRRPSQEVCTTTLSDSSASS
MSMEG_0822|M.smegmatis_MC2_155 QNTDLPV-ETPFTVIAAAPVPARVTRR------------------
MMAR_0283|M.marinum_M APNAHVR-ERPWAIVQPHGLRMIPFPRR-----------------
MAB_1426|M.abscessus_ATCC_1997 LPGQQPRREVTFTGGPEGEILMRLRKRHP----------------
MLBr_02088|M.leprae_Br4923 LAGELVY----KPNVAMRGMSALPVQV------------------