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PTSIPIAPAALPLLGHTLPLLRNPLSFLLSLPARGDLVRIRIGPATAVVACTAELTHEILCDDRIFDKGG IFFDRFREMLGDGLGTCPRSQHRRQRRLLQPAFHTQRLPGYAQTMTTEVAATVGRWQNGQIIDVPAEMMA ITGRTLLATMFSNSLPNPALRQALDDLTAIFAVLYWRMLTPPPLDRLPTVGNRRYHRASARLRHTIGSAV AGRRAAGVDRGDLLSAILASHEVDSSTVAFTDTEVIDQIVSFFIAGTETTALTVAWALYLLAEHPAIEQR VHAEIDPVLAGRAATHADLPRLGLVNRIVTETLRLYPPGWIISRVATADVYLGGHRIPAGATVIFSPYLI HHRPDLYAEPERFDPDRWLPERARAIGRNTYIPFGGGARKCIGDNFGTTEAALALATIAANWRMQRLPGL PVRPAVAASLRPRNLALRVTARTADRVPGEPGRRLTSREIG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_0281 | cyp183B1 | - | 100% (462) | cytochrome P450 183B1 Cyp183B1 |
| M. marinum M | MMAR_0283 | cyp274A1 | 8e-74 | 36.78% (435) | cytochrome P450 274A1 Cyp274A1 |
| M. marinum M | MMAR_0852 | cyp185A4 | 2e-44 | 29.89% (445) | cytochrome P450 185A4 Cyp185A4 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1694c | cyp139 | 5e-44 | 33.33% (357) | cytochrome P450 139 CYP139 |
| M. gilvum PYR-GCK | Mflv_0056 | - | 3e-47 | 30.02% (423) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv1666c | cyp139 | 6e-44 | 33.33% (357) | cytochrome P450 139 CYP139 |
| M. leprae Br4923 | MLBr_02088 | - | 1e-13 | 28.45% (232) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_1426 | - | 2e-46 | 29.69% (448) | putative cytochrome P450 |
| M. avium 104 | MAV_3106 | - | 2e-46 | 33.51% (367) | P450 heme-thiolate protein |
| M. smegmatis MC2 155 | MSMEG_0822 | - | 1e-51 | 32.30% (418) | cytochrome P450 |
| M. thermoresistible (build 8) | TH_3255 | - | 8e-43 | 31.29% (342) | PUTATIVE cytochrome P450 |
| M. ulcerans Agy99 | MUL_0604 | cyp185A4 | 3e-43 | 29.44% (445) | cytochrome P450 185A4 Cyp185A4 |
| M. vanbaalenii PYR-1 | Mvan_0858 | - | 7e-45 | 29.74% (454) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1694c|M.bovis_AF2122/97 -----------------------MRYPLGE--------------------
Rv1666c|M.tuberculosis_H37Rv -----------------------MRYPLGE--------------------
MAV_3106|M.avium_104 -----------------------MRYRPGE--------------------
Mflv_0056|M.gilvum_PYR-GCK MVAG---TEPGVGHLPLAPKNPLPYRRLLT--------------------
Mvan_0858|M.vanbaalenii_PYR-1 MTARDTAAAPEVGSLPLVPRNPLPLWKLVQ--------------------
TH_3255|M.thermoresistible__bu MVVT--TERADVATLPPAPRNPLPYWRQVR--------------------
MUL_0604|M.ulcerans_Agy99 MVDP-----PDIRSLPLAPRNPLPYWQQLK--------------------
MSMEG_0822|M.smegmatis_MC2_155 MVET---ASPPLTELPLAPRNTLPCREQIR--------------------
MMAR_0281|M.marinum_M ----------MPTSIPIAPAALPLLGHTLP--------------------
MAB_1426|M.abscessus_ATCC_1997 MSASALQPEPLSAPVEVAAGECPVNHDLYPGGPTFLRWHHTRVGYLKSWR
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPS-----------------LVE
Mb1694c|M.bovis_AF2122/97 ----ALLALYRWRGPLINAG-----------VGGHGYTYLLGAEANRFVF
Rv1666c|M.tuberculosis_H37Rv ----ALLALYRWRGPLINAG-----------VGGHGYTYLLGAEANRFVF
MAV_3106|M.avium_104 ----ALLALYRRRGPVIDAG-----------AGRRGYTLLLGAEANKFVF
Mflv_0056|M.gilvum_PYR-GCK ----LVRALDTGQLQVRAAGGPITRVQVAPRWLFPPFVAVFSPRGVRDVL
Mvan_0858|M.vanbaalenii_PYR-1 ----LVRRLDTGQEVIRDAGGPITRIQLGPKKLMPPIVAVMSPAGMRDVL
TH_3255|M.thermoresistible__bu ----AVRSFHTGQELLRDAGGPVK-------WAIPPIVLVTSPAGIRDVL
MUL_0604|M.ulcerans_Agy99 ----ALKTLHVGSEALRDAGGSVTRIWLGPKRLVPPMVMVTSPQGARDVL
MSMEG_0822|M.smegmatis_MC2_155 ----CLRSFIDGMQRLRDVGGPVTRIVLGPRWLVPPALLVTSPQGAHDVL
MMAR_0281|M.marinum_M ----LLRNPLSFLLSLPARGDLVR-----IRIGPATAVVACTAELTHEIL
MAB_1426|M.abscessus_ATCC_1997 LALGAVWSTYRHTISEYLADLPGQDDVIVARAPMRKAVIVRNPELARHVL
MLBr_02088|M.leprae_Br4923 AQMLLLRLIDPGTRADPFPVYRALIDYGPMQLPGMPLTVFSSFSDCDEAL
: :
Mb1694c|M.bovis_AF2122/97 ANADAFSWS---QTFESLVPVDGP------TALIVSDGADHRRRRSVVAP
Rv1666c|M.tuberculosis_H37Rv ANADAFSWS---QTFESLVPVDGP------TALIVSDGADHRRRRSVVAP
MAV_3106|M.avium_104 ANADAFSWR---ATFENLALVDGP------TALIVSDGDDHRRRRSVVAP
Mflv_0056|M.gilvum_PYR-GCK GRNDAFSER--CIVHEEVRDMAGD------SLFVLPN-EPWRPRKRALQP
Mvan_0858|M.vanbaalenii_PYR-1 GRNDASSDR--CIIHEQVQEMAGD------SLWVLPN-EQWRPRKRALAP
TH_3255|M.thermoresistible__bu NRRDALSER--CQVHHEVRHLGGD------SLFVLPT-DPWRARRRALAP
MUL_0604|M.ulcerans_Agy99 GRSGALSDRGTLPLLKDLRRAIGE------SVLNLPH-DTWLPRRRTLQP
MSMEG_0822|M.smegmatis_MC2_155 SLPDAVADRGGSRNMRQLQRLMGG------NLLDLPH-DRWLPRRRTLQP
MMAR_0281|M.marinum_M CDDRIFDKG--GIFFDRFREMLGD------GLGTCPR-SQHRRQRRLLQP
MAB_1426|M.abscessus_ATCC_1997 VANQDNYIK--SAEYDLLAVGFGR------GLVTDLNEGLWNRNRRLVQP
MLBr_02088|M.leprae_Br4923 RHPLSASDRLKATLAQQAIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSK
. : :
Mb1694c|M.bovis_AF2122/97 GLRHHHVQRYVATMVSNIDTVIDGWQP----GQRLDIYQELRSAVRRSTA
Rv1666c|M.tuberculosis_H37Rv GLRHHHVQRYVATMVSNIDTVIDGWQP----GQRLDIYQELRSAVRRSTA
MAV_3106|M.avium_104 GLRHRQIQDYVTTMVSCIDRVIDGWRP----GQRLDVYQHCRAAVRRSTA
Mflv_0056|M.gilvum_PYR-GCK VFTPQNVRRFGGHMSRAAEVFVDAWRD----GGDVDLDLECRRITMQSLG
Mvan_0858|M.vanbaalenii_PYR-1 VFTKTSVRAFGGHMSKAAQAFVDRWPS----GGEVDLDAECRRVAMQSLG
TH_3255|M.thermoresistible__bu VFTPTAVRSYGGYMSEAAQRVADGWQA----AREVDLDAECRRLTMRSLG
MUL_0604|M.ulcerans_Agy99 IFTKQRVAGFAGHMSEAANHILLGWPD----GAEVDLNAASHALVLRVVG
MSMEG_0822|M.smegmatis_MC2_155 LFTKKHVPRFAGHMAAAAQSVAVSWAD----GATVDLDRACRALTLRALG
MMAR_0281|M.marinum_M AFHTQRLPGYAQTMTTEVAATVGRWQN----GQIIDVPAEMMAITGRTLL
MAB_1426|M.abscessus_ATCC_1997 IFAKRQVDLFAPQMAEAAARTISRWDELYAEGKPVDITAEMNYLTMDIVA
MLBr_02088|M.leprae_Br4923 AFAPKVVQALEGDIAALVDSLLDKGAA----AGQFDVIADLAFPLAVAVI
: : : . .*:
Mb1694c|M.bovis_AF2122/97 ESLFGQRLA-----------------------------VHSDFLGEQLQP
Rv1666c|M.tuberculosis_H37Rv ESLFGQRLA-----------------------------VHSDFLGEQLQP
MAV_3106|M.avium_104 ESLFGRRLA-----------------------------VHSDALGEYLQP
Mflv_0056|M.gilvum_PYR-GCK RSVLGVDLN-----------------------------ESADVIAEHMHV
Mvan_0858|M.vanbaalenii_PYR-1 RSVLGVDLN-----------------------------ERGETIARCMHV
TH_3255|M.thermoresistible__bu RSVLGLDIN-----------------------------ERADAISEPMHI
MUL_0604|M.ulcerans_Agy99 HSVFGLDLQ-----------------------------DKADVITTGVTL
MSMEG_0822|M.smegmatis_MC2_155 RSVFGVDLD-----------------------------QRAEDVGPALRT
MMAR_0281|M.marinum_M ATMFSNSLP-----------------------------NPALRQALDDLT
MAB_1426|M.abscessus_ATCC_1997 QTMFGIDLSGDMAERMRIYFARLLKLFGVGFIVGAAPPLRWVVDKLAAHG
MLBr_02088|M.leprae_Br4923 CRLLGVPYE-----------------------------------DAPEFG
::.
Mb1694c|M.bovis_AF2122/97 LLDLTR-RPPQVMRLQQRVNSPGWRRAMAARKRIDDLIDAQIADARTA-P
Rv1666c|M.tuberculosis_H37Rv LLDLTR-RPPQVMRLQQRVNSPGWRRAMAARKRIDDLIDAQIADARTA-P
MAV_3106|M.avium_104 LLDLTH-QPPQLVGLQRRINAPAWRRAMAARQRINNLVDTLIAEARAA-P
Mflv_0056|M.gilvum_PYR-GCK ASSYTADRALRPVRAPRWLPTPARRRAAHAVAEMRQVAADMLQVCRDD-P
Mvan_0858|M.vanbaalenii_PYR-1 ASSYTADRALRPVRAPRWLLTPARQRARSAVNAMRAITDEMVKACRDD-P
TH_3255|M.thermoresistible__bu ASSYTADRALRPVRAPRWLPTPARRRARAAVATMRRITDEMLQACRAD-P
MUL_0604|M.ulcerans_Agy99 AAKWAADRSARPVRAPHWLPTPARPRARGAYDAMYKIAADMLAACRAD-P
MSMEG_0822|M.smegmatis_MC2_155 SLSWVADRASRPVNLPQWVPTRGQRKARAGNATLHRLAAEILADVRAD-P
MMAR_0281|M.marinum_M AIFAVLYWRMLTPPPLDRLPTVGNRRYHRASARLRHTIGSAVAGRRAA-G
MAB_1426|M.abscessus_ATCC_1997 PDELSSHTPRLAIRALRIGASVAAPRTMKGLRWVERTIDQLIADHRSGRI
MLBr_02088|M.leprae_Br4923 RVSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLVKCRRGT--
. . . . : : *
Mb1694c|M.bovis_AF2122/97 RPDDHMLTTLISGCS-EEGTT-LSDNEIRDSIVSLITAGYETTSGALAWA
Rv1666c|M.tuberculosis_H37Rv RPDDHMLTTLISGCS-EEGTT-LSDNEIRDSIVSLITAGYETTSGALAWA
MAV_3106|M.avium_104 NPDDHMLTMLIDGRG-DEGYA-LNDNEIRDAIVSLVTAGYETTSGALAWA
Mflv_0056|M.gilvum_PYR-GCK DRDAPLVRALMDARDPETGMA-LSDDDICNDLLIFMLAGHDTTATALTYA
Mvan_0858|M.vanbaalenii_PYR-1 TRDAPLVQALIAATDPETGRP-LTDEEISNDLLIFMLAGHDTTATALTHA
TH_3255|M.thermoresistible__bu DRDAPLVHALIRATDPETGRG-LSDEDICNDLLIFMLAGHDTTATALTYA
MUL_0604|M.ulcerans_Agy99 SREAPLITALIDATGPNTGES-LSDQQICDEMVYFMILGEDTTSTVLTYA
MSMEG_0822|M.smegmatis_MC2_155 DRDAPLVRALLEARDPETGRG-LTDDQICDELVLFMLAGHDTTSTTLCYS
MMAR_0281|M.marinum_M VDRGDLLSAILASHEVDSSTVAFTDTEVIDQIVSFFIAGTETTALTVAWA
MAB_1426|M.abscessus_ATCC_1997 ARQDNLLALLMAAEDPETGAK-YTDLEIRDELMTFLGAGFETTAAALAWT
MLBr_02088|M.leprae_Br4923 -PGEDLISRLIELDE--SGDQ-LTEEEIIATCGLLLVAGHETTVNLIANA
:: :: . .: :: :. * :** : :
Mb1694c|M.bovis_AF2122/97 IYALLTVPGTWESAASEVARVLGGRVPAADDLSALTYLNGVVHETLRLYS
Rv1666c|M.tuberculosis_H37Rv IYALLTVPGTWESAASEVARVLGGRVPAADDLSALTYLNGVVHETLRLYS
MAV_3106|M.avium_104 VYLLLSQPGAWATAAGEVRRVLAGRLPAAADLSGLTYLNGVVHETLRLYP
Mflv_0056|M.gilvum_PYR-GCK LWVLGHHPDVQDRVAAEAA-ALGRRELEPGDVPHLKYTTQVLLEALRLCP
Mvan_0858|M.vanbaalenii_PYR-1 LWVLGHHPDIQDRVAAEAA-AIGDRELTPDDVPALGYTVQVLHESVRLCP
TH_3255|M.thermoresistible__bu LWALGHHPEIQDRVAAEVA-ELPDREITPHDVPRLGYTVQVLRESLRLCP
MUL_0604|M.ulcerans_Agy99 LWALGQHCQLQDRLAAEAA-ELGDRPLTPADVPRLGYTIQVLQEAMRLRP
MSMEG_0822|M.smegmatis_MC2_155 LWALGHHPDIQERVYAEVA-ALGDRELTTDDVPQLTYTMRVLHEALRLCP
MMAR_0281|M.marinum_M LYLLAEHPAIEQRVHAEIDPVLAGRAATHADLPRLGLVNRIVTETLRLYP
MAB_1426|M.abscessus_ATCC_1997 WYLLSRNPDARAKLGQEVDRVLGGRQPTAADVDNLPWTAAVLNEAMRVYP
MLBr_02088|M.leprae_Br4923 VLAMLRNPSQWKALSSNPQ-----------------RAPLVVEETLRYDP
: : :: *::* .
Mb1694c|M.bovis_AF2122/97 PGVISARRVLRDLWFDGHRIRAGRLLIFSAYVTHRLPEIWPEPTEFRPLR
Rv1666c|M.tuberculosis_H37Rv PGVISARRVLRDLWFDGHRIRAGRLLIFSAYVTHRLPEIWPEPTEFRPLR
MAV_3106|M.avium_104 PGVISARRVMRDLRFEGRRIRSGRLLIFSPYVTHRLPEIWPEPMRFAPER
Mflv_0056|M.gilvum_PYR-GCK PAAGVGRMAVRDIDVDGHRVQAGTLVAVGIYALHRDPEIWPDPDRFDPDR
Mvan_0858|M.vanbaalenii_PYR-1 PAAGVARLVTRDFAVDGYRVEAGSLVALGLYALHHDPALWPDPMAFDPDR
TH_3255|M.thermoresistible__bu PAAGVGRLAMSDLAVDGYRVEAGTLLAVGIQAIHRDPSLWPDPMVFDPDR
MUL_0604|M.ulcerans_Agy99 PGPTVARRAMQDIEVDGYRVQAGTYCLVGVYAMHRDPALWDDPLAFDPDR
MSMEG_0822|M.smegmatis_MC2_155 PGSGTMRMLNEEMTVDGYRVEAGTVAIVNFYAMHRSPTLWDAPERFDPDR
MMAR_0281|M.marinum_M PGWIISRVATADVYLGGHRIPAGATVIFSPYLIHHRPDLYAEPERFDPDR
MAB_1426|M.abscessus_ATCC_1997 PILGLARTAKADDVLGDYPISAGTTVMVLIDSIHHNERVWDDAKTFDPAR
MLBr_02088|M.leprae_Br4923 AIHLIGRVAAKDMTIGQTTLTEGDTMVLLLAAANRDPAVYSRPDEFDPDR
. * : . : * . :: :: . * * *
Mb1694c|M.bovis_AF2122/97 WDPNAADYRKPAPHEFIPFSGGLHRCIGAVMATTEMTVILARLVARAMLQ
Rv1666c|M.tuberculosis_H37Rv WDPNAADYRKPAPHEFIPFSGGLHRCIGAVMATTEMTVILARLVARAMLQ
MAV_3106|M.avium_104 WNPDAPGYRRPAPHEFIPFSAGLHRCVGAAMATTEMTVMLARLLARTRLR
Mflv_0056|M.gilvum_PYR-GCK FSPEQTAQRD--RWHFLPFAGGARSCIGEHFARLETTLALATIVRSMRVT
Mvan_0858|M.vanbaalenii_PYR-1 FSPENVKARD--RWQFLPFLGGGRPCIGEHFARLETTLALATVVRACRIE
TH_3255|M.thermoresistible__bu FAPERFKAMD--RWQFVPFIGGPRSCIGEHFAMLESTLAIATLIRSVRIR
MUL_0604|M.ulcerans_Agy99 FAPKKSKGRD--RWQYLPFGGGGRSCLGDHFAMLEASLALATIIREAEIH
MSMEG_0822|M.smegmatis_MC2_155 FSPERSAGRN--RWQYLPFGGGPRSCIGDHFAMLEATLALATVIRAVSVE
MMAR_0281|M.marinum_M WLPERARAIG--RNTYIPFGGGARKCIGDNFGTTEAALALATIAANWRMQ
MAB_1426|M.abscessus_ATCC_1997 FLKENLQPEQ--RKAHMPFGAGKRMCVASGFANLEAIIGIAALAQNYELD
MLBr_02088|M.leprae_Br4923 PSS-----------RHLAFAVGSHFCLGAALARLEATVTLSAISARFPQV
.:.* * : *:. :. * : :: :
Mb1694c|M.bovis_AF2122/97 LP-AQRTHRIRAANFAALRPWPGLTVEIRKSAPAQ------------
Rv1666c|M.tuberculosis_H37Rv LP-AQRTHRIRAANFAALRPWPGLTVEIRKSAPAQ------------
MAV_3106|M.avium_104 LP-AQR---LRAANVAALRPTPGLTVEVIDSVPAQ------------
Mflv_0056|M.gilvum_PYR-GCK SS-DNDFPVDVPFTTVAHGPIPAHLTPR-------------------
Mvan_0858|M.vanbaalenii_PYR-1 SL-DDLFECEVPLTTVAKGPIRARVTPRR------------------
TH_3255|M.thermoresistible__bu SL-DDDFPVEVPFTTVARGPIRAVVSARR------------------
MUL_0604|M.ulcerans_Agy99 SL-DGDFPVAIPLPIVPAGPIRARVNQRRPSQEVCTTTLSDSSASS-
MSMEG_0822|M.smegmatis_MC2_155 SQ-NTDLPVETPFTVIAAAPVPARVTRR-------------------
MMAR_0281|M.marinum_M RL-PGLPVRPAVAASLRPRNLALRVTARTADRVPGEPGRRLTSREIG
MAB_1426|M.abscessus_ATCC_1997 LLPGQQPRREVTFTGGPEGEILMRLRKRHP-----------------
MLBr_02088|M.leprae_Br4923 QL-AGELVYKPNVAMRGMSALPVQV----------------------