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MTNHLLAPAHHVKERLSSVIMVPAPHAVDDRWRRWSRDWPVRELAPAPAGSGLKAVRGDAGLPFVGHTLD YIRFGSDFSRERYDRLGSVSWMGAFGTKMVVIAGPDATREAFTSEAKAFSQDGWSFLIDAFFHRGLMLMS FDEHLMHRRIMQEAFTRPRLTGYVEQVTPCVRSAVPAWPVGPSVRIYPLLKELTLDIATDVFMGGRGKDE SDAVNKAFVATVRAASSLVRAPLPGTRFRAGVQGRRVLEDYFFRHLPAARAGETEDLFAALCQATTEDGE RFSDEDVVNHMIFLMMAAHDTSTITTTAVTYFLAKYPQWQEAAAAEAAAIGDGLPDIEALEKMTVIDRVI KEALRLLAPVPLVMRKTVRDVAIDGYHIPSNTLCAITPAVNHFDRTIWNDPERFDPSRFDEPRREDQHHR FAWVPFGGGAHKCIGMQFGTLEVKAILHRMLRSFTWKVPENYHVRWDNTSLPIPVDGLPLEMKRR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_2078 | - | - | 100% (485) | cytochrome P450 |
| M. abscessus ATCC 19977 | MAB_3423 | - | e-126 | 46.31% (488) | cytochrome P450 |
| M. abscessus ATCC 19977 | MAB_4693 | - | 1e-29 | 27.20% (375) | cytochrome P450 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3085 | cyp136 | 1e-115 | 46.58% (453) | cytochrome P450 136 |
| M. gilvum PYR-GCK | Mflv_4315 | - | 1e-122 | 47.28% (478) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv3059 | cyp136 | 1e-114 | 46.36% (453) | cytochrome P450 136 |
| M. leprae Br4923 | MLBr_02088 | - | 4e-11 | 21.39% (332) | putative cytochrome p450 |
| M. marinum M | MMAR_3135 | cyp136B2 | 0.0 | 85.57% (485) | cytochrome P450 136B2 Cyp136B2 |
| M. avium 104 | MAV_3927 | - | 1e-122 | 45.82% (467) | cytochrome p450 |
| M. smegmatis MC2 155 | MSMEG_2289 | - | 1e-122 | 46.48% (469) | cytochrome p450 |
| M. thermoresistible (build 8) | TH_2954 | - | 1e-122 | 46.53% (475) | PUTATIVE cytochrome P450 |
| M. ulcerans Agy99 | MUL_3402 | cyp136A2 | 1e-114 | 45.41% (458) | cytochrome P450 136A2 Cyp136A2 |
| M. vanbaalenii PYR-1 | Mvan_2031 | - | 1e-121 | 46.56% (479) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
MAB_2078|M.abscessus_ATCC_1997 MT---NHLLAPAHHVKERLS-SVIMVPAPHAVDDRWRRWSRDWPVRELAP
MMAR_3135|M.marinum_M MA---NQLLAITRHPKERLT-SVLLAPAPRVVDDKWRQWSRDWRVRELAP
MSMEG_2289|M.smegmatis_MC2_155 MPTTISTPRYLLDQARRRFTPTPNTIPGMGAIEKRLK--RKQWDQFVFST
Mvan_2031|M.vanbaalenii_PYR-1 MP-SISTTDYVLDQAKRRLKPTPVTIPGMGAVEKRLK--DKHWDQFVLAE
Mflv_4315|M.gilvum_PYR-GCK MT-AISTPEYLLDQAKRRLKPTPVTIPGMGAIEKRLL--EKQWDEIILAE
TH_2954|M.thermoresistible__bu MA-TINTRDYLLDQAKRRLIPTVNNIPGMGIVEKKLR--EREWKQFKLAD
MAV_3927|M.avium_104 MTATISTPQYLLDQARRRFTPTLNTIPGMGAIEKRLL--AHEWQTKVLAE
Mb3085|M.bovis_AF2122/97 MA-TIHPPAYLLDQAKRRFTPSFNNFPGMSLVEHMLL--NTKFPEKKLAE
Rv3059|M.tuberculosis_H37Rv MA-TIHPPAYLLDQAKRRFTPSFNNFPGMSLVEHMLL--NTKFPEKKLAE
MUL_3402|M.ulcerans_Agy99 MA-TISTPAYLLDQAQRRLTPSFNNFPGMGMVERWLL--KTQFPETTLAD
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
* . ::
MAB_2078|M.abscessus_ATCC_1997 APAGSGLKAVRGDAGLPFVGHTLDYIRFGSDFSRERYDRLGSVSWMGAFG
MMAR_3135|M.marinum_M APAGSGLRAVLGDAGLPLLGHTVDYIRFGSEFSRERYERLGSVSWMGAFG
MSMEG_2289|M.smegmatis_MC2_155 PPAGSGLKPIMGDSGLPVLGHMIEIFRGGPDFILEQYRRNGPIHYAYSPA
Mvan_2031|M.vanbaalenii_PYR-1 PPAGSDLKPILGDAGLPIIGHMIEIFRGGPDFILEIYRKHGPVYFAESPA
Mflv_4315|M.gilvum_PYR-GCK PPAGSGLKAVRGDNGLPIVAHMIEMFRGGPDFILHQYRKYGPVYYSGSQV
TH_2954|M.thermoresistible__bu PPPGSGLKPVMGDAGLPILGHMIEAFRGGPDYVLEVYRKYGPVHYAYSPA
MAV_3927|M.avium_104 PPAGSGLKPVLGDAGLPILGHIIELFRGGPDYALFLYRNHGPLIYLDSPI
Mb3085|M.bovis_AF2122/97 PPPGSGLKPVVGDAGLPILGHMIEMLRGGPDYLMFLYKTKGPVVFGDSAV
Rv3059|M.tuberculosis_H37Rv PPPGSGLKPVVGDAGLPILGHMIEMLRGGPDYLMFLYKTKGPVVFGDSAV
MUL_3402|M.ulcerans_Agy99 PPPGSDLKPVVGDAGLPILGHLIEMLRGGPDYLMFLYRTKGPVVFGDSPV
MLBr_02088|M.leprae_Br4923 FP---VYRALIDYGPMQLPGMPLTVFSSFSDCDEALRHPLSASDRLKATL
* :.: . : . . : : .: .. :
MAB_2078|M.abscessus_ATCC_1997 TKMVVIAGPDATREAFTSEAKAFSQDGWSFLIDAFFHRGLMLMSFDEHLM
MMAR_3135|M.marinum_M TKMVVIAGPDATREAFTSEAKAFSQDGWSFLIDAFFHRGLMLMSFDEHLM
MSMEG_2289|M.smegmatis_MC2_155 LSSVMALGPDATQTVFSNRNKDYSQRAWDPVIGPFFEGGLMLLDFDEHMY
Mvan_2031|M.vanbaalenii_PYR-1 LSSVMALGPDATQAVFSNRNKDFSQRAWDPVIGPFFEGGLMLLDFDEHMF
Mflv_4315|M.gilvum_PYR-GCK LPAVGALGPDATQAVFSNRNKDFSQRAWDPVIGPFFEGGLMLRDFEDHMY
TH_2954|M.thermoresistible__bu LASVSALGPDATQEIFSNKNKDYSQKGWHPVIGPFFNRGLMMLDFEEHMY
MAV_3927|M.avium_104 MPAVTALGPDATQAVFSNRNKDYSQKGWHPVIGPFFNRGLMMLDFDEHMY
Mb3085|M.bovis_AF2122/97 LPGVAALGPDAAQVIYSNRNKDYSQQGWVPVIGPFFHRGLMLLDFEEHMF
Rv3059|M.tuberculosis_H37Rv LPGVAALGPDAAQVIYSNRNKDYSQQGWVPVIGPFFHRGLMLLDFEEHMF
MUL_3402|M.ulcerans_Agy99 LSAVVALGPDAAQVIYSNRNKDYSQQGWVPVIGPFFRRGLMLLDFEEHMF
MLBr_02088|M.leprae_Br4923 AQQAIAAGAEPR---------------------PFYASSFMFLDPPDHTR
. *.:. .*: .:*: . :*
MAB_2078|M.abscessus_ATCC_1997 HRRIMQEAFTRPRLTGYVEQVTPCVRSAVP-AWPVG-PSVRIYPLLKELT
MMAR_3135|M.marinum_M HRRIMQEAFTRPRLTGYVGQVAPCVRAAVP-AWPTG-PSVRIYPLLKNLT
MSMEG_2289|M.smegmatis_MC2_155 HRRIMQDAFTRSRLTGYIPHIDSVASQVLANDWVSDDPRFLFYPAIKELT
Mvan_2031|M.vanbaalenii_PYR-1 HRRIMQEAFTRSRLTGYVSHIDSVASAVLANDWVANDPRFLFHPAIKELT
Mflv_4315|M.gilvum_PYR-GCK HRRIMQEAFTRSRLTGYVEHIDQVASAVIANDWVADDRRFLFYPAVKELT
TH_2954|M.thermoresistible__bu HRRIMQEAFTRPRLAGYVEHIDRVASEVVVRDWATDDPRFLFHPSVKKLT
MAV_3927|M.avium_104 HRRIMQEAFTRSRLTGYVEHIDRVATDIVA-DWPTNDARFLFHPAMKELT
Mb3085|M.bovis_AF2122/97 HRRIMQEAFVRSRLAGYLEQMDRVVSRVVADDWVVNDARFLVYPAMKALT
Rv3059|M.tuberculosis_H37Rv HRRIMQEAFVRSRLAGYLEQMDRVVSRVVADDWVVNDARFLVYPAMKALT
MUL_3402|M.ulcerans_Agy99 HRRIMQQAFVRPRLVGYVEHMDEVASRAIAGEWATNDARFLLYPAMKKLT
MLBr_02088|M.leprae_Br4923 LRKLVSKAFAPKVVQALEGDIAALVDSLLDKGAAAG-----QFDVIADLA
*:::..**. : . .: . : . . : *:
MAB_2078|M.abscessus_ATCC_1997 LDIATDVFMG---GRGKDESDAVNKAFVATVRAASSLVRAPLPGTRFRAG
MMAR_3135|M.marinum_M LDIATDVFMG---GRGKDESAAVNEAFVSTVRAASSFVRVPLPGTRFRAG
MSMEG_2289|M.smegmatis_MC2_155 LDIASEVFMGVPAGTDKKLVTTVNHAFTTTTRAGNAIVRTPVPPLKWWRG
Mvan_2031|M.vanbaalenii_PYR-1 LDIASEVFMGVPAGTDRALVTTVNQAFTTTTRAGNAIVRKPVPPLTWWRG
Mflv_4315|M.gilvum_PYR-GCK LDIASVVFMGHKAGTDKQLVTTVNEAFTTTTRAGNAIVRKPVPPLSWWRG
TH_2954|M.thermoresistible__bu LDIASVVFMGHEPGSDKELVTKVNDAFTITTRAGGAIIRTSVPPFKWWRG
MAV_3927|M.avium_104 LDIASLVFMGHEPGTDHDLVTKVNQAFTTTTRAGGAIIRQPIPPFKWWRG
Mb3085|M.bovis_AF2122/97 LDIASMVFMGHEPGTDHELVTKVNKAFTITTRAGNAVIRTSVPPFTWWRG
Rv3059|M.tuberculosis_H37Rv LDIASMVFMGHEPGTDHELVTKVNKAFTITTRAGNAVIRTSVPPFTWWRG
MUL_3402|M.ulcerans_Agy99 LDIASMVFMGHEPGTDHELVTKVNRAFTTTTRAGNAVIRTSVPPFTWWRG
MLBr_02088|M.leprae_Br4923 FPLAVAVICRLLGVPYEDAPEFGRVSALLVQSVDPFITITGEPPEATEER
: :* *: . . : . . . *
MAB_2078|M.abscessus_ATCC_1997 VQGRRVLEDYFFRHLPAARAGETEDLFAALCQATTEDGERFSDEDVVNHM
MMAR_3135|M.marinum_M VHGRRVLEDYFSRHLPAARAGETDDLFAALCQATTEDGERFSDEDVINHM
MSMEG_2289|M.smegmatis_MC2_155 IQARKTLEDYFLSRIDEKRRAESTDMFSVLCHSADEDGQTFTDDQIVSHM
Mvan_2031|M.vanbaalenii_PYR-1 IKARKTLEDYFSSRIGEKRRSESTDMFSVLCHSADEDGQSFTDDQIVSHM
Mflv_4315|M.gilvum_PYR-GCK IRARKTLEDYFNAGIAEKRRSESTDMFSVLCHAQDEDGQSFTDQDVVSHM
TH_2954|M.thermoresistible__bu LQARKVLEDYFVQRVKERRDSGGTDMLSVLCHATDEDGNTFTDEDIVNHM
MAV_3927|M.avium_104 LRARQLLEDYFSERVKERRNATGNDMLTVLCHTEDDDGNSFTDDDIVNHM
Mb3085|M.bovis_AF2122/97 LRARELLENYFTARVKERREASGNDLLTVLCQTEDDDGNRFSDADIVNHM
Rv3059|M.tuberculosis_H37Rv LRARELLENYFTARVKERREASGNDLLTVLCQTEDDDGNRFSDADIVNHM
MUL_3402|M.ulcerans_Agy99 IRARQLLENYFAARVTERRGQEGNDLLTVLCHTADEDGNRFSDQDIVNHM
MLBr_02088|M.leprae_Br4923 LRAGVWLRDYLEQLVKCRRGTPGEDLISRLIELD-ESGDQLTEEEIIATC
::. *.:*: : * *::: * . :.*: ::: :::
MAB_2078|M.abscessus_ATCC_1997 IFLMMAAHDTSTITTTAVTYFLAKYPQWQEAAAAEAAAIGDGLPDIEALE
MMAR_3135|M.marinum_M IFLMMAAHDTSTITTTAVTYFLAKHPEWQEKAAAEARSFGHDSPDIDELE
MSMEG_2289|M.smegmatis_MC2_155 IFLMMAAHDTSTSTMTTMAYHLAANPEWQDRLRDESERIGDGPLDIEALE
Mvan_2031|M.vanbaalenii_PYR-1 IFLMMAAHDTSTSTMTTMAYHLAANPEWQDRLREESARIGDGPLDIEALE
Mflv_4315|M.gilvum_PYR-GCK IFLMMAAHDTSTSTLTTMAYHLAANPEWQDRCREESERIGDGPLDIEALE
TH_2954|M.thermoresistible__bu IFLMMAAHDTSTSTMTTMAYYLAANQDWQQRCRDESDRLGDGPLDIEALE
MAV_3927|M.avium_104 IFLMMAAHDTSTSTTTTMVYNMAAHPEWQERAREESTRLGDGPLDIEALE
Mb3085|M.bovis_AF2122/97 IFLMMAAHDTSTSTATTMAYQLAAHPEWQQRCRDESDRHGDGPLDIESLE
Rv3059|M.tuberculosis_H37Rv IFLMMAAHDTSTSTATTMAYQLAAHPEWQQRCRDESDRHGDGPLDIESLE
MUL_3402|M.ulcerans_Agy99 IFLMMAAHDTSTSTATTMAYHLAAHPEWQQRCRDESDRLGDGPLDIEALE
MLBr_02088|M.leprae_Br4923 GLLLVAGHETTVNLIANAVLAMLRNPSQWKALSSNPQRAP----------
:*::*.*:*:. : . : . . :.
MAB_2078|M.abscessus_ATCC_1997 KMTVIDRVIKEALRLLAPVPLVMRKTVRDVAIDGYHIPSNTLCAITPAVN
MMAR_3135|M.marinum_M RMTVLDLILKEALRLLAPVPLVMRKTVRDVAIDGYHIPRETLCAITPAVN
MSMEG_2289|M.smegmatis_MC2_155 KLETYDLVINEALRMMTPLPFNFRQAVRDTELLGYFIPAGTNVVTWPSIN
Mvan_2031|M.vanbaalenii_PYR-1 KLETYDLVINEALRMMTPLPFNFRQAIRDTDLLGYYIPAGTNVVTWPSIN
Mflv_4315|M.gilvum_PYR-GCK KLETYDLVINEALRMVTPLPFNFREAVRDTELLGYYIPAGTAIMTWPALN
TH_2954|M.thermoresistible__bu KLESLDLVMNESLRLVTPLPFNVRQTVRDTDLLGYYIPAGTNVVTWPGMN
MAV_3927|M.avium_104 KLETLELIMNESLRMVTPLPFNMRQAVRDTELLGHYIPAGTNITIWPGMN
Mb3085|M.bovis_AF2122/97 QLESLDLVMNESIRLVTPVQWAMRQTVRDTELLGYYLPKGTNVIAYPGMN
Rv3059|M.tuberculosis_H37Rv QLESLDLVMNESIRLVTPVQWAMRQTVRDTELLGYYLPKGTNVIAYPGMN
MUL_3402|M.ulcerans_Agy99 KLESLDLVMNESIRLVTPVQWAMRQTVRDTELLGYYLPKGTNVIAYPGMN
MLBr_02088|M.leprae_Br4923 ------LVVEETLRYDPAIHLIGRVAAKDMTIGQTTLTEGDTMVLLLAAA
:::*::* ..: * : :* : :. .
MAB_2078|M.abscessus_ATCC_1997 HFDRTIWNDPERFDPSRFDEPRREDQHHRFAWVPFGGGAHKCIGMQFGTL
MMAR_3135|M.marinum_M HFDRRIWSDPDRFDPSRFDEPRREDQQHRFAWVPFGGGAHKCIGMQFGTL
MSMEG_2289|M.smegmatis_MC2_155 HRLPELWTDPEKFDPERFAEPRSEHKKHRYAFAPFGGGAHKCIGMVFGQL
Mvan_2031|M.vanbaalenii_PYR-1 HRLPELWTDPEKFDPERFAEPRSEHKKHRYAFAPFGGGAHKCIGMVFGQL
Mflv_4315|M.gilvum_PYR-GCK HRLPELWTDPEKFDPARFAEPRNEHKKHRYAFAPFGGGAHKCIGMVFGQL
TH_2954|M.thermoresistible__bu HRLPELWTEPEKFDPERFAEPRSEHKRHRYAFAPFGGGAHKCIGMVFGQL
MAV_3927|M.avium_104 HRLPELWTDPDKFDPERFAEPRAEHKKHRYAFAPFGGGAHKCIGMVFGQL
Mb3085|M.bovis_AF2122/97 HRLPEIWTDPLTFDPERFTEPRNEHKRHRYAFTPFGGGVHKCIGMVFGQL
Rv3059|M.tuberculosis_H37Rv HRLPEIWTDPLTFDPERFTEPRNEHKRHRYAFTPFGGGVHKCIGMVFDQL
MUL_3402|M.ulcerans_Agy99 HRLPEFWTDPMTFDPDRFAEPRNEHKRHRYAFTPFGGGAHKCLGMVFGQL
MLBr_02088|M.leprae_Br4923 NRDPAVYSRPDEFDPDRPSS----------RHLAFAVGSHFCLGAALARL
: .:. * *** * . .*. * * *:* : *
MAB_2078|M.abscessus_ATCC_1997 EVKAILHRMLRSFTWKVP-ENYHVRWDNTSLPIPVDGLPLEMKRR-
MMAR_3135|M.marinum_M EVKAILHQMLRTYTWTVP-NDYHVRWDNTSLPIPVDGLPVTLRHR-
MSMEG_2289|M.smegmatis_MC2_155 EIKTVMHRLLRQYRLELPRPGYTPRYDYGGMPVPIDGMPIVLRPLR
Mvan_2031|M.vanbaalenii_PYR-1 EIKTVVHRLLQNYRLELPRPDYQPRYDYGGMPVPLDGMPIVLRPLH
Mflv_4315|M.gilvum_PYR-GCK EIKTVMHRLLRKYRLEPVSPNYRPRYDHGGMAVPIDGMPIVLRPLH
TH_2954|M.thermoresistible__bu EIKTVMHRLLREYRLELPRPGYTPRYDYGGMPIPMDGMPIVLRRLR
MAV_3927|M.avium_104 EVKTVVHRLLRRYRLELARPGYQPRWDYGGMPIPMDGMPIVLRPL-
Mb3085|M.bovis_AF2122/97 EIKTILHRLLRRYRLELSRPDYQPRWDYSAMPIPMDGMPIVLRPR-
Rv3059|M.tuberculosis_H37Rv EIKTILHRLLRRYRLELSRPDYQPRWDYSAMPIPMDGMPIVLRPR-
MUL_3402|M.ulcerans_Agy99 EIKTILHRLLRRYRLELARPDYRACWDYGGMPVPKDGMPIVLRPL-
MLBr_02088|M.leprae_Br4923 EATVTLSAISARFPQVQLAGELVYKPN-----VAMRGMSALPVQV-
* .. : : : : :. *:.