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VRYRPGEALLALYRRRGPVIDAGAGRRGYTLLLGAEANKFVFANADAFSWRATFENLALVDGPTALIVSD GDDHRRRRSVVAPGLRHRQIQDYVTTMVSCIDRVIDGWRPGQRLDVYQHCRAAVRRSTAESLFGRRLAVH SDALGEYLQPLLDLTHQPPQLVGLQRRINAPAWRRAMAARQRINNLVDTLIAEARAAPNPDDHMLTMLID GRGDEGYALNDNEIRDAIVSLVTAGYETTSGALAWAVYLLLSQPGAWATAAGEVRRVLAGRLPAAADLSG LTYLNGVVHETLRLYPPGVISARRVMRDLRFEGRRIRSGRLLIFSPYVTHRLPEIWPEPMRFAPERWNPD APGYRRPAPHEFIPFSAGLHRCVGAAMATTEMTVMLARLLARTRLRLPAQRLRAANVAALRPTPGLTVEV IDSVPAQ
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_3106 | - | - | 100% (427) | P450 heme-thiolate protein |
| M. avium 104 | MAV_0708 | - | 2e-30 | 27.99% (368) | cytochrome P450 51 |
| M. avium 104 | MAV_3927 | - | 1e-29 | 25.70% (393) | cytochrome p450 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1694c | cyp139 | 0.0 | 75.35% (430) | cytochrome P450 139 CYP139 |
| M. gilvum PYR-GCK | Mflv_0056 | - | 2e-37 | 28.85% (357) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv1666c | cyp139 | 0.0 | 75.35% (430) | cytochrome P450 139 CYP139 |
| M. leprae Br4923 | MLBr_02088 | - | 3e-18 | 25.69% (362) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_3962 | - | 6e-33 | 27.80% (428) | cytochrome P450 |
| M. marinum M | MMAR_2475 | cyp139A3 | 0.0 | 74.00% (427) | cytochrome P450 139A3 Cyp139A3 |
| M. smegmatis MC2 155 | MSMEG_0822 | - | 3e-35 | 28.97% (321) | cytochrome P450 |
| M. thermoresistible (build 8) | TH_3255 | - | 4e-39 | 30.73% (358) | PUTATIVE cytochrome P450 |
| M. ulcerans Agy99 | MUL_0473 | cyp51B1 | 2e-32 | 28.49% (372) | cytochrome P450 51B1 Cyp51B1 |
| M. vanbaalenii PYR-1 | Mvan_0245 | - | 6e-40 | 31.08% (325) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0056|M.gilvum_PYR-GCK --MVAGTEPG-VGHLPLAPKNPLPYRRLLTLVRALDTGQLQVRAAGGPIT
TH_3255|M.thermoresistible__bu --MVVTTERADVATLPPAPRNPLPYWRQVRAVRSFHTGQELLRDAGGPVK
Mvan_0245|M.vanbaalenii_PYR-1 --MVGTVEREDLGALPLAPRNPLPYRQQVRAIRTFHTGLETLRDAGGPVT
MSMEG_0822|M.smegmatis_MC2_155 --MVETASPP-LTELPLAPRNTLPCREQIRCLRSFIDGMQRLRDVGGPVT
Mb1694c|M.bovis_AF2122/97 ----------------------MRYPLGEALLALYRWRGPLINAGVGGHG
Rv1666c|M.tuberculosis_H37Rv ----------------------MRYPLGEALLALYRWRGPLINAGVGGHG
MMAR_2475|M.marinum_M ----------------MSTYRTVPYRPGEALLALYRRRGAFIDAGVGRHG
MAV_3106|M.avium_104 ----------------------MRYRPGEALLALYRRRGPVIDAGAGRRG
MAB_3962|M.abscessus_ATCC_1997 MARITSVPCDGETTTYVSPPKLRVARALARLPRLGDTVGLMLDPTFYLFE
MUL_0473|M.ulcerans_Agy99 ---------MTTAIVPRVSGGEEEHGHLEEFRTDPIGLMQRVRDECGDVG
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
:
Mflv_0056|M.gilvum_PYR-GCK RVQVA-------PRWLFPPFVAVFSPRGVRDVLGRNDAFSER--CIVHEE
TH_3255|M.thermoresistible__bu --------------WAIPPIVLVTSPAGIRDVLNRRDALSER--CQVHHE
Mvan_0245|M.vanbaalenii_PYR-1 RLKLA-------PKWLMPPMVVATSPQGARDILARGGGHIDK--TRVHHE
MSMEG_0822|M.smegmatis_MC2_155 RIVLG-------PRWLVPPALLVTSPQGAHDVLSLPDAVADRGGSRNMRQ
Mb1694c|M.bovis_AF2122/97 -------------------YTYLLGAEANRFVFANADAFSWS---QTFES
Rv1666c|M.tuberculosis_H37Rv -------------------YTYLLGAEANRFVFANADAFSWS---QTFES
MMAR_2475|M.marinum_M -------------------FVYLLGPEANRFVFANADAFSWR---ETFES
MAV_3106|M.avium_104 -------------------YTLLLGAEANKFVFANADAFSWR---ATFEN
MAB_3962|M.abscessus_ATCC_1997 KYLRHGPVFT--VKMPYQTYTVLAGSEAATFMSSKDGRECLTVGSSWRFV
MUL_0473|M.ulcerans_Agy99 WFQLAN-----------KHVVLLSGAKANEFFFRSSDEELDQ--AEAYPF
MLBr_02088|M.leprae_Br4923 FPVYRALIDYGPMQLPGMPLTVFSSFSDCDEALRHPLSASDRLKATLAQQ
.
Mflv_0056|M.gilvum_PYR-GCK VRDMAGDSL------FVLPN-EPWRPRKRALQPVFTPQNVRR-FGGHMSR
TH_3255|M.thermoresistible__bu VRHLGGDSL------FVLPT-DPWRARRRALAPVFTPTAVRS-YGGYMSE
Mvan_0245|M.vanbaalenii_PYR-1 MRRLLGANL------FDLTH-EPWLPRRRALQPIFTKQHVRE-FAGHMAT
MSMEG_0822|M.smegmatis_MC2_155 LQRLMGGNL------LDLPH-DRWLPRRRTLQPLFTKKHVPR-FAGHMAA
Mb1694c|M.bovis_AF2122/97 LVPVDGPTA------LIVSDGADHRRRRSVVAPGLRHHHVQR-YVATMVS
Rv1666c|M.tuberculosis_H37Rv LVPVDGPTA------LIVSDGADHRRRRSVVAPGLRHHHVQR-YVATMVS
MMAR_2475|M.marinum_M LVPVDGPTA------LIVSDGEDHRRRRSIVAPGLRHRSVQD-YVATMVS
MAV_3106|M.avium_104 LALVDGPTA------LIVSDGDDHRRRRSVVAPGLRHRQIQD-YVTTMVS
MAB_3962|M.abscessus_ATCC_1997 EEQFGGKDS------LVAVDGPQHKQWRTLLQRGYSREAIADRYSEAIDV
MUL_0473|M.ulcerans_Agy99 MTPIFGKG--------VVFDASPERRKEMLHNSALRGEHMKG-HATTIER
MLBr_02088|M.leprae_Br4923 AIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKVVQA-LEGDIAA
. . : :
Mflv_0056|M.gilvum_PYR-GCK AAEVFVDAWRDGGDVDLDLECRRITMQSLGRSVLGVD-LNESADVIAEHM
TH_3255|M.thermoresistible__bu AAQRVADGWQAAREVDLDAECRRLTMRSLGRSVLGLD-INERADAISEPM
Mvan_0245|M.vanbaalenii_PYR-1 AAQTVADSWADGTELDLDTECRKLTLRALGRSVLGLD-LDEHSDAIAEPL
MSMEG_0822|M.smegmatis_MC2_155 AAQSVAVSWADGATVDLDRACRALTLRALGRSVFGVD-LDQRAEDVGPAL
Mb1694c|M.bovis_AF2122/97 NIDTVIDGWQPGQRLDIYQELRSAVRRSTAESLFGQR-LAVHSDFLGEQL
Rv1666c|M.tuberculosis_H37Rv NIDTVIDGWQPGQRLDIYQELRSAVRRSTAESLFGQR-LAVHSDFLGEQL
MMAR_2475|M.marinum_M TIDNVIDSWRPGQPLDIYQEFRCAVRRSTTESLFGPR-LASHSDYLGRQL
MAV_3106|M.avium_104 CIDRVIDGWRPGQRLDVYQHCRAAVRRSTAESLFGRR-LAVHSDALGEYL
MAB_3962|M.abscessus_ATCC_1997 IDDAVDKHWRPGESVPVLPAMQKLSIAQVGTFLGGVRPTDDDIEDIALVT
MUL_0473|M.ulcerans_Agy99 EVHRMIENWGQEGEIDLLEFFAELTSYTSTSCLIGTK----FRNQLDSRF
MLBr_02088|M.leprae_Br4923 LVDSLLDKGAAAGQFDVIADLAFPLAVAVICRLLGVP-------YEDAPE
. . . : : *
Mflv_0056|M.gilvum_PYR-GCK HVASSYTADRALRPVRAPRWLPTPARRRAAHAVAEMRQVAADMLQVCRDD
TH_3255|M.thermoresistible__bu HIASSYTADRALRPVRAPRWLPTPARRRARAAVATMRRITDEMLQACRAD
Mvan_0245|M.vanbaalenii_PYR-1 RTALEYIADRALQPISAPRWLPTPARRRARAASSTLHKLADKILQACRTD
MSMEG_0822|M.smegmatis_MC2_155 RTSLSWVADRASRPVNLPQWVPTRGQRKARAGNATLHRLAAEILADVRAD
Mb1694c|M.bovis_AF2122/97 QPLLDLTR-RPPQVMRLQQRVNSPGWRRAMAARKRIDDLIDAQIADARTA
Rv1666c|M.tuberculosis_H37Rv QPLLDLTR-RPPQVMRLQQRVNSPGWRRAMAARKRIDDLIDAQIADARTA
MMAR_2475|M.marinum_M QPLIDLTH-RLPQVMQLQQRLNSPGWRRAMAARTRIDELIDAEIANARAE
MAV_3106|M.avium_104 QPLLDLTH-QPPQLVGLQRRINAPAWRRAMAARQRINNLVDTLIAEARAA
MAB_3962|M.abscessus_ATCC_1997 REILKIAPVQHIPKFMLQLPRYVNARSRVARVAQNALALAGHSSASGRRG
MUL_0473|M.ulcerans_Agy99 AHFCHELERGTDPLCYVDPYLPIESFRRRDEARKGLVALVQDIMHQRVAN
MLBr_02088|M.leprae_Br4923 FGRVSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLVKCRRGT
. .
Mflv_0056|M.gilvum_PYR-GCK P---DRDAPLVRALMDARDPETGMALSDDDICNDLLIFMLAGHDTTATAL
TH_3255|M.thermoresistible__bu P---DRDAPLVHALIRATDPETGRGLSDEDICNDLLIFMLAGHDTTATAL
Mvan_0245|M.vanbaalenii_PYR-1 P---TRDAPLVQALIAASDPATGRPLSDDEIRDELIVFMLAGHDTTATTL
MSMEG_0822|M.smegmatis_MC2_155 P---DRDAPLVRALLEARDPETGRGLTDDQICDELVLFMLAGHDTTSTTL
Mb1694c|M.bovis_AF2122/97 P---RPDDHMLTTLISGCS-EEGTTLSDNEIRDSIVSLITAGYETTSGAL
Rv1666c|M.tuberculosis_H37Rv P---RPDDHMLTTLISGCS-EEGTTLSDNEIRDSIVSLITAGYETTSGAL
MMAR_2475|M.marinum_M P---SPDDRMLTALINGRS-EEGCALSDNEIRDSIVSLIAAGYETTSGAL
MAV_3106|M.avium_104 P---NPDDHMLTMLIDGRG-DEGYALNDNEIRDAIVSLVTAGYETTSGAL
MAB_3962|M.abscessus_ATCC_1997 ------QSTLLEDILESCR-DDPNAANQRNMLFHSVLPYFAGVETTSATA
MUL_0473|M.ulcerans_Agy99 PPTDKRDRDMLDVLVSITDEQGNPRFCTDEVTGMFISLMFAGHHTSSGTS
MLBr_02088|M.leprae_Br4923 P-----GEDLISRLIELDE--SGDQLTEEEIIATCGLLLVAGHETTVNLI
:: :: :: ** .*:
Mflv_0056|M.gilvum_PYR-GCK TYALWVLGHHPDVQDRVAAEAA-ALGRRELEPGDVPHLK-YTTQVLLEAL
TH_3255|M.thermoresistible__bu TYALWALGHHPEIQDRVAAEVA-ELPDREITPHDVPRLG-YTVQVLRESL
Mvan_0245|M.vanbaalenii_PYR-1 TYAMWALGHHHDVQDRVRAEVV-GIGDRELTPEDVPALG-YTIQVLHEAL
MSMEG_0822|M.smegmatis_MC2_155 CYSLWALGHHPDIQERVYAEVA-ALGDRELTTDDVPQLT-YTMRVLHEAL
Mb1694c|M.bovis_AF2122/97 AWAIYALLTVPGTWESAASEVARVLGGRVPAADDLSALT-YLNGVVHETL
Rv1666c|M.tuberculosis_H37Rv AWAIYALLTVPGTWESAASEVARVLGGRVPAADDLSALT-YLNGVVHETL
MMAR_2475|M.marinum_M AWATYSLLTLPGAWETAAREVARVLGGTAPSAETLGALT-YLNGVVHETL
MAV_3106|M.avium_104 AWAVYLLLSQPGAWATAAGEVRRVLAGRLPAAADLSGLT-YLNGVVHETL
MAB_3962|M.abscessus_ATCC_1997 TYALYLILRHPDVLCRIQDEVAVMFERGGITHDSLFHSTPVLHGAIMEAM
MUL_0473|M.ulcerans_Agy99 AWTLIELLRHPDAYAAVIDELDELYADGQLVSFHALRQIPRLENVLKETL
MLBr_02088|M.leprae_Br4923 ANAVLAMLRNPSQWKALSSNPQ------------------RAPLVVEETL
: : : .: *::
Mflv_0056|M.gilvum_PYR-GCK RLCPPAAGVGRMAVRDIDVDGHRVQAGTLVAVGIYALHRDPEIWPDPDRF
TH_3255|M.thermoresistible__bu RLCPPAAGVGRLAMSDLAVDGYRVEAGTLLAVGIQAIHRDPSLWPDPMVF
Mvan_0245|M.vanbaalenii_PYR-1 RLCPPAAATARMAMRDVEVDGYRIEAGSMMAVGIYALHRDPALWERPLVF
MSMEG_0822|M.smegmatis_MC2_155 RLCPPGSGTMRMLNEEMTVDGYRVEAGTVAIVNFYAMHRSPTLWDAPERF
Mb1694c|M.bovis_AF2122/97 RLYSPGVISARRVLRDLWFDGHRIRAGRLLIFSAYVTHRLPEIWPEPTEF
Rv1666c|M.tuberculosis_H37Rv RLYSPGVISARRVLRDLWFDGHRIRAGRLLIFSAYVTHRLPEIWPEPTEF
MMAR_2475|M.marinum_M RLYSPGVVSARRLIRDLWFDGHRINSGRLLIFSAYVTHRIPEVWPNPTQF
MAV_3106|M.avium_104 RLYPPGVISARRVMRDLRFEGRRIRSGRLLIFSPYVTHRLPEIWPEPMRF
MAB_3962|M.abscessus_ATCC_1997 RLRPIASFIIRVAAKDFEFHGHQIRSGEGVFIGTTVPHFLSEFYENPMKF
MUL_0473|M.ulcerans_Agy99 RLHPPLIILMRVAKGEFQVEGYPIHEGELVAASPAISNRIAEDFPDPDEF
MLBr_02088|M.leprae_Br4923 RYDPAIHLIGRVAAKDMTIGQTTLTEGDTMVLLLAAANRDPAVYSRPDEF
* . * :. . : * : . : * *
Mflv_0056|M.gilvum_PYR-GCK DPDRFSPEQTAQRD--RWHFLPFAGGARSCIGEHFARLETTLALATIVRS
TH_3255|M.thermoresistible__bu DPDRFAPERFKAMD--RWQFVPFIGGPRSCIGEHFAMLESTLAIATLIRS
Mvan_0245|M.vanbaalenii_PYR-1 DPDRFSAQNSGGRD--RWQYLPFGAGPRSCIGDHFAMLEATLALATIIRS
MSMEG_0822|M.smegmatis_MC2_155 DPDRFSPERSAGRN--RWQYLPFGGGPRSCIGDHFAMLEATLALATVIRA
Mb1694c|M.bovis_AF2122/97 RPLRWDPNAADYRKPAPHEFIPFSGGLHRCIGAVMATTEMTVILARLVAR
Rv1666c|M.tuberculosis_H37Rv RPLRWDPNAADYRKPAPHEFIPFSGGLHRCIGAVMATTEMTVILARLVAR
MMAR_2475|M.marinum_M LPQRWDPAAPDYRKPAPHEFIPFSGGLHRCIGAVMATTELVVLLARLVAR
MAV_3106|M.avium_104 APERWNPDAPGYRRPAPHEFIPFSAGLHRCVGAAMATTEMTVMLARLLAR
MAB_3962|M.abscessus_ATCC_1997 DVDRYGDSAGPNRT--PGAYSPFGRGPHMCVGKGLAESLMQLMLARIIHR
MUL_0473|M.ulcerans_Agy99 VPERYQEPRQEDLIN-RWTWIPFGAGRHRCVGAAFATMQIKAIFSVLLRE
MLBr_02088|M.leprae_Br4923 DPDRPSS-----------RHLAFAVGSHFCLGAALARLEATVTLSAISAR
* .* * : *:* :* :: :
Mflv_0056|M.gilvum_PYR-GCK MRVTSSDNDFPVDVPFTTVAHGPIPAHLTPR-----------
TH_3255|M.thermoresistible__bu VRIRSLDDDFPVEVPFTTVARGPIRAVVSARR----------
Mvan_0245|M.vanbaalenii_PYR-1 AEIRSSDPHFPMIVPFTTVAAEPIRARVKSVNRIPAADSGGR
MSMEG_0822|M.smegmatis_MC2_155 VSVESQNTDLPVETPFTVIAAAPVPARVTRR-----------
Mb1694c|M.bovis_AF2122/97 AMLQLPAQRTHRIRAANFAALRPWPGLTVEIRKSAPAQ----
Rv1666c|M.tuberculosis_H37Rv AMLQLPAQRTHRIRAANFAALRPWPGLTVEIRKSAPAQ----
MMAR_2475|M.marinum_M TRLRLPAQR---IRAANFAALAPKPGLRVEFVDSVPAQ----
MAV_3106|M.avium_104 TRLRLPAQR---LRAANVAALRPTPGLTVEVIDSVPAQ----
MAB_3962|M.abscessus_ATCC_1997 RTLELSSRSYRLSNRVSSSSPSPKFAVRVVSSRR--------
MUL_0473|M.ulcerans_Agy99 YEFEMAQPADSYRNDHSKMVVQLARPARVRYRRRKLSDNRGH
MLBr_02088|M.leprae_Br4923 FPQVQLAGELVYKPNVAMRGMSALPVQV--------------