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VETASPPLTELPLAPRNTLPCREQIRCLRSFIDGMQRLRDVGGPVTRIVLGPRWLVPPALLVTSPQGAHD VLSLPDAVADRGGSRNMRQLQRLMGGNLLDLPHDRWLPRRRTLQPLFTKKHVPRFAGHMAAAAQSVAVSW ADGATVDLDRACRALTLRALGRSVFGVDLDQRAEDVGPALRTSLSWVADRASRPVNLPQWVPTRGQRKAR AGNATLHRLAAEILADVRADPDRDAPLVRALLEARDPETGRGLTDDQICDELVLFMLAGHDTTSTTLCYS LWALGHHPDIQERVYAEVAALGDRELTTDDVPQLTYTMRVLHEALRLCPPGSGTMRMLNEEMTVDGYRVE AGTVAIVNFYAMHRSPTLWDAPERFDPDRFSPERSAGRNRWQYLPFGGGPRSCIGDHFAMLEATLALATV IRAVSVESQNTDLPVETPFTVIAAAPVPARVTRR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0822 | - | - | 100% (455) | cytochrome P450 |
| M. smegmatis MC2 155 | MSMEG_0968 | - | e-137 | 52.08% (457) | cytochrome P450 |
| M. smegmatis MC2 155 | MSMEG_2289 | - | 2e-29 | 28.09% (388) | cytochrome p450 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1694c | cyp139 | 3e-38 | 30.97% (339) | cytochrome P450 139 CYP139 |
| M. gilvum PYR-GCK | Mflv_0056 | - | 1e-141 | 52.09% (455) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv1666c | cyp139 | 3e-38 | 30.97% (339) | cytochrome P450 139 CYP139 |
| M. leprae Br4923 | MLBr_02088 | - | 3e-11 | 26.48% (219) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_1426 | - | 8e-42 | 32.04% (362) | putative cytochrome P450 |
| M. marinum M | MMAR_0852 | cyp185A4 | 1e-150 | 55.56% (450) | cytochrome P450 185A4 Cyp185A4 |
| M. avium 104 | MAV_3106 | - | 2e-35 | 28.97% (321) | P450 heme-thiolate protein |
| M. thermoresistible (build 8) | TH_3255 | - | 1e-140 | 53.41% (455) | PUTATIVE cytochrome P450 |
| M. ulcerans Agy99 | MUL_0604 | cyp185A4 | 1e-146 | 54.34% (449) | cytochrome P450 185A4 Cyp185A4 |
| M. vanbaalenii PYR-1 | Mvan_0245 | - | 1e-163 | 60.14% (444) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1694c|M.bovis_AF2122/97 -----------------------------------------------MRY
Rv1666c|M.tuberculosis_H37Rv -----------------------------------------------MRY
MAV_3106|M.avium_104 -----------------------------------------------MRY
MMAR_0852|M.marinum_M ---MVDSPDVRSLPLAPRN--------------------------PLPYW
MUL_0604|M.ulcerans_Agy99 ---MVDPPDIRSLPLAPRN--------------------------PLPYW
Mflv_0056|M.gilvum_PYR-GCK MVAGTEPG-VGHLPLAPKN--------------------------PLPYR
TH_3255|M.thermoresistible__bu MVVTTERADVATLPPAPRN--------------------------PLPYW
Mvan_0245|M.vanbaalenii_PYR-1 MVGTVEREDLGALPLAPRN--------------------------PLPYR
MSMEG_0822|M.smegmatis_MC2_155 -MVETASPPLTELPLAPRN--------------------------TLPCR
MAB_1426|M.abscessus_ATCC_1997 MSASALQPEPLSAPVEVAAGECPVNHDLYPGGPTFLRWHHTRVGYLKSWR
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMG-----------------TNPPSLVE
Mb1694c|M.bovis_AF2122/97 PLGEALLALYRWRGPLINAG-----------VGGHGYTYLLGAEANRFVF
Rv1666c|M.tuberculosis_H37Rv PLGEALLALYRWRGPLINAG-----------VGGHGYTYLLGAEANRFVF
MAV_3106|M.avium_104 RPGEALLALYRRRGPVIDAG-----------AGRRGYTLLLGAEANKFVF
MMAR_0852|M.marinum_M QQLKALKTLHVGSEALRDAGGSVTRIWLGPKRLVPPMVMVTSPQGARDVL
MUL_0604|M.ulcerans_Agy99 QQLKALKTLHVGSEALRDAGGSVTRIWLGPKRLVPPMVMVTSPQGARDVL
Mflv_0056|M.gilvum_PYR-GCK RLLTLVRALDTGQLQVRAAGGPITRVQVAPRWLFPPFVAVFSPRGVRDVL
TH_3255|M.thermoresistible__bu RQVRAVRSFHTGQELLRDAGGPVK-------WAIPPIVLVTSPAGIRDVL
Mvan_0245|M.vanbaalenii_PYR-1 QQVRAIRTFHTGLETLRDAGGPVTRLKLAPKWLMPPMVVATSPQGARDIL
MSMEG_0822|M.smegmatis_MC2_155 EQIRCLRSFIDGMQRLRDVGGPVTRIVLGPRWLVPPALLVTSPQGAHDVL
MAB_1426|M.abscessus_ATCC_1997 LALGAVWSTYRHTISEYLADLPGQDDVIVARAPMRKAVIVRNPELARHVL
MLBr_02088|M.leprae_Br4923 AQMLLLRLIDPGTRADPFPVYRALIDYGPMQLPGMPLTVFSSFSDCDEAL
: . :
Mb1694c|M.bovis_AF2122/97 ANADAFSWS---QTFESLVPVDGP------TALIVSDGADHRRRRSVVAP
Rv1666c|M.tuberculosis_H37Rv ANADAFSWS---QTFESLVPVDGP------TALIVSDGADHRRRRSVVAP
MAV_3106|M.avium_104 ANADAFSWR---ATFENLALVDGP------TALIVSDGDDHRRRRSVVAP
MMAR_0852|M.marinum_M GRSGALSDRGTLPLLKDLRRAIGE------SVLNLPH-DTWLPRRRTLQP
MUL_0604|M.ulcerans_Agy99 GRSGALSDRGTLPLLKDLRRAIGE------SVLNLPH-DTWLPRRRTLQP
Mflv_0056|M.gilvum_PYR-GCK GRNDAFSER--CIVHEEVRDMAGD------SLFVLPN-EPWRPRKRALQP
TH_3255|M.thermoresistible__bu NRRDALSER--CQVHHEVRHLGGD------SLFVLPT-DPWRARRRALAP
Mvan_0245|M.vanbaalenii_PYR-1 ARGGGHIDK--TRVHHEMRRLLGA------NLFDLTH-EPWLPRRRALQP
MSMEG_0822|M.smegmatis_MC2_155 SLPDAVADRGGSRNMRQLQRLMGG------NLLDLPH-DRWLPRRRTLQP
MAB_1426|M.abscessus_ATCC_1997 VANQDNYIKS--AEYDLLAVGFGR------GLVTDLNEGLWNRNRRLVQP
MLBr_02088|M.leprae_Br4923 RHPLSASDRLKATLAQQAIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSK
. . : :
Mb1694c|M.bovis_AF2122/97 GLRHHHVQRYVATMVSNIDTVIDGWQP----GQRLDIYQELRSAVRRSTA
Rv1666c|M.tuberculosis_H37Rv GLRHHHVQRYVATMVSNIDTVIDGWQP----GQRLDIYQELRSAVRRSTA
MAV_3106|M.avium_104 GLRHRQIQDYVTTMVSCIDRVIDGWRP----GQRLDVYQHCRAAVRRSTA
MMAR_0852|M.marinum_M IFTKQRVAGFAGHMSEAANHILLGWPD----GAEVDLNAASHALVLRVVG
MUL_0604|M.ulcerans_Agy99 IFTKQRVAGFAGHMSEAANHILLGWPD----GAEVDLNAASHALVLRVVG
Mflv_0056|M.gilvum_PYR-GCK VFTPQNVRRFGGHMSRAAEVFVDAWRD----GGDVDLDLECRRITMQSLG
TH_3255|M.thermoresistible__bu VFTPTAVRSYGGYMSEAAQRVADGWQA----AREVDLDAECRRLTMRSLG
Mvan_0245|M.vanbaalenii_PYR-1 IFTKQHVREFAGHMATAAQTVADSWAD----GTELDLDTECRKLTLRALG
MSMEG_0822|M.smegmatis_MC2_155 LFTKKHVPRFAGHMAAAAQSVAVSWAD----GATVDLDRACRALTLRALG
MAB_1426|M.abscessus_ATCC_1997 IFAKRQVDLFAPQMAEAAARTISRWDELYAEGKPVDITAEMNYLTMDIVA
MLBr_02088|M.leprae_Br4923 AFAPKVVQALEGDIAALVDSLLDKGAA----AGQFDVIADLAFPLAVAVI
: : : . .*:
Mb1694c|M.bovis_AF2122/97 ESLFGQRLAVHSDFLG-----------------------------EQLQP
Rv1666c|M.tuberculosis_H37Rv ESLFGQRLAVHSDFLG-----------------------------EQLQP
MAV_3106|M.avium_104 ESLFGRRLAVHSDALG-----------------------------EYLQP
MMAR_0852|M.marinum_M HSVFGLDLQDKADVIT-----------------------------TGVTL
MUL_0604|M.ulcerans_Agy99 HSVFGLDLQDKADVIT-----------------------------TGVTL
Mflv_0056|M.gilvum_PYR-GCK RSVLGVDLNESADVIA-----------------------------EHMHV
TH_3255|M.thermoresistible__bu RSVLGLDINERADAIS-----------------------------EPMHI
Mvan_0245|M.vanbaalenii_PYR-1 RSVLGLDLDEHSDAIA-----------------------------EPLRT
MSMEG_0822|M.smegmatis_MC2_155 RSVFGVDLDQRAEDVG-----------------------------PALRT
MAB_1426|M.abscessus_ATCC_1997 QTMFGIDLSGDMAERMRIYFARLLKLFGVGFIVGAAPPLRWVVDKLAAHG
MLBr_02088|M.leprae_Br4923 CRLLGVPYEDAPEFGR----------------------------------
::*
Mb1694c|M.bovis_AF2122/97 LLDLTR-RPPQVMRLQQRVNSPGWRRAMAARKRIDDLIDAQIADARTA-P
Rv1666c|M.tuberculosis_H37Rv LLDLTR-RPPQVMRLQQRVNSPGWRRAMAARKRIDDLIDAQIADARTA-P
MAV_3106|M.avium_104 LLDLTH-QPPQLVGLQRRINAPAWRRAMAARQRINNLVDTLIAEARAA-P
MMAR_0852|M.marinum_M AAKWAADRSARPVRAPHWLPTPARRRARGAYDAMYKIAADMLAACRAD-P
MUL_0604|M.ulcerans_Agy99 AAKWAADRSARPVRAPHWLPTPARPRARGAYDAMYKIAADMLAACRAD-P
Mflv_0056|M.gilvum_PYR-GCK ASSYTADRALRPVRAPRWLPTPARRRAAHAVAEMRQVAADMLQVCRDD-P
TH_3255|M.thermoresistible__bu ASSYTADRALRPVRAPRWLPTPARRRARAAVATMRRITDEMLQACRAD-P
Mvan_0245|M.vanbaalenii_PYR-1 ALEYIADRALQPISAPRWLPTPARRRARAASSTLHKLADKILQACRTD-P
MSMEG_0822|M.smegmatis_MC2_155 SLSWVADRASRPVNLPQWVPTRGQRKARAGNATLHRLAAEILADVRAD-P
MAB_1426|M.abscessus_ATCC_1997 PDELSSHTPRLAIRALRIGASVAAPRTMKGLRWVERTIDQLIADHRSGRI
MLBr_02088|M.leprae_Br4923 -VSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLVKCRRGT--
. . . . . . . : : *
Mb1694c|M.bovis_AF2122/97 RPDDHMLTTLISGCS-EEGTTLSDNEIRDSIVSLITAGYETTSGALAWAI
Rv1666c|M.tuberculosis_H37Rv RPDDHMLTTLISGCS-EEGTTLSDNEIRDSIVSLITAGYETTSGALAWAI
MAV_3106|M.avium_104 NPDDHMLTMLIDGRG-DEGYALNDNEIRDAIVSLVTAGYETTSGALAWAV
MMAR_0852|M.marinum_M NREAPLIRALIDATDPNTGESLSDQQICDEMVYFMILGEDTTSTVLTYAL
MUL_0604|M.ulcerans_Agy99 SREAPLITALIDATGPNTGESLSDQQICDEMVYFMILGEDTTSTVLTYAL
Mflv_0056|M.gilvum_PYR-GCK DRDAPLVRALMDARDPETGMALSDDDICNDLLIFMLAGHDTTATALTYAL
TH_3255|M.thermoresistible__bu DRDAPLVHALIRATDPETGRGLSDEDICNDLLIFMLAGHDTTATALTYAL
Mvan_0245|M.vanbaalenii_PYR-1 TRDAPLVQALIAASDPATGRPLSDDEIRDELIVFMLAGHDTTATTLTYAM
MSMEG_0822|M.smegmatis_MC2_155 DRDAPLVRALLEARDPETGRGLTDDQICDELVLFMLAGHDTTSTTLCYSL
MAB_1426|M.abscessus_ATCC_1997 ARQDNLLALLMAAEDPETGAKYTDLEIRDELMTFLGAGFETTAAALAWTW
MLBr_02088|M.leprae_Br4923 -PGEDLISRLIELDE--SGDQLTEEEIIATCGLLLVAGHETTVNLIANAV
:: *: * .: :* :: * :** : :
Mb1694c|M.bovis_AF2122/97 YALLTVPGTWESAASEVARVLGGRVPAADDLSALTYLNGVVHETLRLYSP
Rv1666c|M.tuberculosis_H37Rv YALLTVPGTWESAASEVARVLGGRVPAADDLSALTYLNGVVHETLRLYSP
MAV_3106|M.avium_104 YLLLSQPGAWATAAGEVRRVLAGRLPAAADLSGLTYLNGVVHETLRLYPP
MMAR_0852|M.marinum_M WALGRHSQLQDRVAAEAA-ELGDRPLTPADVPRLGYTIQVLQEAMRLCPP
MUL_0604|M.ulcerans_Agy99 WALGQHCQLQDRLAAEAA-ELGDRPLTPADVPRLGYTIQVLQEAMRLRPP
Mflv_0056|M.gilvum_PYR-GCK WVLGHHPDVQDRVAAEAA-ALGRRELEPGDVPHLKYTTQVLLEALRLCPP
TH_3255|M.thermoresistible__bu WALGHHPEIQDRVAAEVA-ELPDREITPHDVPRLGYTVQVLRESLRLCPP
Mvan_0245|M.vanbaalenii_PYR-1 WALGHHHDVQDRVRAEVV-GIGDRELTPEDVPALGYTIQVLHEALRLCPP
MSMEG_0822|M.smegmatis_MC2_155 WALGHHPDIQERVYAEVA-ALGDRELTTDDVPQLTYTMRVLHEALRLCPP
MAB_1426|M.abscessus_ATCC_1997 YLLSRNPDARAKLGQEVDRVLGGRQPTAADVDNLPWTAAVLNEAMRVYPP
MLBr_02088|M.leprae_Br4923 LAMLRNPSQWKALSSNPQ-----------------RAPLVVEETLRYDPA
: : *: *::* ..
Mb1694c|M.bovis_AF2122/97 GVISARRVLRDLWFDGHRIRAGRLLIFSAYVTHRLPEIWPEPTEFRPLRW
Rv1666c|M.tuberculosis_H37Rv GVISARRVLRDLWFDGHRIRAGRLLIFSAYVTHRLPEIWPEPTEFRPLRW
MAV_3106|M.avium_104 GVISARRVMRDLRFEGRRIRSGRLLIFSPYVTHRLPEIWPEPMRFAPERW
MMAR_0852|M.marinum_M GPTVARRAMQDIEVDGYRVQAGTYCLVGVYAMHRDPALWDDPLAFDPDRF
MUL_0604|M.ulcerans_Agy99 GPTVARRAMQDIEVDGYRVQAGTYCLVGVYAMHRDPALWDDPLAFDPDRF
Mflv_0056|M.gilvum_PYR-GCK AAGVGRMAVRDIDVDGHRVQAGTLVAVGIYALHRDPEIWPDPDRFDPDRF
TH_3255|M.thermoresistible__bu AAGVGRLAMSDLAVDGYRVEAGTLLAVGIQAIHRDPSLWPDPMVFDPDRF
Mvan_0245|M.vanbaalenii_PYR-1 AAATARMAMRDVEVDGYRIEAGSMMAVGIYALHRDPALWERPLVFDPDRF
MSMEG_0822|M.smegmatis_MC2_155 GSGTMRMLNEEMTVDGYRVEAGTVAIVNFYAMHRSPTLWDAPERFDPDRF
MAB_1426|M.abscessus_ATCC_1997 ILGLARTAKADDVLGDYPISAGTTVMVLIDSIHHNERVWDDAKTFDPARF
MLBr_02088|M.leprae_Br4923 IHLIGRVAAKDMTIGQTTLTEGDTMVLLLAAANRDPAVYSRPDEFDPDRP
* : . : * . :: :: . * * *
Mb1694c|M.bovis_AF2122/97 DPNAADYRKPAPHEFIPFSGGLHRCIGAVMATTEMTVILARLVARAMLQL
Rv1666c|M.tuberculosis_H37Rv DPNAADYRKPAPHEFIPFSGGLHRCIGAVMATTEMTVILARLVARAMLQL
MAV_3106|M.avium_104 NPDAPGYRRPAPHEFIPFSAGLHRCVGAAMATTEMTVMLARLLARTRLRL
MMAR_0852|M.marinum_M APKKSKGRD--RWQYLPFGGGGRSCLGDHFAMLEASLALATIIREAEIHS
MUL_0604|M.ulcerans_Agy99 APKKSKGRD--RWQYLPFGGGGRSCLGDHFAMLEASLALATIIREAEIHS
Mflv_0056|M.gilvum_PYR-GCK SPEQTAQRD--RWHFLPFAGGARSCIGEHFARLETTLALATIVRSMRVTS
TH_3255|M.thermoresistible__bu APERFKAMD--RWQFVPFIGGPRSCIGEHFAMLESTLAIATLIRSVRIRS
Mvan_0245|M.vanbaalenii_PYR-1 SAQNSGGRD--RWQYLPFGAGPRSCIGDHFAMLEATLALATIIRSAEIRS
MSMEG_0822|M.smegmatis_MC2_155 SPERSAGRN--RWQYLPFGGGPRSCIGDHFAMLEATLALATVIRAVSVES
MAB_1426|M.abscessus_ATCC_1997 LKENLQPEQ--RKAHMPFGAGKRMCVASGFANLEAIIGIAALAQNYELDL
MLBr_02088|M.leprae_Br4923 SS-----------RHLAFAVGSHFCLGAALARLEATVTLSAISARFPQVQ
.:.* * : *:. :* * : :: :
Mb1694c|M.bovis_AF2122/97 P-AQRTHRIRAANFAALRPWPGLTVEIRKSAPAQ--------------
Rv1666c|M.tuberculosis_H37Rv P-AQRTHRIRAANFAALRPWPGLTVEIRKSAPAQ--------------
MAV_3106|M.avium_104 P-AQR---LRAANVAALRPTPGLTVEVIDSVPAQ--------------
MMAR_0852|M.marinum_M L-DGDFPVAIPLPIVPAGPIRARVNQRRPSQEVCTTTLSDSSASSSAS
MUL_0604|M.ulcerans_Agy99 L-DGDFPVAIPLPIVPAGPIRARVNQRRPSQEVCTTTLSDSSASS---
Mflv_0056|M.gilvum_PYR-GCK S-DNDFPVDVPFTTVAHGPIPAHLTPR---------------------
TH_3255|M.thermoresistible__bu L-DDDFPVEVPFTTVARGPIRAVVSARR--------------------
Mvan_0245|M.vanbaalenii_PYR-1 S-DPHFPMIVPFTTVAAEPIRARVKSVNRIPAADSGGR----------
MSMEG_0822|M.smegmatis_MC2_155 Q-NTDLPVETPFTVIAAAPVPARVTRR---------------------
MAB_1426|M.abscessus_ATCC_1997 LPGQQPRREVTFTGGPEGEILMRLRKRHP-------------------
MLBr_02088|M.leprae_Br4923 L-AGELVYKPNVAMRGMSALPVQV------------------------