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VKVLVTGSAGFINGYVVQELLQAGHEVVGIDNYSKYGKVTKSYDDHPNYHFVEGDVKDVDLMFELVEGCE QMVASAARIGGITYFHEYAYDLLAENERIAAAHFDTAIYAYRKGWLKKINVISSSMVFENASIFPTPEKH ITECPPPTSTYGFQKLACEYFAHGAYEQYGLPYTIIRPFNCVGTGEQRALGGREIPSGNVKLAMSHVVPD LVQKVVKGQDPLHILGDGSQVRHYTYGGDLARGIRTCMEHPAALNGDFNLSTPEATTVLELAEVIWRKMR PDTPFRYESDPPFEHDVQLRSPDVHKATQVLGFEATTTLDAMLDEVIPWIVNAVEAGTI
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_2310 | galE5 | - | 100% (339) | UDP-glucose 4-epimerase, GalE5 |
| M. marinum M | MMAR_5133 | galE1 | 6e-17 | 27.16% (324) | UDP-glucose 4-epimerase GalE1 |
| M. marinum M | MMAR_5346 | rmlB_1 | 3e-15 | 22.96% (331) | dTDP-glucose-4,6-dehydratase, RmlB_1 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3658c | galE1 | 9e-19 | 28.13% (327) | UDP-glucose 4-epimerase GALE1 (galactowaldenase) |
| M. gilvum PYR-GCK | Mflv_4753 | - | 1e-11 | 23.12% (333) | NAD-dependent epimerase/dehydratase |
| M. tuberculosis H37Rv | Rv3634c | galE1 | 9e-19 | 28.13% (327) | UDP-glucose 4-epimerase GALE1 (galactowaldenase) |
| M. leprae Br4923 | MLBr_00204 | rmlB2 | 2e-17 | 27.71% (332) | putative sugar-nucleotide dehydratase |
| M. abscessus ATCC 19977 | MAB_0503 | - | 2e-16 | 27.84% (334) | UDP-glucose 4-epimerase GalE1 |
| M. avium 104 | MAV_4084 | - | 1e-20 | 28.70% (331) | UDP-glucuronic acid decarboxylase 1 |
| M. smegmatis MC2 155 | MSMEG_5956 | - | 7e-55 | 37.46% (331) | NAD dependent epimerase/dehydratase family protein |
| M. thermoresistible (build 8) | TH_3729 | - | 3e-10 | 27.52% (298) | PUTATIVE UDP-galactose 4-epimerase |
| M. ulcerans Agy99 | MUL_1512 | - | 0.0 | 98.82% (339) | UDP-glucose 4-epimerase |
| M. vanbaalenii PYR-1 | Mvan_5389 | - | 3e-10 | 27.06% (303) | UDP-glucose 4-epimerase |
CLUSTAL 2.0.9 multiple sequence alignment
TH_3729|M.thermoresistible__bu --------------------------------MTWLVTGGAGYIGSHVVR
Mvan_5389|M.vanbaalenii_PYR-1 --------------------------------MTWLVTGGAGYIGSHVVR
Mb3658c|M.bovis_AF2122/97 --------------------------------MRALVTGAAGFIGSTLVD
Rv3634c|M.tuberculosis_H37Rv --------------------------------MRALVTGAAGFIGSTLVD
MLBr_00204|M.leprae_Br4923 ---------------------------MYGEPVRALVTGAAGFIGSTLVD
MAB_0503|M.abscessus_ATCC_1997 --------------------------------MRAMVTGAAGFIGSTLVD
MMAR_2310|M.marinum_M --------------------------------MKVLVTGSAGFINGYVVQ
MUL_1512|M.ulcerans_Agy99 --------------------------------MKVLVTGSAGFINGYVVQ
MSMEG_5956|M.smegmatis_MC2_155 -------------------------------MSRILVTGGVGTIGSAVVR
MAV_4084|M.avium_104 MVDMTGATTPKGNGETGFHARPDGYQSPMRSLTRVLITGGAGFLGAHLCA
Mflv_4753|M.gilvum_PYR-GCK -----------------MTASEIVSPRELDRAATFYVAGHRGLVGSAIVR
::* * :.. :
TH_3729|M.thermoresistible__bu ALLEADLPVVVIDDLSTGLEKFVPSEVPLVRGTLLDADLVAR----ALRE
Mvan_5389|M.vanbaalenii_PYR-1 ALRGADLDVVVIDDLSTGRAEFVPDGVPLVRANLLDADAVRT----TLDA
Mb3658c|M.bovis_AF2122/97 RLLADGHSVVGLDNFATGRATNLEHLADNSAHVFVEADIVTADLHAILEQ
Rv3634c|M.tuberculosis_H37Rv RLLADGHSVVGLDNFATGRATNLEHLADNSAHVFVEADIVTADLHAILEQ
MLBr_00204|M.leprae_Br4923 RLLADGHTVVGLDNFATGHAANLEHLASTPALAFVEADIVTADLQTILDE
MAB_0503|M.abscessus_ATCC_1997 RLLADGHEVTGLDNLATGKVANLEAAEANAKFTFVKDDIVEADLDAVVAE
MMAR_2310|M.marinum_M ELLQAGHEVVGIDNYSK-YGKVTKSYDDHPNYHFVEGDVKDVDLMFELVE
MUL_1512|M.ulcerans_Agy99 ELLQAGHEVIGIDNYSK-YGEVTKSYDDHPNYHFVEGDVKDVDLMFELVE
MSMEG_5956|M.smegmatis_MC2_155 RLLHESAYEIRVCDQRP-APQWMN-----EACEIRTGDLRSADEARAAVD
MAV_4084|M.avium_104 RLLDDGVEVVSVDDLST--SGPAVRFGDRPGYRFVQRDVCDPGLIDEVGS
Mflv_4753|M.gilvum_PYR-GCK RLR-----VAGFDNIVGKTSAELDLKNRDAVFDFMS------------EI
* . : :
TH_3729|M.thermoresistible__bu HRVSGVIHIAGFKYAGVSVQQPLHTYEQNVSAMVTLLKAMQDTG----VD
Mvan_5389|M.vanbaalenii_PYR-1 YGVSGVIHIAGYKYAGESVRRPLHTYQQNVSAMVTLLDAMSDAG----VD
Mb3658c|M.bovis_AF2122/97 HRPEVVFHLAAQIDVRRSVADPQFDAAVNVIGTVRLAEAARQTG----VR
Rv3634c|M.tuberculosis_H37Rv HRPEVVFHLAAQIDVRRSVADPQFDAAVNVIGTVRLAEAARQTG----VR
MLBr_00204|M.leprae_Br4923 HRPEVVFHLAAQIDVRHSVVDPQFDASVNVIGTVRLAEAARHTG----VR
MAB_0503|M.abscessus_ATCC_1997 YSPEVIFHLAAQIDVRHSVADPQFDSSVNVVGTVRLAEAARKAG----VR
MMAR_2310|M.marinum_M GCEQMVASAARIGGITYFHEYAYDLLAENERIAAAHFDTAIYAYRKGWLK
MUL_1512|M.ulcerans_Agy99 GCEQMVASAARIGGITYFHEYAYDLLAENERIAAAHFDTAIYAYRKGWLK
MSMEG_5956|M.smegmatis_MC2_155 GCTHVIHLAAIVGGIANFHRLPHTLLEMNTGLYNSVFSAALREG----VE
MAV_4084|M.avium_104 G-FDAVFHLASAASPVDYQRRPIQTLRTGSAGTATALEIAERAG-----A
Mflv_4753|M.gilvum_PYR-GCK KPRYVVLAAAKVGGILANSNYPVDFLSDNIRIQVNVLDAARDCG----VE
: * . . .
TH_3729|M.thermoresistible__bu MMVFSSS-AATFGTPDVDLVTETTPTR-----PESPYGESKLIGEWLLAD
Mvan_5389|M.vanbaalenii_PYR-1 RIVFSSS-AATYGTPDTAVVDETTATR-----PESPYGESKLIGEWLLRD
Mb3658c|M.bovis_AF2122/97 KIVHTSSGGSIYGTPPEYPTPETAPTD-----PASPYAAGKVAGEIYLNT
Rv3634c|M.tuberculosis_H37Rv KIVHTSSGGSIYGTPPEYPTPETAPTD-----PASPYAAGKVAGEIYLNT
MLBr_00204|M.leprae_Br4923 KIVHTSSGGSIYGTPSQYPTPETVPTD-----PTSPYAAGKVAGEIYLNT
MAB_0503|M.abscessus_ATCC_1997 KIVHTSSGGSIYGTPKQIPTSETVPTD-----PHSPYAAGKVAGEIYLNT
MMAR_2310|M.marinum_M KINVISS-SMVFENASIFPTPEKHITEC--PPPTSTYGFQKLACEYFAHG
MUL_1512|M.ulcerans_Agy99 KINVISS-SMVFENASIFPTPEKHITEC--PPPTSTYVFQKLACEYFAHG
MSMEG_5956|M.smegmatis_MC2_155 RLVYVSS-SMVFEQATQFPTTEEHLLDC--RPPRSAYGFSKLTGEIYCRA
MAV_4084|M.avium_104 RFVLAST-SEVYGDPESHPQRESYWGNVNPVGPRSVYDEAKRYAEALTFA
Mflv_4753|M.gilvum_PYR-GCK RLLFLGS-SCIYPKFAEQPIREDSLLTGHLEPTNDAYAIAKIAGILHVQA
: .: . : * . . * *
TH_3729|M.thermoresistible__bu VGRATGLRHTSLRYFNVVGSGSP----------ELFDVSPHNLFPLVFDM
Mvan_5389|M.vanbaalenii_PYR-1 IGVATGLRHTSLRYFNVVGSGPD----------GVFDVSPFNLFPKVFDM
Mb3658c|M.bovis_AF2122/97 FRHLYGLDCSHIAPANVYGPRQD----------PHGEAG---VVAIFAQA
Rv3634c|M.tuberculosis_H37Rv FRHLYGLDCSHIAPANVYGPRQD----------PHGEAG---VVAIFAQA
MLBr_00204|M.leprae_Br4923 FRHLCGLDCSHIAPANVYGPRQD----------PYGEAG---VVAIFVQA
MAB_0503|M.abscessus_ATCC_1997 FRHLYGLECSHIAPANVYGPRQD----------PHGEAG---VVAIFAQA
MMAR_2310|M.marinum_M AYEQYGLPYTIIRPFNCVGTGEQRALGGREIPSGNVKLAMSHVVPDLVQK
MUL_1512|M.ulcerans_Agy99 AYEQYGLPYTIIRPFNCVGTGEQRALGGRGIPSGNVKLAMSHVVPDLVQK
MSMEG_5956|M.smegmatis_MC2_155 VHEEHGLPFTICRPFNAYGPGE--------LP--DTEPGIAHAVPDLIRK
MAV_4084|M.avium_104 YHRLGRADVGVARIFNTYGPGMR--------------ADDGRMVPTFCLQ
Mflv_4753|M.gilvum_PYR-GCK VRRQYGLPWISAMPTNLYGPNDN------------YSPTGSHVLPALIRR
* *. .. .
TH_3729|M.thermoresistible__bu LYRGE-TPRINGDDYPTPDGTCVRDYIHVADLALAHVAAARRLQAGEPVE
Mvan_5389|M.vanbaalenii_PYR-1 LVHGQ-TPRINGDDYPTPDGTCVRDYIHVEDVAAAHVAAAHRLESGLPIE
Mb3658c|M.bovis_AF2122/97 LLSGK-PTRVFGD------GTNTRDYVFVDDVVDAFVRVSADVGGGL---
Rv3634c|M.tuberculosis_H37Rv LLSGK-PTRVFGD------GTNTRDYVFVDDVVDAFVRVSADVGGGL---
MLBr_00204|M.leprae_Br4923 LLSDR-PTKVFGD------GTHTRDYVFVDDVVDAFIKASGDAGGGQ---
MAB_0503|M.abscessus_ATCC_1997 LLSGR-STKVFGD------GGNTRDYVFVDDVVEAFVRASGPDGGGQ---
MMAR_2310|M.marinum_M VVKGQDPLHILGD------GSQVRHYTYGGDLARGIRTCMEHPAALNG--
MUL_1512|M.ulcerans_Agy99 VVKGQDPLHILGD------GSQVRHYTYGGDLARGIRTCMEHPAALNG--
MSMEG_5956|M.smegmatis_MC2_155 ALSGQHPLQIFGS------GTQTRTLTHVDDIADGIVTAMFHPAGENQ--
MAV_4084|M.avium_104 ALRGD-PLTVSGT------GLQTRSLCYVDDTITGLIALAHSDFAGP---
Mflv_4753|M.gilvum_PYR-GCK YDEAVASRAVSVTNWG--TGSPRREFLHSDDMADACLHLLENYDGPEQ--
. : * * . * . .
TH_3729|M.thermoresistible__bu PVYNLGSGSGTSVREIMTAIRKVTGVDFV---PEIAPRRPGDPARIVASG
Mvan_5389|M.vanbaalenii_PYR-1 PVYNLGSGSGTSVREIMTTMRAVTGVDFE---PDVAARRAGDPARIVAAG
Mb3658c|M.bovis_AF2122/97 -RFNIGTGKETSDRQLHSAVAAAVGGPDD---PEFHPPRLGDLKRSCLDI
Rv3634c|M.tuberculosis_H37Rv -RFNIGTGKETSDRQLHSAVAAAVGGPDD---PEFHPPRLGDLKRSCLDI
MLBr_00204|M.leprae_Br4923 -RFNIGTGIETSDRQLHTAVSAAVGGPDD---PEFHPPRLGDLKRSCLDI
MAB_0503|M.abscessus_ATCC_1997 -RFNVGTGVETSDRQLHSLVAAAAGAPDD---PEFHPPRLGDLRQSCLDV
MMAR_2310|M.marinum_M -DFNLSTPEATTVLELAEVIWRKMRPDTP-FRYESDPPFEHDVQLRSPDV
MUL_1512|M.ulcerans_Agy99 -DFNLSTPEATTVLELAEVIWRKMRPDTP-FRYESDPPFEHDVQLRSPDV
MSMEG_5956|M.smegmatis_MC2_155 -DFNISASEEHTIAEIAQMIWTACGLDPEDFALENVPTFEVDVQRRWPSV
MAV_4084|M.avium_104 --VNIGNPTELTVLSAAELIRELAGSTST---IQFTPPATDDPQRRCPDI
Mflv_4753|M.gilvum_PYR-GCK --VNVGSGTDVTIREIAESVAAAVGFSGE---THWDTTKPDGTPQKLLDV
*:. : . : . . .
TH_3729|M.thermoresistible__bu ELAARDLGWRMRHTLEDMVKSAWEAR-QRAGDAYPR-------------
Mvan_5389|M.vanbaalenii_PYR-1 DLAARDLDWRMRHSLTDMVASAWSALPSRATDEAAP-------------
Mb3658c|M.bovis_AF2122/97 GLAERVLGWRPQIELADGVRRTVEYFRHKHTD-----------------
Rv3634c|M.tuberculosis_H37Rv GLAERVLGWRPQIELADGVRRTVEYFRHKHTD-----------------
MLBr_00204|M.leprae_Br4923 GLATTVLGWSPQVQLDDGVRRTVEYFRAAQRS-----------------
MAB_0503|M.abscessus_ATCC_1997 GLAKRVLGWEPRVPLADGIRRTVDFFRS---------------------
MMAR_2310|M.marinum_M HKATQVLGFEATTTLDAMLDEVIPWIVN--AVEAGTI------------
MUL_1512|M.ulcerans_Agy99 HKATQVLGFEATTTLDAMLDEVIPWIVN--AVEAGTI------------
MSMEG_5956|M.smegmatis_MC2_155 EKARMLLGWQARVDLRDGIATTVEWLREQQCIARNS-------------
MAV_4084|M.avium_104 RLARQRLGWRPRVDYRTGLSTTLAWFAERAGRTGESAQQLVATTDRRTR
Mflv_4753|M.gilvum_PYR-GCK SKLT-QAGWTSKISLQEGIERTVAWYREHVGALRG--------------
.: : .