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MEILVIGGAGFQGSHLTESLLADGHWVTVLNTPSKNTTRNMQGFQSHERVSFISGSVTDGETVYRAVRDH HVVFHLAARTNVDESLSDPKSFLETNVMGTYRALEAVRRYRNRLIYVSTCEVYGDGHNLEEGQRLDEHAE LKPNSPYAASKAAADRLCYSYFRSFGIDVTIVRPFNIFGIRQKTGRFGALIPRLVRQAINGKNLTIFGAG TSSRDYLYISDIVNAYNLILQTPSLRGQTINFASGKDTCVKDIVEYVAGKFDATIEHRDARPGEVQRFPA DISLARSIGFEPQVDIWEGIDRYIAWAKDQPQHAYELDGLGDRSTANG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_5346 | rmlB_1 | - | 100% (328) | dTDP-glucose-4,6-dehydratase, RmlB_1 |
| M. marinum M | MMAR_1082 | rmlB | 1e-35 | 32.27% (313) | dTDP-glucose-4,6-dehydratase, RmlB |
| M. marinum M | MMAR_5133 | galE1 | 3e-32 | 29.45% (309) | UDP-glucose 4-epimerase GalE1 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3813 | rfbB | 1e-160 | 82.41% (324) | dTDP-glucose 4,6-dehydratase RfbB |
| M. gilvum PYR-GCK | Mflv_3296 | - | 5e-36 | 33.87% (310) | dTDP-glucose 4,6-dehydratase |
| M. tuberculosis H37Rv | Rv3784 | - | 1e-160 | 82.41% (324) | dTDP-glucose 4,6-dehydratase |
| M. leprae Br4923 | MLBr_01964 | rmlB | 5e-38 | 33.23% (316) | dTDP-glucose 4,6-dehydratase |
| M. abscessus ATCC 19977 | MAB_3779 | - | 9e-39 | 33.44% (311) | dTDP-glucose 4,6-dehydratase RmlB |
| M. avium 104 | MAV_4406 | rfbB | 1e-37 | 33.65% (315) | dTDP-glucose 4,6-dehydratase |
| M. smegmatis MC2 155 | MSMEG_1512 | rfbB | 3e-37 | 34.08% (314) | dTDP-glucose 4,6-dehydratase |
| M. thermoresistible (build 8) | TH_0330 | rfbB | 1e-34 | 34.08% (267) | dTDP-glucose 4,6-dehydratase |
| M. ulcerans Agy99 | MUL_0840 | rmlB | 8e-36 | 32.27% (313) | dTDP-glucose-4,6-dehydratase, RmlB |
| M. vanbaalenii PYR-1 | Mvan_1365 | - | 1e-34 | 31.87% (320) | dTDP-glucose 4,6-dehydratase |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_4406|M.avium_104 -------------MRLLVTGGAGFIGANFVHSTVREHPEDS--VTVLDAL
MUL_0840|M.ulcerans_Agy99 -------------MRLLVTGGAGFIGANFVHSSVREYPDDA--VTVLDAL
MLBr_01964|M.leprae_Br4923 -----------MTMRLLVTGGAGFIGANFVHNAVRDHPDDT--VTVLDAM
MSMEG_1512|M.smegmatis_MC2_155 -------------MRLLVTGGAGFIGANFVHLALREARTSS--ITVLDAL
TH_0330|M.thermoresistible__bu VAAIVAAVRCAAAVSSRSSSGGSIRPRSITPSSEKNPRSEAXXXTGLDAF
Mvan_1365|M.vanbaalenii_PYR-1 -------------MRLLVTGGAGFIGANFVRTTVQQRPDVQ--VTVLDSL
MAB_3779|M.abscessus_ATCC_1997 -------------MRILVTGGAGFIGANFVHATVRERPDVS--VTVLDAL
Mflv_3296|M.gilvum_PYR-GCK ------------MARLLVTGGAGFIGSNFVHH-VLAHTDHH--VTVLDKL
Mb3813|M.bovis_AF2122/97 -------------MEILVTGGAGFQGSHLTESLLANG----HWVTVLDKS
Rv3784|M.tuberculosis_H37Rv -------------MEILVTGGAGFQGSHLTESLLANG----HWVTVLDKS
MMAR_5346|M.marinum_M -------------MEILVIGGAGFQGSHLTESLLADG----HWVTVLNTP
.*..: :. * *:
MAV_4406|M.avium_104 TYAGRRESLAGVEDS-IRLVVGDITDAELVSRLVAESDAVVHFAAESHVD
MUL_0840|M.ulcerans_Agy99 TYAGRRESLADLEDA-IRLVEGDITDAELVSQLVAESDAVVHFAAESHVD
MLBr_01964|M.leprae_Br4923 TYAGRHESLADVDHA-VRLVQGNITDTKLVFRLVAESDVVVHFAAETHVD
MSMEG_1512|M.smegmatis_MC2_155 TYAGSRESLAPVADR-IRLVQGDITDAALVGDLVAESDAVVHFAAETHVD
TH_0330|M.thermoresistible__bu TYAGSRESLAPVADR-IRVVEGDVTDSDLVDKLVAESDAVVHFAAESHVD
Mvan_1365|M.vanbaalenii_PYR-1 TYAGSRESLRGVDSQ-IRLVEGDITDAELVGKLVADSDAVVHFAAETHVD
MAB_3779|M.abscessus_ATCC_1997 TYAGSSESLAPVAAA-VQLVQGDICDPDTVERLVADSDVVVHFAAETHND
Mflv_3296|M.gilvum_PYR-GCK TYAGNRASLDGLPERRLDFVHGDVADADLVDELVAGTDAVVHYAAESHND
Mb3813|M.bovis_AF2122/97 SRNAVRNMQGFRSHDRAAFISGSVTDGQTIDRAVRDHHVVFHLAAHVNVD
Rv3784|M.tuberculosis_H37Rv SRNAVRNMQGFRSHDRAAFISGSVTDGQTIDRAVRDHHVVFHLAAHVNVD
MMAR_5346|M.marinum_M SKNTTRNMQGFQSHERVSFISGSVTDGETVYRAVRDHHVVFHLAARTNVD
: .: *.: * : * ..*.* **. : *
MAV_4406|M.avium_104 NALAGPEPFLHTNVVGTFTILEAVRRHG----VRLHHISTDEVYGD-LEL
MUL_0840|M.ulcerans_Agy99 NALDNPEPFVHTNVLGTFTILEAVRRHG----VRLHHISTDEVYGD-LEL
MLBr_01964|M.leprae_Br4923 NALDDPEPFLRTNVIGTFTILEAVRHHS----VRLHHISTDEVYGD-LEL
MSMEG_1512|M.smegmatis_MC2_155 NALADPEPFLHSNVVGTYTILEAVRRHN----VRLHHVSTDEVYGD-LEL
TH_0330|M.thermoresistible__bu NALAEPEPFLRTNVVGTFTVLEAVRRHR----VRLHHISTDEVYGD-LPL
Mvan_1365|M.vanbaalenii_PYR-1 NALADPEPFVHSNVLGTFTVLEAVRHASVTKPVRLHHISTDEVYGD-LEL
MAB_3779|M.abscessus_ATCC_1997 NSLADPSPFLRSNIIGTYTLLEAVRRHQ----VRLHHISTDEVFGD-LEL
Mflv_3296|M.gilvum_PYR-GCK NSLDRPEPFLHSNVIGTFTVLEAVRRHG----RRLHHVSTDEVYGD-LEL
Mb3813|M.bovis_AF2122/97 QSLGDPESFLETNVMGTYRVLEAVRRYR----NRLIYVSTCEVYGDGHNL
Rv3784|M.tuberculosis_H37Rv QSLGDPESFLETNVMGTYRVLEAVRRYR----NRLIYVSTCEVYGDGHNL
MMAR_5346|M.marinum_M ESLSDPKSFLETNVMGTYRALEAVRRYR----NRLIYVSTCEVYGDGHNL
::* *..*:.:*::**: *****: ** ::** **:** *
MAV_4406|M.avium_104 DDPNRFTESTPYNPSSPYSATKAAADMLVRAWVRSYGVRATISNCSNNYG
MUL_0840|M.ulcerans_Agy99 HDPARFTEATPYNPSSPYSATKAGADMLVRAWVRSYGVAATISNCSNNYG
MLBr_01964|M.leprae_Br4923 DEPTRFTESTPYNPSSPYSATKAAGDMLVRAWVRSYGVRATISNCSNNYG
MSMEG_1512|M.smegmatis_MC2_155 DNPARFNETTPYNPSSPYSSTKAAADLLVRAWVRSYGVRATISNCSNNYG
TH_0330|M.thermoresistible__bu HDPRRFTESTPYNPSSPYSSTKAAADMLVRAWVRSYGVAATISNCSNNYG
Mvan_1365|M.vanbaalenii_PYR-1 DDPARFTDATPYNPSSPYSSTKAAADMLVRAWVRSYRVAATISNCSNNYG
MAB_3779|M.abscessus_ATCC_1997 DDPNRFTETTPYNPSSPYSATKASADLLVRAWIRSFGISATISNCSNNYG
Mflv_3296|M.gilvum_PYR-GCK DDPARFTESSPYNPSSPYSSTKAGSDLLVRAWTRSFGVAATISNCSNNYG
Mb3813|M.bovis_AF2122/97 KEGERLDEHAELKPNSPYGASKAAADRLCYSYFRSYGLDVTIVRPFNIFG
Rv3784|M.tuberculosis_H37Rv KEGERLDEHAELKPNSPYGASKAAADRLCYSYFRSYGLDVTIVRPFNIFG
MMAR_5346|M.marinum_M EEGQRLDEHAELKPNSPYAASKAAADRLCYSYFRSFGIDVTIVRPFNIFG
.: *: : : :*.***.::**..* * :: **: : .** . * :*
MAV_4406|M.avium_104 PYQHVEKF---IPRQITNVLTGRRPKLYGTGANVRDWIHVDDHNSAVRRI
MUL_0840|M.ulcerans_Agy99 PYQHIEKF---IPRQITNVLTGRRPKLYGTGANVRDWIHVDDHNSAVRRI
MLBr_01964|M.leprae_Br4923 PYQHVEKF---IPRQITNVLTGRRPKLYGTGVNVRDWIHVDDHNSAVWQI
MSMEG_1512|M.smegmatis_MC2_155 PYQHVEKF---IPRQITNVLTGRRPKLYGAGANVRDWIHVDDHNSAVWRI
TH_0330|M.thermoresistible__bu PYQHVEKF---IPRQITNVLTGRRPKLYGTGANVRDWIHVEDHNDAVWRI
Mvan_1365|M.vanbaalenii_PYR-1 PYQHVEKF---IPRQITNVLTGRRPELYGTGANVRDWIHVDDHNSAVWRI
MAB_3779|M.abscessus_ATCC_1997 PYQHVEKF---IPRQITNILTGRRPRLYGAGANVRDWIHVDDHNSAVWRI
Mflv_3296|M.gilvum_PYR-GCK PYQHVEKF---IPRQITNVLWGIRPRLYGEGRNVRDWIHADDHSSAVLLI
Mb3813|M.bovis_AF2122/97 VRQKAGRFGALIPRLVRQGINGEGLTIFGAGSATRDYLYVSDIVGAYNLV
Rv3784|M.tuberculosis_H37Rv VRQKAGRFGALIPRLVRQGINGEGLTIFGAGSATRDYLYVSDIVGAYNLV
MMAR_5346|M.marinum_M IRQKTGRFGALIPRLVRQAINGKNLTIFGAGTSSRDYLYISDIVNAYNLI
*: :* *** : : : * ::* * **::: .* .* :
MAV_4406|M.avium_104 LESGEIGRTYLISSEGERDNLTVLRTLLQMMGRDPDDFDHVTDRVGHDLR
MUL_0840|M.ulcerans_Agy99 LEKGQIGKTYLISSEGERDNLSVLRTLLRMMDRDPDDFDHVVDRVGHDLR
MLBr_01964|M.leprae_Br4923 LEKGQIGRTYLIGAENGHNNLTVLRTLLQMMGRDPNDFDHVTDRVGHDLR
MSMEG_1512|M.smegmatis_MC2_155 LTDGTIGRTYLIGAECERNNLTVMRTILKLMGRDPDDFDHVTDRAGHDLR
TH_0330|M.thermoresistible__bu LTAGQIGRTYLIGADGERDNRTVLRTILKLMDRDPDDFDHVTDRAGHDLR
Mvan_1365|M.vanbaalenii_PYR-1 LHDGTVGRTYLIGADGERDNLSVMRTILRLMGRSPEDFDHVTDRVGHDLR
MAB_3779|M.abscessus_ATCC_1997 IEAGTIGRTYLIGADGERDNLSVLHTILELMGKSSDDFDHVTDRAGHDLR
Mflv_3296|M.gilvum_PYR-GCK LEKGRIGETYLIGANGEKDNKTVVELILTLMGEDADAYDRVPDRLGHDLR
Mb3813|M.bovis_AF2122/97 LRTPTLRGQAINFASGK--DTRVRDIVEYVADKFGARIEHRDARPGEVQR
Rv3784|M.tuberculosis_H37Rv LRTPTLRGQAINFASGK--DTRVRDIVEYVADKFGARIEHRDARPGEVQR
MMAR_5346|M.marinum_M LQTPSLRGQTINFASGK--DTCVKDIVEYVAGKFDATIEHRDARPGEVQR
: : : :. : * : : .. :: * *. *
MAV_4406|M.avium_104 YAIDPSTLYDELCWAPKHTDFEEGLRETIDWYRANESWWRPLKDASEARY
MUL_0840|M.ulcerans_Agy99 YAIDPSLLYNELAWAPKHTDFEEGLRTTIDWYRANESWWRPLKDAAEARY
MLBr_01964|M.leprae_Br4923 YAIDPTPLYNELCWAPKHANFDEGLRATIDWYRNNESWWRPLKDAVEARY
MSMEG_1512|M.smegmatis_MC2_155 YAIDPSTLQDELGWAPKHTDFEAGLTDTIDWYRANESWWRPLKDTVEAKY
TH_0330|M.thermoresistible__bu YAIDPSALIDELGWTPRHTDFEAGLRDTIQWYRDNEDWWRPLKDATEDAY
Mvan_1365|M.vanbaalenii_PYR-1 YAIDPTPLRDELGWRPEHTDFESGLRDTIDWYRDNESWWGPLKDAVEATY
MAB_3779|M.abscessus_ATCC_1997 YAIDPTPLRDELGWKPTHSDFTGGLAATIDWYRRNEEWWRPIKDNVESQY
Mflv_3296|M.gilvum_PYR-GCK YAIDPTKLREELGWQPGYGDFEHGLAATIEWYRTHEDWWTPAKEATEAFY
Mb3813|M.bovis_AF2122/97 FPADIS-LAKSIGFQP-QVEIWDGIDRYINWAKDQPQYPYEQDGFSGSSV
Rv3784|M.tuberculosis_H37Rv FPADIS-LAKSIGFQP-QVEIWDGIDRYINWAKDQPQYPYEQDGFSGSSV
MMAR_5346|M.marinum_M FPADIS-LARSIGFEP-QVDIWEGIDRYIAWAKDQPQHAYELDGLGDRST
:. * : * .: : * :: *: * * : : . .
MAV_4406|M.avium_104 EERGQ
MUL_0840|M.ulcerans_Agy99 QERGQ
MLBr_01964|M.leprae_Br4923 EERGR
MSMEG_1512|M.smegmatis_MC2_155 QERGQ
TH_0330|M.thermoresistible__bu AERGQ
Mvan_1365|M.vanbaalenii_PYR-1 QRRRR
MAB_3779|M.abscessus_ATCC_1997 AARGQ
Mflv_3296|M.gilvum_PYR-GCK ARIGQ
Mb3813|M.bovis_AF2122/97 L----
Rv3784|M.tuberculosis_H37Rv L----
MMAR_5346|M.marinum_M ANG--