For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
VKVLVTGSAGFINGYVVQELLQAGHEVIGIDNYSKYGEVTKSYDDHPNYHFVEGDVKDVDLMFELVEGCE QMVASAARIGGITYFHEYAYDLLAENERIAAAHFDTAIYAYRKGWLKKINVISSSMVFENASIFPTPEKH ITECPPPTSTYVFQKLACEYFAHGAYEQYGLPYTIIRPFNCVGTGEQRALGGRGIPSGNVKLAMSHVVPD LVQKVVKGQDPLHILGDGSQVRHYTYGGDLARGIRTCMEHPAALNGDFNLSTPEATTVLELAEVIWRKMR PDTPFRYESDPPFEHDVQLRSPDVHKATQVLGFEATTTLDAMLDEVIPWIVNAVEAGTI
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_1512 | - | - | 100% (339) | UDP-glucose 4-epimerase |
| M. ulcerans Agy99 | MUL_4210 | galE1 | 2e-16 | 26.85% (324) | UDP-glucose 4-epimerase GalE1 |
| M. ulcerans Agy99 | MUL_0635 | galE3 | 3e-10 | 23.61% (360) | UDP-glucose 4-epimerase, GalE3 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3658c | galE1 | 6e-18 | 27.83% (327) | UDP-glucose 4-epimerase GALE1 (galactowaldenase) |
| M. gilvum PYR-GCK | Mflv_4753 | - | 5e-11 | 22.22% (333) | NAD-dependent epimerase/dehydratase |
| M. tuberculosis H37Rv | Rv3634c | galE1 | 6e-18 | 27.83% (327) | UDP-glucose 4-epimerase GALE1 (galactowaldenase) |
| M. leprae Br4923 | MLBr_00204 | rmlB2 | 8e-17 | 27.41% (332) | putative sugar-nucleotide dehydratase |
| M. abscessus ATCC 19977 | MAB_0503 | - | 2e-15 | 27.54% (334) | UDP-glucose 4-epimerase GalE1 |
| M. marinum M | MMAR_2310 | galE5 | 0.0 | 98.82% (339) | UDP-glucose 4-epimerase, GalE5 |
| M. avium 104 | MAV_4084 | - | 3e-20 | 28.40% (331) | UDP-glucuronic acid decarboxylase 1 |
| M. smegmatis MC2 155 | MSMEG_5956 | - | 8e-54 | 37.16% (331) | NAD dependent epimerase/dehydratase family protein |
| M. thermoresistible (build 8) | TH_1114 | - | 8e-10 | 24.12% (369) | PROBABLE CHOLESTEROL DEHYDROGENASE |
| M. vanbaalenii PYR-1 | Mvan_5389 | - | 7e-09 | 26.40% (303) | UDP-glucose 4-epimerase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3658c|M.bovis_AF2122/97 --------------------------------MRALVTGAAGFIGSTLVD
Rv3634c|M.tuberculosis_H37Rv --------------------------------MRALVTGAAGFIGSTLVD
MLBr_00204|M.leprae_Br4923 ---------------------------MYGEPVRALVTGAAGFIGSTLVD
MAB_0503|M.abscessus_ATCC_1997 --------------------------------MRAMVTGAAGFIGSTLVD
Mvan_5389|M.vanbaalenii_PYR-1 --------------------------------MTWLVTGGAGYIGSHVVR
MUL_1512|M.ulcerans_Agy99 --------------------------------MKVLVTGSAGFINGYVVQ
MMAR_2310|M.marinum_M --------------------------------MKVLVTGSAGFINGYVVQ
MSMEG_5956|M.smegmatis_MC2_155 -------------------------------MSRILVTGGVGTIGSAVVR
MAV_4084|M.avium_104 MVDMTGATTPKGNGETGFHARPDGYQSPMRSLTRVLITGGAGFLGAHLCA
Mflv_4753|M.gilvum_PYR-GCK -----------------MTASEIVSPRELDRAATFYVAGHRGLVGSAIVR
TH_1114|M.thermoresistible__bu ----------------------MGDPTLRTDLGRVLVTGGSGFVGTNLVT
::* * :. :
Mb3658c|M.bovis_AF2122/97 RLLADGHSVVGLDNFATGRATNLEHLADNSAHVFVEADIVTADLHAILEQ
Rv3634c|M.tuberculosis_H37Rv RLLADGHSVVGLDNFATGRATNLEHLADNSAHVFVEADIVTADLHAILEQ
MLBr_00204|M.leprae_Br4923 RLLADGHTVVGLDNFATGHAANLEHLASTPALAFVEADIVTADLQTILDE
MAB_0503|M.abscessus_ATCC_1997 RLLADGHEVTGLDNLATGKVANLEAAEANAKFTFVKDDIVEADLDAVVAE
Mvan_5389|M.vanbaalenii_PYR-1 ALRGADLDVVVIDDLSTGRAEFVPDGVPLVRANLLDADAVRTTLDAYGVS
MUL_1512|M.ulcerans_Agy99 ELLQAGHEVIGIDNYSK-YGEVTKSYDDHPNYHFVEGDVKDVDLMFELVE
MMAR_2310|M.marinum_M ELLQAGHEVVGIDNYSK-YGKVTKSYDDHPNYHFVEGDVKDVDLMFELVE
MSMEG_5956|M.smegmatis_MC2_155 RLLHESAYEIRVCDQRP-APQWMN-----EACEIRTGDLRSADEARAAVD
MAV_4084|M.avium_104 RLLDDGVEVVSVDDLST--SGPAVRFGDRPGYRFVQRDVCDPGLIDEVGS
Mflv_4753|M.gilvum_PYR-GCK RLRVAGFDNIVG-----------------KTSAELDLKNRDAVFDFMSEI
TH_1114|M.thermoresistible__bu TLLERGHHVRSCDRVGS-------PLPDHPRLEVIDGDICDADAVAAAVD
* . .
Mb3658c|M.bovis_AF2122/97 HRPEVVFHLAAQIDVRRSV----ADPQFDAAVNVIGTVRLAEAARQTG--
Rv3634c|M.tuberculosis_H37Rv HRPEVVFHLAAQIDVRRSV----ADPQFDAAVNVIGTVRLAEAARQTG--
MLBr_00204|M.leprae_Br4923 HRPEVVFHLAAQIDVRHSV----VDPQFDASVNVIGTVRLAEAARHTG--
MAB_0503|M.abscessus_ATCC_1997 YSPEVIFHLAAQIDVRHSV----ADPQFDSSVNVVGTVRLAEAARKAG--
Mvan_5389|M.vanbaalenii_PYR-1 G----VIHIAGYKYAGESV----RRPLHTYQQNVSAMVTLLDAMSDAG--
MUL_1512|M.ulcerans_Agy99 GCEQMVASAARIGGITYFH----EYAYDLLAENERIAAAHFDTAIYAYRK
MMAR_2310|M.marinum_M GCEQMVASAARIGGITYFH----EYAYDLLAENERIAAAHFDTAIYAYRK
MSMEG_5956|M.smegmatis_MC2_155 GCTHVIHLAAIVGGIANFH----RLPHTLLEMNTGLYNSVFSAALREG--
MAV_4084|M.avium_104 G-FDAVFHLASAASPVDYQ----RRPIQTLRTGSAGTATALEIAERAG--
Mflv_4753|M.gilvum_PYR-GCK KPRYVVLAAAKVGGILANS----NYPVDFLSDNIRIQVNVLDAARDCG--
TH_1114|M.thermoresistible__bu G-IDTVFHTAAVIDLMGGAGVTDEYRERSFAVNVHGTERLVRAAQQAG--
: * .
Mb3658c|M.bovis_AF2122/97 --VRKIVHTSSGGSIYGTPPEYPTPETAPTD-----PASPYAAGKVAGEI
Rv3634c|M.tuberculosis_H37Rv --VRKIVHTSSGGSIYGTPPEYPTPETAPTD-----PASPYAAGKVAGEI
MLBr_00204|M.leprae_Br4923 --VRKIVHTSSGGSIYGTPSQYPTPETVPTD-----PTSPYAAGKVAGEI
MAB_0503|M.abscessus_ATCC_1997 --VRKIVHTSSGGSIYGTPKQIPTSETVPTD-----PHSPYAAGKVAGEI
Mvan_5389|M.vanbaalenii_PYR-1 --VDRIVFSSS-AATYGTPDTAVVDETTATR-----PESPYGESKLIGEW
MUL_1512|M.ulcerans_Agy99 GWLKKINVISS-SMVFENASIFPTPEKHITEC--PPPTSTYVFQKLACEY
MMAR_2310|M.marinum_M GWLKKINVISS-SMVFENASIFPTPEKHITEC--PPPTSTYGFQKLACEY
MSMEG_5956|M.smegmatis_MC2_155 --VERLVYVSS-SMVFEQATQFPTTEEHLLDC--RPPRSAYGFSKLTGEI
MAV_4084|M.avium_104 ---ARFVLAST-SEVYGDPESHPQRESYWGNVNPVGPRSVYDEAKRYAEA
Mflv_4753|M.gilvum_PYR-GCK --VERLLFLGS-SCIYPKFAEQPIREDSLLTGHLEPTNDAYAIAKIAGIL
TH_1114|M.thermoresistible__bu --VRRFVYTASNSVVMGGQPIADGDETLPYTDR---FNDLYTETKVIAER
:: .: . * . * *
Mb3658c|M.bovis_AF2122/97 YLNTFRHLYGLDCSHIAPANVYGPRQD----------PHGEAG---VVAI
Rv3634c|M.tuberculosis_H37Rv YLNTFRHLYGLDCSHIAPANVYGPRQD----------PHGEAG---VVAI
MLBr_00204|M.leprae_Br4923 YLNTFRHLCGLDCSHIAPANVYGPRQD----------PYGEAG---VVAI
MAB_0503|M.abscessus_ATCC_1997 YLNTFRHLYGLECSHIAPANVYGPRQD----------PHGEAG---VVAI
Mvan_5389|M.vanbaalenii_PYR-1 LLRDIGVATGLRHTSLRYFNVVGSGPD----------GVFDVSPFNLFPK
MUL_1512|M.ulcerans_Agy99 FAHGAYEQYGLPYTIIRPFNCVGTGEQRALGGRGIPSGNVKLAMSHVVPD
MMAR_2310|M.marinum_M FAHGAYEQYGLPYTIIRPFNCVGTGEQRALGGREIPSGNVKLAMSHVVPD
MSMEG_5956|M.smegmatis_MC2_155 YCRAVHEEHGLPFTICRPFNAYGPGE--------LP--DTEPGIAHAVPD
MAV_4084|M.avium_104 LTFAYHRLGRADVGVARIFNTYGPGMR--------------ADDGRMVPT
Mflv_4753|M.gilvum_PYR-GCK HVQAVRRQYGLPWISAMPTNLYGPNDN--------YSPTGSHVLPALIRR
TH_1114|M.thermoresistible__bu FVLGQNGIEGMLTCSIRPSGIWGPGDQ------------------TMFRK
. *. .
Mb3658c|M.bovis_AF2122/97 FAQALLSGK-PTRVFGD------GTNTRDYVFVDDVVDAFVRVSADVG-G
Rv3634c|M.tuberculosis_H37Rv FAQALLSGK-PTRVFGD------GTNTRDYVFVDDVVDAFVRVSADVG-G
MLBr_00204|M.leprae_Br4923 FVQALLSDR-PTKVFGD------GTHTRDYVFVDDVVDAFIKASGDAG-G
MAB_0503|M.abscessus_ATCC_1997 FAQALLSGR-STKVFGD------GGNTRDYVFVDDVVEAFVRASGPDG-G
Mvan_5389|M.vanbaalenii_PYR-1 VFDMLVHGQ-TPRINGDDYPTPDGTCVRDYIHVEDVAAAHVAAAHRLE-S
MUL_1512|M.ulcerans_Agy99 LVQKVVKGQDPLHILGD------GSQVRHYTYGGDLARGIRTCMEHPA-A
MMAR_2310|M.marinum_M LVQKVVKGQDPLHILGD------GSQVRHYTYGGDLARGIRTCMEHPA-A
MSMEG_5956|M.smegmatis_MC2_155 LIRKALSGQHPLQIFGS------GTQTRTLTHVDDIADGIVTAMFHPA-G
MAV_4084|M.avium_104 FCLQALRGD-PLTVSGT------GLQTRSLCYVDDTITGLIALAHSDF-A
Mflv_4753|M.gilvum_PYR-GCK YDEAVASRAVSVTNWGT------GSPRREFLHSDDMADACLHLLENYD-G
TH_1114|M.thermoresistible__bu LFESVHAGHVKVLIGSR-------HARLDNSYVHNLVHGFILAAEHLVPG
. . : . .
Mb3658c|M.bovis_AF2122/97 GL----RFNIGTGKETSDRQLHSAVAAAVGGPDD----------------
Rv3634c|M.tuberculosis_H37Rv GL----RFNIGTGKETSDRQLHSAVAAAVGGPDD----------------
MLBr_00204|M.leprae_Br4923 GQ----RFNIGTGIETSDRQLHTAVSAAVGGPDD----------------
MAB_0503|M.abscessus_ATCC_1997 GQ----RFNVGTGVETSDRQLHSLVAAAAGAPDD----------------
Mvan_5389|M.vanbaalenii_PYR-1 GLPIEPVYNLGSGSGTSVREIMTTMRAVTGVDFE----------------
MUL_1512|M.ulcerans_Agy99 LNG---DFNLSTPEATTVLELAEVIWRKMRPDTP-F--------------
MMAR_2310|M.marinum_M LNG---DFNLSTPEATTVLELAEVIWRKMRPDTP-F--------------
MSMEG_5956|M.smegmatis_MC2_155 ENQ---DFNISASEEHTIAEIAQMIWTACGLDPEDF--------------
MAV_4084|M.avium_104 GP-----VNIGNPTELTVLSAAELIRELAGSTST----------------
Mflv_4753|M.gilvum_PYR-GCK PEQ----VNVGSGTDVTIREIAESVAAAVGFSGE----------------
TH_1114|M.thermoresistible__bu GTAPGQAYFINDGEPINMFEFARPVVTACGQRWPTLRVSGPLVRAVMSLW
:. . . :
Mb3658c|M.bovis_AF2122/97 --------PEFHPPRLGDLKRSCLD----IGLAERVLGWRPQIELADGVR
Rv3634c|M.tuberculosis_H37Rv --------PEFHPPRLGDLKRSCLD----IGLAERVLGWRPQIELADGVR
MLBr_00204|M.leprae_Br4923 --------PEFHPPRLGDLKRSCLD----IGLATTVLGWSPQVQLDDGVR
MAB_0503|M.abscessus_ATCC_1997 --------PEFHPPRLGDLRQSCLD----VGLAKRVLGWEPRVPLADGIR
Mvan_5389|M.vanbaalenii_PYR-1 --------PDVAARRAGDPARIVAA----GDLAARDLDWRMRHSLTDMVA
MUL_1512|M.ulcerans_Agy99 -------RYESDPPFEHDVQLRSPD----VHKATQVLGFEATTTLDAMLD
MMAR_2310|M.marinum_M -------RYESDPPFEHDVQLRSPD----VHKATQVLGFEATTTLDAMLD
MSMEG_5956|M.smegmatis_MC2_155 -------ALENVPTFEVDVQRRWPS----VEKARMLLGWQARVDLRDGIA
MAV_4084|M.avium_104 --------IQFTPPATDDPQRRCPD----IRLARQRLGWRPRVDYRTGLS
Mflv_4753|M.gilvum_PYR-GCK --------THWDTTKPDGTPQKLLD----VSKLTQAG-WTSKISLQEGIE
TH_1114|M.thermoresistible__bu QRLHFRFGLPKPPLEPLAVERLYLDNYFSIDKARRELGYRPRYTTEQALQ
. : :
Mb3658c|M.bovis_AF2122/97 RTVEYFRHKHTD-----------------
Rv3634c|M.tuberculosis_H37Rv RTVEYFRHKHTD-----------------
MLBr_00204|M.leprae_Br4923 RTVEYFRAAQRS-----------------
MAB_0503|M.abscessus_ATCC_1997 RTVDFFRS---------------------
Mvan_5389|M.vanbaalenii_PYR-1 SAWSALPSRATDEAAP-------------
MUL_1512|M.ulcerans_Agy99 EVIPWIVN--AVEAGTI------------
MMAR_2310|M.marinum_M EVIPWIVN--AVEAGTI------------
MSMEG_5956|M.smegmatis_MC2_155 TTVEWLREQQCIARNS-------------
MAV_4084|M.avium_104 TTLAWFAERAGRTGESAQQLVATTDRRTR
Mflv_4753|M.gilvum_PYR-GCK RTVAWYREHVGALRG--------------
TH_1114|M.thermoresistible__bu ECLPYYVDLFHRMKAEPATV---------