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TASEIVSPRELDRAATFYVAGHRGLVGSAIVRRLRVAGFDNIVGKTSAELDLKNRDAVFDFMSEIKPRYV VLAAAKVGGILANSNYPVDFLSDNIRIQVNVLDAARDCGVERLLFLGSSCIYPKFAEQPIREDSLLTGHL EPTNDAYAIAKIAGILHVQAVRRQYGLPWISAMPTNLYGPNDNYSPTGSHVLPALIRRYDEAVASRAVSV TNWGTGSPRREFLHSDDMADACLHLLENYDGPEQVNVGSGTDVTIREIAESVAAAVGFSGETHWDTTKPD GTPQKLLDVSKLTQAGWTSKISLQEGIERTVAWYREHVGALRG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4753 | - | - | 100% (324) | NAD-dependent epimerase/dehydratase |
| M. gilvum PYR-GCK | Mflv_3296 | - | 1e-06 | 23.55% (242) | dTDP-glucose 4,6-dehydratase |
| M. gilvum PYR-GCK | Mflv_1401 | - | 2e-06 | 22.42% (330) | UDP-glucose 4-epimerase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3658c | galE1 | 4e-20 | 26.02% (319) | UDP-glucose 4-epimerase GALE1 (galactowaldenase) |
| M. tuberculosis H37Rv | Rv1512 | epiA | 1e-127 | 70.83% (312) | nucleotide-sugar epimerase epiA |
| M. leprae Br4923 | MLBr_00204 | rmlB2 | 1e-20 | 26.42% (318) | putative sugar-nucleotide dehydratase |
| M. abscessus ATCC 19977 | MAB_0503 | - | 3e-21 | 26.81% (317) | UDP-glucose 4-epimerase GalE1 |
| M. marinum M | MMAR_5133 | galE1 | 2e-20 | 25.69% (327) | UDP-glucose 4-epimerase GalE1 |
| M. avium 104 | MAV_0524 | - | 4e-21 | 26.65% (319) | nucleoside-diphosphate-sugar epimerase |
| M. smegmatis MC2 155 | MSMEG_5956 | - | 1e-25 | 29.06% (320) | NAD dependent epimerase/dehydratase family protein |
| M. thermoresistible (build 8) | TH_0330 | rfbB | 8e-07 | 24.47% (331) | dTDP-glucose 4,6-dehydratase |
| M. ulcerans Agy99 | MUL_4210 | galE1 | 2e-20 | 25.69% (327) | UDP-glucose 4-epimerase GalE1 |
| M. vanbaalenii PYR-1 | Mvan_5389 | - | 4e-10 | 24.26% (305) | UDP-glucose 4-epimerase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4753|M.gilvum_PYR-GCK ---------MTASEIVSPRELDRAAT-FYVAGHRGLVGSAIVRRLRVAGF
Rv1512|M.tuberculosis_H37Rv ---------MNAHTSVGP--LDRAAR-VYIAGHRGLVGSALLRTFAGAGF
MLBr_00204|M.leprae_Br4923 ----MYGEPVRALVTGAAGFIGSTLVDRLLADGHTVVGLDNFATGHAANL
MAV_0524|M.avium_104 ---------MRALVTGAAGFIGSTLVDRLLADGHTVVGLDNFASGRASNL
MMAR_5133|M.marinum_M ---------MRALVTGAAGFIGSTLVDRLLADGHTVVGLDNFATGRATNL
MUL_4210|M.ulcerans_Agy99 ---------MRALVTGAAGFIGSTLVDRLLADGHTVVGLDNFATGRATNL
Mb3658c|M.bovis_AF2122/97 ---------MRALVTGAAGFIGSTLVDRLLADGHSVVGLDNFATGRATNL
MAB_0503|M.abscessus_ATCC_1997 ---------MRAMVTGAAGFIGSTLVDRLLADGHEVTGLDNLATGKVANL
Mvan_5389|M.vanbaalenii_PYR-1 ---------MTWLVTGGAGYIGSHVVRALRGADLDVVVIDDLSTGRAEFV
MSMEG_5956|M.smegmatis_MC2_155 --------MSRILVTGGVGTIGSAVVRRLLHESAYEIRVCDQRP------
TH_0330|M.thermoresistible__bu VAAIVAAVRCAAAVSSRSSSGGSIRPRSITPSSEKNPRSEAXXXTGLDAF
.
Mflv_4753|M.gilvum_PYR-GCK DNIVGK-------TSAELDLKNRD-AVFDFMSEIKPRYVVLAAAKVGGIL
Rv1512|M.tuberculosis_H37Rv TNLLVR-------SRAELDLTDRA-ATFDFVLESRPQVVIDAAARVGGIL
MLBr_00204|M.leprae_Br4923 EHLAST-------PALAFVEADIVTADLQTILDEHRPEVVFHLAAQIDVR
MAV_0524|M.avium_104 EHLVGN-------PAHVFVEADIVTADLEAILDEHRPEVVFHLAAQIDVR
MMAR_5133|M.marinum_M EHLVDN-------LAHVFVEADIVDADLQAIFEQHRPEVIFHLAAQIDVR
MUL_4210|M.ulcerans_Agy99 EHLVDN-------LAHVFVEADIVDADLQAIFEQHRPEVIFHLAAQIDVR
Mb3658c|M.bovis_AF2122/97 EHLADN-------SAHVFVEADIVTADLHAILEQHRPEVVFHLAAQIDVR
MAB_0503|M.abscessus_ATCC_1997 EAAEAN-------AKFTFVKDDIVEADLDAVVAEYSPEVIFHLAAQIDVR
Mvan_5389|M.vanbaalenii_PYR-1 PDGVPL-------VRANLLDADAVRTTLDAYGVSG----VIHIAGYKYAG
MSMEG_5956|M.smegmatis_MC2_155 APQWMN-------EACEIRTGDLRSADEARAAVDGCTHVIHLAAIVGGIA
TH_0330|M.thermoresistible__bu TYAGSRESLAPVADRIRVVEGDVTDSDLVDKLVAES-DAVVHFAAESHVD
. : : : *
Mflv_4753|M.gilvum_PYR-GCK ANSNYPVDFLSDNIRIQVNVLDAARDCGVERLLFLGSSCIYPKFAEQPIR
Rv1512|M.tuberculosis_H37Rv ANDTYPADFLSENLQIQVNLLDAAVAARVPRLLFLGSSCIYPKLAPQPIP
MLBr_00204|M.leprae_Br4923 HSVVDPQFDASVNVIGTVRLAEAARHTGVRKIVHTSSGGSIYGTPSQYPT
MAV_0524|M.avium_104 HSVADPQFDASVNVIGTVRLAEAARRTGVRKIVHTSSGGSIYGTPPTYPT
MMAR_5133|M.marinum_M HSVADPQFDASVNVIGTLRLAEAARLTGVRKVVHTSSGGSIYGTPPQYPT
MUL_4210|M.ulcerans_Agy99 HSVADPQFDASVNVIGTLRLAEAARLTGVRKVVHTSSGGSIYGTPPQYPT
Mb3658c|M.bovis_AF2122/97 RSVADPQFDAAVNVIGTVRLAEAARQTGVRKIVHTSSGGSIYGTPPEYPT
MAB_0503|M.abscessus_ATCC_1997 HSVADPQFDSSVNVVGTVRLAEAARKAGVRKIVHTSSGGSIYGTPKQIPT
Mvan_5389|M.vanbaalenii_PYR-1 ESVRRPLHTYQQNVSAMVTLLDAMSDAGVDRIVFSSS-AATYGTPDTAVV
MSMEG_5956|M.smegmatis_MC2_155 NFHRLPHTLLEMNTGLYNSVFSAALREGVERLVYVSSSMVFEQATQFPTT
TH_0330|M.thermoresistible__bu NALAEPEPFLRTNVVGTFTVLEAVRRHRVR-LHHISTDEVYGDLPLHDPR
* * : .* * : . .: .
Mflv_4753|M.gilvum_PYR-GCK --EDSLLTGHLEPTNDAYAIAKIAGILHVQAVRRQYGLPWISAMPTNLYG
Rv1512|M.tuberculosis_H37Rv --ESALLTGPLEPTNDAYAIAKIAGILAVQAVRRQHGLPWISAMPTNLYG
MLBr_00204|M.leprae_Br4923 --PETVPTDPTSP----YAAGKVAGEIYLNTFRHLCGLDCSHIAPANVYG
MAV_0524|M.avium_104 --PETVPTDPASP----YAAGKVAGEIYLNTFRHLYGLDCSHIAPANVYG
MMAR_5133|M.marinum_M --SERVPTDPASP----YAAGKVAGEIYLNTFRHLYGLECSHIAPANVYG
MUL_4210|M.ulcerans_Agy99 --SERVPTDPASP----YAAGKVAGEIYLNTFRHLYGLECSHIAPANVYG
Mb3658c|M.bovis_AF2122/97 --PETAPTDPASP----YAAGKVAGEIYLNTFRHLYGLDCSHIAPANVYG
MAB_0503|M.abscessus_ATCC_1997 --SETVPTDPHSP----YAAGKVAGEIYLNTFRHLYGLECSHIAPANVYG
Mvan_5389|M.vanbaalenii_PYR-1 --DETTATRPESP----YGESKLIGEWLLRDIGVATGLRHTSLRYFNVVG
MSMEG_5956|M.smegmatis_MC2_155 --EEHLLDCRPPRS--AYGFSKLTGEIYCRAVHEEHGLPFTICRPFNAYG
TH_0330|M.thermoresistible__bu RFTESTPYNPSSP----YSSTKAAADMLVRAWVRSYGVAATISNCSNNYG
. *. * . . *: * *
Mflv_4753|M.gilvum_PYR-GCK PNDNYSPTGSHVLPALIRRYDEAVASRAVSVTNWG-----TGSPRREFLH
Rv1512|M.tuberculosis_H37Rv PGDNFSPSGSHLLPALIRRYDEAKASGAPNVTNWG-----TGTPRRELLH
MLBr_00204|M.leprae_Br4923 PRQ--DPYGEAG---VVAIFVQALLSDRPTKVFGD------GTHTRDYVF
MAV_0524|M.avium_104 PRQ--DPHGEAG---VVAIFAQALLSGKPTKVFGD------GTNTRDYVF
MMAR_5133|M.marinum_M PRQ--DPHGEAG---VVAIFAQALLSGKPTKVFGD------GTNTRDYVF
MUL_4210|M.ulcerans_Agy99 PRQ--DPHGEAG---VVAIFAQALLSGKPTKVFGD------GTNTRDYVF
Mb3658c|M.bovis_AF2122/97 PRQ--DPHGEAG---VVAIFAQALLSGKPTRVFGD------GTNTRDYVF
MAB_0503|M.abscessus_ATCC_1997 PRQ--DPHGEAG---VVAIFAQALLSGRSTKVFGD------GGNTRDYVF
Mvan_5389|M.vanbaalenii_PYR-1 SGP--DGVFDVSPFNLFPKVFDMLVHGQTPRINGDDYPTPDGTCVRDYIH
MSMEG_5956|M.smegmatis_MC2_155 PGE--LPDTEPGIAHAVPDLIRKALSGQHPLQIFG-----SGTQTRTLTH
TH_0330|M.thermoresistible__bu PYQ--------HVEKFIPRQITNVLTGRRPKLYGT------GANVRDWIH
. . * * .
Mflv_4753|M.gilvum_PYR-GCK SDDMADACLHLLENYDGPE----QVNVGSGTDVTIREIAESVAAAVGFSG
Rv1512|M.tuberculosis_H37Rv VDDLASACLYLLEHFDGPT----HVNVGTGIDHTIGEIAEMVASAVGYSG
MLBr_00204|M.leprae_Br4923 VDDVVDAFIKASGDAGGGQ----RFNIGTGIETSDRQLHTAVSAAVGGPD
MAV_0524|M.avium_104 VDDVVDAFVKASGDAGGGQ----RFNIGTGVETSDRQLHSAVAAAVGGPD
MMAR_5133|M.marinum_M VDDVVDAFVRAGSDVGGGQ----RFNIGTGVETSDRQLHSAVAAAVGGPD
MUL_4210|M.ulcerans_Agy99 VDDVVDAFVKAGSDVGGGQ----RFNIGTGVETSDRQLHSAVAAAVGGPD
Mb3658c|M.bovis_AF2122/97 VDDVVDAFVRVSADVGGGL----RFNIGTGKETSDRQLHSAVAAAVGGPD
MAB_0503|M.abscessus_ATCC_1997 VDDVVEAFVRASGPDGGGQ----RFNVGTGVETSDRQLHSLVAAAAGAPD
Mvan_5389|M.vanbaalenii_PYR-1 VEDVAAAHVAAAHRLESGLPIEPVYNLGSGSGTSVREIMTTMRAVTGVDF
MSMEG_5956|M.smegmatis_MC2_155 VDDIADGIVTAMFHPAGENQ---DFNISASEEHTIAEIAQMIWTACGLDP
TH_0330|M.thermoresistible__bu VEDHNDAVWRILTAGQIGR----TYLIGADGERDNRTVLRTILKLMDRDP
:* . :.:. : : .
Mflv_4753|M.gilvum_PYR-GCK E---THWDTTKPDGTPQKLLDVSKLT-QAGWTS-KISLQEGIERTVAWYR
Rv1512|M.tuberculosis_H37Rv E---TRWDPSKPDGTPRKLLDVSVLR-EAGWRP-SIALRDGIEATVAWYR
MLBr_00204|M.leprae_Br4923 D---PEFHPPRLGDLKRSCLDIGLATTVLGWSP-QVQLDDGVRRTVEYFR
MAV_0524|M.avium_104 D---PEFHPPRLGDLKRSCLDIGLAARVLGWQP-KVGLQQGVARTVEYFR
MMAR_5133|M.marinum_M D---PEFHPPRLGDLKRSCLDISRAEEVLGWRP-QVELADGVRRTVDYFR
MUL_4210|M.ulcerans_Agy99 D---PEFHPPRLGDLKRSCLDISRAEEVLGWRP-QVELADGVRRTVDYFR
Mb3658c|M.bovis_AF2122/97 D---PEFHPPRLGDLKRSCLDIGLAERVLGWRP-QIELADGVRRTVEYFR
MAB_0503|M.abscessus_ATCC_1997 D---PEFHPPRLGDLRQSCLDVGLAKRVLGWEP-RVPLADGIRRTVDFFR
Mvan_5389|M.vanbaalenii_PYR-1 E---PDVAARRAGDPARIVAAGDLAARDLDWRM-RHSLTDMVASAWSALP
MSMEG_5956|M.smegmatis_MC2_155 EDFALENVPTFEVDVQRRWPSVEKARMLLGWQA-RVDLRDGIATTVEWLR
TH_0330|M.thermoresistible__bu DD--FDHVTDRAGHDLRYAIDPSALIDELGWTPRHTDFEAGLRDTIQWYR
: . : .* : : :
Mflv_4753|M.gilvum_PYR-GCK EHVGALRG--------------
Rv1512|M.tuberculosis_H37Rv EHAGTVRQ--------------
MLBr_00204|M.leprae_Br4923 AAQRS-----------------
MAV_0524|M.avium_104 NQHN------------------
MMAR_5133|M.marinum_M RTHGS-----------------
MUL_4210|M.ulcerans_Agy99 RTHGS-----------------
Mb3658c|M.bovis_AF2122/97 HKHTD-----------------
MAB_0503|M.abscessus_ATCC_1997 S---------------------
Mvan_5389|M.vanbaalenii_PYR-1 SRATDEAAP-------------
MSMEG_5956|M.smegmatis_MC2_155 EQQCIARNS-------------
TH_0330|M.thermoresistible__bu DNEDWWRPLKDATEDAYAERGQ