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M. vanbaalenii PYR-1 Mvan_5389 (-)

annotation: UDP-glucose 4-epimerase
coordinates: 5769338 - 5770318
length: 326

VTWLVTGGAGYIGSHVVRALRGADLDVVVIDDLSTGRAEFVPDGVPLVRANLLDADAVRTTLDAYGVSGV
IHIAGYKYAGESVRRPLHTYQQNVSAMVTLLDAMSDAGVDRIVFSSSAATYGTPDTAVVDETTATRPESP
YGESKLIGEWLLRDIGVATGLRHTSLRYFNVVGSGPDGVFDVSPFNLFPKVFDMLVHGQTPRINGDDYPT
PDGTCVRDYIHVEDVAAAHVAAAHRLESGLPIEPVYNLGSGSGTSVREIMTTMRAVTGVDFEPDVAARRA
GDPARIVAAGDLAARDLDWRMRHSLTDMVASAWSALPSRATDEAAP
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. vanbaalenii PYR-1Mvan_5389--100% (326)UDP-glucose 4-epimerase
M. vanbaalenii PYR-1Mvan_0882-2e-1930.18% (338) NAD-dependent epimerase/dehydratase
M. vanbaalenii PYR-1Mvan_1365-3e-1426.65% (319) dTDP-glucose 4,6-dehydratase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb3658cgalE17e-2932.31% (325) UDP-glucose 4-epimerase GALE1 (galactowaldenase)
M. gilvum PYR-GCKMflv_1401-1e-13374.29% (315) UDP-glucose 4-epimerase
M. tuberculosis H37RvRv3634cgalE17e-2932.31% (325) UDP-glucose 4-epimerase GALE1 (galactowaldenase)
M. leprae Br4923MLBr_00204rmlB21e-2631.41% (312) putative sugar-nucleotide dehydratase
M. abscessus ATCC 19977MAB_0503-5e-2730.74% (309) UDP-glucose 4-epimerase GalE1
M. marinum MMMAR_5133galE17e-2630.77% (312) UDP-glucose 4-epimerase GalE1
M. avium 104MAV_0524-7e-2832.91% (313) nucleoside-diphosphate-sugar epimerase
M. smegmatis MC2 155MSMEG_6142-4e-2731.96% (316) nucleoside-diphosphate-sugar epimerase
M. thermoresistible (build 8)TH_3729-1e-14077.78% (315) PUTATIVE UDP-galactose 4-epimerase
M. ulcerans Agy99MUL_4210galE14e-2630.77% (312) UDP-glucose 4-epimerase GalE1

CLUSTAL 2.0.9 multiple sequence alignment


MLBr_00204|M.leprae_Br4923          MYGEPVRALVTGAAGFIGSTLVDRLLADGHTVVGLDNFATGHAANLEHLA
MAV_0524|M.avium_104                -----MRALVTGAAGFIGSTLVDRLLADGHTVVGLDNFASGRASNLEHLV
Mb3658c|M.bovis_AF2122/97           -----MRALVTGAAGFIGSTLVDRLLADGHSVVGLDNFATGRATNLEHLA
Rv3634c|M.tuberculosis_H37Rv        -----MRALVTGAAGFIGSTLVDRLLADGHSVVGLDNFATGRATNLEHLA
MMAR_5133|M.marinum_M               -----MRALVTGAAGFIGSTLVDRLLADGHTVVGLDNFATGRATNLEHLV
MUL_4210|M.ulcerans_Agy99           -----MRALVTGAAGFIGSTLVDRLLADGHTVVGLDNFATGRATNLEHLV
MAB_0503|M.abscessus_ATCC_1997      -----MRAMVTGAAGFIGSTLVDRLLADGHEVTGLDNLATGKVANLEAAE
MSMEG_6142|M.smegmatis_MC2_155      ---MAVRTLVTGAAGFIGSTLVDRLLADGHGVVGLDDLSSGRAENLHSAE
Mflv_1401|M.gilvum_PYR-GCK          -----MSWLITGGAGYIGSHVARAMLEAGRDVVVIDDLSSGFESFVPDGA
TH_3729|M.thermoresistible__bu      -----MTWLVTGGAGYIGSHVVRALLEADLPVVVIDDLSTGLEKFVPSEV
Mvan_5389|M.vanbaalenii_PYR-1       -----MTWLVTGGAGYIGSHVVRALRGADLDVVVIDDLSTGRAEFVPDGV
                                         :  ::**.**:*** :.  :   .  *. :*::::*    :    

MLBr_00204|M.leprae_Br4923          STPALAFVEADIVTADLQTILDEHRPEVVFHLAAQIDVRHSVVDPQFDAS
MAV_0524|M.avium_104                GNPAHVFVEADIVTADLEAILDEHRPEVVFHLAAQIDVRHSVADPQFDAS
Mb3658c|M.bovis_AF2122/97           DNSAHVFVEADIVTADLHAILEQHRPEVVFHLAAQIDVRRSVADPQFDAA
Rv3634c|M.tuberculosis_H37Rv        DNSAHVFVEADIVTADLHAILEQHRPEVVFHLAAQIDVRRSVADPQFDAA
MMAR_5133|M.marinum_M               DNLAHVFVEADIVDADLQAIFEQHRPEVIFHLAAQIDVRHSVADPQFDAS
MUL_4210|M.ulcerans_Agy99           DNLAHVFVEADIVDADLQAIFEQHRPEVIFHLAAQIDVRHSVADPQFDAS
MAB_0503|M.abscessus_ATCC_1997      ANAKFTFVKDDIVEADLDAVVAEYSPEVIFHLAAQIDVRHSVADPQFDSS
MSMEG_6142|M.smegmatis_MC2_155      NSDKFEFVKADIVDADLTGLLAEFKPEVIFHLAAQISVKRSVDDPPFDAT
Mflv_1401|M.gilvum_PYR-GCK          AFVEGTLLDAALVDD----TLARFDVDGVIHIAGYKYAGESVKRPLHTYE
TH_3729|M.thermoresistible__bu      PLVRGTLLDADLVAR----ALREHRVSGVIHIAGFKYAGVSVQQPLHTYE
Mvan_5389|M.vanbaalenii_PYR-1       PLVRANLLDADAVRT----TLDAYGVSGVIHIAGYKYAGESVRRPLHTYQ
                                          ::.   *       .  .  . ::*:*.   .  **  * .   

MLBr_00204|M.leprae_Br4923          VNVIGTVRLAEAARHTGVRKIVHTSSGGSIYGTPSQYPTPETVPTDPTSP
MAV_0524|M.avium_104                VNVIGTVRLAEAARRTGVRKIVHTSSGGSIYGTPPTYPTPETVPTDPASP
Mb3658c|M.bovis_AF2122/97           VNVIGTVRLAEAARQTGVRKIVHTSSGGSIYGTPPEYPTPETAPTDPASP
Rv3634c|M.tuberculosis_H37Rv        VNVIGTVRLAEAARQTGVRKIVHTSSGGSIYGTPPEYPTPETAPTDPASP
MMAR_5133|M.marinum_M               VNVIGTLRLAEAARLTGVRKVVHTSSGGSIYGTPPQYPTSERVPTDPASP
MUL_4210|M.ulcerans_Agy99           VNVIGTLRLAEAARLTGVRKVVHTSSGGSIYGTPPQYPTSERVPTDPASP
MAB_0503|M.abscessus_ATCC_1997      VNVVGTVRLAEAARKAGVRKIVHTSSGGSIYGTPKQIPTSETVPTDPHSP
MSMEG_6142|M.smegmatis_MC2_155      VNVVGTVRLAEAARLAGVRKVVHTSSGGSVYGTPPAYPTSEDMPVNPASP
Mflv_1401|M.gilvum_PYR-GCK          QNVSTTVILLQAMEARGVGQIVFSSS-AATFGTPDVDIVDESTPTTPESP
TH_3729|M.thermoresistible__bu      QNVSAMVTLLKAMQDTGVDMMVFSSS-AATFGTPDVDLVTETTPTRPESP
Mvan_5389|M.vanbaalenii_PYR-1       QNVSAMVTLLDAMSDAGVDRIVFSSS-AATYGTPDTAVVDETTATRPESP
                                     **   : * .*    **  :*.:** .: :***    . *  .. * **

MLBr_00204|M.leprae_Br4923          YAAGKVAGEIYLNTFRHLCGLDCSHIAPANVYGPRQDPYGEAG---VVAI
MAV_0524|M.avium_104                YAAGKVAGEIYLNTFRHLYGLDCSHIAPANVYGPRQDPHGEAG---VVAI
Mb3658c|M.bovis_AF2122/97           YAAGKVAGEIYLNTFRHLYGLDCSHIAPANVYGPRQDPHGEAG---VVAI
Rv3634c|M.tuberculosis_H37Rv        YAAGKVAGEIYLNTFRHLYGLDCSHIAPANVYGPRQDPHGEAG---VVAI
MMAR_5133|M.marinum_M               YAAGKVAGEIYLNTFRHLYGLECSHIAPANVYGPRQDPHGEAG---VVAI
MUL_4210|M.ulcerans_Agy99           YAAGKVAGEIYLNTFRHLYGLECSHIAPANVYGPRQDPHGEAG---VVAI
MAB_0503|M.abscessus_ATCC_1997      YAAGKVAGEIYLNTFRHLYGLECSHIAPANVYGPRQDPHGEAG---VVAI
MSMEG_6142|M.smegmatis_MC2_155      YAAGKVAGEVYLNMYRNLYDLDCSHIAPANVYGPRQDPHGEAG---VVAI
Mflv_1401|M.gilvum_PYR-GCK          YGETKLIGEWLLRDAGRASGLRHTSLRYFNVVGSGAVELFDASPHNLFPL
TH_3729|M.thermoresistible__bu      YGESKLIGEWLLADVGRATGLRHTSLRYFNVVGSGSPELFDVSPHNLFPL
Mvan_5389|M.vanbaalenii_PYR-1       YGESKLIGEWLLRDIGVATGLRHTSLRYFNVVGSGPDGVFDVSPFNLFPK
                                    *.  *: **  *       .*  : :   ** *.      :..   :.. 

MLBr_00204|M.leprae_Br4923          FVQALLSDRPTKVFGD------GTHTRDYVFVDDVVDAFIKASGDAGGGQ
MAV_0524|M.avium_104                FAQALLSGKPTKVFGD------GTNTRDYVFVDDVVDAFVKASGDAGGGQ
Mb3658c|M.bovis_AF2122/97           FAQALLSGKPTRVFGD------GTNTRDYVFVDDVVDAFVRVSADVGGGL
Rv3634c|M.tuberculosis_H37Rv        FAQALLSGKPTRVFGD------GTNTRDYVFVDDVVDAFVRVSADVGGGL
MMAR_5133|M.marinum_M               FAQALLSGKPTKVFGD------GTNTRDYVFVDDVVDAFVRAGSDVGGGQ
MUL_4210|M.ulcerans_Agy99           FAQALLSGKPTKVFGD------GTNTRDYVFVDDVVDAFVKAGSDVGGGQ
MAB_0503|M.abscessus_ATCC_1997      FAQALLSGRSTKVFGD------GGNTRDYVFVDDVVEAFVRASGPDGGGQ
MSMEG_6142|M.smegmatis_MC2_155      FSEALLAGRTTKIFGD------GSDTRDYVFVDDVVDAFVRAGGPAGGGQ
Mflv_1401|M.gilvum_PYR-GCK          VFDMLFRGETPRINGDDYPTPDGTCVRDYIHVSDLALAHVAAAQRLAAGE
TH_3729|M.thermoresistible__bu      VFDMLYRGETPRINGDDYPTPDGTCVRDYIHVADLALAHVAAARRLQAGE
Mvan_5389|M.vanbaalenii_PYR-1       VFDMLVHGQTPRINGDDYPTPDGTCVRDYIHVEDVAAAHVAAAHRLESGL
                                    . : *  ....:: **      *  .***:.* *:. *.: ..    .* 

MLBr_00204|M.leprae_Br4923          ----RFNIGTGIETSDRQLHTAVSAAVGGPDDPEFHPPRLGDLKRSCLDI
MAV_0524|M.avium_104                ----RFNIGTGVETSDRQLHSAVAAAVGGPDDPEFHPPRLGDLKRSCLDI
Mb3658c|M.bovis_AF2122/97           ----RFNIGTGKETSDRQLHSAVAAAVGGPDDPEFHPPRLGDLKRSCLDI
Rv3634c|M.tuberculosis_H37Rv        ----RFNIGTGKETSDRQLHSAVAAAVGGPDDPEFHPPRLGDLKRSCLDI
MMAR_5133|M.marinum_M               ----RFNIGTGVETSDRQLHSAVAAAVGGPDDPEFHPPRLGDLKRSCLDI
MUL_4210|M.ulcerans_Agy99           ----RFNIGTGVETSDRQLHSAVAAAVGGPDDPEFHPPRLGDLKRSCLDI
MAB_0503|M.abscessus_ATCC_1997      ----RFNVGTGVETSDRQLHSLVAAAAGAPDDPEFHPPRLGDLRQSCLDV
MSMEG_6142|M.smegmatis_MC2_155      ----RFNVGTGVETSTRELHTAIAGAVGAPDEPEFHPPRLGDLRRSRLDN
Mflv_1401|M.gilvum_PYR-GCK          PVEPVYNLGSGAGTSVREIMTAMRTVTGVDFEPVVMPRRPGDPARIVAAG
TH_3729|M.thermoresistible__bu      PVEPVYNLGSGSGTSVREIMTAIRKVTGVDFVPEIAPRRPGDPARIVASG
Mvan_5389|M.vanbaalenii_PYR-1       PIEPVYNLGSGSGTSVREIMTTMRAVTGVDFEPDVAARRAGDPARIVAAG
                                         :*:*:*  ** *:: : :  ..*    * . . * **  :     

MLBr_00204|M.leprae_Br4923          GLATTVLGWSPQVQLDDGVRRTVEYFRAAQRS----
MAV_0524|M.avium_104                GLAARVLGWQPKVGLQQGVARTVEYFRNQHN-----
Mb3658c|M.bovis_AF2122/97           GLAERVLGWRPQIELADGVRRTVEYFRHKHTD----
Rv3634c|M.tuberculosis_H37Rv        GLAERVLGWRPQIELADGVRRTVEYFRHKHTD----
MMAR_5133|M.marinum_M               SRAEEVLGWRPQVELADGVRRTVDYFRRTHGS----
MUL_4210|M.ulcerans_Agy99           SRAEEVLGWRPQVELADGVRRTVDYFRRTHGS----
MAB_0503|M.abscessus_ATCC_1997      GLAKRVLGWEPRVPLADGIRRTVDFFRS--------
MSMEG_6142|M.smegmatis_MC2_155      TRAREVLGWQPQVALAEGIAKTVEFFRNKSQ-----
Mflv_1401|M.gilvum_PYR-GCK          DLAARDLGWSNRHSLEEMVASAWRAR-QHAGDAYPR
TH_3729|M.thermoresistible__bu      ELAARDLGWRMRHTLEDMVKSAWEAR-QRAGDAYPR
Mvan_5389|M.vanbaalenii_PYR-1       DLAARDLDWRMRHSLTDMVASAWSALPSRATDEAAP
                                      *   *.*  :  * : :  :