For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MVDMTGATTPKGNGETGFHARPDGYQSPMRSLTRVLITGGAGFLGAHLCARLLDDGVEVVSVDDLSTSGP AVRFGDRPGYRFVQRDVCDPGLIDEVGSGFDAVFHLASAASPVDYQRRPIQTLRTGSAGTATALEIAERA GARFVLASTSEVYGDPESHPQRESYWGNVNPVGPRSVYDEAKRYAEALTFAYHRLGRADVGVARIFNTYG PGMRADDGRMVPTFCLQALRGDPLTVSGTGLQTRSLCYVDDTITGLIALAHSDFAGPVNIGNPTELTVLS AAELIRELAGSTSTIQFTPPATDDPQRRCPDIRLARQRLGWRPRVDYRTGLSTTLAWFAERAGRTGESAQ QLVATTDRRTR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_4084 | - | - | 100% (361) | UDP-glucuronic acid decarboxylase 1 |
| M. avium 104 | MAV_0524 | - | 6e-28 | 30.60% (317) | nucleoside-diphosphate-sugar epimerase |
| M. avium 104 | MAV_3269 | - | 6e-21 | 27.56% (352) | NAD dependent epimerase/dehydratase family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3658c | galE1 | 1e-27 | 29.25% (318) | UDP-glucose 4-epimerase GALE1 (galactowaldenase) |
| M. gilvum PYR-GCK | Mflv_3296 | - | 2e-25 | 29.94% (314) | dTDP-glucose 4,6-dehydratase |
| M. tuberculosis H37Rv | Rv3634c | galE1 | 1e-27 | 29.25% (318) | UDP-glucose 4-epimerase GALE1 (galactowaldenase) |
| M. leprae Br4923 | MLBr_00204 | rmlB2 | 1e-26 | 30.25% (314) | putative sugar-nucleotide dehydratase |
| M. abscessus ATCC 19977 | MAB_0503 | - | 1e-27 | 29.52% (315) | UDP-glucose 4-epimerase GalE1 |
| M. marinum M | MMAR_5346 | rmlB_1 | 3e-27 | 28.92% (332) | dTDP-glucose-4,6-dehydratase, RmlB_1 |
| M. smegmatis MC2 155 | MSMEG_6142 | - | 5e-27 | 31.15% (321) | nucleoside-diphosphate-sugar epimerase |
| M. thermoresistible (build 8) | TH_0330 | rfbB | 1e-17 | 28.68% (272) | dTDP-glucose 4,6-dehydratase |
| M. ulcerans Agy99 | MUL_4210 | galE1 | 6e-27 | 31.06% (322) | UDP-glucose 4-epimerase GalE1 |
| M. vanbaalenii PYR-1 | Mvan_1365 | - | 6e-25 | 28.91% (339) | dTDP-glucose 4,6-dehydratase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3658c|M.bovis_AF2122/97 --------------------------------MRALVTG---AAGFIGST
Rv3634c|M.tuberculosis_H37Rv --------------------------------MRALVTG---AAGFIGST
MUL_4210|M.ulcerans_Agy99 --------------------------------MRALVTG---AAGFIGST
MLBr_00204|M.leprae_Br4923 ---------------------------MYGEPVRALVTG---AAGFIGST
MAB_0503|M.abscessus_ATCC_1997 --------------------------------MRAMVTG---AAGFIGST
MSMEG_6142|M.smegmatis_MC2_155 ------------------------------MAVRTLVTG---AAGFIGST
TH_0330|M.thermoresistible__bu -----------------------VAAIVAAVRCAAAVSSRSSSGGSIRPR
Mvan_1365|M.vanbaalenii_PYR-1 --------------------------------MRLLVTG---GAGFIGAN
Mflv_3296|M.gilvum_PYR-GCK -------------------------------MARLLVTG---GAGFIGSN
MMAR_5346|M.marinum_M --------------------------------MEILVIG---GAGFQGSH
MAV_4084|M.avium_104 MVDMTGATTPKGNGETGFHARPDGYQSPMRSLTRVLITG---GAGFLGAH
: . ..* .
Mb3658c|M.bovis_AF2122/97 LVDRLLADGH-----SVVGLDNFATGRATNLEHLADNSAHVFVEADIVTA
Rv3634c|M.tuberculosis_H37Rv LVDRLLADGH-----SVVGLDNFATGRATNLEHLADNSAHVFVEADIVTA
MUL_4210|M.ulcerans_Agy99 LVDRLLADGH-----TVVGLDNFATGRATNLEHLVDNLAHVFVEADIVDA
MLBr_00204|M.leprae_Br4923 LVDRLLADGH-----TVVGLDNFATGHAANLEHLASTPALAFVEADIVTA
MAB_0503|M.abscessus_ATCC_1997 LVDRLLADGH-----EVTGLDNLATGKVANLEAAEANAKFTFVKDDIVEA
MSMEG_6142|M.smegmatis_MC2_155 LVDRLLADGH-----GVVGLDDLSSGRAENLHSAENSDKFEFVKADIVDA
TH_0330|M.thermoresistible__bu SITPSSEKNPRSEAXXXTGLDAFTYAGSRESLAPVAD-RIRVVEGDVTDS
Mvan_1365|M.vanbaalenii_PYR-1 FVRTTVQQRP---DVQVTVLDSLTYAGSRESLRGVDS-QIRLVEGDITDA
Mflv_3296|M.gilvum_PYR-GCK FVHHVLAHTD----HHVTVLDKLTYAGNRASLDGLPERRLDFVHGDVADA
MMAR_5346|M.marinum_M LTESLLADGH-----WVTVLNTPSKNTTRNMQGFQSHERVSFISGSVTDG
MAV_4084|M.avium_104 LCARLLDDGV-----EVVSVDDLSTSG--PAVRFGDRPGYRFVQRDVCDP
. . :: : .: .:
Mb3658c|M.bovis_AF2122/97 DLHAILEQHRPEVVFHLAAQIDVRRSVADPQFDAAVNVIGTVRLAEAAR-
Rv3634c|M.tuberculosis_H37Rv DLHAILEQHRPEVVFHLAAQIDVRRSVADPQFDAAVNVIGTVRLAEAAR-
MUL_4210|M.ulcerans_Agy99 DLQAIFEQHRPEVIFHLAAQIDVRHSVADPQFDASVNVIGTLRLAEAAR-
MLBr_00204|M.leprae_Br4923 DLQTILDEHRPEVVFHLAAQIDVRHSVVDPQFDASVNVIGTVRLAEAAR-
MAB_0503|M.abscessus_ATCC_1997 DLDAVVAEYSPEVIFHLAAQIDVRHSVADPQFDSSVNVVGTVRLAEAAR-
MSMEG_6142|M.smegmatis_MC2_155 DLTGLLAEFKPEVIFHLAAQISVKRSVDDPPFDATVNVVGTVRLAEAAR-
TH_0330|M.thermoresistible__bu DLVDKLVAES-DAVVHFAAESHVDNALAEPEPFLRTNVVGTFTVLEAVR-
Mvan_1365|M.vanbaalenii_PYR-1 ELVGKLVADS-DAVVHFAAETHVDNALADPEPFVHSNVLGTFTVLEAVRH
Mflv_3296|M.gilvum_PYR-GCK DLVDELVAGT-DAVVHYAAESHNDNSLDRPEPFLHSNVIGTFTVLEAVR-
MMAR_5346|M.marinum_M ETVYRAVRDH-HVVFHLAARTNVDESLSDPKSFLETNVMGTYRALEAVR-
MAV_4084|M.avium_104 GLIDEVGSGF-DAVFHLASAASPVDYQRRPIQTLRTGSAGTATALEIAER
..:.* *: * . ** * ..
Mb3658c|M.bovis_AF2122/97 -QTGVRKIVHTSSGGSIYGTPPEYPTP-----ETAPTDPASPYAAGKVAG
Rv3634c|M.tuberculosis_H37Rv -QTGVRKIVHTSSGGSIYGTPPEYPTP-----ETAPTDPASPYAAGKVAG
MUL_4210|M.ulcerans_Agy99 -LTGVRKVVHTSSGGSIYGTPPQYPTS-----ERVPTDPASPYAAGKVAG
MLBr_00204|M.leprae_Br4923 -HTGVRKIVHTSSGGSIYGTPSQYPTP-----ETVPTDPTSPYAAGKVAG
MAB_0503|M.abscessus_ATCC_1997 -KAGVRKIVHTSSGGSIYGTPKQIPTS-----ETVPTDPHSPYAAGKVAG
MSMEG_6142|M.smegmatis_MC2_155 -LAGVRKVVHTSSGGSVYGTPPAYPTS-----EDMPVNPASPYAAGKVAG
TH_0330|M.thermoresistible__bu ---RHRVRLHHISTDEVYGD-LPLHDPRRFT-ESTPYNPSSPYSSTKAAA
Mvan_1365|M.vanbaalenii_PYR-1 ASVTKPVRLHHISTDEVYGD-LELDDPARFT-DATPYNPSSPYSSTKAAA
Mflv_3296|M.gilvum_PYR-GCK ---RHGRRLHHVSTDEVYGD-LELDDPARFT-ESSPYNPSSPYSSTKAGS
MMAR_5346|M.marinum_M ---RYRNRLIYVSTCEVYGDGHNLEEGQRLD-EHAELKPNSPYAASKAAA
MAV_4084|M.avium_104 ----AGARFVLASTSEVYGDPESHPQRESYWGNVNPVGPRSVYDEAKRYA
. * .:** : * * * * .
Mb3658c|M.bovis_AF2122/97 EIYLNTFRHLYGLDCSHIAPANVYGPRQDPHGEAGVVAIFAQALLSGKPT
Rv3634c|M.tuberculosis_H37Rv EIYLNTFRHLYGLDCSHIAPANVYGPRQDPHGEAGVVAIFAQALLSGKPT
MUL_4210|M.ulcerans_Agy99 EIYLNTFRHLYGLECSHIAPANVYGPRQDPHGEAGVVAIFAQALLSGKPT
MLBr_00204|M.leprae_Br4923 EIYLNTFRHLCGLDCSHIAPANVYGPRQDPYGEAGVVAIFVQALLSDRPT
MAB_0503|M.abscessus_ATCC_1997 EIYLNTFRHLYGLECSHIAPANVYGPRQDPHGEAGVVAIFAQALLSGRST
MSMEG_6142|M.smegmatis_MC2_155 EVYLNMYRNLYDLDCSHIAPANVYGPRQDPHGEAGVVAIFSEALLAGRTT
TH_0330|M.thermoresistible__bu DMLVRAWVRSYGVAATISNCSNNYGPYQHVEKF---IPRQITNVLTGRRP
Mvan_1365|M.vanbaalenii_PYR-1 DMLVRAWVRSYRVAATISNCSNNYGPYQHVEKF---IPRQITNVLTGRRP
Mflv_3296|M.gilvum_PYR-GCK DLLVRAWTRSFGVAATISNCSNNYGPYQHVEKF---IPRQITNVLWGIRP
MMAR_5346|M.marinum_M DRLCYSYFRSFGIDVTIVRPFNIFGIRQKTGRFGALIPRLVRQAINGKNL
MAV_4084|M.avium_104 EALTFAYHRLGRADVGVARIFNTYGPGMR-ADDGRMVPTFCLQALRGDPL
: : . * :* :. : .
Mb3658c|M.bovis_AF2122/97 RVFGDGTNTRDYVFVDDVVDAFVRVSADVGGGLRFNIGTGKETSDRQLHS
Rv3634c|M.tuberculosis_H37Rv RVFGDGTNTRDYVFVDDVVDAFVRVSADVGGGLRFNIGTGKETSDRQLHS
MUL_4210|M.ulcerans_Agy99 KVFGDGTNTRDYVFVDDVVDAFVKAGSDVGGGQRFNIGTGVETSDRQLHS
MLBr_00204|M.leprae_Br4923 KVFGDGTHTRDYVFVDDVVDAFIKASGDAGGGQRFNIGTGIETSDRQLHT
MAB_0503|M.abscessus_ATCC_1997 KVFGDGGNTRDYVFVDDVVEAFVRASGPDGGGQRFNVGTGVETSDRQLHS
MSMEG_6142|M.smegmatis_MC2_155 KIFGDGSDTRDYVFVDDVVDAFVRAGGPAGGGQRFNVGTGVETSTRELHT
TH_0330|M.thermoresistible__bu KLYGTGANVRDWIHVEDHNDAVWRILTAGQIGRTYLIGADGERDNRTVLR
Mvan_1365|M.vanbaalenii_PYR-1 ELYGTGANVRDWIHVDDHNSAVWRILHDGTVGRTYLIGADGERDNLSVMR
Mflv_3296|M.gilvum_PYR-GCK RLYGEGRNVRDWIHADDHSSAVLLILEKGRIGETYLIGANGEKDNKTVVE
MMAR_5346|M.marinum_M TIFGAGTSSRDYLYISDIVNAYNLILQTPSLRGQTINFASGK--DTCVKD
MAV_4084|M.avium_104 TVSGTGLQTRSLCYVDDTITGLIALAHSDFAG-PVNIGNPTELTVLSAAE
: * * *. . .* . :
Mb3658c|M.bovis_AF2122/97 AVAAAVGG-PDDPEFHPPRLGDLKRSCLDIGLAERVLGWRP-QIELADGV
Rv3634c|M.tuberculosis_H37Rv AVAAAVGG-PDDPEFHPPRLGDLKRSCLDIGLAERVLGWRP-QIELADGV
MUL_4210|M.ulcerans_Agy99 AVAAAVGG-PDDPEFHPPRLGDLKRSCLDISRAEEVLGWRP-QVELADGV
MLBr_00204|M.leprae_Br4923 AVSAAVGG-PDDPEFHPPRLGDLKRSCLDIGLATTVLGWSP-QVQLDDGV
MAB_0503|M.abscessus_ATCC_1997 LVAAAAGA-PDDPEFHPPRLGDLRQSCLDVGLAKRVLGWEP-RVPLADGI
MSMEG_6142|M.smegmatis_MC2_155 AIAGAVGA-PDEPEFHPPRLGDLRRSRLDNTRAREVLGWQP-QVALAEGI
TH_0330|M.thermoresistible__bu TILKLMDRDPDDFDHVTDRAGHDLRYAIDPSALIDELGWTPRHTDFEAGL
Mvan_1365|M.vanbaalenii_PYR-1 TILRLMGRSPEDFDHVTDRVGHDLRYAIDPTPLRDELGWRPEHTDFESGL
Mflv_3296|M.gilvum_PYR-GCK LILTLMGEDADAYDRVPDRLGHDLRYAIDPTKLREELGWQPGYGDFEHGL
MMAR_5346|M.marinum_M IVEYVAGKFDATIEHRDARPGEVQRFPADIS-LARSIGFEP-QVDIWEGI
MAV_4084|M.avium_104 LIRELAGS-TSTIQFTPPATDDPQRRCPDIRLARQRLGWRP-RVDYRTGL
: . : .. : * :*: * *:
Mb3658c|M.bovis_AF2122/97 RRTVEYFRHKHTD-----------------
Rv3634c|M.tuberculosis_H37Rv RRTVEYFRHKHTD-----------------
MUL_4210|M.ulcerans_Agy99 RRTVDYFRRTHGS-----------------
MLBr_00204|M.leprae_Br4923 RRTVEYFRAAQRS-----------------
MAB_0503|M.abscessus_ATCC_1997 RRTVDFFRS---------------------
MSMEG_6142|M.smegmatis_MC2_155 AKTVEFFRNKSQ------------------
TH_0330|M.thermoresistible__bu RDTIQWYRDNEDWWRPLKDATEDAYAERGQ
Mvan_1365|M.vanbaalenii_PYR-1 RDTIDWYRDNESWWGPLKDAVEATYQRRRR
Mflv_3296|M.gilvum_PYR-GCK AATIEWYRTHEDWWTPAKEATEAFYARIGQ
MMAR_5346|M.marinum_M DRYIAWAKDQPQHAYELDGLGDRSTANG--
MAV_4084|M.avium_104 STTLAWFAERAGRTGESAQQLVATTDRRTR
: :