For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
SRILVTGGVGTIGSAVVRRLLHESAYEIRVCDQRPAPQWMNEACEIRTGDLRSADEARAAVDGCTHVIHL AAIVGGIANFHRLPHTLLEMNTGLYNSVFSAALREGVERLVYVSSSMVFEQATQFPTTEEHLLDCRPPRS AYGFSKLTGEIYCRAVHEEHGLPFTICRPFNAYGPGELPDTEPGIAHAVPDLIRKALSGQHPLQIFGSGT QTRTLTHVDDIADGIVTAMFHPAGENQDFNISASEEHTIAEIAQMIWTACGLDPEDFALENVPTFEVDVQ RRWPSVEKARMLLGWQARVDLRDGIATTVEWLREQQCIARNS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5956 | - | - | 100% (323) | NAD dependent epimerase/dehydratase family protein |
| M. smegmatis MC2 155 | MSMEG_6142 | - | 6e-24 | 30.43% (322) | nucleoside-diphosphate-sugar epimerase |
| M. smegmatis MC2 155 | MSMEG_0386 | - | 1e-16 | 24.79% (363) | NAD dependent epimerase/dehydratase family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3658c | galE1 | 8e-23 | 28.96% (328) | UDP-glucose 4-epimerase GALE1 (galactowaldenase) |
| M. gilvum PYR-GCK | Mflv_4753 | - | 1e-25 | 29.06% (320) | NAD-dependent epimerase/dehydratase |
| M. tuberculosis H37Rv | Rv1512 | epiA | 1e-29 | 31.10% (328) | nucleotide-sugar epimerase epiA |
| M. leprae Br4923 | MLBr_00204 | rmlB2 | 9e-26 | 31.33% (332) | putative sugar-nucleotide dehydratase |
| M. abscessus ATCC 19977 | MAB_0503 | - | 5e-25 | 30.65% (323) | UDP-glucose 4-epimerase GalE1 |
| M. marinum M | MMAR_2310 | galE5 | 7e-55 | 37.46% (331) | UDP-glucose 4-epimerase, GalE5 |
| M. avium 104 | MAV_4084 | - | 8e-27 | 30.24% (334) | UDP-glucuronic acid decarboxylase 1 |
| M. thermoresistible (build 8) | TH_3827 | - | 7e-18 | 26.71% (337) | PUTATIVE putative dehydrogenase |
| M. ulcerans Agy99 | MUL_1512 | - | 5e-54 | 37.16% (331) | UDP-glucose 4-epimerase |
| M. vanbaalenii PYR-1 | Mvan_0882 | - | 3e-14 | 27.03% (344) | NAD-dependent epimerase/dehydratase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_2310|M.marinum_M --------------------------------MKVLVTGSAGFINGYVVQ
MUL_1512|M.ulcerans_Agy99 --------------------------------MKVLVTGSAGFINGYVVQ
MSMEG_5956|M.smegmatis_MC2_155 -------------------------------MSRILVTGGVGTIGSAVVR
Mb3658c|M.bovis_AF2122/97 --------------------------------MRALVTGAAGFIGSTLVD
MLBr_00204|M.leprae_Br4923 ---------------------------MYGEPVRALVTGAAGFIGSTLVD
MAB_0503|M.abscessus_ATCC_1997 --------------------------------MRAMVTGAAGFIGSTLVD
Mvan_0882|M.vanbaalenii_PYR-1 --------------------------------MRVLLTGAAGFIGTRIRE
Mflv_4753|M.gilvum_PYR-GCK ----------------------------------MTASEIVSPRELDRAA
Rv1512|M.tuberculosis_H37Rv ----------------------------------MNAHTSVGP--LDRAA
MAV_4084|M.avium_104 MVDMTGATTPKGNGETGFHARPDGYQSPMRSLTRVLITGGAGFLGAHLCA
TH_3827|M.thermoresistible__bu ------------------MTDEDRIPCGAMSRPSVFITGANGFIGRSLGA
.
MMAR_2310|M.marinum_M ELLQAGHEVVGIDNYSK-YGKVTKSYDDHPNYHFVEGDVKDVDLMFELVE
MUL_1512|M.ulcerans_Agy99 ELLQAGHEVIGIDNYSK-YGEVTKSYDDHPNYHFVEGDVKDVDLMFELVE
MSMEG_5956|M.smegmatis_MC2_155 RLLHESAYEIRVCDQRP-APQWMN-----EACEIRTGDLRSADEARAAVD
Mb3658c|M.bovis_AF2122/97 RLLADGHSVVGLDNFATGRATNLEHLADNSAHVFVEADIVTADLHAILEQ
MLBr_00204|M.leprae_Br4923 RLLADGHTVVGLDNFATGHAANLEHLASTPALAFVEADIVTADLQTILDE
MAB_0503|M.abscessus_ATCC_1997 RLLADGHEVTGLDNLATGKVANLEAAEANAKFTFVKDDIVEADLDAVVAE
Mvan_0882|M.vanbaalenii_PYR-1 RLIDGGHDVVAVDAMLPAAHGEDAAPPDDVARVDVRDAAAVADAVAG---
Mflv_4753|M.gilvum_PYR-GCK TFYVAGHRGLVGSAIVRRLRVAGFDNIVGKTSAELDLKNRDAVFDFMSEI
Rv1512|M.tuberculosis_H37Rv RVYIAGHRGLVGSALLRTFAGAGFTNLLVRSRAELDLTDRAATFDFVLES
MAV_4084|M.avium_104 RLLDDGVEVVSVDDLST--SGPAVRFGDRPGYRFVQRDVCDPGLIDEVGS
TH_3827|M.thermoresistible__bu HFAENGYDVRGVD------------LAADPARNVVAGDVVNPRPWKSHLQ
. .
MMAR_2310|M.marinum_M GCEQMVASAARIGGITYFHEYAYDLLAENERIAAAHFDTAIYAYRKGWLK
MUL_1512|M.ulcerans_Agy99 GCEQMVASAARIGGITYFHEYAYDLLAENERIAAAHFDTAIYAYRKGWLK
MSMEG_5956|M.smegmatis_MC2_155 GCTHVIHLAAIVGGIANFHRLPHTLLEMNTGLYNSVFSAALREG----VE
Mb3658c|M.bovis_AF2122/97 HRPEVVFHLAAQIDVRRSVADPQFDAAVNVIGTVRLAEAARQTG----VR
MLBr_00204|M.leprae_Br4923 HRPEVVFHLAAQIDVRHSVVDPQFDASVNVIGTVRLAEAARHTG----VR
MAB_0503|M.abscessus_ATCC_1997 YSPEVIFHLAAQIDVRHSVADPQFDSSVNVVGTVRLAEAARKAG----VR
Mvan_0882|M.vanbaalenii_PYR-1 --VDVVCHQAAVVGAGVDAADAPSYAAHNDFATAVLLAQMFGAG----CR
Mflv_4753|M.gilvum_PYR-GCK KPRYVVLAAAKVGGILANSNYPVDFLSDNIRIQVNVLDAARDCG----VE
Rv1512|M.tuberculosis_H37Rv RPQVVIDAAARVGGILANDTYPADFLSENLQIQVNLLDAAVAAR----VP
MAV_4084|M.avium_104 G-FDAVFHLASAASPVDYQRRPIQTLRTGSAGTATALEIAERAG-----A
TH_3827|M.thermoresistible__bu GCAVVLHTAAVVSNAVAAG----QQWQANVLGTRRVLEAAARAG----VE
: * . .
MMAR_2310|M.marinum_M KINVIS-----------------------------------SSMVFENAS
MUL_1512|M.ulcerans_Agy99 KINVIS-----------------------------------SSMVFENAS
MSMEG_5956|M.smegmatis_MC2_155 RLVYVS-----------------------------------SSMVFEQAT
Mb3658c|M.bovis_AF2122/97 KIVHTS----------------------------------SGGSIYGTPP
MLBr_00204|M.leprae_Br4923 KIVHTS----------------------------------SGGSIYGTPS
MAB_0503|M.abscessus_ATCC_1997 KIVHTS----------------------------------SGGSIYGTPK
Mvan_0882|M.vanbaalenii_PYR-1 RLVLASSMVVYGQGRYVCPGHGDVDPVPRTRSDLDAGAFDHRCPICGEPV
Mflv_4753|M.gilvum_PYR-GCK RLLFLG-----------------------------------SSCIYPKFA
Rv1512|M.tuberculosis_H37Rv RLLFLG-----------------------------------SSCIYPKLA
MAV_4084|M.avium_104 RFVLAS-----------------------------------TSEVYGDPE
TH_3827|M.thermoresistible__bu RVVHFS-----------------------------------SVRAYGDLG
:. .
MMAR_2310|M.marinum_M IFPTPEKHITECP--PPTSTYGFQKLACEYFAHGAYEQYGLPYTIIRPFN
MUL_1512|M.ulcerans_Agy99 IFPTPEKHITECP--PPTSTYVFQKLACEYFAHGAYEQYGLPYTIIRPFN
MSMEG_5956|M.smegmatis_MC2_155 QFPTTEEHLLDCR--PPRSAYGFSKLTGEIYCRAVHEEHGLPFTICRPFN
Mb3658c|M.bovis_AF2122/97 EYPTP-ETAPTD----PASPYAAGKVAGEIYLNTFRHLYGLDCSHIAPAN
MLBr_00204|M.leprae_Br4923 QYPTP-ETVPTD----PTSPYAAGKVAGEIYLNTFRHLCGLDCSHIAPAN
MAB_0503|M.abscessus_ATCC_1997 QIPTS-ETVPTD----PHSPYAAGKVAGEIYLNTFRHLYGLECSHIAPAN
Mvan_0882|M.vanbaalenii_PYR-1 DWALVGEGAPLR----PRSLYAASKVAQEHYALAWSESTGGSVVALRYHN
Mflv_4753|M.gilvum_PYR-GCK EQPIREDSLLTGHLEPTNDAYAIAKIAGILHVQAVRRQYGLPWISAMPTN
Rv1512|M.tuberculosis_H37Rv PQPIPESALLTGPLEPTNDAYAIAKIAGILAVQAVRRQHGLPWISAMPTN
MAV_4084|M.avium_104 SHPQRESYWGNVNPVGPRSVYDEAKRYAEALTFAYHRLGRADVGVARIFN
TH_3827|M.thermoresistible__bu FPDGVKETWPLR---ADGRAYVDTKVAAEATAFAAHASGEIAVTVVRPGD
. * * :
MMAR_2310|M.marinum_M CVGTGEQRALGGREIPSGNVKLAMSHVVPDLVQKVVKGQDP----LHILG
MUL_1512|M.ulcerans_Agy99 CVGTGEQRALGGRGIPSGNVKLAMSHVVPDLVQKVVKGQDP----LHILG
MSMEG_5956|M.smegmatis_MC2_155 AYGPGE--------LP--DTEPGIAHAVPDLIRKALSGQHP----LQIFG
Mb3658c|M.bovis_AF2122/97 VYGPRQ-------------DPHG-EAGVVAIFAQALLSGKP----TRVFG
MLBr_00204|M.leprae_Br4923 VYGPRQ-------------DPYG-EAGVVAIFVQALLSDRP----TKVFG
MAB_0503|M.abscessus_ATCC_1997 VYGPRQ-------------DPHG-EAGVVAIFAQALLSGRS----TKVFG
Mvan_0882|M.vanbaalenii_PYR-1 VYGPGM-------------PRDTPYSGVAAIFRSALEAGDV----PRVFE
Mflv_4753|M.gilvum_PYR-GCK LYGPND------------NYSPTGSHVLPALIRRYDEAVASRAVSVTNWG
Rv1512|M.tuberculosis_H37Rv LYGPGD------------NFSPSGSHLLPALIRRYDEAKASGAPNVTNWG
MAV_4084|M.avium_104 TYGPGMR--------------ADDGRMVPTFCLQALRGDP-----LTVSG
TH_3827|M.thermoresistible__bu VYGPGS-------------------RPWTIIPVEEIKKGR-----LILPA
*. :
MMAR_2310|M.marinum_M DGSQVRHYTYGGDLARGIRTCMEHPAALNGDFNLSTPEATTVL-------
MUL_1512|M.ulcerans_Agy99 DGSQVRHYTYGGDLARGIRTCMEHPAALNGDFNLSTPEATTVL-------
MSMEG_5956|M.smegmatis_MC2_155 SGTQTRTLTHVDDIADGIVTAMFHPAGENQDFNISASEEHTIA-------
Mb3658c|M.bovis_AF2122/97 DGTNTRDYVFVDDVVDAFVRVSADVGGGL-RFNIGTGKETSDR-------
MLBr_00204|M.leprae_Br4923 DGTHTRDYVFVDDVVDAFIKASGDAGGGQ-RFNIGTGIETSDR-------
MAB_0503|M.abscessus_ATCC_1997 DGGNTRDYVFVDDVVEAFVRASGPDGGGQ-RFNVGTGVETSDR-------
Mvan_0882|M.vanbaalenii_PYR-1 DGGQMRDFVHVDDVAAANVAAVEAGTEGFNAFNVCSGKPVSIL-------
Mflv_4753|M.gilvum_PYR-GCK TGSPRREFLHSDDMADACLHLLENYDGPE-QVNVGSGTDVTIR-------
Rv1512|M.tuberculosis_H37Rv TGTPRRELLHVDDLASACLYLLEHFDGPT-HVNVGTGIDHTIG-------
MAV_4084|M.avium_104 TGLQTRSLCYVDDTITGLIALAHSDFAGP--VNIGNPTELTVL-------
TH_3827|M.thermoresistible__bu GGQGVFSPVYIDDLIAGILLAATHPDAAGQDFNLPGVEPVTCKTFFGHYT
* . .* . .*: :
MMAR_2310|M.marinum_M -------------ELAEVIWRKMRPDTP---FRYESDPPFEHDVQLRS-P
MUL_1512|M.ulcerans_Agy99 -------------ELAEVIWRKMRPDTP---FRYESDPPFEHDVQLRS-P
MSMEG_5956|M.smegmatis_MC2_155 -------------EIAQMIWTACGLDPED--FALENVPTFEVDVQRRW-P
Mb3658c|M.bovis_AF2122/97 -------------QLHSAVAAAVGGPDD-----PEFHPPRLGDLKRSC-L
MLBr_00204|M.leprae_Br4923 -------------QLHTAVSAAVGGPDD-----PEFHPPRLGDLKRSC-L
MAB_0503|M.abscessus_ATCC_1997 -------------QLHSLVAAAAGAPDD-----PEFHPPRLGDLRQSC-L
Mvan_0882|M.vanbaalenii_PYR-1 -------------DVATALCEARGDVSP-----LVTGQYRSGDVRHIV-A
Mflv_4753|M.gilvum_PYR-GCK -------------EIAESVAAAVGFSGE-----THWDTTKPDGTPQKL-L
Rv1512|M.tuberculosis_H37Rv -------------EIAEMVASAVGYSGE-----TRWDPSKPDGTPRKL-L
MAV_4084|M.avium_104 -------------SAAELIRELAGSTST-----IQFTPPATDDPQRRC-P
TH_3827|M.thermoresistible__bu RMLNKPPPRTVPTRVAIALATAAGTVERFRGRSSELNAETVYYLTRAGGY
:
MMAR_2310|M.marinum_M DVHKATQVLGFEATTTLDAMLDEVIPWIVN--AVEAGTI-----------
MUL_1512|M.ulcerans_Agy99 DVHKATQVLGFEATTTLDAMLDEVIPWIVN--AVEAGTI-----------
MSMEG_5956|M.smegmatis_MC2_155 SVEKARMLLGWQARVDLRDGIATTVEWLREQQCIARNS------------
Mb3658c|M.bovis_AF2122/97 DIGLAERVLGWRPQIELADGVRRTVEYFRHKHTD----------------
MLBr_00204|M.leprae_Br4923 DIGLATTVLGWSPQVQLDDGVRRTVEYFRAAQRS----------------
MAB_0503|M.abscessus_ATCC_1997 DVGLAKRVLGWEPRVPLADGIRRTVDFFRS--------------------
Mvan_0882|M.vanbaalenii_PYR-1 DPARAADVLGFRAVVDPADGLCEFATAPLRGPALPS--------------
Mflv_4753|M.gilvum_PYR-GCK DVSKLT-QAGWTSKISLQEGIERTVAWYREHVGALRG-------------
Rv1512|M.tuberculosis_H37Rv DVSVLR-EAGWRPSIALRDGIEATVAWYREHAGTVRQ-------------
MAV_4084|M.avium_104 DIRLARQRLGWRPRVDYRTGLSTTLAWFAERAGRTGESAQQLVATTDRRT
TH_3827|M.thermoresistible__bu SRAKAERVLGWVPQVSLDEGMARTEAWLRTEGYLD---------------
. *: . :
MMAR_2310|M.marinum_M -
MUL_1512|M.ulcerans_Agy99 -
MSMEG_5956|M.smegmatis_MC2_155 -
Mb3658c|M.bovis_AF2122/97 -
MLBr_00204|M.leprae_Br4923 -
MAB_0503|M.abscessus_ATCC_1997 -
Mvan_0882|M.vanbaalenii_PYR-1 -
Mflv_4753|M.gilvum_PYR-GCK -
Rv1512|M.tuberculosis_H37Rv -
MAV_4084|M.avium_104 R
TH_3827|M.thermoresistible__bu -