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RALVTGAAGFIGSTLVDRLLADGHTVVGLDNFATGRATNLEHLVDNLAHVFVEADIVDADLQAIFEQHRP EVIFHLAAQIDVRHSVADPQFDASVNVIGTLRLAEAARLTGVRKVVHTSSGGSIYGTPPQYPTSERVPTD PASPYAAGKVAGEIYLNTFRHLYGLECSHIAPANVYGPRQDPHGEAGVVAIFAQALLSGKPTKVFGDGTN TRDYVFVDDVVDAFVRAGSDVGGGQRFNIGTGVETSDRQLHSAVAAAVGGPDDPEFHPPRLGDLKRSCLD ISRAEEVLGWRPQVELADGVRRTVDYFRRTHGS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_5133 | galE1 | - | 100% (314) | UDP-glucose 4-epimerase GalE1 |
| M. marinum M | MMAR_5346 | rmlB_1 | 3e-32 | 29.45% (309) | dTDP-glucose-4,6-dehydratase, RmlB_1 |
| M. marinum M | MMAR_1082 | rmlB | 6e-27 | 30.75% (322) | dTDP-glucose-4,6-dehydratase, RmlB |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3658c | galE1 | 1e-165 | 90.38% (312) | UDP-glucose 4-epimerase GALE1 (galactowaldenase) |
| M. gilvum PYR-GCK | Mflv_3296 | - | 9e-26 | 30.00% (320) | dTDP-glucose 4,6-dehydratase |
| M. tuberculosis H37Rv | Rv3634c | galE1 | 1e-165 | 90.38% (312) | UDP-glucose 4-epimerase GALE1 (galactowaldenase) |
| M. leprae Br4923 | MLBr_00204 | rmlB2 | 1e-155 | 84.39% (314) | putative sugar-nucleotide dehydratase |
| M. abscessus ATCC 19977 | MAB_0503 | - | 1e-146 | 80.91% (309) | UDP-glucose 4-epimerase GalE1 |
| M. avium 104 | MAV_0524 | - | 1e-162 | 89.10% (312) | nucleoside-diphosphate-sugar epimerase |
| M. smegmatis MC2 155 | MSMEG_6142 | - | 1e-136 | 74.43% (309) | nucleoside-diphosphate-sugar epimerase |
| M. thermoresistible (build 8) | TH_3729 | - | 5e-27 | 32.28% (316) | PUTATIVE UDP-galactose 4-epimerase |
| M. ulcerans Agy99 | MUL_4210 | galE1 | 0.0 | 99.68% (314) | UDP-glucose 4-epimerase GalE1 |
| M. vanbaalenii PYR-1 | Mvan_1365 | - | 3e-27 | 29.69% (320) | dTDP-glucose 4,6-dehydratase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_5133|M.marinum_M -----MRALVTGAAGFIGSTLVDRLLADG--HTVVGLDNFATGRATNLEH
MUL_4210|M.ulcerans_Agy99 -----MRALVTGAAGFIGSTLVDRLLADG--HTVVGLDNFATGRATNLEH
Mb3658c|M.bovis_AF2122/97 -----MRALVTGAAGFIGSTLVDRLLADG--HSVVGLDNFATGRATNLEH
Rv3634c|M.tuberculosis_H37Rv -----MRALVTGAAGFIGSTLVDRLLADG--HSVVGLDNFATGRATNLEH
MLBr_00204|M.leprae_Br4923 MYGEPVRALVTGAAGFIGSTLVDRLLADG--HTVVGLDNFATGHAANLEH
MAV_0524|M.avium_104 -----MRALVTGAAGFIGSTLVDRLLADG--HTVVGLDNFASGRASNLEH
MAB_0503|M.abscessus_ATCC_1997 -----MRAMVTGAAGFIGSTLVDRLLADG--HEVTGLDNLATGKVANLEA
MSMEG_6142|M.smegmatis_MC2_155 ---MAVRTLVTGAAGFIGSTLVDRLLADG--HGVVGLDDLSSGRAENLHS
TH_3729|M.thermoresistible__bu -----MTWLVTGGAGYIGSHVVRALLEAD--LPVVVIDDLSTGLEKFVPS
Mflv_3296|M.gilvum_PYR-GCK ----MARLLVTGGAGFIGSNFVHHVLAHT-DHHVTVLDKLTYAGNRASLD
Mvan_1365|M.vanbaalenii_PYR-1 -----MRLLVTGGAGFIGANFVRTTVQQRPDVQVTVLDSLTYAGSRESLR
:***.**:**: .* : *. :*.:: .
MMAR_5133|M.marinum_M LVDNLAHVFVEADIVDADLQAIFEQHRPEVIFHLAAQIDVRHSVADPQFD
MUL_4210|M.ulcerans_Agy99 LVDNLAHVFVEADIVDADLQAIFEQHRPEVIFHLAAQIDVRHSVADPQFD
Mb3658c|M.bovis_AF2122/97 LADNSAHVFVEADIVTADLHAILEQHRPEVVFHLAAQIDVRRSVADPQFD
Rv3634c|M.tuberculosis_H37Rv LADNSAHVFVEADIVTADLHAILEQHRPEVVFHLAAQIDVRRSVADPQFD
MLBr_00204|M.leprae_Br4923 LASTPALAFVEADIVTADLQTILDEHRPEVVFHLAAQIDVRHSVVDPQFD
MAV_0524|M.avium_104 LVGNPAHVFVEADIVTADLEAILDEHRPEVVFHLAAQIDVRHSVADPQFD
MAB_0503|M.abscessus_ATCC_1997 AEANAKFTFVKDDIVEADLDAVVAEYSPEVIFHLAAQIDVRHSVADPQFD
MSMEG_6142|M.smegmatis_MC2_155 AENSDKFEFVKADIVDADLTGLLAEFKPEVIFHLAAQISVKRSVDDPPFD
TH_3729|M.thermoresistible__bu EVPLVRGTLLDADLVARALR----EHRVSGVIHIAGFKYAGVSVQQPLHT
Mflv_3296|M.gilvum_PYR-GCK GLPERRLDFVHGDVADADLVD-ELVAGTDAVVHYAAESHNDNSLDRPEPF
Mvan_1365|M.vanbaalenii_PYR-1 GVDS-QIRLVEGDITDAELVG-KLVADSDAVVHFAAETHVDNALADPEPF
::. *:. * . :.* *. :: *
MMAR_5133|M.marinum_M ASVNVIGTLRLAEAARLTGVR--KVVHTSSGGSIYGTPPQYPTS---ERV
MUL_4210|M.ulcerans_Agy99 ASVNVIGTLRLAEAARLTGVR--KVVHTSSGGSIYGTPPQYPTS---ERV
Mb3658c|M.bovis_AF2122/97 AAVNVIGTVRLAEAARQTGVR--KIVHTSSGGSIYGTPPEYPTP---ETA
Rv3634c|M.tuberculosis_H37Rv AAVNVIGTVRLAEAARQTGVR--KIVHTSSGGSIYGTPPEYPTP---ETA
MLBr_00204|M.leprae_Br4923 ASVNVIGTVRLAEAARHTGVR--KIVHTSSGGSIYGTPSQYPTP---ETV
MAV_0524|M.avium_104 ASVNVIGTVRLAEAARRTGVR--KIVHTSSGGSIYGTPPTYPTP---ETV
MAB_0503|M.abscessus_ATCC_1997 SSVNVVGTVRLAEAARKAGVR--KIVHTSSGGSIYGTPKQIPTS---ETV
MSMEG_6142|M.smegmatis_MC2_155 ATVNVVGTVRLAEAARLAGVR--KVVHTSSGGSVYGTPPAYPTS---EDM
TH_3729|M.thermoresistible__bu YEQNVSAMVTLLKAMQDTGVD--MMVFSSS-AATFGTPDVDLVT---ETT
Mflv_3296|M.gilvum_PYR-GCK LHSNVIGTFTVLEAVRRHGR----RLHHVSTDEVYGDLELDDPARFTESS
Mvan_1365|M.vanbaalenii_PYR-1 VHSNVLGTFTVLEAVRHASVTKPVRLHHISTDEVYGDLELDDPARFTDAT
** . . : :* : . :. * :* . :
MMAR_5133|M.marinum_M PTDPASPYAAGKVAGEIYLNTFRHLYGLECSHIAPANVYG---PRQDPHG
MUL_4210|M.ulcerans_Agy99 PTDPASPYAAGKVAGEIYLNTFRHLYGLECSHIAPANVYG---PRQDPHG
Mb3658c|M.bovis_AF2122/97 PTDPASPYAAGKVAGEIYLNTFRHLYGLDCSHIAPANVYG---PRQDPHG
Rv3634c|M.tuberculosis_H37Rv PTDPASPYAAGKVAGEIYLNTFRHLYGLDCSHIAPANVYG---PRQDPHG
MLBr_00204|M.leprae_Br4923 PTDPTSPYAAGKVAGEIYLNTFRHLCGLDCSHIAPANVYG---PRQDPYG
MAV_0524|M.avium_104 PTDPASPYAAGKVAGEIYLNTFRHLYGLDCSHIAPANVYG---PRQDPHG
MAB_0503|M.abscessus_ATCC_1997 PTDPHSPYAAGKVAGEIYLNTFRHLYGLECSHIAPANVYG---PRQDPHG
MSMEG_6142|M.smegmatis_MC2_155 PVNPASPYAAGKVAGEVYLNMYRNLYDLDCSHIAPANVYG---PRQDPHG
TH_3729|M.thermoresistible__bu PTRPESPYGESKLIGEWLLADVGRATGLRHTSLRYFNVVGSGSPELFDVS
Mflv_3296|M.gilvum_PYR-GCK PYNPSSPYSSTKAGSDLLVRAWTRSFGVAATISNCSNNYG------PYQH
Mvan_1365|M.vanbaalenii_PYR-1 PYNPSSPYSSTKAAADMLVRAWVRSYRVAATISNCSNNYG------PYQH
* * ***. * .: : . : : * *
MMAR_5133|M.marinum_M EAGVVAIFAQALLSGKPTKVFGD------GTNTRDYVFVDDVVDAFVRAG
MUL_4210|M.ulcerans_Agy99 EAGVVAIFAQALLSGKPTKVFGD------GTNTRDYVFVDDVVDAFVKAG
Mb3658c|M.bovis_AF2122/97 EAGVVAIFAQALLSGKPTRVFGD------GTNTRDYVFVDDVVDAFVRVS
Rv3634c|M.tuberculosis_H37Rv EAGVVAIFAQALLSGKPTRVFGD------GTNTRDYVFVDDVVDAFVRVS
MLBr_00204|M.leprae_Br4923 EAGVVAIFVQALLSDRPTKVFGD------GTHTRDYVFVDDVVDAFIKAS
MAV_0524|M.avium_104 EAGVVAIFAQALLSGKPTKVFGD------GTNTRDYVFVDDVVDAFVKAS
MAB_0503|M.abscessus_ATCC_1997 EAGVVAIFAQALLSGRSTKVFGD------GGNTRDYVFVDDVVEAFVRAS
MSMEG_6142|M.smegmatis_MC2_155 EAGVVAIFSEALLAGRTTKIFGD------GSDTRDYVFVDDVVDAFVRAG
TH_3729|M.thermoresistible__bu PHNLFPLVFDMLYRGETPRINGDDYPTPDGTCVRDYIHVADLALAHVAAA
Mflv_3296|M.gilvum_PYR-GCK VEKFIPRQITNVLWGIRPRLYGE------GRNVRDWIHADDHSSAVLLIL
Mvan_1365|M.vanbaalenii_PYR-1 VEKFIPRQITNVLTGRRPELYGT------GANVRDWIHVDDHNSAVWRIL
... : . ..: * * .**::.. * *
MMAR_5133|M.marinum_M SDVGGGQ----RFNIGTGVETSDRQLHSAVAAAVG-GPDDPEFHPPRLGD
MUL_4210|M.ulcerans_Agy99 SDVGGGQ----RFNIGTGVETSDRQLHSAVAAAVG-GPDDPEFHPPRLGD
Mb3658c|M.bovis_AF2122/97 ADVGGGL----RFNIGTGKETSDRQLHSAVAAAVG-GPDDPEFHPPRLGD
Rv3634c|M.tuberculosis_H37Rv ADVGGGL----RFNIGTGKETSDRQLHSAVAAAVG-GPDDPEFHPPRLGD
MLBr_00204|M.leprae_Br4923 GDAGGGQ----RFNIGTGIETSDRQLHTAVSAAVG-GPDDPEFHPPRLGD
MAV_0524|M.avium_104 GDAGGGQ----RFNIGTGVETSDRQLHSAVAAAVG-GPDDPEFHPPRLGD
MAB_0503|M.abscessus_ATCC_1997 GPDGGGQ----RFNVGTGVETSDRQLHSLVAAAAG-APDDPEFHPPRLGD
MSMEG_6142|M.smegmatis_MC2_155 GPAGGGQ----RFNVGTGVETSTRELHTAIAGAVG-APDEPEFHPPRLGD
TH_3729|M.thermoresistible__bu RRLQAGEPVEPVYNLGSGSGTSVREIMTAIRKVTG-VDFVPEIAPRRPGD
Mflv_3296|M.gilvum_PYR-GCK EKGRIGE----TYLIGANGEKDNKTVVELILTLMGEDADAYDRVPDRLGH
Mvan_1365|M.vanbaalenii_PYR-1 HDGTVGR----TYLIGADGERDNLSVMRTILRLMGRSPEDFDHVTDRVGH
* : :*:. . : : * : . * *.
MMAR_5133|M.marinum_M LKRSCLDISRAEEVLGWRP-QVELADGVRRTVDYFRRTHGS---------
MUL_4210|M.ulcerans_Agy99 LKRSCLDISRAEEVLGWRP-QVELADGVRRTVDYFRRTHGS---------
Mb3658c|M.bovis_AF2122/97 LKRSCLDIGLAERVLGWRP-QIELADGVRRTVEYFRHKHTD---------
Rv3634c|M.tuberculosis_H37Rv LKRSCLDIGLAERVLGWRP-QIELADGVRRTVEYFRHKHTD---------
MLBr_00204|M.leprae_Br4923 LKRSCLDIGLATTVLGWSP-QVQLDDGVRRTVEYFRAAQRS---------
MAV_0524|M.avium_104 LKRSCLDIGLAARVLGWQP-KVGLQQGVARTVEYFRNQHN----------
MAB_0503|M.abscessus_ATCC_1997 LRQSCLDVGLAKRVLGWEP-RVPLADGIRRTVDFFRS-------------
MSMEG_6142|M.smegmatis_MC2_155 LRRSRLDNTRAREVLGWQP-QVALAEGIAKTVEFFRNKSQ----------
TH_3729|M.thermoresistible__bu PARIVASGELAARDLGWRM-RHTLEDMVKSAWEARQRAGDAYPR------
Mflv_3296|M.gilvum_PYR-GCK DLRYAIDPTKLREELGWQPGYGDFEHGLAATIEWYRTHEDWWTPAKEATE
Mvan_1365|M.vanbaalenii_PYR-1 DLRYAIDPTPLRDELGWRPEHTDFESGLRDTIDWYRDNESWWGPLKDAVE
: . *** : : : : :
MMAR_5133|M.marinum_M --------
MUL_4210|M.ulcerans_Agy99 --------
Mb3658c|M.bovis_AF2122/97 --------
Rv3634c|M.tuberculosis_H37Rv --------
MLBr_00204|M.leprae_Br4923 --------
MAV_0524|M.avium_104 --------
MAB_0503|M.abscessus_ATCC_1997 --------
MSMEG_6142|M.smegmatis_MC2_155 --------
TH_3729|M.thermoresistible__bu --------
Mflv_3296|M.gilvum_PYR-GCK AFYARIGQ
Mvan_1365|M.vanbaalenii_PYR-1 ATYQRRRR