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RALVTGAAGFIGSTLVDRLLADGHSVVGLDNFATGRATNLEHLADNSAHVFVEADIVTADLHAILEQHRP EVVFHLAAQIDVRRSVADPQFDAAVNVIGTVRLAEAARQTGVRKIVHTSSGGSIYGTPPEYPTPETAPTD PASPYAAGKVAGEIYLNTFRHLYGLDCSHIAPANVYGPRQDPHGEAGVVAIFAQALLSGKPTRVFGDGTN TRDYVFVDDVVDAFVRVSADVGGGLRFNIGTGKETSDRQLHSAVAAAVGGPDDPEFHPPRLGDLKRSCLD IGLAERVLGWRPQIELADGVRRTVEYFRHKHTD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3634c | galE1 | - | 100% (314) | UDP-GLUCOSE 4-EPIMERASE GALE1 (GALACTOWALDENASE) (UDP-GALACTOSE 4-EPIMERASE) (URIDINE DIPHOSPHATE GALACTOSE 4-EPIMERASE) (URIDINE DIPHOSPHO-GALACTOSE 4-EPIMERASE) |
| M. tuberculosis H37Rv | Rv3784 | - | 4e-36 | 31.83% (311) | dTDP-glucose 4,6-dehydratase |
| M. tuberculosis H37Rv | Rv0536 | galE3 | 2e-26 | 32.17% (345) | UDP-glucose 4-epimerase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3658c | galE1 | 0.0 | 100.00% (314) | UDP-glucose 4-epimerase GALE1 (galactowaldenase) |
| M. gilvum PYR-GCK | Mflv_3296 | - | 3e-25 | 30.70% (316) | dTDP-glucose 4,6-dehydratase |
| M. leprae Br4923 | MLBr_00204 | rmlB2 | 1e-156 | 86.41% (309) | putative sugar-nucleotide dehydratase |
| M. abscessus ATCC 19977 | MAB_0503 | - | 1e-144 | 78.96% (309) | UDP-glucose 4-epimerase GalE1 |
| M. marinum M | MMAR_5133 | galE1 | 1e-165 | 90.38% (312) | UDP-glucose 4-epimerase GalE1 |
| M. avium 104 | MAV_0524 | - | 1e-165 | 90.06% (312) | nucleoside-diphosphate-sugar epimerase |
| M. smegmatis MC2 155 | MSMEG_6142 | - | 1e-132 | 71.70% (311) | nucleoside-diphosphate-sugar epimerase |
| M. thermoresistible (build 8) | TH_3729 | - | 3e-28 | 33.44% (320) | PUTATIVE UDP-galactose 4-epimerase |
| M. ulcerans Agy99 | MUL_4210 | galE1 | 1e-165 | 90.06% (312) | UDP-glucose 4-epimerase GalE1 |
| M. vanbaalenii PYR-1 | Mvan_5389 | - | 1e-28 | 32.31% (325) | UDP-glucose 4-epimerase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv3634c|M.tuberculosis_H37Rv -----MRALVTGAAGFIGSTLVDRLLADG-HSVVGLDNFATGRATNLEHL
Mb3658c|M.bovis_AF2122/97 -----MRALVTGAAGFIGSTLVDRLLADG-HSVVGLDNFATGRATNLEHL
MMAR_5133|M.marinum_M -----MRALVTGAAGFIGSTLVDRLLADG-HTVVGLDNFATGRATNLEHL
MUL_4210|M.ulcerans_Agy99 -----MRALVTGAAGFIGSTLVDRLLADG-HTVVGLDNFATGRATNLEHL
MLBr_00204|M.leprae_Br4923 MYGEPVRALVTGAAGFIGSTLVDRLLADG-HTVVGLDNFATGHAANLEHL
MAV_0524|M.avium_104 -----MRALVTGAAGFIGSTLVDRLLADG-HTVVGLDNFASGRASNLEHL
MAB_0503|M.abscessus_ATCC_1997 -----MRAMVTGAAGFIGSTLVDRLLADG-HEVTGLDNLATGKVANLEAA
MSMEG_6142|M.smegmatis_MC2_155 ---MAVRTLVTGAAGFIGSTLVDRLLADG-HGVVGLDDLSSGRAENLHSA
TH_3729|M.thermoresistible__bu -----MTWLVTGGAGYIGSHVVRALLEAD-LPVVVIDDLSTGLEKFVPSE
Mvan_5389|M.vanbaalenii_PYR-1 -----MTWLVTGGAGYIGSHVVRALRGAD-LDVVVIDDLSTGRAEFVPDG
Mflv_3296|M.gilvum_PYR-GCK ----MARLLVTGGAGFIGSNFVHHVLAHTDHHVTVLDKLTYAGNRASLDG
:***.**:*** .* : *. :*.:: .
Rv3634c|M.tuberculosis_H37Rv ADNSAHVFVEADIVTADLHAILEQHRPEVVFHLAAQIDVRRSVADPQFDA
Mb3658c|M.bovis_AF2122/97 ADNSAHVFVEADIVTADLHAILEQHRPEVVFHLAAQIDVRRSVADPQFDA
MMAR_5133|M.marinum_M VDNLAHVFVEADIVDADLQAIFEQHRPEVIFHLAAQIDVRHSVADPQFDA
MUL_4210|M.ulcerans_Agy99 VDNLAHVFVEADIVDADLQAIFEQHRPEVIFHLAAQIDVRHSVADPQFDA
MLBr_00204|M.leprae_Br4923 ASTPALAFVEADIVTADLQTILDEHRPEVVFHLAAQIDVRHSVVDPQFDA
MAV_0524|M.avium_104 VGNPAHVFVEADIVTADLEAILDEHRPEVVFHLAAQIDVRHSVADPQFDA
MAB_0503|M.abscessus_ATCC_1997 EANAKFTFVKDDIVEADLDAVVAEYSPEVIFHLAAQIDVRHSVADPQFDS
MSMEG_6142|M.smegmatis_MC2_155 ENSDKFEFVKADIVDADLTGLLAEFKPEVIFHLAAQISVKRSVDDPPFDA
TH_3729|M.thermoresistible__bu VPLVRGTLLDADLVAR----ALREHRVSGVIHIAGFKYAGVSVQQPLHTY
Mvan_5389|M.vanbaalenii_PYR-1 VPLVRANLLDADAVRT----TLDAYGVSGVIHIAGYKYAGESVRRPLHTY
Mflv_3296|M.gilvum_PYR-GCK LPERRLDFVHGDVADADLVDELVAG-TDAVVHYAAESHNDNSLDRPEPFL
::. * . . . :.* *. *: *
Rv3634c|M.tuberculosis_H37Rv AVNVIGTVRLAEAARQTGVRKIVHTSSGGSIYG---TPPEYPTPETAPTD
Mb3658c|M.bovis_AF2122/97 AVNVIGTVRLAEAARQTGVRKIVHTSSGGSIYG---TPPEYPTPETAPTD
MMAR_5133|M.marinum_M SVNVIGTLRLAEAARLTGVRKVVHTSSGGSIYG---TPPQYPTSERVPTD
MUL_4210|M.ulcerans_Agy99 SVNVIGTLRLAEAARLTGVRKVVHTSSGGSIYG---TPPQYPTSERVPTD
MLBr_00204|M.leprae_Br4923 SVNVIGTVRLAEAARHTGVRKIVHTSSGGSIYG---TPSQYPTPETVPTD
MAV_0524|M.avium_104 SVNVIGTVRLAEAARRTGVRKIVHTSSGGSIYG---TPPTYPTPETVPTD
MAB_0503|M.abscessus_ATCC_1997 SVNVVGTVRLAEAARKAGVRKIVHTSSGGSIYG---TPKQIPTSETVPTD
MSMEG_6142|M.smegmatis_MC2_155 TVNVVGTVRLAEAARLAGVRKVVHTSSGGSVYG---TPPAYPTSEDMPVN
TH_3729|M.thermoresistible__bu EQNVSAMVTLLKAMQDTGVDMMVFSSS-AATFG---TPDVDLVTETTPTR
Mvan_5389|M.vanbaalenii_PYR-1 QQNVSAMVTLLDAMSDAGVDRIVFSSS-AATYG---TPDTAVVDETTATR
Mflv_3296|M.gilvum_PYR-GCK HSNVIGTFTVLEAVRRHGRR--LHHVSTDEVYGDLELDDPARFTESSPYN
** . . : .* * :. * :* * .
Rv3634c|M.tuberculosis_H37Rv PASPYAAGKVAGEIYLNTFRHLYGLDCSHIAPANVYGPRQDPHGEAG---
Mb3658c|M.bovis_AF2122/97 PASPYAAGKVAGEIYLNTFRHLYGLDCSHIAPANVYGPRQDPHGEAG---
MMAR_5133|M.marinum_M PASPYAAGKVAGEIYLNTFRHLYGLECSHIAPANVYGPRQDPHGEAG---
MUL_4210|M.ulcerans_Agy99 PASPYAAGKVAGEIYLNTFRHLYGLECSHIAPANVYGPRQDPHGEAG---
MLBr_00204|M.leprae_Br4923 PTSPYAAGKVAGEIYLNTFRHLCGLDCSHIAPANVYGPRQDPYGEAG---
MAV_0524|M.avium_104 PASPYAAGKVAGEIYLNTFRHLYGLDCSHIAPANVYGPRQDPHGEAG---
MAB_0503|M.abscessus_ATCC_1997 PHSPYAAGKVAGEIYLNTFRHLYGLECSHIAPANVYGPRQDPHGEAG---
MSMEG_6142|M.smegmatis_MC2_155 PASPYAAGKVAGEVYLNMYRNLYDLDCSHIAPANVYGPRQDPHGEAG---
TH_3729|M.thermoresistible__bu PESPYGESKLIGEWLLADVGRATGLRHTSLRYFNVVGSGSPELFDVSPHN
Mvan_5389|M.vanbaalenii_PYR-1 PESPYGESKLIGEWLLRDIGVATGLRHTSLRYFNVVGSGPDGVFDVSPFN
Mflv_3296|M.gilvum_PYR-GCK PSSPYSSTKAGSDLLVRAWTRSFGVAATISNCSNNYGPYQHVEKFIP---
* ***. * .: : .: : * *.
Rv3634c|M.tuberculosis_H37Rv VVAIFAQALLSGKPTRVFGD------GTNTRDYVFVDDVVDAFVRVSADV
Mb3658c|M.bovis_AF2122/97 VVAIFAQALLSGKPTRVFGD------GTNTRDYVFVDDVVDAFVRVSADV
MMAR_5133|M.marinum_M VVAIFAQALLSGKPTKVFGD------GTNTRDYVFVDDVVDAFVRAGSDV
MUL_4210|M.ulcerans_Agy99 VVAIFAQALLSGKPTKVFGD------GTNTRDYVFVDDVVDAFVKAGSDV
MLBr_00204|M.leprae_Br4923 VVAIFVQALLSDRPTKVFGD------GTHTRDYVFVDDVVDAFIKASGDA
MAV_0524|M.avium_104 VVAIFAQALLSGKPTKVFGD------GTNTRDYVFVDDVVDAFVKASGDA
MAB_0503|M.abscessus_ATCC_1997 VVAIFAQALLSGRSTKVFGD------GGNTRDYVFVDDVVEAFVRASGPD
MSMEG_6142|M.smegmatis_MC2_155 VVAIFSEALLAGRTTKIFGD------GSDTRDYVFVDDVVDAFVRAGGPA
TH_3729|M.thermoresistible__bu LFPLVFDMLYRGETPRINGDDYPTPDGTCVRDYIHVADLALAHVAAARRL
Mvan_5389|M.vanbaalenii_PYR-1 LFPKVFDMLVHGQTPRINGDDYPTPDGTCVRDYIHVEDVAAAHVAAAHRL
Mflv_3296|M.gilvum_PYR-GCK ---RQITNVLWGIRPRLYGE------GRNVRDWIHADDHSSAVLLILEKG
: . .:: *: * .**::.. * * :
Rv3634c|M.tuberculosis_H37Rv GGGL----RFNIGTGKETSDRQLHSAVAAAVGGPDDP-EFHPPRLGDLKR
Mb3658c|M.bovis_AF2122/97 GGGL----RFNIGTGKETSDRQLHSAVAAAVGGPDDP-EFHPPRLGDLKR
MMAR_5133|M.marinum_M GGGQ----RFNIGTGVETSDRQLHSAVAAAVGGPDDP-EFHPPRLGDLKR
MUL_4210|M.ulcerans_Agy99 GGGQ----RFNIGTGVETSDRQLHSAVAAAVGGPDDP-EFHPPRLGDLKR
MLBr_00204|M.leprae_Br4923 GGGQ----RFNIGTGIETSDRQLHTAVSAAVGGPDDP-EFHPPRLGDLKR
MAV_0524|M.avium_104 GGGQ----RFNIGTGVETSDRQLHSAVAAAVGGPDDP-EFHPPRLGDLKR
MAB_0503|M.abscessus_ATCC_1997 GGGQ----RFNVGTGVETSDRQLHSLVAAAAGAPDDP-EFHPPRLGDLRQ
MSMEG_6142|M.smegmatis_MC2_155 GGGQ----RFNVGTGVETSTRELHTAIAGAVGAPDEP-EFHPPRLGDLRR
TH_3729|M.thermoresistible__bu QAGEPVEPVYNLGSGSGTSVREIMTAIRKVTGVDFVP-EIAPRRPGDPAR
Mvan_5389|M.vanbaalenii_PYR-1 ESGLPIEPVYNLGSGSGTSVREIMTTMRAVTGVDFEP-DVAARRAGDPAR
Mflv_3296|M.gilvum_PYR-GCK RIGET----YLIGANGEKDNKTVVELILTLMGEDADAYDRVPDRLGHDLR
* : :*:. .. : : : * . : . * *. :
Rv3634c|M.tuberculosis_H37Rv SCLDIGLAERVLGWRP-QIELADGVRRTVEYFRHKHTD------------
Mb3658c|M.bovis_AF2122/97 SCLDIGLAERVLGWRP-QIELADGVRRTVEYFRHKHTD------------
MMAR_5133|M.marinum_M SCLDISRAEEVLGWRP-QVELADGVRRTVDYFRRTHGS------------
MUL_4210|M.ulcerans_Agy99 SCLDISRAEEVLGWRP-QVELADGVRRTVDYFRRTHGS------------
MLBr_00204|M.leprae_Br4923 SCLDIGLATTVLGWSP-QVQLDDGVRRTVEYFRAAQRS------------
MAV_0524|M.avium_104 SCLDIGLAARVLGWQP-KVGLQQGVARTVEYFRNQHN-------------
MAB_0503|M.abscessus_ATCC_1997 SCLDVGLAKRVLGWEP-RVPLADGIRRTVDFFRS----------------
MSMEG_6142|M.smegmatis_MC2_155 SRLDNTRAREVLGWQP-QVALAEGIAKTVEFFRNKSQ-------------
TH_3729|M.thermoresistible__bu IVASGELAARDLGWRM-RHTLEDMVKSAWEAR-QRAGDAYPR--------
Mvan_5389|M.vanbaalenii_PYR-1 IVAAGDLAARDLDWRM-RHSLTDMVASAWSALPSRATDEAAP--------
Mflv_3296|M.gilvum_PYR-GCK YAIDPTKLREELGWQPGYGDFEHGLAATIEWYRTHEDWWTPAKEATEAFY
*.* : . : : .
Rv3634c|M.tuberculosis_H37Rv -----
Mb3658c|M.bovis_AF2122/97 -----
MMAR_5133|M.marinum_M -----
MUL_4210|M.ulcerans_Agy99 -----
MLBr_00204|M.leprae_Br4923 -----
MAV_0524|M.avium_104 -----
MAB_0503|M.abscessus_ATCC_1997 -----
MSMEG_6142|M.smegmatis_MC2_155 -----
TH_3729|M.thermoresistible__bu -----
Mvan_5389|M.vanbaalenii_PYR-1 -----
Mflv_3296|M.gilvum_PYR-GCK ARIGQ