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DFGALPPEINSTRMYAGAGAAPLMAAGATWNGLAVELSTTASSVESVIMQLTTEQWLGPASMSMVVAAQP YLAWLTYTAESAAHAAAQAMASAAAFEAAFAMTVPPAEVAANRALLAALVATNVLGQNTPAIMATEAHYG EMWAQDALAMYGYAASSAAAGRLNPLITPSQTANMAGLAGQAAAVSHAAAASTVQQVGLGSLISNLPNAV MGFASPLTSAADAAGLGGIIQDIEELLGITFVQNAINGAVNTTAWFVMATIPNAVFLGHAFAALNPATVT AAADAVPAAAAAAGLAHTVTPVGVGGASLTASLGEASSVGGLSVPAGWSTAAPAMTSGTTALEGSGWAVP EEAGPVAAMPGMAGISGAAKGAGAYAGPRYGFKPIVMPKQVVV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2768c | PPE43 | - | 100% (394) | PPE FAMILY PROTEIN |
| M. tuberculosis H37Rv | Rv1039c | PPE15 | e-148 | 70.10% (398) | PPE family protein |
| M. tuberculosis H37Rv | Rv2770c | PPE44 | e-123 | 60.56% (393) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2790c | PPE43 | 0.0 | 99.75% (394) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 7e-31 | 29.38% (422) | PPE protein |
| M. leprae Br4923 | MLBr_01182 | - | 1e-47 | 32.67% (401) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0809c | - | 2e-29 | 31.90% (373) | PPE family protein |
| M. marinum M | MMAR_1950 | - | 1e-165 | 74.62% (394) | PPE family protein, PPE15_1 |
| M. avium 104 | MAV_1347 | - | 7e-97 | 50.89% (393) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 2e-34 | 32.54% (378) | PPE family protein |
| M. thermoresistible (build 8) | TH_3113 | - | 9e-32 | 32.23% (391) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_4621 | - | 1e-148 | 69.19% (396) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 7e-33 | 30.26% (390) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv2768c|M.tuberculosis_H37Rv -------------MDFGALPPEINSTRMYAGAGAAPLMAAGATWNGLAVE
Mb2790c|M.bovis_AF2122/97 -------------MDFGALPPEINSTRMYAGAGAAPLMAAGATWNGLAVE
MMAR_1950|M.marinum_M -------------MDFGALPPEINSTRMYAGAGATPMMAAAAAWNRLAVE
MUL_4621|M.ulcerans_Agy99 -------------MDFGALPPEINSARMYAGAGAGPMMAASAAWNGLAVE
MAV_1347|M.avium_104 -----------MTFDFGALPPEVNSTRMYTGAGAAPMMAAAAAFSNLADE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
MAB_0809c|M.abscessus_ATCC_199 ---------MLAAPVWMASPPEVHSALLSSGPGPGPLLAAAAEWSSLGAH
TH_3113|M.thermoresistible__bu ----------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDE
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
* .** :*: : *.*. .: :*. : *. .
Rv2768c|M.tuberculosis_H37Rv LSTTASSVESVIMQLTTEQWLGPASMSMVVAAQPYLAWLTYTAESAAHAA
Mb2790c|M.bovis_AF2122/97 LSTTASSVESVIMQLTTEQWLGPASMSMVVAAQPYLAWLTYTAESAAHAA
MMAR_1950|M.marinum_M LGTTAASFESVVTQLTTEQWMGPASTSMAVAVQPYLAWLTYTAESAAHAG
MUL_4621|M.ulcerans_Agy99 LGTTAASYESVITRLTTESWMGPASMAMIAAAQPYLAWLTYTSEAAMHAG
MAV_1347|M.avium_104 LSTTAAATQSAIANLTGEEWMGPSAAAMVTAVQPYVQWMHTTAGQLQQAA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
MAB_0809c|M.abscessus_ATCC_199 YSATAQELRAILAATHASAWHGPSAETYVAAHTPYLEWLNQGALESNARA
TH_3113|M.thermoresistible__bu YRAAAVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAG
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLT-TFEGESAAALAERVTPYEKWLTQNAASAELTA
::* : : : * .: ** *: : .
Rv2768c|M.tuberculosis_H37Rv AQAMASAAAFEAAFAMTVPPAEVAANRALLAALVATNVLGQNTPAIMATE
Mb2790c|M.bovis_AF2122/97 AQAMASAAAFEAAFAMTVPPAEVAANRALLAALVATNVLGQNTPAIMATE
MMAR_1950|M.marinum_M AQATASAAAFEAAFAATVPPAAVAANRAQLAMLVSTNILGQNTPAIAATE
MUL_4621|M.ulcerans_Agy99 AQAAASAAAYEAAFAMTVPPPVVAANRSLLAALVATNFLGINTPAIMATE
MAV_1347|M.avium_104 AQAMASAAAYETAFAMTVPPALVAANRAQLAALIASNVLGQNAAAIAATE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
MAB_0809c|M.abscessus_ATCC_199 VQHGAAAGAYSTALAVMPTLAELAANHATHAALVATNFFGINTIPILATE
TH_3113|M.thermoresistible__bu AQLEAAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
.* .:* *. :*:: . : *:: *: :*.:* *: .* .*
Rv2768c|M.tuberculosis_H37Rv AHYGEMWAQDALAMYGYAASSAAAGRLNPLITPSQTANMAGLAGQAAAVS
Mb2790c|M.bovis_AF2122/97 AHYGEMWAQDALAMYGYAASSAAAGRLNPLITPSQTANMAGLAGQAAAVS
MMAR_1950|M.marinum_M AQYGEMWAQDALAMYGYAASSAAAGTLNPLTTPAQIANPAGLASQAAAVS
MUL_4621|M.ulcerans_Agy99 ALYAEMWAQDAGAMYGYAAASSTSGSLQPLSTPQQTTNPGGLAAQSAAVS
MAV_1347|M.avium_104 AQYGEMWAQDAAAMYGYAASSATAGKLSPLTSPAPTNQPGGLGAQAAAVS
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA
MAB_0809c|M.abscessus_ATCC_199 ADYVRMWVQAATTMATYQTASEVALASAPPSTPPPSILHD----------
TH_3113|M.thermoresistible__bu ADYARMWIQAATTMATYEAVASAAVSATPRTVAPPPILGAGTGESATAAI
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEVVEE
* * .** * * :* * : : .
Rv2768c|M.tuberculosis_H37Rv HAAAASTVQQVG--------------------------------------
Mb2790c|M.bovis_AF2122/97 HAAAASTVQQVG--------------------------------------
MMAR_1950|M.marinum_M QAAAATTVEQVG--------------------------------------
MUL_4621|M.ulcerans_Agy99 QAAAS-AAATDG--------------------------------------
MAV_1347|M.avium_104 GATAT-SAQTSG--------------------------------------
Mflv_0325|M.gilvum_PYR-GCK DMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLR---
Mvan_0415|M.vanbaalenii_PYR-1 DVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLR---
MSMEG_0619|M.smegmatis_MC2_155 SVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGG-QAILDFLK---
MAB_0809c|M.abscessus_ATCC_199 --HDHGHDDHDHEHGHDDDHG---------HGDLDPTDPEWWVHVAG---
TH_3113|M.thermoresistible__bu TGAHVTAELRAAESRTLLDEINELIDRLFAPLFPPGFADALPDGLLGTLL
MLBr_01182|M.leprae_Br4923 VVEEVVEEVVEAEQAIS---------------------------------
Rv2768c|M.tuberculosis_H37Rv --------------------LGSLISNLPNAVMGFASPLTSAADAA----
Mb2790c|M.bovis_AF2122/97 --------------------LGSLISNLPNAVMGFASPLTSAADAA----
MMAR_1950|M.marinum_M --------------------LGNLITNVPGAVMGLASPAASLVDAT----
MUL_4621|M.ulcerans_Agy99 --------------------TTSLLSNLPNTIMGLASPITSAIDAT----
MAV_1347|M.avium_104 --------------------LQGTVANVPNVVRTLAAP----ADPP----
Mflv_0325|M.gilvum_PYR-GCK -----------DPIGNTFALITDFLTNPVQALITWGPFLLAVVYQA----
Mvan_0415|M.vanbaalenii_PYR-1 -----------DPLGNTIKLITDFLTNPAQALITWGPFLAAVAYQA----
MSMEG_0619|M.smegmatis_MC2_155 -----------DPLGNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNL
MAB_0809c|M.abscessus_ATCC_199 -----------EMVEHFELLLNNLLTDPAALLTNLPMVLADVAFHA----
TH_3113|M.thermoresistible__bu APLLPGATGDGPPMATIMSFLLMGLSNPAYLFPVLVYLLFTGVVHTTVAV
MLBr_01182|M.leprae_Br4923 ------------------QAALDQAVNEGMEATVVPQVDQQVNVDVATPQ
:
Rv2768c|M.tuberculosis_H37Rv -GLGGIIQDIEELLGITFVQNAIN--------------------GAVNTT
Mb2790c|M.bovis_AF2122/97 -GLGGIIQDIEELLGITFVQNAIN--------------------GAVNTT
MMAR_1950|M.marinum_M -GLSTLVQDISSVLGTPFLQNAIN--------------------GAVNTA
MUL_4621|M.ulcerans_Agy99 -GLGGIIQDIEDFLGIPFVANVIN--------------------GAVNTA
MAV_1347|M.avium_104 -GLS----ALDNLLGNPVVNNVGN--------------------AGFNVV
Mflv_0325|M.gilvum_PYR-GCK VSWVGASILYPSLFLLPLLATT---LAIVAGVG--QHLLSLLNTPPAEEA
Mvan_0415|M.vanbaalenii_PYR-1 VSWVGASILYPSLLLLPLVATT---LAIVLGVG--AYLLENLPAPAEDAP
MSMEG_0619|M.smegmatis_MC2_155 VGWPTWGMIFASPFLIPALAALGI-TGLVLLID--HVLNNPVDVPAEDEA
MAB_0809c|M.abscessus_ATCC_199 AQLASTIGQFAPALIQPALALAIANLGWAAGFAGLAGIQPSPEILAVEPG
TH_3113|M.thermoresistible__bu SGMLAQLVPLMPALLPVAVAALGGLAGVWAGLSGLAGLAGLTAVPAADGG
MLBr_01182|M.leprae_Br4923 TAVPDSSSAAAPQLWGGFAQHLSP-----------------INDTLSMIN
:
Rv2768c|M.tuberculosis_H37Rv AWFVMATIPNAVFLGHAFAALNPATVTA-AADAVP-AAAAAAGLAHTVTP
Mb2790c|M.bovis_AF2122/97 AWFVMATIRNAVFLGHAFAALNPATVTA-AADAVP-AAAAAAGLAHTVTP
MMAR_1950|M.marinum_M AWFVMAAIPNSVFLGHTLNAIETAGAPV-AADLAP-ALAPAAGLRHAVAP
MUL_4621|M.ulcerans_Agy99 AWYTTATIPTAIFLANALNTGAPVIAAEGAIEAAEGAAAATAGLANTVTP
MAV_1347|M.avium_104 SWNVFNTIVSNILYNHTLDTAAAAGVAGEVGGAVG--GGALVGAAAPAT-
Mflv_0325|M.gilvum_PYR-GCK AEEPAPAQSAPSRPDQQSFPATMSAPPPPSGAPIAANTVSAGSPPAPGAP
Mvan_0415|M.vanbaalenii_PYR-1 AEEPAASSPAPTRADQPSPAIAVSAPPPPSSAAATVGTVATGTAPAPGAP
MSMEG_0619|M.smegmatis_MC2_155 PQEVAAAP----RTDQP-LAVGISPAGVPGSAATAAAPAPAPAGTTVAAP
MAB_0809c|M.abscessus_ATCC_199 SVEDAPMAASAGTALAPSPPASAAAPAAPASAPAPTASGTAPAPPSP-PP
TH_3113|M.thermoresistible__bu ASAAPVPAGGPSLPSGSSAPPAPTGSAAPTTGTAPGGAGSPPPAGHSVPP
MLBr_01182|M.leprae_Br4923 NHAGMANAGLSLVNGMGSAMKSLAPTTTKAAESAFKAMGSAVQSTGRGLL
.
Rv2768c|M.tuberculosis_H37Rv VGVGGASLTASLGEASSVGGLSVPAGWSTAAPAMTSGTTALEGSGWAVPE
Mb2790c|M.bovis_AF2122/97 VGVGGASLTASLGEASSVGGLSVPAGWSTAAPAMTSGTTALEGSGWAVPE
MMAR_1950|M.marinum_M LSFGGAGVEAGLGQAAGVGKLSVPVGWSSAAPALTSGTTALDGSGWAVPE
MUL_4621|M.ulcerans_Agy99 TGVG-----AALGEATLVGKLAVPTSWSNALPKTAATTGALGGSGWTVPE
MAV_1347|M.avium_104 AGVGAAPVLASMGSAATVGELSTPATWSAPTPEPAATT--VGATEWASPA
Mflv_0325|M.gilvum_PYR-GCK AAAAATFVPYVVAGRD-PYEGFSPTVRDSTGAKAPAGTIPAAASGIAASA
Mvan_0415|M.vanbaalenii_PYR-1 AAATASFVPYAVAGRD-PGTGFSPTVRDSTSAKAPASGIPAAASGVAASA
MSMEG_0619|M.smegmatis_MC2_155 APAAATFVPYAVANRD-PGEGFTPTLGNKSQVAAPASGVPAAASGVAASL
MAB_0809c|M.abscessus_ATCC_199 VGDPGFSFPYAVGGGPRLGTGLALAAQVRRGTSAAARSSAREQAAAAETA
TH_3113|M.thermoresistible__bu APHSAPPVGTSGPPYLIAAQPAPGVARRSAGARRAASIVEPAGSAAAAAA
MLBr_01182|M.leprae_Br4923 GSSSGGHVTAQLGRAASIGSLRVPQTWTTASQPVTAATRALSPARVAVAT
.: : : .
Rv2768c|M.tuberculosis_H37Rv EAGPVAAMPG----------------------------MAGISGAAKGAG
Mb2790c|M.bovis_AF2122/97 EAGPVAAMPG----------------------------MAGISGAAKGAG
MMAR_1950|M.marinum_M ESGPIAAMPG----------------------------GPGMAVAGKG-G
MUL_4621|M.ulcerans_Agy99 EAAPVSGVAG----------------------------VPGMAAAAKGAG
MAV_1347|M.avium_104 EEPHTAWATG----------------------------MPAVASAGRG-G
Mflv_0325|M.gilvum_PYR-GCK AERRKRRRRQKEEIKGRGYADAYADYEELPDDGPPEQPAPRVTASTRGAG
Mvan_0415|M.vanbaalenii_PYR-1 AERRKRRRRQKDEIAGRAYADAYADYEPEPDDEPPVRQEPRIAATERGAG
MSMEG_0619|M.smegmatis_MC2_155 ASRRKRRRKKGAQIEERGYADAYMDYEE-PDEDPAPQPEPRVRASERGSD
MAB_0809c|M.abscessus_ATCC_199 AARQARRRRDKGKQQGRG-----IEYMDMNATARCEEPAPDTTASHRGAG
TH_3113|M.thermoresistible__bu ARESAPIRRRRGQKDGLHG--------HRHEHQQPASMSAATAPSAAGIR
MLBr_01182|M.leprae_Br4923 ESESAPLLGGG---------------------------LPMAPMVPGGGS
. *
Rv2768c|M.tuberculosis_H37Rv AYAGPRYGFKPIVMPKQVVV------------------------------
Mb2790c|M.bovis_AF2122/97 AYAGPRYGFKPIVMPKQVVV------------------------------
MMAR_1950|M.marinum_M GFAGPRYGFKPTVMPKQVVV------------------------------
MUL_4621|M.ulcerans_Agy99 AYAGPRYGFKPIVMPKQVVV------------------------------
MAV_1347|M.avium_104 YGMGPRYGVKPKVMPTRLPV------------------------------
Mflv_0325|M.gilvum_PYR-GCK PMGFAGTVSRGDEQAGGLTTLA-GDSFGGGPREPMLPGTWDPDATDDRHT
Mvan_0415|M.vanbaalenii_PYR-1 PMGFAGTVSRDAAQAGGLTTLP-GDPFGGGPKAPMLPGTWDPDTEPD---
MSMEG_0619|M.smegmatis_MC2_155 AMGFTGTVTRHDVTAAGLTTLT-GDTFDDRPVTPMLPGTWDGDENPAP--
MAB_0809c|M.abscessus_ATCC_199 TMGFAGTVIKTGATASGLAMLSRDDDLFEGVRAPMVPNTWDP--------
TH_3113|M.thermoresistible__bu VLGGAGRISRTRGSVPHAEITP-GDPTEPSSPTDRAHRPAEPN-------
MLBr_01182|M.leprae_Br4923 GTGGVNTALRLQPRAFVMPRNPAAG-------------------------
:
Rv2768c|M.tuberculosis_H37Rv ---------------
Mb2790c|M.bovis_AF2122/97 ---------------
MMAR_1950|M.marinum_M ---------------
MUL_4621|M.ulcerans_Agy99 ---------------
MAV_1347|M.avium_104 ---------------
Mflv_0325|M.gilvum_PYR-GCK DGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 ---ERHNHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 ----SPDDPEGGPRR
MAB_0809c|M.abscessus_ATCC_199 ----EHGRQD-----
TH_3113|M.thermoresistible__bu ---------------
MLBr_01182|M.leprae_Br4923 ---------------