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DFGSLPPEINSGRIYSGPGSAPLLAAAAAWHGLAAEMHSAAASYGSAIAELRTLWHGPSSTAMAAAAAPF IAWLDGTAVQAEQTAAQATAAAAAYDSVFAATVPPPVIAANRALLASLIATNVLGQNTPAIAATEAHYAE MWAQDAAAMYAYAGASAVATRLTPFGAPPQTADANAAADQSAAAASALQSSTASSVESALSQAVSQVPVA AQVNATAVTAAAQLPLSLTDITGILKTFNSVMGTISGPYTPLGVANLAKNWYQIALSIPSVGTGIQGIGP LLHPKALTGVLAPLLRSDLLTGSTALSSAGTVSASAGRAGLVGALSVPANWASAVPAVRTVAAELPETML DAAPAMAVNGQQGMFGPTALSSLAGRAVGGTATRAVAGSTVRVPGAVAVDDLATTSTVIVIPPNAK*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_3356 | - | - | 100% (417) | PPE family protein |
| M. avium 104 | MAV_2906 | - | e-102 | 50.95% (422) | PPE family protein |
| M. avium 104 | MAV_2910 | - | e-100 | 51.18% (422) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1837 | PPE32 | 1e-110 | 51.92% (416) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 6e-34 | 32.93% (416) | PPE protein |
| M. tuberculosis H37Rv | Rv1808 | PPE32 | 1e-110 | 51.92% (416) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 1e-45 | 35.25% (366) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0809c | - | 3e-30 | 42.42% (165) | PPE family protein |
| M. marinum M | MMAR_2684 | - | 1e-103 | 51.42% (424) | PPE family protein, PPE32 |
| M. smegmatis MC2 155 | MSMEG_0064 | - | 5e-32 | 30.19% (414) | PPE family protein |
| M. thermoresistible (build 8) | TH_3569 | - | 3e-33 | 37.98% (208) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_3072 | - | 1e-103 | 51.18% (424) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 1e-34 | 32.45% (413) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
TH_3569|M.thermoresistible__bu ---------MMTAPIWMALPPEVHSALLSSGPGPGSLLAAASAWHALSAE
MAB_0809c|M.abscessus_ATCC_199 ---------MLAAPVWMASPPEVHSALLSSGPGPGPLLAAAAEWSSLGAH
Mb1837|M.bovis_AF2122/97 -------------MDFGALPPEINSGRMYAGPGSGPLLAAAAAWDALAAE
Rv1808|M.tuberculosis_H37Rv -------------MDFGALPPEINSGRMYAGPGSGPLLAAAAAWDALAAE
MMAR_2684|M.marinum_M ------------MIDFGALPPEINSGRMYVGPGAAPLIAAAAAWDELAAE
MUL_3072|M.ulcerans_Agy99 ------------MIDFGALPPEINSGRMYVGPGAAPLIAAAAAWDELAAE
MAV_3356|M.avium_104 -------------MDFGSLPPEINSGRIYSGPGSAPLLAAAAAWHGLAAE
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
MSMEG_0064|M.smegmatis_MC2_155 --------------MWIALPPEINTARLMVGAGPAPMLQAAAGWEGLAVL
: : .** :: : *.*...:: *. * *.
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
TH_3569|M.thermoresistible__bu YASAAAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSAATA
MAB_0809c|M.abscessus_ATCC_199 YSATAQELRAILAATHASAWHGPSAETYVAAHTPYLEWLNQGALESNARA
Mb1837|M.bovis_AF2122/97 LYSAAASYGSTIEGLTVAPWMGPSSITMAAAVAPYVAWISVTAGQAEQAG
Rv1808|M.tuberculosis_H37Rv LYSAAASYGSTIEGLTVAPWMGPSSITMAAAVAPYVAWISVTAGQAEQAG
MMAR_2684|M.marinum_M LQSMAASYGSTVQGLTVAPWTGASSITMAAAAAPYVTWINTTGVQAEQAA
MUL_3072|M.ulcerans_Agy99 LQSMAASYGSTVQGLTVAPWTGASSITMAAAAAPYVTWINTTGVQAEQAA
MAV_3356|M.avium_104 MHSAAASYGSAIAELRTL-WHGPSSTAMAAAAAPFIAWLDGTAVQAEQTA
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLTT-FEGESAAALAERVTPYEKWLTQNAASAELTA
MSMEG_0064|M.smegmatis_MC2_155 LETQAAELAAALTN-LTSVWTGAASERAVAATMPMITWLQTTAAQAQKRA
: * : : : * :: . * *: . . .
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
TH_3569|M.thermoresistible__bu GRHETAAAAYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIPIALNE
MAB_0809c|M.abscessus_ATCC_199 VQHGAAAGAYSTALAVMPTLAELAANHATHAALVATNFFGINTIPILATE
Mb1837|M.bovis_AF2122/97 AQAKIAAGVYETAFAATVPPPVIEANRALLMSLVATNIFGQNTPAIAATE
Rv1808|M.tuberculosis_H37Rv AQAKIAAGVYETAFAATVPPPVIEANRALLMSLVATNIFGQNTPAIAATE
MMAR_2684|M.marinum_M TQAKLAAGAYETAFAATVPPPVIAANRALLMALIATNIFGQNTPAIAAAE
MUL_3072|M.ulcerans_Agy99 TQAKLAAGAYETASAATVPPPVIAANRALLMALIATNIFGQNTPAIAAAE
MAV_3356|M.avium_104 AQATAAAAAYDSVFAATVPPPVIAANRALLASLIATNVLGQNTPAIAATE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
MSMEG_0064|M.smegmatis_MC2_155 LQASAQASSYSLALATTPPLPEIEQNHITHGVLEATNFLGINTVPIALNE
: * * . : . : *: * :*.:* *: .* *
Mflv_0325|M.gilvum_PYR-GCK ADY-VRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAA
Mvan_0415|M.vanbaalenii_PYR-1 ADY-VRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAA
TH_3569|M.thermoresistible__bu ADY-VRMWIQAATSMSTYQAVAGTAVMSAPASSPAPLLLAPGVSEAADAM
MAB_0809c|M.abscessus_ATCC_199 ADY-VRMWVQAATTMATYQTASEVALASAPPSTPPPSILHD---HDHGHD
Mb1837|M.bovis_AF2122/97 AHY-AEMWAQDAAAMYGYAGSSATASQLAPFSEPP---------QTTNPS
Rv1808|M.tuberculosis_H37Rv AHY-AEMWAQDAAAMYGYAGSSATASQLAPFSEPP---------QTTNPS
MMAR_2684|M.marinum_M AQY-LEMWAQDAAAMYAYAGTAAAASALTPFTEPP---------QTTNPV
MUL_3072|M.ulcerans_Agy99 AQY-LEMWAQDAAAMYAYAGTAAAASALTPFTEPP---------QTTNPV
MAV_3356|M.avium_104 AHY-AEMWAQDAAAMYAYAGASAVATRLTPFGAPP---------QTADAN
MLBr_01182|M.leprae_Br4923 AEY-TEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVN----EVGLAQ
MSMEG_0064|M.smegmatis_MC2_155 MDYFVRMWNQAAGAMDVYHAETTVNLLFEPIMPMKPIVLP----GVGETT
.* .** * * :* *
Mflv_0325|M.gilvum_PYR-GCK ADMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLRDP
Mvan_0415|M.vanbaalenii_PYR-1 ADVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLRDP
TH_3569|M.thermoresistible__bu ATTQQIGSQATAADSGTALNLSDLIANLLQYYQDYLDQLFGPIVDFLRDP
MAB_0809c|M.abscessus_ATCC_199 DHDHEHGHDDDHGHGDLDPTDPEWWVHVAGEMVEHFELLLNNLLTDPAAL
Mb1837|M.bovis_AF2122/97 ATAAQSAVVAQAAGAAASSDITAQLSQLISLLPSTLQSLATTATATSAS-
Rv1808|M.tuberculosis_H37Rv ATAAQSAVVAQAAGAAASSDITAQLSQLISLLPSTLQSLATTATATSAS-
MMAR_2684|M.marinum_M AGAAQSAAVAQASSTAASSDVVSQLAGLITSVPNALQTLATTSAAPTAAS
MUL_3072|M.ulcerans_Agy99 AGAAQSAAVAQASSTAASSDVVSQLAGLITSVPNALQTLATTSAAPTAAS
MAV_3356|M.avium_104 AAADQSAAAASALQSSTASSVESALSQAVSQVPVAAQVNATAVTAAAQLP
MLBr_01182|M.leprae_Br4923 EVVEEVVEEVVEEVVEAEQAISQAALDQAVNEGMEATVVPQVDQQVNVDV
MSMEG_0064|M.smegmatis_MC2_155 AAAALAQTAPRVAEGVMRNAVIEGVSAIATIESVGLAAGHAAAQANFAEQ
Mflv_0325|M.gilvum_PYR-GCK IGNTFALITDFLTNPVQALITWGPFLLAVVYQAVSWVGASILYPSLFLLP
Mvan_0415|M.vanbaalenii_PYR-1 LGNTIKLITDFLTNPAQALITWGPFLAAVAYQAVSWVGASILYPSLLLLP
TH_3569|M.thermoresistible__bu IGNLFQLIDDFLTNPAGALVTWWPLLFAVAYQVFTNLVGWPTWAMILASP
MAB_0809c|M.abscessus_ATCC_199 LTNLPMVLADVAFHAAQLASTIGQFAPALIQPALALAIANLGWAAGFAGL
Mb1837|M.bovis_AF2122/97 --------AGWDTVLQSITTILANLTGPYSIIGLGAIPGGW-WLTFGQIL
Rv1808|M.tuberculosis_H37Rv --------AGWDTVLQSITTILANLTGPYSIIGLGAIPGGW-WLTFGQIL
MMAR_2684|M.marinum_M ILPEVSLPPWLATNLANWNTIMATLTGPFSLQGISSIPGGP-FLSFGQVY
MUL_3072|M.ulcerans_Agy99 ILPEVSLPPWLATNLANWNTIMATLTGPFSLQGISSIPGGP-FLSFGQVY
MAV_3356|M.avium_104 LS-----LTDITGILKTFNSVMGTISGPYTPLGVANLAKNW-YQIALSIP
MLBr_01182|M.leprae_Br4923 ATPQTAVPDSSSAAAPQLWGGFAQHLSPINDTLSMINNHAGMANAGLSLV
MSMEG_0064|M.smegmatis_MC2_155 RGQGAAQKGENAGQEAGRESGKNMQQGMQMVMQMGSQAAQAPAQLASMFQ
Mflv_0325|M.gilvum_PYR-GCK LLATTLAIVAGVG-QHLLSLLNTPPAEEAAEEPAPAQSAPSRPDQQSFPA
Mvan_0415|M.vanbaalenii_PYR-1 LVATTLAIVLGVG-AYLLENLPAPAEDAPAEEPAASSPAPTRADQPSPAI
TH_3569|M.thermoresistible__bu VLIP-LAITLGVAGLVMIADQAQPPAEEAAPE--EDVAAPVRAEPQN---
MAB_0809c|M.abscessus_ATCC_199 AGIQPSPEILAVE-PGSVEDAPMAASAGTALAPSPPASAAAPAAPAS---
Mb1837|M.bovis_AF2122/97 GLAQNAPGVAALLGPKAAAGALSPLAPLR--GGYIADITPLGGGATG---
Rv1808|M.tuberculosis_H37Rv GLAQNAPGVAALLGPKAAAGALSPLAPLR--GGYIGDITPLGGGATG---
MMAR_2684|M.marinum_M AYVQNAQGLNAFYSPKAITGTLAPLVPEISPGGVGLTSASVSNSVSG---
MUL_3072|M.ulcerans_Agy99 AYVQNAQGLNAFYSPKAITGTLAPLVPEISPGGVGLTSASVSNSVSG---
MAV_3356|M.avium_104 SVGTGIQGIGPLLHPKALTGVLAPLLRSDLLTGSTALSS--AGTVSA---
MLBr_01182|M.leprae_Br4923 NGMGSAMKSLAPTTTKAAESAFKAMGSAVQSTGRGLLGSSSGGHVTA---
MSMEG_0064|M.smegmatis_MC2_155 SGVQTMTQPLQQATQMVSQFASMGGSERAMQVGLMGASPFSNHPMLG---
.
Mflv_0325|M.gilvum_PYR-GCK TMSAPPPPSGAPIAANTVSAGSPPAPGAPAAAAATFVPYVVAGRDPYEGF
Mvan_0415|M.vanbaalenii_PYR-1 AVSAPPPPSSAAATVGTVATGTAPAPGAPAAATASFVPYAVAGRDPGTGF
TH_3569|M.thermoresistible__bu ----PLPLTXXX--------------------------------------
MAB_0809c|M.abscessus_ATCC_199 ---APAPTASGTAPA-------PPSPPPVGDPGFSFPYAVGGGPRLGTGL
Mb1837|M.bovis_AF2122/97 ----------GIARAIYVGSLSVPQGWAEAAPVMRAVASVLPG--TGAAP
Rv1808|M.tuberculosis_H37Rv ----------GIARAIYVGSLSVPQGWAEAAPVMRAVASVLPG--TGAAP
MMAR_2684|M.marinum_M ----------TMGRAALVGSMSVPQGWTQAAPAMRLVSSVLSTN-LAAAP
MUL_3072|M.ulcerans_Agy99 ----------TMGRAALVGSMSVPQGWTQAAPAMRLVSSVLSTN-LAAAP
MAV_3356|M.avium_104 ----------SAGRAGLVGALSVPANWASAVPAVRTVAAELPETMLDAAP
MLBr_01182|M.leprae_Br4923 ----------QLGRAASIGSLRVPQTWTTASQPVTAATRALSPARVAVAT
MSMEG_0064|M.smegmatis_MC2_155 -------GSGPSTGAGLVRAMSLPGAGGTAPRTPLLSNLLGISGEMKAAP
Mflv_0325|M.gilvum_PYR-GCK SPTVRDSTGAKAPAGTIPAAASGIAASAAERRKRRRRQKEEIKGRGYADA
Mvan_0415|M.vanbaalenii_PYR-1 SPTVRDSTSAKAPASGIPAAASGVAASAAERRKRRRRQKDEIAGRAYADA
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_0809c|M.abscessus_ATCC_199 ALAAQVRRGTSAAARSSAREQAAAAETAAARQARRRRDKGKQQGRG----
Mb1837|M.bovis_AF2122/97 ALAAEAPGALFGEMALSSLAGRALAGTAVR--------------------
Rv1808|M.tuberculosis_H37Rv ALAAEAPGALFGEMALSSLAGRALAGTAVR--------------------
MMAR_2684|M.marinum_M TAGLPGEAGVFGQMALSSLAGRAMGASTFG--------------------
MUL_3072|M.ulcerans_Agy99 TAGLPGEAGVFGQMALSSLAGRAMGASTFG--------------------
MAV_3356|M.avium_104 AMAVNGQQGMFGPTALSSLAGRAVGGTATR--------------------
MLBr_01182|M.leprae_Br4923 ESESAPLLGGGLPMAPMVPGGGSGTG------------------------
MSMEG_0064|M.smegmatis_MC2_155 AGAGSAAAGGLAPVGAGAGGGAGAPVAHAG--------------------
Mflv_0325|M.gilvum_PYR-GCK YADYEELPDDGPPEQPAPRVTASTRGAGPMGFAGTVSRGDEQAGGLTTLA
Mvan_0415|M.vanbaalenii_PYR-1 YADYEPEPDDEPPVRQEPRIAATERGAGPMGFAGTVSRDAAQAGGLTTLP
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_0809c|M.abscessus_ATCC_199 -IEYMDMNATARCEEPAPDTTASHRGAGTMGFAGTVIKTGATASGLAMLS
Mb1837|M.bovis_AF2122/97 ---------------------SGAG--AARVAGGSVTEDVASTTTIIVIP
Rv1808|M.tuberculosis_H37Rv ---------------------SGAG--AARVAGGSVTEDVASTTTIIVIP
MMAR_2684|M.marinum_M ---------------------SSSGGAVANSLGGVVAEADPAAATIIVIP
MUL_3072|M.ulcerans_Agy99 ---------------------SSSGGAVANSLGGVVAEADPAAATIIVIP
MAV_3356|M.avium_104 ---------------------AVAG-STVRVPGAVAVDDLATTSTVIVIP
MLBr_01182|M.leprae_Br4923 ----------------------GVNTALRLQPRAFVMPRNPAAG------
MSMEG_0064|M.smegmatis_MC2_155 ------------------------QNSKSGGKKDGLVAPTPLTYDLSEDE
Mflv_0325|M.gilvum_PYR-GCK -GDSFGGGPREPMLPGTWDPDATDDRHTDGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 -GDPFGGGPKAPMLPGTWDPDTEPD------ERHNHHDGKDSQ
TH_3569|M.thermoresistible__bu -------------------------------------------
MAB_0809c|M.abscessus_ATCC_199 RDDDLFEGVRAPMVPNTWDP------------EHGRQD-----
Mb1837|M.bovis_AF2122/97 AD-----------------------------------------
Rv1808|M.tuberculosis_H37Rv AD-----------------------------------------
MMAR_2684|M.marinum_M ALDE---------------------------------------
MUL_3072|M.ulcerans_Agy99 ALDE---------------------------------------
MAV_3356|M.avium_104 PNAK---------------------------------------
MLBr_01182|M.leprae_Br4923 -------------------------------------------
MSMEG_0064|M.smegmatis_MC2_155 DDEW---------------------------------------