For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
IFSVLAPEINSARMYSGAGSGPLLAAAAAWDALAGELGSAVASFGSVTSSLAEGAWQGAASQAMASAAAP YAGWLGLAAARATTAAAQAKVAAGAFEAARAATVHPALVAINRTRLVSLVTSNLLGLNAPAIAAVEADYE QMWAQDVTAMSGYHGGVSAAAAQLTSWQQALQSLPGLSGFNLGIGNIGTGNIGSGNTGNDNLGGGNNGPS SAGGGNGNVGLGNYGSFNIGAGNGSAALDTAGLQYPGASYHNVGTGNIGIGNIGLGNIGLGNIGFGNGDL ANAVLDGTQSTYNVGGANVGNHNVGLGNVGNNNVGIGNLGNNNIGIGLTGDNQIGIGGLNANGAGWNFGF GNSGSFNLGFGNTGDGNIGLANTGNGNIGIGLTGADQIGFGGWNSGSGNSGLFNSGNDNSGFFNSGSHNW GVANTGSTNWGMVNSGSVNTGIGNTGGTNTGLWNAGTANTGSLNAGMNNVGLGNSGVADLGAFNSGGNTK HSHDIGIFNAGQHNVGMFNAGSGNLGLSNAGIDNTGAFNSGGNGVSPIFPGAPGQAGNTGFFNSGFTNTG LFNSGNTNTGLWNAGNVNTGFGGIGTYSGNSGFFNSGTGNSGFFNSSDDNSGFGNSSSGGHNSGAANSGS GGYNAGFGNSNTGGGSTGYFNYGDGSLSAGIFNTGTHNAGLLNSGLENIGFFNSGAYDSGWDNSGNSGQV KSLGNSGFGNSGTSSSGGFNAGSGQSGFFNPA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_0926 | - | - | 100% (733) | PPE family protein |
| M. marinum M | MMAR_4218 | - | 0.0 | 68.67% (731) | PPE family protein |
| M. marinum M | MMAR_1550 | - | 0.0 | 51.54% (749) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3563c | PPE62 | 1e-171 | 52.20% (659) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_5091 | - | 4e-34 | 28.69% (582) | triple helix repeat-containing collagen |
| M. tuberculosis H37Rv | Rv3533c | PPE62 | 1e-171 | 52.20% (659) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 8e-31 | 44.03% (159) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0047 | - | 5e-24 | 37.50% (168) | PPE family protein |
| M. avium 104 | MAV_4704 | - | 5e-51 | 54.31% (197) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0868 | - | 3e-31 | 28.52% (568) | hypothetical protein MSMEG_0868 |
| M. thermoresistible (build 8) | TH_3569 | - | 1e-28 | 37.13% (202) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_0964 | - | 1e-161 | 50.00% (660) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_1264 | - | 2e-37 | 28.55% (648) | triple helix repeat-containing collagen |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3563c|M.bovis_AF2122/97 --------------------------------------------------
Rv3533c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_0964|M.ulcerans_Agy99 --------------------------------------------------
MMAR_0926|M.marinum_M --------------------------------------------------
MAV_4704|M.avium_104 --------------------------------------------------
MAB_0047|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3569|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 ------------------------------------------MMFLAPPG
MSMEG_0868|M.smegmatis_MC2_155 MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAALAPES
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
Mb3563c|M.bovis_AF2122/97 --------------------------------------------------
Rv3533c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_0964|M.ulcerans_Agy99 --------------------------------------------------
MMAR_0926|M.marinum_M --------------------------------------------------
MAV_4704|M.avium_104 --------------------------------------------------
MAB_0047|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3569|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK ---------------------------------------MVTFGGGATPT
Mvan_1264|M.vanbaalenii_PYR-1 GPGPISAAIQLTSTGSEATEP----------------WYVVSFGGSGAPT
MSMEG_0868|M.smegmatis_MC2_155 PLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTNTTDQPT
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
Mb3563c|M.bovis_AF2122/97 --------------------------------------------------
Rv3533c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_0964|M.ulcerans_Agy99 --------------------------------------------------
MMAR_0926|M.marinum_M --------------------------------------------------
MAV_4704|M.avium_104 --------------------------------------------------
MAB_0047|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3569|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK PTSLGAA-------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 PNNLAAS-------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155 SDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSVVTLGTTLIPNA
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
Mb3563c|M.bovis_AF2122/97 --------------------------------------------------
Rv3533c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_0964|M.ulcerans_Agy99 --------------------------------------------------
MMAR_0926|M.marinum_M --------------------------------------------------
MAV_4704|M.avium_104 --------------------------------------------------
MAB_0047|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3569|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155 PTEPADMPGVWAVMAWARRQPMYSDPAMRTTVNPQAQLPVPTVASAVLDP
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
Mb3563c|M.bovis_AF2122/97 --------------------------------------------------
Rv3533c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_0964|M.ulcerans_Agy99 --------------------------------------------------
MMAR_0926|M.marinum_M --------------------------------------------------
MAV_4704|M.avium_104 --------------------------------------------------
MAB_0047|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3569|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK --------------------AVDLSGTSCG----------LICNGQDGTG
Mvan_1264|M.vanbaalenii_PYR-1 --------------------LVDLSGTSCG----------LICNGQDGTG
MSMEG_0868|M.smegmatis_MC2_155 TQIVNWLIYQPLHAAGQQFWVVSPIGSTLGGVINTISGQYLIGNGINGTA
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
Mb3563c|M.bovis_AF2122/97 ------MN---YAVLPPELNSLRMFTGAGSAP---MLAAAVAWDGLAAEL
Rv3533c|M.tuberculosis_H37Rv ------MN---YAVLPPELNSLRMFTGAGSAP---MLAAAVAWDGLAAEL
MUL_0964|M.ulcerans_Agy99 ------MN---FMMLPPEVNSALMFTGAGSAP---TLAAATAWDGLVAEL
MMAR_0926|M.marinum_M ------MI---FSVLAPEINSARMYSGAGSGP---LLAAAAAWDALAGEL
MAV_4704|M.avium_104 ------MTNPHFAWLPPEVNSALIYSGPGPGP---LLAAAAAWDGLAEEL
MAB_0047|M.abscessus_ATCC_1997 ------MSAPIWMASPPEVHSALLSAGPGPGA---LLAAAAQWQALSTQY
TH_3569|M.thermoresistible__bu -----MMTAPIWMALPPEVHSALLSSGPGPGS---LLAAASAWHALSAEY
Mflv_5091|M.gilvum_PYR-GCK QN-----GGILFGNGGSGWNSDVVGMDGGNGGNGGLFGGNGGNGGNGLGG
Mvan_1264|M.vanbaalenii_PYR-1 QN-----GGILFGNGGSGWNSEIAGVSGGNGGNAGLFGGNGGNGGNGLGS
MSMEG_0868|M.smegmatis_MC2_155 DNPNGGTGGLLFGDGGHGYDGSAAGLAGGNGGNAGLFG-NGGNGGVGWAG
MLBr_01182|M.leprae_Br4923 --------MFDFAALSPETNSTRMYLGPGSSP---ILTAAAAWVVLAKEL
: .. * . :
Mb3563c|M.bovis_AF2122/97 GSAASSFGSVTSDLASQAWQGPAAAAMAAAAAPYAGWLSAAAARAAGAAA
Rv3533c|M.tuberculosis_H37Rv GSAASSFGSVTSDLASQAWQGPAAAAMAAAAAPYAGWLSAAAARAAGAAA
MUL_0964|M.ulcerans_Agy99 GEAAEAFSSVTSGLASGSWQGPAAAAMAAAAAPYAGWLSAAATRALGAAT
MMAR_0926|M.marinum_M GSAVASFGSVTSSLAEGAWQGAASQAMASAAAPYAGWLGLAAARATTAAA
MAV_4704|M.avium_104 ASSAQSFSSVTSDLASGSWQGASSAAMMTVANQYVSWLSAAAAQAEEVSH
MAB_0047|M.abscessus_ATCC_1997 ATAATELTELLGSTVAGSWQGPSAMQYAASHAPYLAWLTQQSAMSATNAV
TH_3569|M.thermoresistible__bu ASAAAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSAATAG
Mflv_5091|M.gilvum_PYR-GCK GNGGNGGNAGAFALFGNGGNGGNGGVGVVGATGAVG--APGVAGATGATG
Mvan_1264|M.vanbaalenii_PYR-1 GDGGNGGDAGLFSLFGRGGNGGNGGVGIAGATGAVG--APGVAGATGATG
MSMEG_0868|M.smegmatis_MC2_155 LDGGNGGSGG--LLMGIGGAGGAGGVGADGTSAHVDGGTGGTGGTGGGTG
MLBr_01182|M.leprae_Br4923 TAAAQGLQSAVEALLT-TFEGESAAALAERVTPYEKWLTQNAASAELTAT
. * . : :
Mb3563c|M.bovis_AF2122/97 QAKAVASAFEAARAATVHPLLVAANRNAFAQLVMSN-------------W
Rv3533c|M.tuberculosis_H37Rv QAKAVASAFEAARAATVHPLLVAANRNAFAQLVMSN-------------W
MUL_0964|M.ulcerans_Agy99 QAKAAAAVFESAQAATVHPELVLANRNQLVSLVLSN-------------L
MMAR_0926|M.marinum_M QAKVAAGAFEAARAATVHPALVAINRTRLVSLVTSN-------------L
MAV_4704|M.avium_104 QASAIATAFEVALAATVQPAVVAANRALVQALAATN-------------W
MAB_0047|M.abscessus_ATCC_1997 LHETSAAAYTTALAAMPTLAELAANHMIHGVLLATN-------------F
TH_3569|M.thermoresistible__bu RHETAAAAYSTALATMPTMAELTLNKTTHAVLVATN-------------F
Mflv_5091|M.gilvum_PYR-GCK VTSGVVGGNGEDAVGYGATGAAGAAGAAGAAGAAG--------------A
Mvan_1264|M.vanbaalenii_PYR-1 VTSNVTGGNGADAVGYGATGAAGAAGAAGAAGKAG--------------A
MSMEG_0868|M.smegmatis_MC2_155 GTGGIGGTGGGLFGLLGHSGSTGAAGAAGNGGDGGNGGFGYVLIAGPNVT
MLBr_01182|M.leprae_Br4923 QLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSN-------------I
Mb3563c|M.bovis_AF2122/97 FGLNAPLIAAVEGAYEQMWAADVAAMVGYHSGAS----------------
Rv3533c|M.tuberculosis_H37Rv FGLNAPLIAAVEGAYEQMWAADVAAMVGYHSGAS----------------
MUL_0964|M.ulcerans_Agy99 FGQNAPAIAATESTYEELWAQDVAATVGYHGGAS----------------
MMAR_0926|M.marinum_M LGLNAPAIAAVEADYEQMWAQDVTAMSGYHGGVS----------------
MAV_4704|M.avium_104 LGQNTPAIADIEAAYEQMWASDVAAMFGYHADAS----------------
MAB_0047|M.abscessus_ATCC_1997 FGINTIPIALNEADYIRMWIQAATTMGVYQGVSS----------------
TH_3569|M.thermoresistible__bu LGINTIPIALNEADYVRMWIQAATSMSTYQAVAG----------------
Mflv_5091|M.gilvum_PYR-GCK VGSAGAAGEAGETGTWG--NAGLPGKAGDAGGAG----AVGAAG------
Mvan_1264|M.vanbaalenii_PYR-1 VGSAGTAGSAGAPGVWG--NAGLPGAAGAAGGAG----AIGTAG------
MSMEG_0868|M.smegmatis_MC2_155 VGSETRGGTGGAGGTGGQSTAAGPGKGGGGGGGGGGAILIGANGGTVDGH
MLBr_01182|M.leprae_Br4923 FGQNSTAIAEKEAEYTEMWIQDAAAMTSYQASVL----------------
.* . .
Mb3563c|M.bovis_AF2122/97 ------AAAEQLVPFQQALQQLP-------NLGIGNIGNANLGGGNTGDL
Rv3533c|M.tuberculosis_H37Rv ------AAAEQLVPFQQALQQLP-------NLGIGNIGNANLGGGNTGDL
MUL_0964|M.ulcerans_Agy99 ------AVAAQLAPWQQAIQALPGRVAAMATTGPAASAAAALASGPAAAL
MMAR_0926|M.marinum_M ------AAAAQLTSWQQALQSLPGLSG--FNLGIGNIGTGNIGSGNTGND
MAV_4704|M.avium_104 ------AAVAKLPPWNEVLQNLG---------------------------
MAB_0047|M.abscessus_ATCC_1997 ------AALAATTPTQPSPMIMAPGG------------------------
TH_3569|M.thermoresistible__bu ------TAVMSAPASSPAPLLLAPGVS-----------------------
Mflv_5091|M.gilvum_PYR-GCK -AAGTVGTAGATGGTGTGANGGAGGVG-----GVGGTGAAGAAGGAGGLG
Mvan_1264|M.vanbaalenii_PYR-1 -VAGAAGTAGATGGTGVGGNGGAGQAG-----GIGGTGAAGAAGQAGTAG
MSMEG_0868|M.smegmatis_MC2_155 AIGGNGGNGGNGSTTAAGGNGGTGGTGRVIAEGTGSTAEGTATGGDGGHS
MLBr_01182|M.leprae_Br4923 ------EAVGATKAFTAPPLGVNEVG------------------------
Mb3563c|M.bovis_AF2122/97 NTGN----------------------------------------------
Rv3533c|M.tuberculosis_H37Rv NTGN----------------------------------------------
MUL_0964|M.ulcerans_Agy99 DIGNNGSG------------------------------------------
MMAR_0926|M.marinum_M NLGGGNNGPSSAG-------------------------------------
MAV_4704|M.avium_104 --------------------------------------------------
MAB_0047|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3569|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK ETGTTGGAGGVG--------------------GQGTAGGTGGVGGIGGAG
Mvan_1264|M.vanbaalenii_PYR-1 ETGVTGGVGGIG--------------------GQGTEGGTGGVGGVGGVG
MSMEG_0868|M.smegmatis_MC2_155 TGTGIGGNGGIGSVYAYGNNGAVSGTATGGRGGDGIDGGTGGAGGMGEIY
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
Mb3563c|M.bovis_AF2122/97 --------------------------GNIGNTNLGSGN------------
Rv3533c|M.tuberculosis_H37Rv --------------------------GNIGNTNLGSGN------------
MUL_0964|M.ulcerans_Agy99 ---------------------NFLSIGNIGNNNLGSGN------------
MMAR_0926|M.marinum_M ------------------GGNGNVGLGNYGSFNIGAGNGSAALDTAGLQY
MAV_4704|M.avium_104 --------------------------------------------------
MAB_0047|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3569|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK ----------STGAVGG-------VGGKG----IQGGQG-----------
Mvan_1264|M.vanbaalenii_PYR-1 ----------ATGGAGG-------VGGKG----IQGGQG-----------
MSMEG_0868|M.smegmatis_MC2_155 SGADGEATGISAGGDGGSATGADSLGGRGGTSWVQAGYGPTTGGKASGTA
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
Mb3563c|M.bovis_AF2122/97 --RGDANLGSGNIGNSNVGGGNVGNGNFGSGNG------RAGLPGSGNVG
Rv3533c|M.tuberculosis_H37Rv --RGDANLGSGNIGNSNVGGGNVGNGNFGSGNG------RAGLPGSGNVG
MUL_0964|M.ulcerans_Agy99 --TGSANLGGGNIGNGNLGSGNTGNVNLGNGNNGFF-NFGNGNLGDTNFG
MMAR_0926|M.marinum_M PGASYHNVGTGNIGIGNIGLGNIGLGNIGFGNGDLANAVLDGTQSTYNVG
MAV_4704|M.avium_104 --------------------------------------------------
MAB_0047|M.abscessus_ATCC_1997 -----------------------------------------------EMS
TH_3569|M.thermoresistible__bu -----------------------------------------------EAA
Mflv_5091|M.gilvum_PYR-GCK --LQGGKGGDGGAGGKGGDADSMGS------------------AGATGGK
Mvan_1264|M.vanbaalenii_PYR-1 --LQGGQGGDGGTGGTGGDATSMGE------------------AGATGGK
MSMEG_0868|M.smegmatis_MC2_155 KAGHGGKASDGGKGGNGGDALVMAAGATGVATGNTAIGGNGGAASANGAV
MLBr_01182|M.leprae_Br4923 ----------------------------------------LAQEVVEEVV
Mb3563c|M.bovis_AF2122/97 NGNLGNSNLGSGN-----------------TGNSNVGFG-----------
Rv3533c|M.tuberculosis_H37Rv NGNLGNSNLGSGN-----------------TGNSNVGFG-----------
MUL_0964|M.ulcerans_Agy99 SGNSGNLNLGSGNR----------------FGSGNIGFGNR---------
MMAR_0926|M.marinum_M GANVGNHNVGLGN-----------------VGNNNVGIGN----------
MAV_4704|M.avium_104 --------------------------------------------------
MAB_0047|M.abscessus_ATCC_1997 RMSADMMSMAAQPQ----------------AAES----------------
TH_3569|M.thermoresistible__bu DAMATTQQIGSQAT----------------AADS----------------
Mflv_5091|M.gilvum_PYR-GCK GGNGGNGGRGGLFG---------------KGGNAGNGAD-----------
Mvan_1264|M.vanbaalenii_PYR-1 GGNGGNGGRGSLFG---------------RGGNAGNGGN-----------
MSMEG_0868|M.smegmatis_MC2_155 GGNGGFTNIAAIHGSITDSSATSGHGGAAQGGNGGNGGNGWVQAYDPNGP
MLBr_01182|M.leprae_Br4923 EEVVEEVVEAEQAIS-----------------------------------
Mb3563c|M.bovis_AF2122/97 ---------------------NTGNNNVGTG-------------------
Rv3533c|M.tuberculosis_H37Rv ---------------------NTGNNNVGTG-------------------
MUL_0964|M.ulcerans_Agy99 ------------FGDGNFGSGNAGSYNFGTG-------------------
MMAR_0926|M.marinum_M ------------LGNNNIGIGLTGDNQIGIGGLNA---------------
MAV_4704|M.avium_104 --------------------------------------------------
MAB_0047|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3569|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK -----------GGTGGAGGAGGTGG-TGGAGGTGG---------------
Mvan_1264|M.vanbaalenii_PYR-1 -----------GGTGGNGGNGGTGG-TGGNGGTGG---------------
MSMEG_0868|M.smegmatis_MC2_155 AGTTIDKGKAAGGNGGDGGFNGTGGATGGRGGDGAGASVWKANGQHSTGQ
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
Mb3563c|M.bovis_AF2122/97 ---NAGSGNIGAGNTGSSNWGFGNNGIGNIGFGNTGNGNIGFGLTGNNQV
Rv3533c|M.tuberculosis_H37Rv ---NAGSGNIGAGNTGSSNWGFGNNGIGNIGFGNTGNGNIGFGLTGNNQV
MUL_0964|M.ulcerans_Agy99 ---NNGSFNIGSGNNGDSNIGFGNLGTNNLGFGNNGSNNIGFGLSGSNQI
MMAR_0926|M.marinum_M ---NGAGWNFGFGNSGSFNLGFGNTGDGNIGLANTGNGNIGIGLTGADQI
MAV_4704|M.avium_104 ---------------------FSNASTAVT--RPAGSGAVARGYTSR---
MAB_0047|M.abscessus_ATCC_1997 ----GSALDSS----------NNIMDQLMR----FMTNPLGTLQDMIEDF
TH_3569|M.thermoresistible__bu ----GTALNLSDLIANLLQYYQDYLDQLFGPIVDFLRDPIGNLFQLIDDF
Mflv_5091|M.gilvum_PYR-GCK --TGGTGGIGGAGSTGGTGGTGGTGGTGGTGGTG-GTGGTGGTGGTGGKG
Mvan_1264|M.vanbaalenii_PYR-1 --TGGTGGIGGAGSTGGTGGTGGTGGTGGTGGTG-GTGGTGGTGGTGGKG
MSMEG_0868|M.smegmatis_MC2_155 TDTGGNGGRGGDGGTFVNAGANGNGGAGGAGGVSEGEGGTGGHGGDGGRG
MLBr_01182|M.leprae_Br4923 ----QAALDQAVNEGMEATVVPQVDQQVNVDVATPQTAVPDSSSAAAPQL
Mb3563c|M.bovis_AF2122/97 GIGGLNSGSGNIGLFNSGTNNVGFFNSGNGN-------------------
Rv3533c|M.tuberculosis_H37Rv GIGGLNSGSGNIGLFNSGTNNVGFFNSGNGN-------------------
MUL_0964|M.ulcerans_Agy99 GIGGLNAGIGNMGFGNAGDNNVGFFNSGSNN-------------------
MMAR_0926|M.marinum_M GFGGWNSGSGNSGLFNSGNDNSGFFNSGSHN-------------------
MAV_4704|M.avium_104 --------------------IAGFLAPRAPQ-------------------
MAB_0047|M.abscessus_ATCC_1997 MRNPVAAFFAWFPLLFFIAYEAFFIPFGFTF-------------------
TH_3569|M.thermoresistible__bu LTNPAGALVTWWPLLFAVAYQVFTNLVGWPT-------------------
Mflv_5091|M.gilvum_PYR-GCK GTGGTGGAGGTG----GDGGTGGTGGTGGTG---------GTGGTGGTGG
Mvan_1264|M.vanbaalenii_PYR-1 GTGGTGGDGGTG----GTGGTGGTGGTGGTG---------GTGGTGGTGG
MSMEG_0868|M.smegmatis_MC2_155 GDGALGGNGGTGGVGLGNGGKGGNGGNGGNGGTYVDPSHTGAGGNGGNGG
MLBr_01182|M.leprae_Br4923 WGGFAQHLSPINDTLSMINNHAGMANAGLSLVN-----------------
Mb3563c|M.bovis_AF2122/97 ----------------LGIGNSSDANVGIGNSGATVGPF-----------
Rv3533c|M.tuberculosis_H37Rv ----------------LGIGNSSDANVGIGNSGATVGPF-----------
MUL_0964|M.ulcerans_Agy99 ----------------IGFFNSGDGNFGFAHAGST---------------
MMAR_0926|M.marinum_M ----------------WGVANTGSTNWGMVNSGSVNTGIGN---------
MAV_4704|M.avium_104 --------------------------------------------------
MAB_0047|M.abscessus_ATCC_1997 ----------------WGVLLSAPAWLPIVLGLALSALVP----------
TH_3569|M.thermoresistible__bu ----------------WAMILASPVLIPLAITLGVAGLVM----------
Mflv_5091|M.gilvum_PYR-GCK AG-----------DGTGGTGGTGG----TGGQGGQGGQGG----------
Mvan_1264|M.vanbaalenii_PYR-1 AG-----------DGLGGTGGTGG----TGGFGGQGGQGG----------
MSMEG_0868|M.smegmatis_MC2_155 AGRIRVNNGTATGTATGGNGGNGGNGDADGHRGGKGGDGGEALIRATVIG
MLBr_01182|M.leprae_Br4923 -----------------GMGSAMKSLAPTTTKAAESAFKAMG--------
Mb3563c|M.bovis_AF2122/97 ------VAGHNTGFGNSGSLNTGMG-----------------------NA
Rv3533c|M.tuberculosis_H37Rv ------VAGHNTGFGNSGSLNTGMG-----------------------NA
MUL_0964|M.ulcerans_Agy99 ----------NTGFWNSGGTNTGFG-----------------------NG
MMAR_0926|M.marinum_M ------TGGTNTGLWNAGTANTGSL-----------------------NA
MAV_4704|M.avium_104 --------------------------------------------------
MAB_0047|M.abscessus_ATCC_1997 ----------PAGIEEP-GQEDEPG-----------------------RE
TH_3569|M.thermoresistible__bu ----------IADQAQPPAEEAAPE-----------------------ED
Mflv_5091|M.gilvum_PYR-GCK -------TGGTGGQGG-LGGGGGTG-----------------------GQ
Mvan_1264|M.vanbaalenii_PYR-1 -------TGGTGGQGG-LGGVGGTG-----------------------GT
MSMEG_0868|M.smegmatis_MC2_155 SNASGTATGGDGGNGGTLGATNGTGGAATIVAYNVVQANPQASGTATDGH
MLBr_01182|M.leprae_Br4923 -----------SAVQSTGRGLLGSS-----------------------SG
Mb3563c|M.bovis_AF2122/97 GGVNTGFGNGGAINLGFGN---------------SGQLNAGSFNAGSI--
Rv3533c|M.tuberculosis_H37Rv GGVNTGFGNGGAINLGFGN---------------SGQLNAGSFNAGSI--
MUL_0964|M.ulcerans_Agy99 GSLNFGFGNGGVENMGHGN---------------AGSFNMGFGNGGGG--
MMAR_0926|M.marinum_M GMNNVGLGNSGVADLGAFNSGGNTKHSHDIGIFNAGQHNVGMFNAGSGNL
MAV_4704|M.avium_104 --------------------------------------------------
MAB_0047|M.abscessus_ATCC_1997 PTRIERRSPQQDLQLAHVPSGSPT---------PGGSTTTTVTSGGSAP-
TH_3569|M.thermoresistible__bu VAAPVRAEPQNPLPLTXXX-------------------------------
Mflv_5091|M.gilvum_PYR-GCK GGTGGTGGQGGTGGTGGTGGTG--------GTGGAGGDGGLGGLGGFGGS
Mvan_1264|M.vanbaalenii_PYR-1 GGTGGTGGQGGTGGTGGTGGTG--------GTGGAGGDGGLGGLGGFGGV
MSMEG_0868|M.smegmatis_MC2_155 GGSGINGGHGGNGGQGTIEANGPSAVASGIGAGGNGGDGIDGGLGGNGGD
MLBr_01182|M.leprae_Br4923 GHVTAQLGRAASIGSLRVP-------------------------------
Mb3563c|M.bovis_AF2122/97 --------NTGNFNSG--------------QGNTGDFN--------AGVR
Rv3533c|M.tuberculosis_H37Rv --------NTGNFNSG--------------QGNTGDFN--------AGVR
MUL_0964|M.ulcerans_Agy99 --------NTGFYNSG--------------TYNTGFSN--------AAET
MMAR_0926|M.marinum_M GLSNAGIDNTGAFNSGGNGVSPIFPGAPGQAGNTGFFN--------SGFT
MAV_4704|M.avium_104 --------------------------------------------------
MAB_0047|M.abscessus_ATCC_1997 -------PAPAPATATP-------------AYMVYAVQ--------EDPP
TH_3569|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK GGTGGQGGLGGPGGSTGGAGGAGG--QAGTAGKGGLFG----GSGSAGKA
Mvan_1264|M.vanbaalenii_PYR-1 GGTGGQGGQGGPGGSTGGAGGAGG--QAGVAGKGGLFG----GSGSAGTA
MSMEG_0868|M.smegmatis_MC2_155 GVVNTTANAANPGSATGTATGGDGGKATGTASQGGNGGPSWVQSGYGSTL
MLBr_01182|M.leprae_Br4923 ------------------------------------------------QT
Mb3563c|M.bovis_AF2122/97 NTGWSNSGLTNTGAFNAGSLNTGFG------AVGTGSGPNSGFGNAGTNN
Rv3533c|M.tuberculosis_H37Rv NTGWSNSGLTNTGAFNAGSLNTGFG------AVGTGSGPNSGFGNAGTNN
MUL_0964|M.ulcerans_Agy99 NTGWENSGNVNTGGYNSGGLNTGIG------SPDTQAGPNSGFGHSGSGN
MMAR_0926|M.marinum_M NTGLFNSGNTNTGLWNAGNVNTGFG------GIGTYSG-NSGFFNSGTGN
MAV_4704|M.avium_104 --------------------------------------------------
MAB_0047|M.abscessus_ATCC_1997 AARFGPTLNEGSGAKAPAAGISAAA------AAAASARSRARRKRAARIK
TH_3569|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK GATGAAGASGGKGAQGATGAQGATG------AQGATG-ATGAAGKAGATG
Mvan_1264|M.vanbaalenii_PYR-1 GVTGASGASGGKGAQGATGAQGATG------AQGATG-ATGASGAQGSAG
MSMEG_0868|M.smegmatis_MC2_155 GGNATGTATAGKGGEASNGGVAGNGGNALVMAAGTTGVATGNTATGGDGG
MLBr_01182|M.leprae_Br4923 WTTASQPVTAATRALSPARVAVATE------------SESAPLLGGGLPM
Mb3563c|M.bovis_AF2122/97 SGFFNTGVGSSG---------------------FQNG-----GSNNSGLQ
Rv3533c|M.tuberculosis_H37Rv SGFFNTGVGSSG---------------------FQNG-----GSNNSGLQ
MUL_0964|M.ulcerans_Agy99 SGFFNSGDGNSG---------------------FENSNTCVSANGHSGVR
MMAR_0926|M.marinum_M SGFFNSSDDNSG---------------------FGNSS---SGGHNSGAA
MAV_4704|M.avium_104 --------------------------------------------------
MAB_0047|M.abscessus_ATCC_1997 DPAPQFMDMNSS---------------------VAPDFSESAARQTTGVG
TH_3569|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK AAGAAGAAGSAG-----------TTGAQGSAGTNGA-NGANGSQGAAGKA
Mvan_1264|M.vanbaalenii_PYR-1 SAGSAGVAGSAG-----------TTGAQGSAGTNGA-NGANGSQGAAGKA
MSMEG_0868|M.smegmatis_MC2_155 AATTAGATGGAGGFSNIAAIHGAITDSTAISGHGGAGNGGNGGKGADGWV
MLBr_01182|M.leprae_Br4923 APMVPGGGSGTG--------------------------GVNTALRLQPRA
Mb3563c|M.bovis_AF2122/97 NAVGTVIAAG---------FGNT--------------GAQTVG-------
Rv3533c|M.tuberculosis_H37Rv NAVGTVIAAG---------FGNT--------------GAQTVG-------
MUL_0964|M.ulcerans_Agy99 NS-GDATNVG---------FSNS--------------GSNNTG-------
MMAR_0926|M.marinum_M NSGSGGYNAG---------FGNSNTGGGSTGYFNYGDGSLSAG-------
MAV_4704|M.avium_104 --------------------------------------------------
MAB_0047|M.abscessus_ATCC_1997 ASARGAGRLG---------FAGTAPAAAG--------TTAAAG-------
TH_3569|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK GATGTTGATG--------AAGEDGDAGSGGSG-INGGAGGAGG-------
Mvan_1264|M.vanbaalenii_PYR-1 GATGTTGATG--------AAGDAGDPGSEAVD-INGGAGGAGG-------
MSMEG_0868|M.smegmatis_MC2_155 QAYDPAGPVGSKIANSSAVAGNGGDGGVNGTGGASGGDGGNGGNTSVWKS
MLBr_01182|M.leprae_Br4923 FVMPRNPAAG----------------------------------------
Mb3563c|M.bovis_AF2122/97 ---IANSGVLNSGFFNSG--------------------------------
Rv3533c|M.tuberculosis_H37Rv ---IANSGVLNSGFFNSG--------------------------------
MUL_0964|M.ulcerans_Agy99 ---IFNTGTFNTGIANSGSD---------------------------SSG
MMAR_0926|M.marinum_M ---IFNTGTHNAGLLNSGLENIGFFNSGAYDSGWDNSGNSGQVKSLGNSG
MAV_4704|M.avium_104 --------------------------------------------------
MAB_0047|M.abscessus_ATCC_1997 ---LVERDSGTAEALDGART------------------------------
TH_3569|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK ----AGGEGGEGGDGGKGGAGAE--------GGAGGGGGAGGSGAGGAG-
Mvan_1264|M.vanbaalenii_PYR-1 ----AGGEGGEGGAGGAGGDGSE--------GGAGGSGGAGGSGTGGAG-
MSMEG_0868|M.smegmatis_MC2_155 GGQTADGEHNTGGNGGNGGDGSEPGPGGNGAGGAGGNGGTGGTTAGGSGN
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
Mb3563c|M.bovis_AF2122/97 -----VHNSGGFNSENQRSGFGN----
Rv3533c|M.tuberculosis_H37Rv -----VHNSGGFNSENQRSGFGN----
MUL_0964|M.ulcerans_Agy99 LLISGTNSSGALNSGDDQSGFNN----
MMAR_0926|M.marinum_M FGNSGTSSSGGFNAGSGQSGFFNPA--
MAV_4704|M.avium_104 ---------------------------
MAB_0047|M.abscessus_ATCC_1997 VPMLPTSWGTDSEHGPDRPAEGGSST-
TH_3569|M.thermoresistible__bu ---------------------------
Mflv_5091|M.gilvum_PYR-GCK -GAGGSGGSGGSGGSGGSGGAAGDSDD
Mvan_1264|M.vanbaalenii_PYR-1 -GAGGSGGSGGSGGAGGSGGAAGDSD-
MSMEG_0868|M.smegmatis_MC2_155 GGNGGNGGNGGADGTPGTAGTTGANNP
MLBr_01182|M.leprae_Br4923 ---------------------------