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VTFGGGATPTPTSLGAAAVDLSGTSCGLICNGQDGTGQNGGILFGNGGSGWNSDVVGMDGGNGGNGGLFG GNGGNGGNGLGGGNGGNGGNAGAFALFGNGGNGGNGGVGVVGATGAVGAPGVAGATGATGVTSGVVGGNG EDAVGYGATGAAGAAGAAGAAGAAGAVGSAGAAGEAGETGTWGNAGLPGKAGDAGGAGAVGAAGAAGTVG TAGATGGTGTGANGGAGGVGGVGGTGAAGAAGGAGGLGETGTTGGAGGVGGQGTAGGTGGVGGIGGAGST GAVGGVGGKGIQGGQGLQGGKGGDGGAGGKGGDADSMGSAGATGGKGGNGGNGGRGGLFGKGGNAGNGAD GGTGGAGGAGGTGGTGGAGGTGGTGGTGGIGGAGSTGGTGGTGGTGGTGGTGGTGGTGGTGGTGGTGGKG GTGGTGGAGGTGGDGGTGGTGGTGGTGGTGGTGGTGGAGDGTGGTGGTGGTGGQGGQGGQGGTGGTGGQG GLGGGGGTGGQGGTGGTGGQGGTGGTGGTGGTGGTGGAGGDGGLGGLGGFGGSGGTGGQGGLGGPGGSTG GAGGAGGQAGTAGKGGLFGGSGSAGKAGATGAAGASGGKGAQGATGAQGATGAQGATGATGAAGKAGATG AAGAAGAAGSAGTTGAQGSAGTNGANGANGSQGAAGKAGATGTTGATGAAGEDGDAGSGGSGINGGAGGA GGAGGEGGEGGDGGKGGAGAEGGAGGGGGAGGSGAGGAGGAGGSGGSGGSGGSGGSGGAAGDSDD*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. gilvum PYR-GCK | Mflv_5091 | - | - | 100% (766) | triple helix repeat-containing collagen |
M. gilvum PYR-GCK | Mflv_2178 | - | 3e-95 | 44.55% (505) | hypothetical protein Mflv_2178 |
M. gilvum PYR-GCK | Mflv_1516 | - | 1e-66 | 40.49% (452) | hypothetical protein Mflv_1516 |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb3543 | PE_PGRS57 | 0.0 | 52.33% (795) | PE-PGRS family protein |
M. tuberculosis H37Rv | Rv3514 | PE_PGRS57 | 0.0 | 49.05% (893) | PE-PGRS family protein |
M. leprae Br4923 | MLBr_01556 | infB | 7e-10 | 42.22% (90) | translation initiation factor IF-2 |
M. abscessus ATCC 19977 | MAB_4284c | - | 1e-62 | 33.78% (527) | hypothetical protein MAB_4284c |
M. marinum M | MMAR_2033 | - | 0.0 | 48.60% (895) | PE-PGRS family protein |
M. avium 104 | MAV_4827 | - | 5e-28 | 47.75% (178) | hypothetical protein MAV_4827 |
M. smegmatis MC2 155 | MSMEG_0868 | - | 1e-151 | 39.15% (1055) | hypothetical protein MSMEG_0868 |
M. thermoresistible (build 8) | TH_3810 | - | 1e-50 | 40.30% (335) | PUTATIVE - |
M. ulcerans Agy99 | MUL_4367 | - | 0.0 | 48.18% (851) | PE-PGRS family protein |
M. vanbaalenii PYR-1 | Mvan_1264 | - | 0.0 | 86.67% (765) | triple helix repeat-containing collagen |
CLUSTAL 2.0.9 multiple sequence alignment Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb3543|M.bovis_AF2122/97 -------------------------------------------------- Rv3514|M.tuberculosis_H37Rv -------------------------------------------------- MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2033|M.marinum_M -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAALAPES TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 ----------------------------MMFLAPPGGPGPISAAIQLTST Mb3543|M.bovis_AF2122/97 ---------------------------MSFVLIAPEFVTAAAGDLTNLGS Rv3514|M.tuberculosis_H37Rv ---------------------------MSFVLIAPEFVTAAAGDLTNLGS MUL_4367|M.ulcerans_Agy99 ---------------------------MSFVSVGPGLLEAAARDLAGLGA MMAR_2033|M.marinum_M ---------------------------MSYLAIAPEIVAAAAADMDGIGS MSMEG_0868|M.smegmatis_MC2_155 PLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTNTTDQPT TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ---------------------------MSIIDFILNLFRDPVEAASYVAD MAV_4827|M.avium_104 -----------------------------MNIVLGVSMAPSSIQMVVLEG MLBr_01556|M.leprae_Br4923 ---------------------------MAGKARVHELAKELGVTSKEVLA Mflv_5091|M.gilvum_PYR-GCK ---------MVTFGGGATPTPTSLGAA----------------------- Mvan_1264|M.vanbaalenii_PYR-1 GSEATEPWYVVSFGGSGAPTPNNLAAS----------------------- Mb3543|M.bovis_AF2122/97 SISAANASAASATTQVLAAGADEVSAR----------------------- Rv3514|M.tuberculosis_H37Rv SISAANASAASATTQVLAAGADEVSAR----------------------- MUL_4367|M.ulcerans_Agy99 GLREANLAAAGATVGVLPAAGDEVSAA----------------------- MMAR_2033|M.marinum_M AITAANAAAAIPTSAIAAAAADEISAA----------------------- MSMEG_0868|M.smegmatis_MC2_155 SDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSVVTLGTTLIPNA TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 PEAALANAGLSAVSAAQVGAVMPVVAES---------------------- MAV_4827|M.avium_104 EYADGATVEEDAIDVTGADDAATASAP----------------------- MLBr_01556|M.leprae_Br4923 RLNEQGEFVKSASSTVEAPVARRLRESFG--------------------- Mflv_5091|M.gilvum_PYR-GCK -----------AVDLSG-----------------------TSCG------ Mvan_1264|M.vanbaalenii_PYR-1 -----------LVDLSG-----------------------TSCG------ Mb3543|M.bovis_AF2122/97 -----------IAALFGGFGLEYQAISAQVAAYHQRFVQALSTGAGAYAS Rv3514|M.tuberculosis_H37Rv -----------IAALFGGFGLEYQAISAQVAAYHQRFVQALSTGAGAYAS MUL_4367|M.ulcerans_Agy99 -----------IAELFGGFGREYQAMGARVALLHDDFVRALTAGGSAYGQ MMAR_2033|M.marinum_M -----------IAELFGNHAQQYQALSAQIARFHDQFVRSLSGAAQTYAS MSMEG_0868|M.smegmatis_MC2_155 PTEPADMPGVWAVMAWARRQPMYSDPAMRTTVNPQAQLPVPTVASAVLDP TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK ----------------------------------------LICNGQD--- Mvan_1264|M.vanbaalenii_PYR-1 ----------------------------------------LICNGQD--- Mb3543|M.bovis_AF2122/97 AEAA---------------AAEQIVLGVINAPTQALLGRPLIGDGAN-AT Rv3514|M.tuberculosis_H37Rv AEAA---------------AAEQIVLGVINAPTQALLGRPLIGDGAN-AT MUL_4367|M.ulcerans_Agy99 AEALNMWPLQ---------ELEQQALGVVNAPSMALFGRPSIGNGVDGVA MMAR_2033|M.marinum_M AEATG----A---------APLQPVLDLINGPTQALLGRPLIGNGASGAP MSMEG_0868|M.smegmatis_MC2_155 TQIVNWLIYQPLHAAGQQFWVVSPIGSTLGGVINTISGQYLIGNGIN-GT TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------VASNYG MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 ------------------------------------GIKPAADKGAEQVA Mflv_5091|M.gilvum_PYR-GCK ---GTGQNGGILFGNGGSGWNSDVVGMDGGNGGNGGLFGGNGGNGGNGLG Mvan_1264|M.vanbaalenii_PYR-1 ---GTGQNGGILFGNGGSGWNSEIAGVSGGNGGNAGLFGGNGGNGGNGLG Mb3543|M.bovis_AF2122/97 TPGGAGGAGGLLFGNGGAGA-AGAPGQAGGPGGPAGLWGNGGPGGAGGSG Rv3514|M.tuberculosis_H37Rv TPGGAGGAGGLLFGNGGAGA-AGAPGQAGGPGGPAGLWGNGGPGGAGGSG MUL_4367|M.ulcerans_Agy99 GTGQAGGAGGILWGNGGNGG-LGAAGANGGAGGSAGLIGTGGVGGAGGVG MMAR_2033|M.marinum_M GTGQAGGDGGLLIGNGGAGG-SGAAGQAGGAGGAAGLIGSGGAGGIGGTG MSMEG_0868|M.smegmatis_MC2_155 ADNPNGGTGGLLFGDGGHGYDGSAAGLAGGNGGNAGLFGNGGNGGVGWAG TH_3810|M.thermoresistible__bu ------------------------VDGDGGSGGRTGLFSKLSRGGDGGDG MAB_4284c|M.abscessus_ATCC_199 YQSQWVNTGNPIHDLSGNLQNYYAAQPDGPSILSPSLLSPRDNDFLSHND MAV_4827|M.avium_104 -----DRVISAILGTREGAADAGLQLSSIGVTWTDQLEAAALRDALAARR MLBr_01556|M.leprae_Br4923 TKAQAKRLGESLDQTLDRALDKAVAGNGATTAAPVQVDHSAAVVPIVAGE : Mflv_5091|M.gilvum_PYR-GCK ------GGNGGNGGNAGAFALFGNGGNGGNGG------------------ Mvan_1264|M.vanbaalenii_PYR-1 ------SGDGGNGGDAGLFSLFGRGGNGGNGG------------------ Mb3543|M.bovis_AF2122/97 -----GGTGGAGGAGGWLFGVGGAGGVGGAGGG-----TGGAGGPGGLIW Rv3514|M.tuberculosis_H37Rv -----GGTGGAGGAGGWLFGVGGAGGVGGAGGG-----TGGAGGPGGLIW MUL_4367|M.ulcerans_Agy99 AAGMTGGSGGAGGGGGWLWGAGGSGGAAGAGG---------SGGSGGWLW MMAR_2033|M.marinum_M -------AAGGKGGNAVLFGAGGNGGIGGTGAVGGTGAAGGAGGNGGFLF MSMEG_0868|M.smegmatis_MC2_155 ------LDGGNGGSGGLLMGIGGAGGAGGVGAD----------GTSAHVD TH_3810|M.thermoresistible__bu -------------------GLGGNGGHG---------------------- MAB_4284c|M.abscessus_ATCC_199 T---DFASHNPIASGNQVMSPSGNVDSFNRGP------------------ MAV_4827|M.avium_104 -------IDNVMLVSAFLAAAALAQNVGGAMG------------------ MLBr_01556|M.leprae_Br4923 --------GPSTAHREELAPPAGQPSEQPGVPLP---------------- . Mflv_5091|M.gilvum_PYR-GCK ----------VGVVGATGAVGAPGVAGATGAT--GVTSGVVGGNGEDA-- Mvan_1264|M.vanbaalenii_PYR-1 ----------VGIAGATGAVGAPGVAGATGAT--GVTSNVTGGNGADA-- Mb3543|M.bovis_AF2122/97 GGGG---AGGVG--GAGGGTGGAGGRAELLFG--AGGAGGAGGAGTDG-- Rv3514|M.tuberculosis_H37Rv GGGG---AGGVG--GAGGGTGGAGGRAELLFG--AGGAG---GAGTDG-- MUL_4367|M.ulcerans_Agy99 GNAGQTAGAGVG--GAGG-AGGAGDAGDQGVS--GVAPGEAGAVGFAG-- MMAR_2033|M.marinum_M GHGG---DGGTGGTGASGVAGANGGAGQTGLAGTDGGTGGVGGAGGKGGL MSMEG_0868|M.smegmatis_MC2_155 GGTG----GTGGTGGGTGGTGGIGGTGGGLFG-LLGHSGSTGAAGAAGN- TH_3810|M.thermoresistible__bu --------------------GGTGIISLLSLA------------------ MAB_4284c|M.abscessus_ATCC_199 ------------LLDLSFGDLQFGNRDTTAIGDGAVAVGGSNSGPIAS-- MAV_4827|M.avium_104 ---------------YERTAVLLVEPDTATLAVVETSDGSIPDVYKQQIR MLBr_01556|M.leprae_Br4923 ---------GQQGTPAAPHPGHPGMPTGPHPGPAPKPGGRPPRVGNNPFS Mflv_5091|M.gilvum_PYR-GCK -VGYGATGAAGAAGAAG-----AAGAAGAVGSAG-AAGEAGETGTWGNAG Mvan_1264|M.vanbaalenii_PYR-1 -VGYGATGAAGAAGAAG-----AAGKAGAVGSAG-TAGSAGAPGVWGNAG Mb3543|M.bovis_AF2122/97 --GPGATGGTGGHGGVG-----GDGGWLAPGGAGGAGGQGGAGGAGSDGG Rv3514|M.tuberculosis_H37Rv --GPGATGGTGGHGGVG-----GDGGWLAPGGAGGAGGQGGAGGAGSDGG MUL_4367|M.ulcerans_Agy99 --GAGGAGGAGGNGVGG-----GVNGAGGAGGAGGVGGGGGAGASGVGAG MMAR_2033|M.marinum_M LFGAGGEGGAGGTGGAG-----GAGGTGGDGLAATTAGGTGGNAGDGGGG MSMEG_0868|M.smegmatis_MC2_155 -GGDGGNGGFGYVLIAGPNVTVGSETRGGTGGAGGTGGQSTAAGPGKGGG TH_3810|M.thermoresistible__bu --GNGGNGGNGYRTTDN---------NALDGGHG---------------- MAB_4284c|M.abscessus_ATCC_199 --GQGSTAVNGDVRDSN------IINADHGSNVGVDQSQTRVGGDYTNVS MAV_4827|M.avium_104 AESYGDAAGQLSAMVAG-----------LEKLESLPGGLLLVGSGVDVAP MLBr_01556|M.leprae_Br4923 SAQSVARPIPRPPAPRPSASPSSMSPRPGGAVGGGGPRPPRTGVPRPGGG . Mflv_5091|M.gilvum_PYR-GCK LPGKAGDAGGAGAVG-----AAGAAGTVGTAGATGGTGTGANGGAGGVG- Mvan_1264|M.vanbaalenii_PYR-1 LPGAAGAAGGAGAIG-----TAGVAGAAGTAGATGGTGVGGNGGAGQAG- Mb3543|M.bovis_AF2122/97 ALGGTGGTGGTGGAGGAGGRGALLLGAGGQGGLGGAGGQGGMGGAGGAG- Rv3514|M.tuberculosis_H37Rv ALGGTGGTGGTGGAGGAGGRGALLLGAGGQGGLGGAGGQGGTGGAGGDG- MUL_4367|M.ulcerans_Agy99 VAGGDGGTGGAGGAAGVGG-AAGTGGTGGAAGVAGTGGDGGDGGAGGAGS MMAR_2033|M.marinum_M GTGGNAGDGGAGGQGGLFG-NAGTTGAGGDGGNGGNGGLAGNGGAGGNGD MSMEG_0868|M.smegmatis_MC2_155 GGGGGGGAILIGANGGTVD-GHAIGGNGGNGGNGSTTAAGGNGGTGGTG- TH_3810|M.thermoresistible__bu -------------------------GNGGNVGFFSLFNLGGAGGWGGSG- MAB_4284c|M.abscessus_ATCC_199 GHGSADIDKSVTVVDDHSQRNTTNINDSFNTDRSTNIGSGNTTNTEIGS- MAV_4827|M.avium_104 LKQVLQTTTFLDVSVAEEPETALARGAALAAANAPLFASSTAALAYAQD- MLBr_01556|M.leprae_Br4923 RPGAPVGGRSDAGGGNYRGGGVGALPGGGSGGFRGRPGGGGHGGGGRPG- . . Mflv_5091|M.gilvum_PYR-GCK ---------------GVGGTGAAGAAG-----------------GAGGLG Mvan_1264|M.vanbaalenii_PYR-1 ---------------GIGGTGAAGAAG-----------------QAGTAG Mb3543|M.bovis_AF2122/97 ----------ADNPTGIGGTGGDGGTG------GSAG-----EGGAGGAA Rv3514|M.tuberculosis_H37Rv ----------VLG--GVGGTGGKGGVG------GVAG-----LGGAGGAA MUL_4367|M.ulcerans_Agy99 DASLAGQAGFAGGSGGAGGVGGSAGAG------GVNG-----SGGDGGAG MMAR_2033|M.marinum_M ASNPNGGTGGNGANPGAGGAGGAGGNGSRTGAPGTTGNTPTTAAGHGGKG MSMEG_0868|M.smegmatis_MC2_155 ----------RVIAEGTGSTAEGTATGGDGGHSTGTG-----IGGNGGIG TH_3810|M.thermoresistible__bu ----------------VDGVDVVGGNP----------------------- MAB_4284c|M.abscessus_ATCC_199 --------------HNQANIGTSTSAG----------------------- MAV_4827|M.avium_104 -----------------PGTGAVDQYS----------------------- MLBr_01556|M.leprae_Br4923 --------------QRGGAAGAFGRPG-----------------GAPRRG Mflv_5091|M.gilvum_PYR-GCK -------ETGTTG-GAGGVGG------QGTAGGTGG-------------- Mvan_1264|M.vanbaalenii_PYR-1 -------ETGVTG-GVGGIGG------QGTEGGTGG-------------- Mb3543|M.bovis_AF2122/97 GQLFSASGAAGNA-GVGGAGG------QGGDGGAGGAGADADQPGA--TG Rv3514|M.tuberculosis_H37Rv GQLFSASGAAGNA-GVGGAGG------QGGDGGAGGAGADADQPGA--TG MUL_4367|M.ulcerans_Agy99 AAGGAGGASATVA-GSGGVGG------DGGAGGAAGGGVGAASLGG--DG MMAR_2033|M.marinum_M GDGFSPATSGQDG-GSGGKGGDAGRFGNGGNGGNGGNGAAGDAAGSGHTG MSMEG_0868|M.smegmatis_MC2_155 SVYAYGNNGAVSGTATGGRGGDG---IDGGTGGAGGMGEIYSGADG--EA TH_3810|M.thermoresistible__bu ---------------------------DGGTPGAHG-------------- MAB_4284c|M.abscessus_ATCC_199 --------------GSAAVGG------NAGLAGNAG-------------- MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 RKSKRQKRQEYDSMQAPVVGGVRLPHGNGETIRLARG------------- Mflv_5091|M.gilvum_PYR-GCK ----VGGIGG-----------AGSTGAVGGVGG-----KGIQ------GG Mvan_1264|M.vanbaalenii_PYR-1 ----VGGVGG-----------VGATGGAGGVGG-----KGIQ------GG Mb3543|M.bovis_AF2122/97 GTGFAGGAGG-----------AGGAGGSSGAGG-----TNG------SGG Rv3514|M.tuberculosis_H37Rv GTGFAGGAGG-----------AGGAGGSSGAGG-----TNG------SGG MUL_4367|M.ulcerans_Agy99 GHAGAGGAGGEGLSGGFNTGAAGGIGGAGGAGG-----TGGD-----SGG MMAR_2033|M.marinum_M GNGGAGGGGGN--AGQFGEPGTGGSGGNGGKGG-----DGAAGGLAQAGG MSMEG_0868|M.smegmatis_MC2_155 TGISAGGDGGS----ATGADSLGGRGGTSWVQAGYGPTTGGKASGTAKAG TH_3810|M.thermoresistible__bu ---------------------ESHTPGVYTDRQ----------------- MAB_4284c|M.abscessus_ATCC_199 ---------------------LAGNAGLAGNAG--------------LAG MAV_4827|M.avium_104 ---------------------LPDYLYVPVDPE----------------- MLBr_01556|M.leprae_Br4923 ---------------------ASLSDFAEKIDANPAALVQALFNLGEMVT Mflv_5091|M.gilvum_PYR-GCK QGLQGGKGGDGGAGG-----KGGDA------DSMGSAGATGGK----GGN Mvan_1264|M.vanbaalenii_PYR-1 QGLQGGQGGDGGTGG-----TGGDA------TSMGEAGATGGK----GGN Mb3543|M.bovis_AF2122/97 AGGTGGQGGMGGAGG-----AGADN-----PTGIGGTGGDGGT----GGA Rv3514|M.tuberculosis_H37Rv AG---GQGGAGGAGG-----AGADN-----PTGIGGTGGDGGT----GGA MUL_4367|M.ulcerans_Agy99 VGGVNGDGGAGGGGG-----RGGDGGSSTSTSGVGGAGGAGGN----GGN MMAR_2033|M.marinum_M NGGEGGAGGNAGAGG-----LSGTG-DSTGNAGTGGNGGAGGN----GGT MSMEG_0868|M.smegmatis_MC2_155 HGGKASDGGKGGNGGDALVMAAGATGVATGNTAIGGNGGAASANGAVGGN TH_3810|M.thermoresistible__bu -----GEDGEDGTGT-----------------GIGGRGGNGGS------- MAB_4284c|M.abscessus_ATCC_199 NAGLAGNAGLAGNAG------------------LAGNAGLAGN------- MAV_4827|M.avium_104 ----PGDDELAYS-------------------AVGEEDAESPT------- MLBr_01556|M.leprae_Br4923 ATQSVGDETLELLGS-------------EMNYNVQVVSPEDED------R . Mflv_5091|M.gilvum_PYR-GCK GG----NGGRGGLFGKGGNAGNGA----DGGTGGAGGA------GGTGGT Mvan_1264|M.vanbaalenii_PYR-1 GG----NGGRGSLFGRGGNAGNGG----NGGTGGNGGN------GGTGGT Mb3543|M.bovis_AF2122/97 AG----AGGAGGAAGTGGTGGMIG-TTGNAGVGGAGGQ------GGDGGA Rv3514|M.tuberculosis_H37Rv AG----AGGAGGAAGTGGTGGMIG-TTGNAGVGGAGGQ------GGDGGA MUL_4367|M.ulcerans_Agy99 AGFGVSAGGTGGSAGDGGAGGGAGGVDGVGGASGNGGA------AGAGGA MMAR_2033|M.marinum_M GGDG-SDGGPGGAGGKGGNSGPGG-TNGTGGHGGNGGT------GGDGGD MSMEG_0868|M.smegmatis_MC2_155 GGFTNIAAIHGSITDSSATSGHGG--AAQGGNGGNGGNGWVQAYDPNGPA TH_3810|M.thermoresistible__bu ------SSGTHPMAEDGEHVKALD-----GRPGLDGGN------------ MAB_4284c|M.abscessus_ATCC_199 ----------AGLAGNAGLAGNAG----LAGNAGLAGN------------ MAV_4827|M.avium_104 ------VVIEKLFLPEDSEPRRRPVLLVGSGLAVVGIS------------ MLBr_01556|M.leprae_Br4923 ELLEPFDLTYGEDQGDEDELQVRPPVVTVMGHVDHGKTR----------- . Mflv_5091|M.gilvum_PYR-GCK GGA-------GGTGGTGGTGGIGGAGSTGGTGGTGG---------TGGTG Mvan_1264|M.vanbaalenii_PYR-1 GGN-------GGTGGTGGTGGIGGAGSTGGTGGTGG---------TGGTG Mb3543|M.bovis_AF2122/97 GGAGADADQPGATGGTGFAGGAGGAGGAGGSSGAGG---------TNGSG Rv3514|M.tuberculosis_H37Rv GGAGADADQPGATGGTGFAGGAGGAGGAGGSSGAGG---------TNGSG MUL_4367|M.ulcerans_Agy99 GGSGIGAGIDGGAGGAGGTGGAAGFPGGGGTTGAWG---------TGGAG MMAR_2033|M.marinum_M GASGVGLGKAGGTGATGGNGGNAGSGGAAGTGGTGG---------TNGSA MSMEG_0868|M.smegmatis_MC2_155 GTTIDKGKAAGGNGGDGGFNGTGGATGGRGGDGAGASVWKANGQHSTGQT TH_3810|M.thermoresistible__bu ----------GSHGGNGGHGGRGGFLGIGGS------------------- MAB_4284c|M.abscessus_ATCC_199 ----------AGLAGNAGLAGNAGLAGNAGLAGNAG---------LAGNA MAV_4827|M.avium_104 ----AVLALEIALAIGIRTTGTVALQPTPNQHLIVP---------TEQAP MLBr_01556|M.leprae_Br4923 -------LLDTIRKANVREAEAGGITQHIGAYQVGVD--------LDGSE . . Mflv_5091|M.gilvum_PYR-GCK GTGGTGGTGGTGGTGGTGGKGGTG----GTGGAGGTG-GDGGTGGTGGTG Mvan_1264|M.vanbaalenii_PYR-1 GTGGTGGTGGTGGTGGTGGKGGTG----GTGGDGGTG-GTGGTGGTGGTG Mb3543|M.bovis_AF2122/97 GAGGTGGQGGAGGAGGAGADNPTG--IGGTGGDGGTG-GAAGAGGAGGAA Rv3514|M.tuberculosis_H37Rv GAGGTGGQGGAGGAGGAGADNPTG--IGGTGGDGGTG-GAAGAGGAGGAA MUL_4367|M.ulcerans_Agy99 GAGGAGGAGDHGGVGVNPGDSGTAGWAGGAGGAGGAG-GSAAFNGVNGAG MMAR_2033|M.marinum_M GTGGTGGTGGNGGAGDKGAVGDSG-FAGGTGGAGGTG-GNSGPGGTNGTG MSMEG_0868|M.smegmatis_MC2_155 DTGGNGGRGGDGGTFVNAGANGNG----GAGGAGGVSEGEGGTGGHGGDG TH_3810|M.thermoresistible__bu --GGWGGHGGNGGD---------------TDADGGNG----GDGGNGGSA MAB_4284c|M.abscessus_ATCC_199 GLAGNAGLAGNAGLAGNAGLAGNAAVAGNAAVAGNAA--VAGNAAVGGVL MAV_4827|M.avium_104 APPPVQASAPQPKISVPEPVAAPKPLSPPVAAPLPAAPPPAAPPLPEAPP MLBr_01556|M.leprae_Br4923 RLITFIDTPGHEAFTAMRARGAKATDIAILVVAADDGVMPQTVEAINHAQ . Mflv_5091|M.gilvum_PYR-GCK GTGGTGGTGGTGGAGDG------TGGTGGTGGTG---------------- Mvan_1264|M.vanbaalenii_PYR-1 GTGGTGGTGGTGGAGDG------LGGTGGTGGTG---------------- Mb3543|M.bovis_AF2122/97 GTGGTGGMIG--TTGNAGVGG--AGGQGGDGGAG---------------- Rv3514|M.tuberculosis_H37Rv GTGGTGGMIG--TTGNAGVGG--AGGQGGDGGAGGAGADADQPGATGGTG MUL_4367|M.ulcerans_Agy99 GAGGNGGAGGGGGAGASGIGAGVAGGDGGTGGTG---------------- MMAR_2033|M.marinum_M GHGGNGGTGGDGGDGASGVGQGKAGGTGATGGNGG--------------- MSMEG_0868|M.smegmatis_MC2_155 GRGGDGALGGNGGTGGVGLGNGGKGGNGGNGGNGG--------------- TH_3810|M.thermoresistible__bu GRGGTGGLRG---------------VFGINGGNG---------------- MAB_4284c|M.abscessus_ATCC_199 NTGVSGAIGGSSHVGGAIN-----ESLGGSGSVG---------------- MAV_4827|M.avium_104 IPAAPPVVPVPVVVPPVPVPVPVRIPVPDPVSPPQ--------------- MLBr_01556|M.leprae_Br4923 AADVPIVVAVNKIDKEGADPAKIRGQLTEYGLVAEDFG------------ Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb3543|M.bovis_AF2122/97 -------------------------------------------------- Rv3514|M.tuberculosis_H37Rv FAGGAGGAGKAGGSSSAGGTNSSGSAGGTGRQSGTGGAGGAGADNPTGIG MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2033|M.marinum_M ---------------------------------------NAGSGGAAGTG MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK ------------------------------------GQGGQGGQGGTG-- Mvan_1264|M.vanbaalenii_PYR-1 ------------------------------------GFGGQGGQGGTG-- Mb3543|M.bovis_AF2122/97 ------------------------------------GAGGAGGSSGAG-- Rv3514|M.tuberculosis_H37Rv GTGGDGGTGGAAGAGGAGGAAGTGGTGGMIGTTGNAGVGGAGGSSGAG-- MUL_4367|M.ulcerans_Agy99 ------------------------------------GAAGTGGAAGTG-- MMAR_2033|M.marinum_M GDASGGGTNGSAGTGGTGGTGGNGGDGDKGAVGDSGFAGGTGGAGGTG-- MSMEG_0868|M.smegmatis_MC2_155 ----------------------------TYVDPSHTGAGGNGGNGGAGRI TH_3810|M.thermoresistible__bu -------------------------------------RAGLGGRGXXX-- MAB_4284c|M.abscessus_ATCC_199 ------------------------------------GSTAVGGGAHTG-- MAV_4827|M.avium_104 ------------------------------------LLAPPRLSVPQP-- MLBr_01556|M.leprae_Br4923 ---------------------------------GDTMFIDISAKVGTN-- Mflv_5091|M.gilvum_PYR-GCK ----------GTGGQGGLGGGG-GTGGQGGTGG-----------TGGQGG Mvan_1264|M.vanbaalenii_PYR-1 ----------GTGGQGGLGGVG-GTGGTGGTGG-----------TGGQGG Mb3543|M.bovis_AF2122/97 ----------GTNGSGGAGGTG-GQGGAGGAGGAGADNPTGIGGTGGDGG Rv3514|M.tuberculosis_H37Rv ----------GTNGSGGAGGTD-GQGGAGGAGGAGADNPTGIGGTGGDGG MUL_4367|M.ulcerans_Agy99 ----------GTGGAAGAAGSA-GDGGAGGAGGAGDDGSAGV--VSGDPG MMAR_2033|M.marinum_M ----------GNSGPGGTNGTG-GHGGNGGTGGDGGDGASGVG-QGKAGG MSMEG_0868|M.smegmatis_MC2_155 RVNNGTATGTATGGNGGNGGNGDADGHRGGKGGDGGEALIRATVIGSNAS TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ------------VGGGVSTGVG----------------------VGSHVG MAV_4827|M.avium_104 --------------------------------------------VQPPVR MLBr_01556|M.leprae_Br4923 ----------IEALLEAVLLTADAALDLRANSG-----------MEAQGV Mflv_5091|M.gilvum_PYR-GCK TGGTGGTGGTGGTGGAG-GDGGLG-----------------GLGGFGGSG Mvan_1264|M.vanbaalenii_PYR-1 TGGTGGTGGTGGTGGAG-GDGGLG-----------------GLGGFGGVG Mb3543|M.bovis_AF2122/97 TGGAAGAGGAGGAAGTG-GTGGMI-----------------GTTGNAGVG Rv3514|M.tuberculosis_H37Rv TGGAAGAGGAGGAAGTG-GTGGMI-----------------GTTGNAGVG MUL_4367|M.ulcerans_Agy99 T--AGKAGGAGGAGGVG-GNGVAG-----------------GVNGSGGAG MMAR_2033|M.marinum_M TGATGGSGGNAGSGGAA-GTGGNG-----------------GTNGNAGTG MSMEG_0868|M.smegmatis_MC2_155 GTATGGDGGNGGTLGATNGTGGAATIVAYNVVQANPQASGTATDGHGGSG TH_3810|M.thermoresistible__bu -----XGGGVGAAVRS-------------------------------GNG MAB_4284c|M.abscessus_ATCC_199 GGISESLGGSGSVGGSTAVGGGAH------------------TGVGGGVS MAV_4827|M.avium_104 VPQPPSPPQVGGTVPQSPPQHQTP----------------------PGEG MLBr_01556|M.leprae_Br4923 AIEAHLDRGRGPVATVLVQRGTLR----------------IGDSVVAGDA . * . Mflv_5091|M.gilvum_PYR-GCK GTGGQGGLGGPG----------------GSTGGAGGAGGQAGTAGK---- Mvan_1264|M.vanbaalenii_PYR-1 GTGGQGGQGGPG----------------GSTGGAGGAGGQAGVAGK---- Mb3543|M.bovis_AF2122/97 GAGGQGGDGGAGGAGADADQ-------PGATGGTGFAGGAGGAGG----- Rv3514|M.tuberculosis_H37Rv GAGGQGGDGGAGGAGADADQ-------PGATGGTGFAGGAGGAGGSGGSS MUL_4367|M.ulcerans_Agy99 GAGGAGGTGGAGASGVPASV-------DGGDGGAGGAGGAAGTGGSGGSA MMAR_2033|M.marinum_M GTGGTGGNGGDGDKGAVGDSGF-----AGGTGGNGGTGGNSGPGGTNGTG MSMEG_0868|M.smegmatis_MC2_155 INGGHGGNGGQGTIEANGPSAVASGIGAGGNGGDGIDGGLGGNGGDGVVN TH_3810|M.thermoresistible__bu VFSGGGGT---------------------PSAGFGVPTTIQFPAGS---- MAB_4284c|M.abscessus_ATCC_199 TGVGVGSHVGGG--------------ISESLGGSGSVGGSTAVGGG---- MAV_4827|M.avium_104 TPPKPDGPGNYG-------------------GGHVPTPGAGGSGGS---- MLBr_01556|M.leprae_Br4923 YGRVRRMVDEHGVDIEAALP--------SSPVQVIGFTSVPGAGDN---- .. Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb3543|M.bovis_AF2122/97 -------------------------------------------------- Rv3514|M.tuberculosis_H37Rv CAGGTNGSGGAGGTCGQVVAGGAGISFSNGSNGGTGGTGGVGGTGGDGGN MUL_4367|M.ulcerans_Agy99 GNTG---------------------------------------------- MMAR_2033|M.marinum_M GHGGNGGTGGDGGDGRNGSTGAIGGNGGTGGTGGIGG------------- MSMEG_0868|M.smegmatis_MC2_155 TTANAANPGS---------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb3543|M.bovis_AF2122/97 -------------------------------------------------- Rv3514|M.tuberculosis_H37Rv AGTGAGDPGKGGTGGTGGTGGSGGAGGSGGANFNGGTGGTGGTGGKGGLN MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2033|M.marinum_M -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb3543|M.bovis_AF2122/97 -------------------------------------------------- Rv3514|M.tuberculosis_H37Rv TDGLSSATSGTGGTGGTGGKGGTGGAGDDSAGGTGGTGGAGGNAGAGGLA MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2033|M.marinum_M -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK ----------------------------------------GGLFGGSGSA Mvan_1264|M.vanbaalenii_PYR-1 ----------------------------------------GGLFGGSGSA Mb3543|M.bovis_AF2122/97 ---------------------------------------------AGGSS Rv3514|M.tuberculosis_H37Rv NTGGTAGNAGIGGDGGQGGNGGQGDSGSGLGGQPGFAGGAGGKGGAGGSS MUL_4367|M.ulcerans_Agy99 ------------------------------------AGGAGGAGGAGGSA MMAR_2033|M.marinum_M ------------------------------------TAGTGGTGGSAGSA MSMEG_0868|M.smegmatis_MC2_155 ------------------------------------ATGTATGGDGGKAT TH_3810|M.thermoresistible__bu --------------------------------------------CTSRAV MAB_4284c|M.abscessus_ATCC_199 ----------------------------------------AHTGVGGGVN MAV_4827|M.avium_104 ---------------------------------------------GGGHV MLBr_01556|M.leprae_Br4923 ----------------------------------------FLVVDEDRIA Mflv_5091|M.gilvum_PYR-GCK GKAGATGAAGAS--------GGKGAQGATGAQGATGAQGATGATG----- Mvan_1264|M.vanbaalenii_PYR-1 GTAGVTGASGAS--------GGKGAQGATGAQGATGAQGATGATG----- Mb3543|M.bovis_AF2122/97 GAGGTNGSGGAG------GTGGQGGAGGAGISFSNGSNGGTGGTG----- Rv3514|M.tuberculosis_H37Rv GAGGTNGSGGAG------GAGGQGGAGGAGISFSNGSNGGTGGTG----- MUL_4367|M.ulcerans_Agy99 ASTGVNGDGGAG------GAGGVGGLGGD--SAATAGGGGAGGDG----- MMAR_2033|M.marinum_M GTGGTGGNGGAGDSGASGGTGGTGGEGGAGIGGKDGGTGGTGGTGGTGGA MSMEG_0868|M.smegmatis_MC2_155 GTASQGGNGGPS----WVQSGYGSTLGGNATGTATAGKGGEASNG----- TH_3810|M.thermoresistible__bu SREGIMPSSRAA-------SARAGAACASSTSRSRRSFCCSRA------- MAB_4284c|M.abscessus_ATCC_199 TGVGVGSHVGGG------ISESLGGSGSVGGSTAVGGGAHTSAIN----- MAV_4827|M.avium_104 PTPGAGGSGGSG-------GGHVPTPGTGGPGGTGGSGGGHVPTP----- MLBr_01556|M.leprae_Br4923 RQIADRRSARKR------NALAARSRKRISLEDLDSALKETSQLN----- . . Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb3543|M.bovis_AF2122/97 -----------GVGGTGGDGGNAG--TGAGDPGKGGTG------------ Rv3514|M.tuberculosis_H37Rv -----------GVGGTGGDGGNAG--TGAGDPGKGGTGGTGGTGGSGGAG MUL_4367|M.ulcerans_Agy99 -----------GKGGAGGAGVNG---VGGGDGGKGGTGGAGGAGGAGS-- MMAR_2033|M.marinum_M GVVSGLSAFPGGIGGAGGAGGQGGQATGGGNAGDGGTGGQGGTGGQGATS MSMEG_0868|M.smegmatis_MC2_155 -----------GVAGNGGNALVMAAGTTGVATGNTATGGDGG-------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb3543|M.bovis_AF2122/97 -------------------------------------------------- Rv3514|M.tuberculosis_H37Rv GSGGANFNGGTGGTGGTGGTGGKGGMGGIAGDGGPGGDGGNAGVGGKGGT MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2033|M.marinum_M LFEASSGGTGGAGGAG---------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb3543|M.bovis_AF2122/97 -------------------------------------------------- Rv3514|M.tuberculosis_H37Rv NGNGGSGGTGGTGGAGGNAGAGGLANTGGTAGNAGIGGDGGQGGNGGQGD MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2033|M.marinum_M -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb3543|M.bovis_AF2122/97 -------------------------------------------------- Rv3514|M.tuberculosis_H37Rv SGSGLGGQPGFAGGPGGKGGAGGNAGTGGTNGSGAGGAGGQGGAGGAGIS MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2033|M.marinum_M -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -----------------------------------------AAGKAGATG Mvan_1264|M.vanbaalenii_PYR-1 -----------------------------------------ASGAQGSAG Mb3543|M.bovis_AF2122/97 -----------------------------------------GTGGSGGAG Rv3514|M.tuberculosis_H37Rv FSNGSNGGTGGTGGVGGTGGDGGNAGTGAGDPGKGGTGGTGGTGGSGGAG MUL_4367|M.ulcerans_Agy99 ---------------------------------DGIIPSNGGLGGNGGNG MMAR_2033|M.marinum_M --------------------GLGGQAADGGNAGDGGTGGQGGTGGQGAAG MSMEG_0868|M.smegmatis_MC2_155 --------------------------------------AATTAGATGGAG TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ----------------------------------------DALGGSGSVG MAV_4827|M.avium_104 -----------------------------------------GAGTPGGSG MLBr_01556|M.leprae_Br4923 -----------------------------------------LILKGDNAG Mflv_5091|M.gilvum_PYR-GCK -------AAGAAGAAGSAGTTGAQGSAG--TNGANGANGSQGAAGKAGAT Mvan_1264|M.vanbaalenii_PYR-1 -------SAGSAGVAGSAGTTGAQGSAG--TNGANGANGSQGAAGKAGAT Mb3543|M.bovis_AF2122/97 -------GSGGANFNGGTGGTGGTGGTG--GKGGMGGIAGDGGPGGDGGN Rv3514|M.tuberculosis_H37Rv -------GSGGANFNGGTGGTGGTGGTG--GKGGMGGIAGDGGPGGDGGN MUL_4367|M.ulcerans_Agy99 -------GNGGQAFGDGVGGAGGIGGKG--GNAAIGTIVINGGVGGAGGS MMAR_2033|M.marinum_M PTVNDTAGDGGAGGDGGVGGAGGQGGQA--TDGGNAGNAGDGGNGGQGGT MSMEG_0868|M.smegmatis_MC2_155 ------GFSNIAAIHGAITDSTAISGHGGAGNGGNGGKGADGWVQAYDPA TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ---------GSTAVGGGAHTSAINESMNSSINASHSSSMNESFGSSMGSH MAV_4827|M.avium_104 --------GGHLPFPGAGSTPGGSGGGHLPTPGAGTPGGGLGGFGGGHAP MLBr_01556|M.leprae_Br4923 TVEALEEALMGIQVDDEVALRVIDRGVGGITETNVNLASASDAIIIGFNV Mflv_5091|M.gilvum_PYR-GCK GTTG-------------ATGAAGEDGDA-------GSGGSGIN------- Mvan_1264|M.vanbaalenii_PYR-1 GTTG-------------ATGAAGDAGDP-------GSEAVDIN------- Mb3543|M.bovis_AF2122/97 AGVG-------------GKGGTNGNGGS------GGTGGTG----GPGGS Rv3514|M.tuberculosis_H37Rv AGVG-------------GKGGTNGNGGS------GGTGGTG----GPGGS MUL_4367|M.ulcerans_Agy99 GGLGGAT--------EDGVGGVGCAGGA------GGNGGRGDMLFTVGGS MMAR_2033|M.marinum_M GGQGAAAPSAAKAAGNGGAGGVGGDGGNGADASGGGNGGDGGKS-GGGGT MSMEG_0868|M.smegmatis_MC2_155 GPVG---------SKIANSSAVAGNGGD------GGVNGTGGASGGDGGN TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 GAAG---------------------------------------------- MAV_4827|M.avium_104 APGG---------------------------------------------- MLBr_01556|M.leprae_Br4923 RAEG------------KATELASREGVEIRYYLVIYQAIDDIEKALRGML Mflv_5091|M.gilvum_PYR-GCK ------------------GGAGGAGGAGGEGGEGGDGGKGGAGAEGGAGG Mvan_1264|M.vanbaalenii_PYR-1 ------------------GGAGGAGGAGGEGGEGGAGGAGGDGSEGGAGG Mb3543|M.bovis_AF2122/97 GGAPT---------GSGTGGKGGAGGDGGDGADGGAATGVGDGGDGGNGG Rv3514|M.tuberculosis_H37Rv GGAPT---------GSGTGGKGGAGGDGGDGADGGAATGVGDGGDGGNGG MUL_4367|M.ulcerans_Agy99 GGTGG---------DGGGGGSASGSGTGGSGGTGGVGGIGGDGKLGGFGG MMAR_2033|M.marinum_M GGTGGKSLGNLPSGDGGVGGNAGTGGNGGNATDGGAGGKGGDGAAGGTGG MSMEG_0868|M.smegmatis_MC2_155 GGNTS-------------VWKSGGQTADGEHNTGGNGGNGGDGSEPGPGG TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ------------------------TGFEAQGHAQGHASETAHTTLPGAEH MAV_4827|M.avium_104 --------------------GLGGGGGHAPAPGGGLGGFGGGHSGGGLGG MLBr_01556|M.leprae_Br4923 KPIYE-------------ENQLGRAEIRALFRSSKVGIIAGCIISSGVVR Mflv_5091|M.gilvum_PYR-GCK GG---------GAGGSG-AGGAGGAGGSG---GSGGSGGSG--------- Mvan_1264|M.vanbaalenii_PYR-1 SG---------GAGGSG-TGGAGGAGGSG---GSGGSGGAG--------- Mb3543|M.bovis_AF2122/97 NG---------GNGGTG-VGSPGGLGGAG---GTGGLGGAG-AGGGADGD Rv3514|M.tuberculosis_H37Rv NG---------GNGGTG-VGSPGGLGGAG---GTGGLGGAG-AGGGADGD MUL_4367|M.ulcerans_Agy99 DG---------GDGGDGGFGVIGGQGGGG---GFGGLGGTG-AGG-APSD MMAR_2033|M.marinum_M NAGEFQSLLGIGKGGDGGTGGDGGNGGTGTPVGAGGLAGTGGAGGFGVFP MSMEG_0868|M.smegmatis_MC2_155 NG----------AGGAGGNGGTGGTTAGGS--GNGGNGGNG-GNGGADGT TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 H------------------------------------------------- MAV_4827|M.avium_104 LG-----------GGHK--------------------------------- MLBr_01556|M.leprae_Br4923 RNAKVRLLRDNIVVTDNLTVTSLRREKDDVTEVREGFECGMTLGYSDIKE Mflv_5091|M.gilvum_PYR-GCK -GSGGAAGDSDD--- Mvan_1264|M.vanbaalenii_PYR-1 -GSGGAAGDSD---- Mb3543|M.bovis_AF2122/97 DGDDGQPGNNGS--- Rv3514|M.tuberculosis_H37Rv DGDDGQPGNNGS--- MUL_4367|M.ulcerans_Agy99 KGINGEPGNPG---- MMAR_2033|M.marinum_M GGQTGQNGTDGKAG- MSMEG_0868|M.smegmatis_MC2_155 PGTAGTTGANNP--- TH_3810|M.thermoresistible__bu --------------- MAB_4284c|M.abscessus_ATCC_199 --------------- MAV_4827|M.avium_104 --------------- MLBr_01556|M.leprae_Br4923 GDVIESYELVEKQRA