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MDWAFLPPEINSARMYTGAGAASLLAAAGSWDALSAELTATADGYESVLSGLGLQWHGPAADAMAFAAAR YLTWLRATAEQTKQTAMQARTAAAAYEQAYAMTVPPPVIAANRTLLASLVATNIMGQNTAAIADTEAQYA DFWAQDTAAMAGYSASSTAATQLPRFASANNSTNESGVTAQNAAVSAANANAAANKAVTQSFSPLADNPP GTTINNYYVDASSTSAANSNAFRVLDVIQGTGLGFSAPYNMEQFVSGIIGAENNLGMLAKPGAAAANIAP ALAAPALRGATAGLGGGLGGGLGNVTATLSHAGTIGPMSVPATWSAPTSTHVSPLAPAGFTTLPGTEEPM ASGYPGYPGMPGGGAARSAGVGVPPRYGVRLTVMPRPPAAG
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. avium 104 | MAV_4014 | - | - | 100% (391) | PPE family protein |
M. avium 104 | MAV_4015 | - | 4e-93 | 51.15% (393) | PPE family protein |
M. avium 104 | MAV_0535 | - | 1e-69 | 40.91% (418) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb3160 | PPE51 | 4e-95 | 50.12% (401) | PPE family protein |
M. gilvum PYR-GCK | Mflv_0325 | - | 4e-27 | 36.97% (211) | PPE protein |
M. tuberculosis H37Rv | Rv3136 | PPE51 | 4e-95 | 50.12% (401) | PPE family protein |
M. leprae Br4923 | MLBr_01182 | - | 6e-49 | 34.13% (419) | PPE-family protein |
M. abscessus ATCC 19977 | MAB_0809c | - | 6e-26 | 39.53% (172) | PPE family protein |
M. marinum M | MMAR_1513 | - | 1e-100 | 50.38% (393) | PPE family protein, PPE51 |
M. smegmatis MC2 155 | MSMEG_0619 | - | 8e-29 | 29.02% (410) | PPE family protein |
M. thermoresistible (build 8) | TH_3113 | - | 2e-31 | 31.58% (399) | PUTATIVE PPE protein |
M. ulcerans Agy99 | MUL_2428 | - | 1e-99 | 50.13% (393) | PPE family protein |
M. vanbaalenii PYR-1 | Mvan_0415 | - | 2e-28 | 37.91% (211) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE MAB_0809c|M.abscessus_ATCC_199 ---------MLAAPVWMASPPEVHSALLSSGPGPGPLLAAAAEWSSLGAH TH_3113|M.thermoresistible__bu ----------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDE Mb3160|M.bovis_AF2122/97 -------------MDFALLPPEVNSARMYTGPGAGSLLAAAGGWDSLAAE Rv3136|M.tuberculosis_H37Rv -------------MDFALLPPEVNSARMYTGPGAGSLLAAAGGWDSLAAE MMAR_1513|M.marinum_M -------------MDFSLLPPEVNSARMYTGPGSGSLLAAAASWDALAAE MUL_2428|M.ulcerans_Agy99 -------------MDFSLLPPEVNSARMYTGPGSGSLLAAAASWDALAAE MAV_4014|M.avium_104 -------------MDWAFLPPEINSARMYTGAGAASLLAAAGSWDALSAE MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE .** :*: : *.*...: :*. * *. . Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA MAB_0809c|M.abscessus_ATCC_199 YSATAQELRAILAATHASAWHGPSAETYVAAHTPYLEWLNQGALESNARA TH_3113|M.thermoresistible__bu YRAAAVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAG Mb3160|M.bovis_AF2122/97 LATTAEAYGSVLSGLAALHWRGPAAESMAVTAAPYIGWLYTTAEKTQQTA Rv3136|M.tuberculosis_H37Rv LATTAEAYGSVLSGLAALHWRGPAAESMAVTAAPYIGWLYTTAEKTQQTA MMAR_1513|M.marinum_M LGTTAETCGSILTGLTDLSWRGPASESMAASAAPYVGWLYRTAEQTQQAA MUL_2428|M.ulcerans_Agy99 LGTTAETCGSILTGLTDLSWRGPASESMAASAAPCVGWLYRTAEQTQQAA MAV_4014|M.avium_104 LTATADGYESVLSGLG-LQWHGPAADAMAFAAARYLTWLRATAEQTKQTA MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALL-TTFEGESAAALAERVTPYEKWLTQNAASAELTA ::* : : :.* .: . ** : . Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE MAB_0809c|M.abscessus_ATCC_199 VQHGAAAGAYSTALAVMPTLAELAANHATHAALVATNFFGINTIPILATE TH_3113|M.thermoresistible__bu AQLEAAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNE Mb3160|M.bovis_AF2122/97 IQARAAALAFEQAYAMTLPPPVVAANRIQLLALIATNFFGQNTAAIAATE Rv3136|M.tuberculosis_H37Rv IQARAAALAFEQAYAMTLPPPVVAANRIQLLALIATNFFGQNTAAIAATE MMAR_1513|M.marinum_M IQARTAALAFEQAYAMTVPPPLVAANRAQLLVLIATNFFGQNTSAIAANE MUL_2428|M.ulcerans_Agy99 IQARTAALAFEQAYAMTVPPPLVAANRAQLLVLIATNFFGQNTSAIAANE MAV_4014|M.avium_104 MQARTAAAAYEQAYAMTVPPPVIAANRTLLASLVATNIMGQNTAAIADTE MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE * .** *. * : . : *: *: :*::* *: .* .* Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA MAB_0809c|M.abscessus_ATCC_199 ADYVRMWVQAATTMATYQTASEVALASAPPSTPPPSILHD---------- TH_3113|M.thermoresistible__bu ADYARMWIQAATTMATYEAVASAAVSATPRTVAPPPILGAGTGESATAAI Mb3160|M.bovis_AF2122/97 AQYAEMWAQDAAAMYGYATASAAAA-LLTPFSPPRQTTNPA--------- Rv3136|M.tuberculosis_H37Rv AQYAEMWAQDAAAMYGYATASAAAA-LLTPFSPPRQTTNPA--------- MMAR_1513|M.marinum_M AQYAEMWAQDAAAMYGYATTSAAAG-MLTPFSSPNQATSPA--------- MUL_2428|M.ulcerans_Agy99 AQYAEMWAQDAAAMYGYATTSAAAG-MLTPFSSPNQATSPA--------- MAV_4014|M.avium_104 AQYADFWAQDTAAMAGYSASSTAAT-QLPRFASANNSTNES--------- MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEVVEE *:*. :* * :::* * : * .. Mflv_0325|M.gilvum_PYR-GCK DMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLR--- Mvan_0415|M.vanbaalenii_PYR-1 DVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLR--- MSMEG_0619|M.smegmatis_MC2_155 SVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGG-QAILDFLK--- MAB_0809c|M.abscessus_ATCC_199 --HDHGHDDHDHEHGHDDDHG---------HGDLDPTDPEWWVHVAG--- TH_3113|M.thermoresistible__bu TGAHVTAELRAAESRTLLDEINELIDRLFAPLFPPGFADALPDGLLGTLL Mb3160|M.bovis_AF2122/97 -------GLTAQAAAVSQA------TDPLSLLIETVTQALQALT------ Rv3136|M.tuberculosis_H37Rv -------GLTAQAAAVSQA------TDPLSLLIETVTQALQALT------ MMAR_1513|M.marinum_M -------GLAAQSTAVTQANATAAATDPITQLVSSLTQSLGAIQA----- MUL_2428|M.ulcerans_Agy99 -------GLAAQSTAVTQANATAAATDPITQLVSSLTQSLGAIQA----- MAV_4014|M.avium_104 -------GVTAQNAAVSAANANAAANKAVTQSFSPLADNPPGTTINNYY- MLBr_01182|M.leprae_Br4923 VVEEVVEEVVEAEQAISQAALDQAVNEGMEATVVPQVDQQVNVDVATP-- Mflv_0325|M.gilvum_PYR-GCK -----------DPIGNTFALITDFLTNPVQALITWGPFLLAVVYQA---- Mvan_0415|M.vanbaalenii_PYR-1 -----------DPLGNTIKLITDFLTNPAQALITWGPFLAAVAYQA---- MSMEG_0619|M.smegmatis_MC2_155 -----------DPLGNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNL MAB_0809c|M.abscessus_ATCC_199 -----------EMVEHFELLLNNLLTDPAALLTNLPMVLADVAFHA---- TH_3113|M.thermoresistible__bu APLLPGATGDGPPMATIMSFLLMGLSNPAYLFPVLVYLLFTGVVHTTVAV Mb3160|M.bovis_AF2122/97 --------------------IPSFIPEDFTFLDAIFAGYATVGVTQD--- Rv3136|M.tuberculosis_H37Rv --------------------IPSFIPEDFTFLDAIFAGYATVGVTQD--- MMAR_1513|M.marinum_M --------------------IPSILPDDFTILDGVFSAYATVGVTQD--- MUL_2428|M.ulcerans_Agy99 --------------------IPSILPDDFTILDGVFSAYATVGVTQD--- MAV_4014|M.avium_104 ---------------VDASSTSAANSNAFRVLDVIQGTGLGFSAPYN--- MLBr_01182|M.leprae_Br4923 -------------------QTAVPDSSSAAAPQLWGGFAQHLSPIND--- .. Mflv_0325|M.gilvum_PYR-GCK VSWVGASILYPSLFLLPLLATT---LAIVAGVG--QHLLSLLNTPPAEEA Mvan_0415|M.vanbaalenii_PYR-1 VSWVGASILYPSLLLLPLVATT---LAIVLGVG--AYLLENLPAPAEDAP MSMEG_0619|M.smegmatis_MC2_155 VGWPTWGMIFASPFLIPALAALGI-TGLVLLID--HVLNNPVDVPAEDEA MAB_0809c|M.abscessus_ATCC_199 AQLASTIGQFAPALIQPALALAIANLGWAAGFAGLAGIQPSPEILAVEPG TH_3113|M.thermoresistible__bu SGMLAQLVPLMPALLPVAVAALGGLAGVWAGLSGLAGLAGLTAVPAADGG Mb3160|M.bovis_AF2122/97 ----------VESFVAGTIGAESN-LGLLNVGDENPAEVTPGDFGIGELV Rv3136|M.tuberculosis_H37Rv ----------VESFVAGTIGAESN-LGLLNVGDENPAEVTPGDFGIGELV MMAR_1513|M.marinum_M ----------IESFCAGVIGAENN-LGLIGS-SENPAEVTPSDFGLGSLI MUL_2428|M.ulcerans_Agy99 ----------IESFCAGVIGAENN-LGLIGS-SENPAEVTPSDFGLGSLI MAV_4014|M.avium_104 ----------MEQFVSGIIGAENN-LGMLAKPGAAAANIAP-ALAAPALR MLBr_01182|M.leprae_Br4923 ----------TLSMINNHAGMANAGLSLVNGMGSAMKSLAPTTTKAAESA : . . Mflv_0325|M.gilvum_PYR-GCK AEEPAPAQSAPSRPDQQSFPATMSAPPPPSGAPIAANTVSAGSPPAPGAP Mvan_0415|M.vanbaalenii_PYR-1 AEEPAASSPAPTRADQPSPAIAVSAPPPPSSAAATVGTVATGTAPAPGAP MSMEG_0619|M.smegmatis_MC2_155 PQEVAAAP----RTDQP-LAVGISPAGVPGSAATAAAPAPAPAGTTVAAP MAB_0809c|M.abscessus_ATCC_199 SVEDAPMAASAGTALAPSPPASAAAPAAPASAPAPTASGTAPAPPSP-PP TH_3113|M.thermoresistible__bu ASAAPVPAGGPSLPSGSSAPPAPTGSAAPTTGTAPGGAGSPPPAGHSVPP Mb3160|M.bovis_AF2122/97 SATSPGGGVSASGAGGAASVGNTVLASVGRANSIGQLSVPPSWA---APS Rv3136|M.tuberculosis_H37Rv SATSPGGGVSASGAGGAASVGNTVLASVGRANSIGQLSVPPSWA---APS MMAR_1513|M.marinum_M SSTAPAS--AASGGG----LGSAVAASVGRSGSIGQLSVPPSWS---APS MUL_2428|M.ulcerans_Agy99 SSTAPAS--AASGGG----LGSAVAASVGRSGSIGQLSVPPSWS---APS MAV_4014|M.avium_104 GATAGLG--GGLGGG-----LGNVTATLSHAGTIGPMSVPATWS---APT MLBr_01182|M.leprae_Br4923 FKAMGSAVQSTGRGLLGSSSGGHVTAQLGRAASIGSLRVPQTWTTASQPV . . . . Mflv_0325|M.gilvum_PYR-GCK AAAAATFVPYVVAGRD-PYEGFSPTVRDSTGAKAPAGTIPAAASGIAASA Mvan_0415|M.vanbaalenii_PYR-1 AAATASFVPYAVAGRD-PGTGFSPTVRDSTSAKAPASGIPAAASGVAASA MSMEG_0619|M.smegmatis_MC2_155 APAAATFVPYAVANRD-PGEGFTPTLGNKSQVAAPASGVPAAASGVAASL MAB_0809c|M.abscessus_ATCC_199 VGDPGFSFPYAVGGGPRLGTGLALAAQVRRGTSAAARSSAREQAAAAETA TH_3113|M.thermoresistible__bu APHSAPPVGTSGPPYLIAAQPAPGVARRSAGARRAASIVEPAGSAAAAAA Mb3160|M.bovis_AF2122/97 TRPVSALSPA----------GLTTLPG-TDVAEHGMPGVPG-VPVAAGRA Rv3136|M.tuberculosis_H37Rv TRPVSALSPA----------GLTTLPG-TDVAEHGMPGVPG-VPVAAGRA MMAR_1513|M.marinum_M ARMVSALSPS----------GLTTIPGTEEAAAAGSPGFPGMVAPPATRA MUL_2428|M.ulcerans_Agy99 ARMVSALSPS----------GLTTIPGTEEAAAAGSPGFPGMVAPPATRA MAV_4014|M.avium_104 STHVSPLAPA----------GFTTLPGTEEPMASGYPGYPGMPGGGAARS MLBr_01182|M.leprae_Br4923 TAATRALSPARV--------AVATESESAPLLGGGLPMAPMVPGGGSGTG . : Mflv_0325|M.gilvum_PYR-GCK AERRKRRRRQKEEIKGRGYADAYADYEELPDDGPPEQPAPRVTASTRGAG Mvan_0415|M.vanbaalenii_PYR-1 AERRKRRRRQKDEIAGRAYADAYADYEPEPDDEPPVRQEPRIAATERGAG MSMEG_0619|M.smegmatis_MC2_155 ASRRKRRRKKGAQIEERGYADAYMDYEE-PDEDPAPQPEPRVRASERGSD MAB_0809c|M.abscessus_ATCC_199 AARQARRRRDKGKQQGRG-----IEYMDMNATARCEEPAPDTTASHRGAG TH_3113|M.thermoresistible__bu ARESAPIRRRRGQKDGLHG--------HRHEHQQPASMSAATAPSAAGIR Mb3160|M.bovis_AF2122/97 S--GVLPR------------------------------------------ Rv3136|M.tuberculosis_H37Rv S--GVLPR------------------------------------------ MMAR_1513|M.marinum_M S--GVLPR------------------------------------------ MUL_2428|M.ulcerans_Agy99 S--GVLPR------------------------------------------ MAV_4014|M.avium_104 AGVGVPPR------------------------------------------ MLBr_01182|M.leprae_Br4923 G-VNTALR------------------------------------------ . * Mflv_0325|M.gilvum_PYR-GCK PMGFAGTVSRGDEQAGGLTTLA-GDSFGGGPREPMLPGTWDPDATDDRHT Mvan_0415|M.vanbaalenii_PYR-1 PMGFAGTVSRDAAQAGGLTTLP-GDPFGGGPKAPMLPGTWDPDTEPD--- MSMEG_0619|M.smegmatis_MC2_155 AMGFTGTVTRHDVTAAGLTTLT-GDTFDDRPVTPMLPGTWDGDENPAP-- MAB_0809c|M.abscessus_ATCC_199 TMGFAGTVIKTGATASGLAMLSRDDDLFEGVRAPMVPNTWDP-------- TH_3113|M.thermoresistible__bu VLGGAGRISRTRGSVPHAEITP-GDPTEPSSPTDRAHRPAEPN------- Mb3160|M.bovis_AF2122/97 -YGVRLTVMAHPPAAG---------------------------------- Rv3136|M.tuberculosis_H37Rv -YGVRLTVMAHPPAAG---------------------------------- MMAR_1513|M.marinum_M -YGVRLTVMAHPPAAG---------------------------------- MUL_2428|M.ulcerans_Agy99 -YGVRLTVMAHPPAAG---------------------------------- MAV_4014|M.avium_104 -YGVRLTVMPRPPAAG---------------------------------- MLBr_01182|M.leprae_Br4923 -LQPRAFVMPRNPAAG---------------------------------- : . Mflv_0325|M.gilvum_PYR-GCK DGRDGHDGHDGKEKP Mvan_0415|M.vanbaalenii_PYR-1 ---ERHNHHDGKDSQ MSMEG_0619|M.smegmatis_MC2_155 ----SPDDPEGGPRR MAB_0809c|M.abscessus_ATCC_199 ----EHGRQD----- TH_3113|M.thermoresistible__bu --------------- Mb3160|M.bovis_AF2122/97 --------------- Rv3136|M.tuberculosis_H37Rv --------------- MMAR_1513|M.marinum_M --------------- MUL_2428|M.ulcerans_Agy99 --------------- MAV_4014|M.avium_104 --------------- MLBr_01182|M.leprae_Br4923 ---------------