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M. avium 104 MAV_4014 (-)

annotation: PPE family protein
coordinates: 4134717 - 4135892
length: 391

MDWAFLPPEINSARMYTGAGAASLLAAAGSWDALSAELTATADGYESVLSGLGLQWHGPAADAMAFAAAR
YLTWLRATAEQTKQTAMQARTAAAAYEQAYAMTVPPPVIAANRTLLASLVATNIMGQNTAAIADTEAQYA
DFWAQDTAAMAGYSASSTAATQLPRFASANNSTNESGVTAQNAAVSAANANAAANKAVTQSFSPLADNPP
GTTINNYYVDASSTSAANSNAFRVLDVIQGTGLGFSAPYNMEQFVSGIIGAENNLGMLAKPGAAAANIAP
ALAAPALRGATAGLGGGLGGGLGNVTATLSHAGTIGPMSVPATWSAPTSTHVSPLAPAGFTTLPGTEEPM
ASGYPGYPGMPGGGAARSAGVGVPPRYGVRLTVMPRPPAAG
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. avium 104MAV_4014--100% (391)PPE family protein
M. avium 104MAV_4015-4e-9351.15% (393) PPE family protein
M. avium 104MAV_0535-1e-6940.91% (418) PPE family protein

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb3160PPE514e-9550.12% (401) PPE family protein
M. gilvum PYR-GCKMflv_0325-4e-2736.97% (211) PPE protein
M. tuberculosis H37RvRv3136PPE514e-9550.12% (401) PPE family protein
M. leprae Br4923MLBr_01182-6e-4934.13% (419) PPE-family protein
M. abscessus ATCC 19977MAB_0809c-6e-2639.53% (172) PPE family protein
M. marinum MMMAR_1513-1e-10050.38% (393) PPE family protein, PPE51
M. smegmatis MC2 155MSMEG_0619-8e-2929.02% (410) PPE family protein
M. thermoresistible (build 8)TH_3113-2e-3131.58% (399) PUTATIVE PPE protein
M. ulcerans Agy99MUL_2428-1e-9950.13% (393) PPE family protein
M. vanbaalenii PYR-1Mvan_0415-2e-2837.91% (211) PPE protein

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_0325|M.gilvum_PYR-GCK          MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1       ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155      ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
MAB_0809c|M.abscessus_ATCC_199      ---------MLAAPVWMASPPEVHSALLSSGPGPGPLLAAAAEWSSLGAH
TH_3113|M.thermoresistible__bu      ----------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDE
Mb3160|M.bovis_AF2122/97            -------------MDFALLPPEVNSARMYTGPGAGSLLAAAGGWDSLAAE
Rv3136|M.tuberculosis_H37Rv         -------------MDFALLPPEVNSARMYTGPGAGSLLAAAGGWDSLAAE
MMAR_1513|M.marinum_M               -------------MDFSLLPPEVNSARMYTGPGSGSLLAAAASWDALAAE
MUL_2428|M.ulcerans_Agy99           -------------MDFSLLPPEVNSARMYTGPGSGSLLAAAASWDALAAE
MAV_4014|M.avium_104                -------------MDWAFLPPEINSARMYTGAGAASLLAAAGSWDALSAE
MLBr_01182|M.leprae_Br4923          ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
                                                       .** :*: :  *.*...: :*.  *  *. .

Mflv_0325|M.gilvum_PYR-GCK          YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1       YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155      YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
MAB_0809c|M.abscessus_ATCC_199      YSATAQELRAILAATHASAWHGPSAETYVAAHTPYLEWLNQGALESNARA
TH_3113|M.thermoresistible__bu      YRAAAVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAG
Mb3160|M.bovis_AF2122/97            LATTAEAYGSVLSGLAALHWRGPAAESMAVTAAPYIGWLYTTAEKTQQTA
Rv3136|M.tuberculosis_H37Rv         LATTAEAYGSVLSGLAALHWRGPAAESMAVTAAPYIGWLYTTAEKTQQTA
MMAR_1513|M.marinum_M               LGTTAETCGSILTGLTDLSWRGPASESMAASAAPYVGWLYRTAEQTQQAA
MUL_2428|M.ulcerans_Agy99           LGTTAETCGSILTGLTDLSWRGPASESMAASAAPCVGWLYRTAEQTQQAA
MAV_4014|M.avium_104                LTATADGYESVLSGLG-LQWHGPAADAMAFAAARYLTWLRATAEQTKQTA
MLBr_01182|M.leprae_Br4923          LTAAAQGLQSAVEALL-TTFEGESAAALAERVTPYEKWLTQNAASAELTA
                                      ::*    : :       :.* .:   .        **   :      .

Mflv_0325|M.gilvum_PYR-GCK          VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1       AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155      VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
MAB_0809c|M.abscessus_ATCC_199      VQHGAAAGAYSTALAVMPTLAELAANHATHAALVATNFFGINTIPILATE
TH_3113|M.thermoresistible__bu      AQLEAAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNE
Mb3160|M.bovis_AF2122/97            IQARAAALAFEQAYAMTLPPPVVAANRIQLLALIATNFFGQNTAAIAATE
Rv3136|M.tuberculosis_H37Rv         IQARAAALAFEQAYAMTLPPPVVAANRIQLLALIATNFFGQNTAAIAATE
MMAR_1513|M.marinum_M               IQARTAALAFEQAYAMTVPPPLVAANRAQLLVLIATNFFGQNTSAIAANE
MUL_2428|M.ulcerans_Agy99           IQARTAALAFEQAYAMTVPPPLVAANRAQLLVLIATNFFGQNTSAIAANE
MAV_4014|M.avium_104                MQARTAAAAYEQAYAMTVPPPVIAANRTLLASLVATNIMGQNTAAIADTE
MLBr_01182|M.leprae_Br4923          TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
                                     *  .** *.  * :   .   :  *:     *: :*::* *: .*  .*

Mflv_0325|M.gilvum_PYR-GCK          ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA
Mvan_0415|M.vanbaalenii_PYR-1       ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA
MSMEG_0619|M.smegmatis_MC2_155      ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA
MAB_0809c|M.abscessus_ATCC_199      ADYVRMWVQAATTMATYQTASEVALASAPPSTPPPSILHD----------
TH_3113|M.thermoresistible__bu      ADYARMWIQAATTMATYEAVASAAVSATPRTVAPPPILGAGTGESATAAI
Mb3160|M.bovis_AF2122/97            AQYAEMWAQDAAAMYGYATASAAAA-LLTPFSPPRQTTNPA---------
Rv3136|M.tuberculosis_H37Rv         AQYAEMWAQDAAAMYGYATASAAAA-LLTPFSPPRQTTNPA---------
MMAR_1513|M.marinum_M               AQYAEMWAQDAAAMYGYATTSAAAG-MLTPFSSPNQATSPA---------
MUL_2428|M.ulcerans_Agy99           AQYAEMWAQDAAAMYGYATTSAAAG-MLTPFSSPNQATSPA---------
MAV_4014|M.avium_104                AQYADFWAQDTAAMAGYSASSTAAT-QLPRFASANNSTNES---------
MLBr_01182|M.leprae_Br4923          AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEVVEE
                                    *:*. :* * :::*  * :    *        ..                

Mflv_0325|M.gilvum_PYR-GCK          DMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLR---
Mvan_0415|M.vanbaalenii_PYR-1       DVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLR---
MSMEG_0619|M.smegmatis_MC2_155      SVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGG-QAILDFLK---
MAB_0809c|M.abscessus_ATCC_199      --HDHGHDDHDHEHGHDDDHG---------HGDLDPTDPEWWVHVAG---
TH_3113|M.thermoresistible__bu      TGAHVTAELRAAESRTLLDEINELIDRLFAPLFPPGFADALPDGLLGTLL
Mb3160|M.bovis_AF2122/97            -------GLTAQAAAVSQA------TDPLSLLIETVTQALQALT------
Rv3136|M.tuberculosis_H37Rv         -------GLTAQAAAVSQA------TDPLSLLIETVTQALQALT------
MMAR_1513|M.marinum_M               -------GLAAQSTAVTQANATAAATDPITQLVSSLTQSLGAIQA-----
MUL_2428|M.ulcerans_Agy99           -------GLAAQSTAVTQANATAAATDPITQLVSSLTQSLGAIQA-----
MAV_4014|M.avium_104                -------GVTAQNAAVSAANANAAANKAVTQSFSPLADNPPGTTINNYY-
MLBr_01182|M.leprae_Br4923          VVEEVVEEVVEAEQAISQAALDQAVNEGMEATVVPQVDQQVNVDVATP--
                                                                                      

Mflv_0325|M.gilvum_PYR-GCK          -----------DPIGNTFALITDFLTNPVQALITWGPFLLAVVYQA----
Mvan_0415|M.vanbaalenii_PYR-1       -----------DPLGNTIKLITDFLTNPAQALITWGPFLAAVAYQA----
MSMEG_0619|M.smegmatis_MC2_155      -----------DPLGNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNL
MAB_0809c|M.abscessus_ATCC_199      -----------EMVEHFELLLNNLLTDPAALLTNLPMVLADVAFHA----
TH_3113|M.thermoresistible__bu      APLLPGATGDGPPMATIMSFLLMGLSNPAYLFPVLVYLLFTGVVHTTVAV
Mb3160|M.bovis_AF2122/97            --------------------IPSFIPEDFTFLDAIFAGYATVGVTQD---
Rv3136|M.tuberculosis_H37Rv         --------------------IPSFIPEDFTFLDAIFAGYATVGVTQD---
MMAR_1513|M.marinum_M               --------------------IPSILPDDFTILDGVFSAYATVGVTQD---
MUL_2428|M.ulcerans_Agy99           --------------------IPSILPDDFTILDGVFSAYATVGVTQD---
MAV_4014|M.avium_104                ---------------VDASSTSAANSNAFRVLDVIQGTGLGFSAPYN---
MLBr_01182|M.leprae_Br4923          -------------------QTAVPDSSSAAAPQLWGGFAQHLSPIND---
                                                             ..                       

Mflv_0325|M.gilvum_PYR-GCK          VSWVGASILYPSLFLLPLLATT---LAIVAGVG--QHLLSLLNTPPAEEA
Mvan_0415|M.vanbaalenii_PYR-1       VSWVGASILYPSLLLLPLVATT---LAIVLGVG--AYLLENLPAPAEDAP
MSMEG_0619|M.smegmatis_MC2_155      VGWPTWGMIFASPFLIPALAALGI-TGLVLLID--HVLNNPVDVPAEDEA
MAB_0809c|M.abscessus_ATCC_199      AQLASTIGQFAPALIQPALALAIANLGWAAGFAGLAGIQPSPEILAVEPG
TH_3113|M.thermoresistible__bu      SGMLAQLVPLMPALLPVAVAALGGLAGVWAGLSGLAGLAGLTAVPAADGG
Mb3160|M.bovis_AF2122/97            ----------VESFVAGTIGAESN-LGLLNVGDENPAEVTPGDFGIGELV
Rv3136|M.tuberculosis_H37Rv         ----------VESFVAGTIGAESN-LGLLNVGDENPAEVTPGDFGIGELV
MMAR_1513|M.marinum_M               ----------IESFCAGVIGAENN-LGLIGS-SENPAEVTPSDFGLGSLI
MUL_2428|M.ulcerans_Agy99           ----------IESFCAGVIGAENN-LGLIGS-SENPAEVTPSDFGLGSLI
MAV_4014|M.avium_104                ----------MEQFVSGIIGAENN-LGMLAKPGAAAANIAP-ALAAPALR
MLBr_01182|M.leprae_Br4923          ----------TLSMINNHAGMANAGLSLVNGMGSAMKSLAPTTTKAAESA
                                                 :     .      .                       

Mflv_0325|M.gilvum_PYR-GCK          AEEPAPAQSAPSRPDQQSFPATMSAPPPPSGAPIAANTVSAGSPPAPGAP
Mvan_0415|M.vanbaalenii_PYR-1       AEEPAASSPAPTRADQPSPAIAVSAPPPPSSAAATVGTVATGTAPAPGAP
MSMEG_0619|M.smegmatis_MC2_155      PQEVAAAP----RTDQP-LAVGISPAGVPGSAATAAAPAPAPAGTTVAAP
MAB_0809c|M.abscessus_ATCC_199      SVEDAPMAASAGTALAPSPPASAAAPAAPASAPAPTASGTAPAPPSP-PP
TH_3113|M.thermoresistible__bu      ASAAPVPAGGPSLPSGSSAPPAPTGSAAPTTGTAPGGAGSPPPAGHSVPP
Mb3160|M.bovis_AF2122/97            SATSPGGGVSASGAGGAASVGNTVLASVGRANSIGQLSVPPSWA---APS
Rv3136|M.tuberculosis_H37Rv         SATSPGGGVSASGAGGAASVGNTVLASVGRANSIGQLSVPPSWA---APS
MMAR_1513|M.marinum_M               SSTAPAS--AASGGG----LGSAVAASVGRSGSIGQLSVPPSWS---APS
MUL_2428|M.ulcerans_Agy99           SSTAPAS--AASGGG----LGSAVAASVGRSGSIGQLSVPPSWS---APS
MAV_4014|M.avium_104                GATAGLG--GGLGGG-----LGNVTATLSHAGTIGPMSVPATWS---APT
MLBr_01182|M.leprae_Br4923          FKAMGSAVQSTGRGLLGSSSGGHVTAQLGRAASIGSLRVPQTWTTASQPV
                                                             .      .      .        . 

Mflv_0325|M.gilvum_PYR-GCK          AAAAATFVPYVVAGRD-PYEGFSPTVRDSTGAKAPAGTIPAAASGIAASA
Mvan_0415|M.vanbaalenii_PYR-1       AAATASFVPYAVAGRD-PGTGFSPTVRDSTSAKAPASGIPAAASGVAASA
MSMEG_0619|M.smegmatis_MC2_155      APAAATFVPYAVANRD-PGEGFTPTLGNKSQVAAPASGVPAAASGVAASL
MAB_0809c|M.abscessus_ATCC_199      VGDPGFSFPYAVGGGPRLGTGLALAAQVRRGTSAAARSSAREQAAAAETA
TH_3113|M.thermoresistible__bu      APHSAPPVGTSGPPYLIAAQPAPGVARRSAGARRAASIVEPAGSAAAAAA
Mb3160|M.bovis_AF2122/97            TRPVSALSPA----------GLTTLPG-TDVAEHGMPGVPG-VPVAAGRA
Rv3136|M.tuberculosis_H37Rv         TRPVSALSPA----------GLTTLPG-TDVAEHGMPGVPG-VPVAAGRA
MMAR_1513|M.marinum_M               ARMVSALSPS----------GLTTIPGTEEAAAAGSPGFPGMVAPPATRA
MUL_2428|M.ulcerans_Agy99           ARMVSALSPS----------GLTTIPGTEEAAAAGSPGFPGMVAPPATRA
MAV_4014|M.avium_104                STHVSPLAPA----------GFTTLPGTEEPMASGYPGYPGMPGGGAARS
MLBr_01182|M.leprae_Br4923          TAATRALSPARV--------AVATESESAPLLGGGLPMAPMVPGGGSGTG
                                                          .                       :   

Mflv_0325|M.gilvum_PYR-GCK          AERRKRRRRQKEEIKGRGYADAYADYEELPDDGPPEQPAPRVTASTRGAG
Mvan_0415|M.vanbaalenii_PYR-1       AERRKRRRRQKDEIAGRAYADAYADYEPEPDDEPPVRQEPRIAATERGAG
MSMEG_0619|M.smegmatis_MC2_155      ASRRKRRRKKGAQIEERGYADAYMDYEE-PDEDPAPQPEPRVRASERGSD
MAB_0809c|M.abscessus_ATCC_199      AARQARRRRDKGKQQGRG-----IEYMDMNATARCEEPAPDTTASHRGAG
TH_3113|M.thermoresistible__bu      ARESAPIRRRRGQKDGLHG--------HRHEHQQPASMSAATAPSAAGIR
Mb3160|M.bovis_AF2122/97            S--GVLPR------------------------------------------
Rv3136|M.tuberculosis_H37Rv         S--GVLPR------------------------------------------
MMAR_1513|M.marinum_M               S--GVLPR------------------------------------------
MUL_2428|M.ulcerans_Agy99           S--GVLPR------------------------------------------
MAV_4014|M.avium_104                AGVGVPPR------------------------------------------
MLBr_01182|M.leprae_Br4923          G-VNTALR------------------------------------------
                                    .      *                                          

Mflv_0325|M.gilvum_PYR-GCK          PMGFAGTVSRGDEQAGGLTTLA-GDSFGGGPREPMLPGTWDPDATDDRHT
Mvan_0415|M.vanbaalenii_PYR-1       PMGFAGTVSRDAAQAGGLTTLP-GDPFGGGPKAPMLPGTWDPDTEPD---
MSMEG_0619|M.smegmatis_MC2_155      AMGFTGTVTRHDVTAAGLTTLT-GDTFDDRPVTPMLPGTWDGDENPAP--
MAB_0809c|M.abscessus_ATCC_199      TMGFAGTVIKTGATASGLAMLSRDDDLFEGVRAPMVPNTWDP--------
TH_3113|M.thermoresistible__bu      VLGGAGRISRTRGSVPHAEITP-GDPTEPSSPTDRAHRPAEPN-------
Mb3160|M.bovis_AF2122/97            -YGVRLTVMAHPPAAG----------------------------------
Rv3136|M.tuberculosis_H37Rv         -YGVRLTVMAHPPAAG----------------------------------
MMAR_1513|M.marinum_M               -YGVRLTVMAHPPAAG----------------------------------
MUL_2428|M.ulcerans_Agy99           -YGVRLTVMAHPPAAG----------------------------------
MAV_4014|M.avium_104                -YGVRLTVMPRPPAAG----------------------------------
MLBr_01182|M.leprae_Br4923          -LQPRAFVMPRNPAAG----------------------------------
                                           :      .                                   

Mflv_0325|M.gilvum_PYR-GCK          DGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1       ---ERHNHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155      ----SPDDPEGGPRR
MAB_0809c|M.abscessus_ATCC_199      ----EHGRQD-----
TH_3113|M.thermoresistible__bu      ---------------
Mb3160|M.bovis_AF2122/97            ---------------
Rv3136|M.tuberculosis_H37Rv         ---------------
MMAR_1513|M.marinum_M               ---------------
MUL_2428|M.ulcerans_Agy99           ---------------
MAV_4014|M.avium_104                ---------------
MLBr_01182|M.leprae_Br4923          ---------------