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M. leprae Br4923 MLBr_00411 (-)

annotation: serine-rich antigen
coordinates: 508764 - 509990
length: 408

MFDFMVYSPEVNAFLMSRGPGSTPLWGAAEAWISLAEQLMEAAQEVSDTIVVAVPASFAGETSDMLASRV
STFVAWLNGNAENAGLIARVLHAVAYAFEEARAGMVPLLTVLGNIIHTMALKAINWFGQVSTTVAALEAD
YDLMWVQNSTAMTTYRDTVLRETGKMENFEPAPQLVSRYCMDRRDSVNSFDSSSSSDSLYESIDNLYDSV
AQSEEHGSDSMSQSYNTCGSVAQSELCDSPFGTPSQSSQSNDLSATSLTQQLGGLDSIISSASASLLTTN
SISSSTASSIMPIVASQVTETLGRSQVAVEKMIQSISSTAVSVDVAASKVVAGVGQAVSVGALRVPENWA
TASQPVMATAHSVPAGCSAITTAVSGPLEGVTQPAEEVLTASVAGGSGTGGPAFNEAV
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. leprae Br4923MLBr_00411--100% (408)serine-rich antigen
M. leprae Br4923MLBr_01182-1e-4331.48% (413) PPE-family protein
M. leprae Br4923MLBr_01828PPE5e-1829.53% (193) PPE-family protein

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1228PPE181e-3127.97% (379) PPE family protein
M. gilvum PYR-GCKMflv_0325-6e-1427.75% (173) PPE protein
M. tuberculosis H37RvRv1196PPE181e-3227.97% (379) PPE family protein
M. abscessus ATCC 19977MAB_4783-2e-1831.03% (174) PPE family protein
M. marinum MMMAR_4240-3e-3327.09% (406) PPE family protein, PPE18
M. avium 104MAV_2006-4e-2727.60% (366) PPE family protein
M. smegmatis MC2 155MSMEG_0619-8e-1732.00% (175) PPE family protein
M. thermoresistible (build 8)TH_3569-1e-1827.23% (224) PUTATIVE PPE protein
M. ulcerans Agy99MUL_0947-2e-3227.27% (407) PPE family protein
M. vanbaalenii PYR-1Mvan_0415-1e-1530.00% (170) PPE protein

CLUSTAL 2.0.9 multiple sequence alignment


MSMEG_0619|M.smegmatis_MC2_155      ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
TH_3569|M.thermoresistible__bu      ---------MMTAPIWMALPPEVHSALLSSGPGPGSLLAAASAWHALSAE
Mflv_0325|M.gilvum_PYR-GCK          MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1       ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MAB_4783|M.abscessus_ATCC_1997      ----------MTAPVWMAAPPEVHSALLSSGPGPGSLFAAADAWRSLSTE
Mb1228|M.bovis_AF2122/97            ------------MVDFGALPPEINSARMYAGPGSASLVAAAQMWDSVASD
Rv1196|M.tuberculosis_H37Rv         ------------MVDFGALPPEINSARMYAGPGSASLVAAAQMWDSVASD
MMAR_4240|M.marinum_M               -------------MDFGSLPPEINSAKMYAGAGSGSILVAAEAWDSVAVD
MUL_0947|M.ulcerans_Agy99           -------------MDFGSLPPEFNSGKMYAGAGSGSILVAAEAWDSVAVD
MAV_2006|M.avium_104                -------------MHFAVLPPEVNSGRMYSGPGSGSMLAAASAWDELANE
MLBr_00411|M.leprae_Br4923          ------------MFDFMVYSPEVNAFLMSRGPGSTPLWGAAEAWISLAEQ
                                                   :   .**.::  :  *.*. .:  *.  *  :: :

MSMEG_0619|M.smegmatis_MC2_155      YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
TH_3569|M.thermoresistible__bu      YASAAAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSAATA
Mflv_0325|M.gilvum_PYR-GCK          YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1       YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MAB_4783|M.abscessus_ATCC_1997      YSSAANELTTTLGSVRAGVWDGASAEQYQTAHVPYLSWLHETSAVSAGVA
Mb1228|M.bovis_AF2122/97            LFSAASAFQSVVWGLTVGSWIGSSAGLMVAAASPYVAWMSVTAGQAELTA
Rv1196|M.tuberculosis_H37Rv         LFSAASAFQSVVWGLTVGSWIGSSAGLMVAAASPYVAWMSVTAGQAELTA
MMAR_4240|M.marinum_M               LYSAASSCQSVIWGLAFGQWVGASASLMGAAAAPYVAWLGATATRAELAA
MUL_0947|M.ulcerans_Agy99           LYSAASSCQSVIWGLAFGQWVGASASLMGAAAAPYVAWLGATATQAELAA
MAV_2006|M.avium_104                LHVTAANIESVISGLTSEPWQGPSAAAVTAAAATQVEWLTATAEQAAQTG
MLBr_00411|M.leprae_Br4923          LMEAAQEVSDTIVVAVPASFAGETSDMLASRVSTFVAWLNGNAENAGLIA
                                       :*      :       : * ::    :   . : *:   :  .   .

MSMEG_0619|M.smegmatis_MC2_155      VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
TH_3569|M.thermoresistible__bu      GRHETAAAAYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIPIALNE
Mflv_0325|M.gilvum_PYR-GCK          VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1       AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MAB_4783|M.abscessus_ATCC_1997      AQTETAATAYSEALATMPTLGELAANHATHGALVATNFFGINTIPIAVNE
Mb1228|M.bovis_AF2122/97            AQVRVAAAAYETAYGLTVPPPVIAENRAELMILIATNLLGQNTPAIAVNE
Rv1196|M.tuberculosis_H37Rv         AQVRVAAAAYETAYGLTVPPPVIAENRAELMILIATNLLGQNTPAIAVNE
MMAR_4240|M.marinum_M               NQARGAAVAYESAFAATVPPALILENRLQLVTLIATNIFGQNTPAIATTE
MUL_0947|M.ulcerans_Agy99           NQARGAAVAYESAFAATVPPALILENRLQLVTLIATNIFGQNTPAIATTE
MAV_2006|M.avium_104                AQLKAAATAYESAYAMTVPPSVVAANRSRLASLVATNLLGQNTPAIAATE
MLBr_00411|M.leprae_Br4923          RVLHAVAYAFEEARAGMVPLLTVLGNIIHTMALKAINWFGQVSTTVAALE
                                         .* *:  * .   .   :  *      * . * :*  : .:*  *

MSMEG_0619|M.smegmatis_MC2_155      ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA
TH_3569|M.thermoresistible__bu      ADYVRMWIQAATSMSTYQAVAGTAVMSAPASSPAPLLLAPGVSEAADAMA
Mflv_0325|M.gilvum_PYR-GCK          ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA
Mvan_0415|M.vanbaalenii_PYR-1       ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA
MAB_4783|M.abscessus_ATCC_1997      ADYIRMWIQAATVMSTYQAVSESSVSAAPPTSPAPPVLSPDSGAAARTAA
Mb1228|M.bovis_AF2122/97            AEYGEMWAQDAAAMFGYAAATATATATLLPFEEAPEMTSAGG--------
Rv1196|M.tuberculosis_H37Rv         AEYGEMWAQDAAAMFGYAAATATATATLLPFEEAPEMTSAGG--------
MMAR_4240|M.marinum_M               AEYGEMWAQDAAAMYGYAGSAAMLAETLTPFEEAPEVANAGG--------
MUL_0947|M.ulcerans_Agy99           AEYGEMWAQDAAAMYGYAGSAAMLAETLTPFEEAPEVANAGG--------
MAV_2006|M.avium_104                VAYGEMWAQDVAAMYGYAG-AAQAASRVTPFTPPQRTTNEAG--------
MLBr_00411|M.leprae_Br4923          ADYDLMWVQNSTAMTTYRDTVLRETGKMENFEPAPQLVSRYC--------
                                    . *  ** *  : *  *                .                

MSMEG_0619|M.smegmatis_MC2_155      SVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGGQ-AILDFLKDPL
TH_3569|M.thermoresistible__bu      TTQQIGSQATAADSGTALNLSDLIANLLQYYQDYLDQLFGPIVDFLRDPI
Mflv_0325|M.gilvum_PYR-GCK          DMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLRDPI
Mvan_0415|M.vanbaalenii_PYR-1       DVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLRDPL
MAB_4783|M.abscessus_ATCC_1997      -------QDATKPPPIVPDPNDPIEMLLKNSQHFL-GMYRALKGLITDPV
Mb1228|M.bovis_AF2122/97            ----LLEQAAAVEEASDTAAANQLMNNVPQALQQLAQPT-QGTTPSSKLG
Rv1196|M.tuberculosis_H37Rv         ----LLEQAAAVEEASDTAAANQLMNNVPQALQQLAQPT-QGTTPSSKLG
MMAR_4240|M.marinum_M               ----LVNQTAAVGQAIDSAAAGQLMSNVPQALQQLAAPAPQGASTATAPK
MUL_0947|M.ulcerans_Agy99           ----LVKQTAAVGQAIDSAAAGQLMSNVPQALQQLAATAPQGASTATAPK
MAV_2006|M.avium_104                ----MGAQNASVAQAAGTSAG-HVQSAVSNSNAMSAVPNALQNLASSSSS
MLBr_00411|M.leprae_Br4923          -----MDRRDSVNSFDSSSSSDSLYESIDNLYDSVAQSEEHGSDSMSQSY
                                           :  :            :   :                      

MSMEG_0619|M.smegmatis_MC2_155      GNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNLVGWPTWGMIFASPF
TH_3569|M.thermoresistible__bu      GNLFQLIDDFLTNPAGALVTWWPLLFAVAYQVFTNLVGWPTWAMILASPV
Mflv_0325|M.gilvum_PYR-GCK          GNTFALITDFLTNPVQALITWGPFLLAVVYQAVSWVGASILYPSLFLLPL
Mvan_0415|M.vanbaalenii_PYR-1       GNTIKLITDFLTNPAQALITWGPFLAAVAYQAVSWVGASILYPSLLLLPL
MAB_4783|M.abscessus_ATCC_1997      GTIVRIIIDFSTNPAAAIVTWTPLFYVFAYAATFAVMGTPIYAAIMGP--
Mb1228|M.bovis_AF2122/97            GLWKTVSP--HLSPISNMVSMANNHVSMTNSGVSMTNTLSSMLKGFAP-A
Rv1196|M.tuberculosis_H37Rv         GLWKTVSP--HRSPISNMVSMANNHMSMTNSGVSMTNTLSSMLKGFAPAA
MMAR_4240|M.marinum_M               SLLQSVTSSFSLSNLSTIVGMENTHLSMANSGASIFKTMGDSVKGFIP-S
MUL_0947|M.ulcerans_Agy99           SLLQSVTSSFSSSNLSTIVGMENTHLSMANSGASILKTMGDSVKGFIP-S
MAV_2006|M.avium_104                SSAASGLS--DFSSFLNPYNLVSLGSAFFGNGTGLIGVSG--AAGFISDA
MLBr_00411|M.leprae_Br4923          NTCGSVAQSELCDSPFGTPSQSSQSNDLSATSLTQQLGGLDSIISSAS-A
                                    .           .              .                      

MSMEG_0619|M.smegmatis_MC2_155      LIPALAALGITGLVLLIDHVLNNPVDVPAEDEAPQEVAAAPRTDQPLAVG
TH_3569|M.thermoresistible__bu      LIPLAITLGVAGLVMIADQAQP-----PAEEAAPEEDVAAP---------
Mflv_0325|M.gilvum_PYR-GCK          LATTLAIVAGVGQHLLSLLNTP-PAEEAAEEPAPAQSAPSRPDQQSFPAT
Mvan_0415|M.vanbaalenii_PYR-1       VATTLAIVLGVGAYLLENLPAP-AEDAPAEEPAASSPAPTRADQPSPAIA
MAB_4783|M.abscessus_ATCC_1997      -AAGISIPLAITLASLSQMPEAPPVDAPAETVPARIDQPHAVAMGGAPAP
Mb1228|M.bovis_AF2122/97            AAQAVETAAQNGVRAMSS-LGSSLGSSGLGGGVAAN-LGRAASVGSLSVP
Rv1196|M.tuberculosis_H37Rv         AAQAVQTAAQNGVRAMSS-LGSSLGSSGLGGGVAAN-LGRAASVGSLSVP
MMAR_4240|M.marinum_M               ASKAAETAVEHAARNAVS-MVGGGGPAGIGGWAPQGGVGQALSVGGLKVP
MUL_0947|M.ulcerans_Agy99           ASKAAETAVEHAARNAVS-MVGGGGPAGIGGWAPQGGVGQALSVGGLKVP
MAV_2006|M.avium_104                EHKMTEPSAKSKAVAAPERLEPPAGSRSSGATTVSAGMGRASSLGGMSVP
MLBr_00411|M.leprae_Br4923          SLLTTNSISSSTASSIMPIVASQVTETLGRSQVAVEKMIQSISSTAVSVD
                                                                                      

MSMEG_0619|M.smegmatis_MC2_155      ISPAGVPGSAATAAAPAPAPAGTTVAAPAPAAATFVP-YAVANRDPGEGF
TH_3569|M.thermoresistible__bu      ----------VRAEPQNPLPLTXXX-------------------------
Mflv_0325|M.gilvum_PYR-GCK          MSAPPPPSGAPIAANTVSAGSPPAPGAPAAAAATFVP-YVVAGRDPYEGF
Mvan_0415|M.vanbaalenii_PYR-1       VSAPPPPSSAAATVGTVATGTAPAPGAPAAATASFVP-YAVAGRDPGTGF
MAB_4783|M.abscessus_ATCC_1997      TASTAAP--TPTTTSPATPGSAPAP-TPPPAGAEGLG-YAVRGDGPGFGF
Mb1228|M.bovis_AF2122/97            QAWAAANQAVTPAARALPLTSLTSAAERGP--------GQMLGGLP-VGQ
Rv1196|M.tuberculosis_H37Rv         QAWAAANQAVTPAARALPLTSLTSAAERGP--------GQMLGGLP-VGQ
MMAR_4240|M.marinum_M               QAWAEANQSVVPAARALPISPVTGAVEGAH--------GAPLPGMP-FGQ
MUL_0947|M.ulcerans_Agy99           QAWAEANQAVVPAARALPISPVTGAVEGAH--------GAPLPGMP-FGQ
MAV_2006|M.avium_104                QGWSTAAPELRLTALQAPAAAAAPPGRPGPFGEMPLFGGAPLMGLPGRGA
MLBr_00411|M.leprae_Br4923          VAASKVVAGVGQAVSVGALRVPENWATASQP-------VMATAHSVPAGC
                                                :    .                                

MSMEG_0619|M.smegmatis_MC2_155      TPTLGNKSQVAAPASGVPAAASGVAASLASRRKRRRKKGAQIEERGYADA
TH_3569|M.thermoresistible__bu      --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK          SPTVRDSTGAKAPAGTIPAAASGIAASAAERRKRRRRQKEEIKGRGYADA
Mvan_0415|M.vanbaalenii_PYR-1       SPTVRDSTSAKAPASGIPAAASGVAASAAERRKRRRRQKDEIAGRAYADA
MAB_4783|M.abscessus_ATCC_1997      GPTIGASTGATAHAPSSAVSAAAALACNPATGKSRRRRRRTIDDRGYRHE
Mb1228|M.bovis_AF2122/97            MGARAG--GGLSGVLRVPPRPYVMPHSPAAG-------------------
Rv1196|M.tuberculosis_H37Rv         MGARAG--GGLSGVLRVPPRPYVMPHSPAAG-------------------
MMAR_4240|M.marinum_M               LAGNGG--NGVSGVLRVTPKAYVMPRPPAAG-------------------
MUL_0947|M.ulcerans_Agy99           LAGNGG--NGVSGVLRVTPKAYVMPRPPAAG-------------------
MAV_2006|M.avium_104                ADSRDGRSSGDAGTAGRGRRAAASHGPAGAARTASTGTTAELREITDLLG
MLBr_00411|M.leprae_Br4923          SAITTAVSGPLEGVTQPAEEVLTASVAGGSGTGGPAFNEAV---------
                                                                                      

MSMEG_0619|M.smegmatis_MC2_155      YMDYEE-PDEDPAPQPEPRVRASERGSDAMGFTGTVTRH-DVTAAGLTTL
TH_3569|M.thermoresistible__bu      --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK          YADYEELPDDGPPEQPAPRVTASTRGAGPMGFAGTVSRG-DEQAGGLTTL
Mvan_0415|M.vanbaalenii_PYR-1       YADYEPEPDDEPPVRQEPRIAATERGAGPMGFAGTVSRD-AAQAGGLTTL
MAB_4783|M.abscessus_ATCC_1997      YATMDDHTPTGP--QDPVTAVASGTGAGRLGFAGVHTATTAVEATGLSTL
Mb1228|M.bovis_AF2122/97            --------------------------------------------------
Rv1196|M.tuberculosis_H37Rv         --------------------------------------------------
MMAR_4240|M.marinum_M               --------------------------------------------------
MUL_0947|M.ulcerans_Agy99           --------------------------------------------------
MAV_2006|M.avium_104                KLAELRATGALTDTEFAEQKQRLLRAR-----------------------
MLBr_00411|M.leprae_Br4923          --------------------------------------------------
                                                                                      

MSMEG_0619|M.smegmatis_MC2_155      TGDTFDDRPVTPMLPGTWDGDENPAPSPDDPEGGPRR------
TH_3569|M.thermoresistible__bu      -------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK          AGDSFGGGPREPMLPGTWDPDATDDRHTDGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1       PGDPFGGGPKAPMLPGTWDPDTEPD------ERHNHHDGKDSQ
MAB_4783|M.abscessus_ATCC_1997      DGDAEN--RTIPMLPGTWDVTDDDR------------------
Mb1228|M.bovis_AF2122/97            -------------------------------------------
Rv1196|M.tuberculosis_H37Rv         -------------------------------------------
MMAR_4240|M.marinum_M               -------------------------------------------
MUL_0947|M.ulcerans_Agy99           -------------------------------------------
MAV_2006|M.avium_104                -------------------------------------------
MLBr_00411|M.leprae_Br4923          -------------------------------------------