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MFDFMVYSPEVNAFLMSRGPGSTPLWGAAEAWISLAEQLMEAAQEVSDTIVVAVPASFAGETSDMLASRV STFVAWLNGNAENAGLIARVLHAVAYAFEEARAGMVPLLTVLGNIIHTMALKAINWFGQVSTTVAALEAD YDLMWVQNSTAMTTYRDTVLRETGKMENFEPAPQLVSRYCMDRRDSVNSFDSSSSSDSLYESIDNLYDSV AQSEEHGSDSMSQSYNTCGSVAQSELCDSPFGTPSQSSQSNDLSATSLTQQLGGLDSIISSASASLLTTN SISSSTASSIMPIVASQVTETLGRSQVAVEKMIQSISSTAVSVDVAASKVVAGVGQAVSVGALRVPENWA TASQPVMATAHSVPAGCSAITTAVSGPLEGVTQPAEEVLTASVAGGSGTGGPAFNEAV
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. leprae Br4923 | MLBr_00411 | - | - | 100% (408) | serine-rich antigen |
M. leprae Br4923 | MLBr_01182 | - | 1e-43 | 31.48% (413) | PPE-family protein |
M. leprae Br4923 | MLBr_01828 | PPE | 5e-18 | 29.53% (193) | PPE-family protein |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb1228 | PPE18 | 1e-31 | 27.97% (379) | PPE family protein |
M. gilvum PYR-GCK | Mflv_0325 | - | 6e-14 | 27.75% (173) | PPE protein |
M. tuberculosis H37Rv | Rv1196 | PPE18 | 1e-32 | 27.97% (379) | PPE family protein |
M. abscessus ATCC 19977 | MAB_4783 | - | 2e-18 | 31.03% (174) | PPE family protein |
M. marinum M | MMAR_4240 | - | 3e-33 | 27.09% (406) | PPE family protein, PPE18 |
M. avium 104 | MAV_2006 | - | 4e-27 | 27.60% (366) | PPE family protein |
M. smegmatis MC2 155 | MSMEG_0619 | - | 8e-17 | 32.00% (175) | PPE family protein |
M. thermoresistible (build 8) | TH_3569 | - | 1e-18 | 27.23% (224) | PUTATIVE PPE protein |
M. ulcerans Agy99 | MUL_0947 | - | 2e-32 | 27.27% (407) | PPE family protein |
M. vanbaalenii PYR-1 | Mvan_0415 | - | 1e-15 | 30.00% (170) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE TH_3569|M.thermoresistible__bu ---------MMTAPIWMALPPEVHSALLSSGPGPGSLLAAASAWHALSAE Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE MAB_4783|M.abscessus_ATCC_1997 ----------MTAPVWMAAPPEVHSALLSSGPGPGSLFAAADAWRSLSTE Mb1228|M.bovis_AF2122/97 ------------MVDFGALPPEINSARMYAGPGSASLVAAAQMWDSVASD Rv1196|M.tuberculosis_H37Rv ------------MVDFGALPPEINSARMYAGPGSASLVAAAQMWDSVASD MMAR_4240|M.marinum_M -------------MDFGSLPPEINSAKMYAGAGSGSILVAAEAWDSVAVD MUL_0947|M.ulcerans_Agy99 -------------MDFGSLPPEFNSGKMYAGAGSGSILVAAEAWDSVAVD MAV_2006|M.avium_104 -------------MHFAVLPPEVNSGRMYSGPGSGSMLAAASAWDELANE MLBr_00411|M.leprae_Br4923 ------------MFDFMVYSPEVNAFLMSRGPGSTPLWGAAEAWISLAEQ : .**.:: : *.*. .: *. * :: : MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA TH_3569|M.thermoresistible__bu YASAAAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSAATA Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA MAB_4783|M.abscessus_ATCC_1997 YSSAANELTTTLGSVRAGVWDGASAEQYQTAHVPYLSWLHETSAVSAGVA Mb1228|M.bovis_AF2122/97 LFSAASAFQSVVWGLTVGSWIGSSAGLMVAAASPYVAWMSVTAGQAELTA Rv1196|M.tuberculosis_H37Rv LFSAASAFQSVVWGLTVGSWIGSSAGLMVAAASPYVAWMSVTAGQAELTA MMAR_4240|M.marinum_M LYSAASSCQSVIWGLAFGQWVGASASLMGAAAAPYVAWLGATATRAELAA MUL_0947|M.ulcerans_Agy99 LYSAASSCQSVIWGLAFGQWVGASASLMGAAAAPYVAWLGATATQAELAA MAV_2006|M.avium_104 LHVTAANIESVISGLTSEPWQGPSAAAVTAAAATQVEWLTATAEQAAQTG MLBr_00411|M.leprae_Br4923 LMEAAQEVSDTIVVAVPASFAGETSDMLASRVSTFVAWLNGNAENAGLIA :* : : * :: : . : *: : . . MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE TH_3569|M.thermoresistible__bu GRHETAAAAYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIPIALNE Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE MAB_4783|M.abscessus_ATCC_1997 AQTETAATAYSEALATMPTLGELAANHATHGALVATNFFGINTIPIAVNE Mb1228|M.bovis_AF2122/97 AQVRVAAAAYETAYGLTVPPPVIAENRAELMILIATNLLGQNTPAIAVNE Rv1196|M.tuberculosis_H37Rv AQVRVAAAAYETAYGLTVPPPVIAENRAELMILIATNLLGQNTPAIAVNE MMAR_4240|M.marinum_M NQARGAAVAYESAFAATVPPALILENRLQLVTLIATNIFGQNTPAIATTE MUL_0947|M.ulcerans_Agy99 NQARGAAVAYESAFAATVPPALILENRLQLVTLIATNIFGQNTPAIATTE MAV_2006|M.avium_104 AQLKAAATAYESAYAMTVPPSVVAANRSRLASLVATNLLGQNTPAIAATE MLBr_00411|M.leprae_Br4923 RVLHAVAYAFEEARAGMVPLLTVLGNIIHTMALKAINWFGQVSTTVAALE .* *: * . . : * * . * :* : .:* * MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA TH_3569|M.thermoresistible__bu ADYVRMWIQAATSMSTYQAVAGTAVMSAPASSPAPLLLAPGVSEAADAMA Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA MAB_4783|M.abscessus_ATCC_1997 ADYIRMWIQAATVMSTYQAVSESSVSAAPPTSPAPPVLSPDSGAAARTAA Mb1228|M.bovis_AF2122/97 AEYGEMWAQDAAAMFGYAAATATATATLLPFEEAPEMTSAGG-------- Rv1196|M.tuberculosis_H37Rv AEYGEMWAQDAAAMFGYAAATATATATLLPFEEAPEMTSAGG-------- MMAR_4240|M.marinum_M AEYGEMWAQDAAAMYGYAGSAAMLAETLTPFEEAPEVANAGG-------- MUL_0947|M.ulcerans_Agy99 AEYGEMWAQDAAAMYGYAGSAAMLAETLTPFEEAPEVANAGG-------- MAV_2006|M.avium_104 VAYGEMWAQDVAAMYGYAG-AAQAASRVTPFTPPQRTTNEAG-------- MLBr_00411|M.leprae_Br4923 ADYDLMWVQNSTAMTTYRDTVLRETGKMENFEPAPQLVSRYC-------- . * ** * : * * . MSMEG_0619|M.smegmatis_MC2_155 SVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGGQ-AILDFLKDPL TH_3569|M.thermoresistible__bu TTQQIGSQATAADSGTALNLSDLIANLLQYYQDYLDQLFGPIVDFLRDPI Mflv_0325|M.gilvum_PYR-GCK DMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLRDPI Mvan_0415|M.vanbaalenii_PYR-1 DVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLRDPL MAB_4783|M.abscessus_ATCC_1997 -------QDATKPPPIVPDPNDPIEMLLKNSQHFL-GMYRALKGLITDPV Mb1228|M.bovis_AF2122/97 ----LLEQAAAVEEASDTAAANQLMNNVPQALQQLAQPT-QGTTPSSKLG Rv1196|M.tuberculosis_H37Rv ----LLEQAAAVEEASDTAAANQLMNNVPQALQQLAQPT-QGTTPSSKLG MMAR_4240|M.marinum_M ----LVNQTAAVGQAIDSAAAGQLMSNVPQALQQLAAPAPQGASTATAPK MUL_0947|M.ulcerans_Agy99 ----LVKQTAAVGQAIDSAAAGQLMSNVPQALQQLAATAPQGASTATAPK MAV_2006|M.avium_104 ----MGAQNASVAQAAGTSAG-HVQSAVSNSNAMSAVPNALQNLASSSSS MLBr_00411|M.leprae_Br4923 -----MDRRDSVNSFDSSSSSDSLYESIDNLYDSVAQSEEHGSDSMSQSY : : : : MSMEG_0619|M.smegmatis_MC2_155 GNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNLVGWPTWGMIFASPF TH_3569|M.thermoresistible__bu GNLFQLIDDFLTNPAGALVTWWPLLFAVAYQVFTNLVGWPTWAMILASPV Mflv_0325|M.gilvum_PYR-GCK GNTFALITDFLTNPVQALITWGPFLLAVVYQAVSWVGASILYPSLFLLPL Mvan_0415|M.vanbaalenii_PYR-1 GNTIKLITDFLTNPAQALITWGPFLAAVAYQAVSWVGASILYPSLLLLPL MAB_4783|M.abscessus_ATCC_1997 GTIVRIIIDFSTNPAAAIVTWTPLFYVFAYAATFAVMGTPIYAAIMGP-- Mb1228|M.bovis_AF2122/97 GLWKTVSP--HLSPISNMVSMANNHVSMTNSGVSMTNTLSSMLKGFAP-A Rv1196|M.tuberculosis_H37Rv GLWKTVSP--HRSPISNMVSMANNHMSMTNSGVSMTNTLSSMLKGFAPAA MMAR_4240|M.marinum_M SLLQSVTSSFSLSNLSTIVGMENTHLSMANSGASIFKTMGDSVKGFIP-S MUL_0947|M.ulcerans_Agy99 SLLQSVTSSFSSSNLSTIVGMENTHLSMANSGASILKTMGDSVKGFIP-S MAV_2006|M.avium_104 SSAASGLS--DFSSFLNPYNLVSLGSAFFGNGTGLIGVSG--AAGFISDA MLBr_00411|M.leprae_Br4923 NTCGSVAQSELCDSPFGTPSQSSQSNDLSATSLTQQLGGLDSIISSAS-A . . . MSMEG_0619|M.smegmatis_MC2_155 LIPALAALGITGLVLLIDHVLNNPVDVPAEDEAPQEVAAAPRTDQPLAVG TH_3569|M.thermoresistible__bu LIPLAITLGVAGLVMIADQAQP-----PAEEAAPEEDVAAP--------- Mflv_0325|M.gilvum_PYR-GCK LATTLAIVAGVGQHLLSLLNTP-PAEEAAEEPAPAQSAPSRPDQQSFPAT Mvan_0415|M.vanbaalenii_PYR-1 VATTLAIVLGVGAYLLENLPAP-AEDAPAEEPAASSPAPTRADQPSPAIA MAB_4783|M.abscessus_ATCC_1997 -AAGISIPLAITLASLSQMPEAPPVDAPAETVPARIDQPHAVAMGGAPAP Mb1228|M.bovis_AF2122/97 AAQAVETAAQNGVRAMSS-LGSSLGSSGLGGGVAAN-LGRAASVGSLSVP Rv1196|M.tuberculosis_H37Rv AAQAVQTAAQNGVRAMSS-LGSSLGSSGLGGGVAAN-LGRAASVGSLSVP MMAR_4240|M.marinum_M ASKAAETAVEHAARNAVS-MVGGGGPAGIGGWAPQGGVGQALSVGGLKVP MUL_0947|M.ulcerans_Agy99 ASKAAETAVEHAARNAVS-MVGGGGPAGIGGWAPQGGVGQALSVGGLKVP MAV_2006|M.avium_104 EHKMTEPSAKSKAVAAPERLEPPAGSRSSGATTVSAGMGRASSLGGMSVP MLBr_00411|M.leprae_Br4923 SLLTTNSISSSTASSIMPIVASQVTETLGRSQVAVEKMIQSISSTAVSVD MSMEG_0619|M.smegmatis_MC2_155 ISPAGVPGSAATAAAPAPAPAGTTVAAPAPAAATFVP-YAVANRDPGEGF TH_3569|M.thermoresistible__bu ----------VRAEPQNPLPLTXXX------------------------- Mflv_0325|M.gilvum_PYR-GCK MSAPPPPSGAPIAANTVSAGSPPAPGAPAAAAATFVP-YVVAGRDPYEGF Mvan_0415|M.vanbaalenii_PYR-1 VSAPPPPSSAAATVGTVATGTAPAPGAPAAATASFVP-YAVAGRDPGTGF MAB_4783|M.abscessus_ATCC_1997 TASTAAP--TPTTTSPATPGSAPAP-TPPPAGAEGLG-YAVRGDGPGFGF Mb1228|M.bovis_AF2122/97 QAWAAANQAVTPAARALPLTSLTSAAERGP--------GQMLGGLP-VGQ Rv1196|M.tuberculosis_H37Rv QAWAAANQAVTPAARALPLTSLTSAAERGP--------GQMLGGLP-VGQ MMAR_4240|M.marinum_M QAWAEANQSVVPAARALPISPVTGAVEGAH--------GAPLPGMP-FGQ MUL_0947|M.ulcerans_Agy99 QAWAEANQAVVPAARALPISPVTGAVEGAH--------GAPLPGMP-FGQ MAV_2006|M.avium_104 QGWSTAAPELRLTALQAPAAAAAPPGRPGPFGEMPLFGGAPLMGLPGRGA MLBr_00411|M.leprae_Br4923 VAASKVVAGVGQAVSVGALRVPENWATASQP-------VMATAHSVPAGC : . MSMEG_0619|M.smegmatis_MC2_155 TPTLGNKSQVAAPASGVPAAASGVAASLASRRKRRRKKGAQIEERGYADA TH_3569|M.thermoresistible__bu -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK SPTVRDSTGAKAPAGTIPAAASGIAASAAERRKRRRRQKEEIKGRGYADA Mvan_0415|M.vanbaalenii_PYR-1 SPTVRDSTSAKAPASGIPAAASGVAASAAERRKRRRRQKDEIAGRAYADA MAB_4783|M.abscessus_ATCC_1997 GPTIGASTGATAHAPSSAVSAAAALACNPATGKSRRRRRRTIDDRGYRHE Mb1228|M.bovis_AF2122/97 MGARAG--GGLSGVLRVPPRPYVMPHSPAAG------------------- Rv1196|M.tuberculosis_H37Rv MGARAG--GGLSGVLRVPPRPYVMPHSPAAG------------------- MMAR_4240|M.marinum_M LAGNGG--NGVSGVLRVTPKAYVMPRPPAAG------------------- MUL_0947|M.ulcerans_Agy99 LAGNGG--NGVSGVLRVTPKAYVMPRPPAAG------------------- MAV_2006|M.avium_104 ADSRDGRSSGDAGTAGRGRRAAASHGPAGAARTASTGTTAELREITDLLG MLBr_00411|M.leprae_Br4923 SAITTAVSGPLEGVTQPAEEVLTASVAGGSGTGGPAFNEAV--------- MSMEG_0619|M.smegmatis_MC2_155 YMDYEE-PDEDPAPQPEPRVRASERGSDAMGFTGTVTRH-DVTAAGLTTL TH_3569|M.thermoresistible__bu -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK YADYEELPDDGPPEQPAPRVTASTRGAGPMGFAGTVSRG-DEQAGGLTTL Mvan_0415|M.vanbaalenii_PYR-1 YADYEPEPDDEPPVRQEPRIAATERGAGPMGFAGTVSRD-AAQAGGLTTL MAB_4783|M.abscessus_ATCC_1997 YATMDDHTPTGP--QDPVTAVASGTGAGRLGFAGVHTATTAVEATGLSTL Mb1228|M.bovis_AF2122/97 -------------------------------------------------- Rv1196|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_4240|M.marinum_M -------------------------------------------------- MUL_0947|M.ulcerans_Agy99 -------------------------------------------------- MAV_2006|M.avium_104 KLAELRATGALTDTEFAEQKQRLLRAR----------------------- MLBr_00411|M.leprae_Br4923 -------------------------------------------------- MSMEG_0619|M.smegmatis_MC2_155 TGDTFDDRPVTPMLPGTWDGDENPAPSPDDPEGGPRR------ TH_3569|M.thermoresistible__bu ------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK AGDSFGGGPREPMLPGTWDPDATDDRHTDGRDGHDGHDGKEKP Mvan_0415|M.vanbaalenii_PYR-1 PGDPFGGGPKAPMLPGTWDPDTEPD------ERHNHHDGKDSQ MAB_4783|M.abscessus_ATCC_1997 DGDAEN--RTIPMLPGTWDVTDDDR------------------ Mb1228|M.bovis_AF2122/97 ------------------------------------------- Rv1196|M.tuberculosis_H37Rv ------------------------------------------- MMAR_4240|M.marinum_M ------------------------------------------- MUL_0947|M.ulcerans_Agy99 ------------------------------------------- MAV_2006|M.avium_104 ------------------------------------------- MLBr_00411|M.leprae_Br4923 -------------------------------------------