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VVDFGALPPEINSARMYAGPGSASLVAAAQMWDSVASDLFSAASAFQSVVWGLTVGSWIGSSAGLMVAAA SPYVAWMSVTAGQAELTAAQVRVAAAAYETAYGLTVPPPVIAENRAELMILIATNLLGQNTPAIAVNEAE YGEMWAQDAAAMFGYAAATATATATLLPFEEAPEMTSAGGLLEQAAAVEEASDTAAANQLMNNVPQALQQ LAQPTQGTTPSSKLGGLWKTVSPHLSPISNIVSMLNNHVSMTNSGVSMTNTLHSMLKGFAPAAAQAVETA AQNGVQAMSSLGSQLGSSLGSSGLGAGVAANLGRAASVGSLSVPPAWAAANQAVTPAARALPLTSLTSAA QTAPGHMLGGLPLGQLTNSGGGFGGVSNALRMPPRAYVMPRVPAAG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1396c | PPE19 | - | 100% (396) | PPE family protein |
| M. bovis AF2122 / 97 | Mb1228 | PPE18 | 0.0 | 92.42% (396) | PPE family protein |
| M. bovis AF2122 / 97 | Mb3505 | PPE60 | 0.0 | 85.10% (396) | PE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0325 | - | 4e-30 | 30.45% (381) | PPE protein |
| M. tuberculosis H37Rv | Rv1361c | PPE19 | 0.0 | 92.93% (396) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 1e-79 | 42.38% (420) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0669 | - | 3e-31 | 36.10% (205) | PPE-family protein |
| M. marinum M | MMAR_4240 | - | 1e-119 | 56.97% (402) | PPE family protein, PPE18 |
| M. avium 104 | MAV_2924 | - | 5e-76 | 41.94% (422) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 3e-30 | 35.00% (220) | PPE family protein |
| M. thermoresistible (build 8) | TH_3569 | - | 4e-32 | 40.72% (194) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_0947 | - | 1e-118 | 56.25% (400) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 9e-33 | 38.21% (212) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1396c|M.bovis_AF2122/97 ------------MVDFGALPPEINSARMYAGPGSASLVAAAQMWDSVASD
Rv1361c|M.tuberculosis_H37Rv ------------MVDFGALPPEINSARMYAGPGSASLVAAAKMWDSVASD
MMAR_4240|M.marinum_M -------------MDFGSLPPEINSAKMYAGAGSGSILVAAEAWDSVAVD
MUL_0947|M.ulcerans_Agy99 -------------MDFGSLPPEFNSGKMYAGAGSGSILVAAEAWDSVAVD
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
MAV_2924|M.avium_104 -------------MDYGAFPPEFNSARIYSGPGSGSLVAAASAWSSLAAE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
TH_3569|M.thermoresistible__bu ---------MMTAPIWMALPPEVHSALLSSGPGPGSLLAAASAWHALSAE
MAB_0669|M.abscessus_ATCC_1997 ----------MTAPIWMAEPPEVHSALLSAGPGPGAVLAAAVQWQEIGNN
: : .** :* : *.*...::.*. * :. :
Mb1396c|M.bovis_AF2122/97 LFSAASAFQSVVWGLTVGSWIGSSAGLMVAAASPYVAWMSVTAGQAELTA
Rv1361c|M.tuberculosis_H37Rv LFSAASAFQSVVWGLTTGSWIGSSAGLMVAAASPYVAWMSVTAGQAELTA
MMAR_4240|M.marinum_M LYSAASSCQSVIWGLAFGQWVGASASLMGAAAAPYVAWLGATATRAELAA
MUL_0947|M.ulcerans_Agy99 LYSAASSCQSVIWGLAFGQWVGASASLMGAAAAPYVAWLGATATQAELAA
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLT-TFEGESAAALAERVTPYEKWLTQNAASAELTA
MAV_2924|M.avium_104 LNAAALSYDKVVTALASEEWLGSASASMASAVAPYVGWMSTTAAQAEEAA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
TH_3569|M.thermoresistible__bu YASAAAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSAATA
MAB_0669|M.abscessus_ATCC_1997 YANTAVELAQVLAGVRAGSWQGPSASEYVAAHLPYLAWLEQAAAESSVIA
:* . : : : * :: ** *: : . *
Mb1396c|M.bovis_AF2122/97 AQVRVAAAAYETAYGLTVPPPVIAENRAELMILIATNLLGQNTPAIAVNE
Rv1361c|M.tuberculosis_H37Rv AQVRVAAAAYETAYGLTVPPPVIAENRAELMILIATNLLGQNTPAIAVNE
MMAR_4240|M.marinum_M NQARGAAVAYESAFAATVPPALILENRLQLVTLIATNIFGQNTPAIATTE
MUL_0947|M.ulcerans_Agy99 NQARGAAVAYESAFAATVPPALILENRLQLVTLIATNIFGQNTPAIATTE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
MAV_2924|M.avium_104 SQARAAAAAYEAALAASVPPPLIAANRMQVSQLQATNVLGQNTPLIAQLE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
TH_3569|M.thermoresistible__bu GRHETAAAAYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIPIALNE
MAB_0669|M.abscessus_ATCC_1997 AQHETTAAAYNSALAAMPTLAELAANHITHGVLVGTNFFGINTIPIALNE
: :* ** :* . : *: * :*.:* *: ** *
Mb1396c|M.bovis_AF2122/97 AEYGEMWAQDAAAMFGYAAATATATATLLPFEEAPEMTSAGGL-------
Rv1361c|M.tuberculosis_H37Rv AEYGEMWAQDAAAMFGYAATAATATEALLPFEDAPLITNPGGL-------
MMAR_4240|M.marinum_M AEYGEMWAQDAAAMYGYAGSAAMLAETLTPFEEAPEVANAGGL-------
MUL_0947|M.ulcerans_Agy99 AEYGEMWAQDAAAMYGYAGSAAMLAETLTPFEEAPEVANAGGL-------
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEVVEE
MAV_2924|M.avium_104 AQYGEYWAQDAAAMYSYAGQSASAS-KVTPFQKAPQVTNPSGQ-------
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA
TH_3569|M.thermoresistible__bu ADYVRMWIQAATSMSTYQAVAGTAVMSAPASSPAPLLLAPGVSEAADAMA
MAB_0669|M.abscessus_ATCC_1997 ADYVRMWVQAAATMSAYQATTEAMTSAIPPTQQPPAILSPG-GEARSDQS
*:* . * * *::* * . .*
Mb1396c|M.bovis_AF2122/97 -----LEQAAAVEEASDTAAANQLMNN----------------------V
Rv1361c|M.tuberculosis_H37Rv -----LEQAVAVEEAIDTAAANQLMNN----------------------V
MMAR_4240|M.marinum_M -----VNQTAAVGQAIDSAAAGQLMSN----------------------V
MUL_0947|M.ulcerans_Agy99 -----VKQTAAVGQAIDSAAAGQLMSN----------------------V
MLBr_01182|M.leprae_Br4923 VVEEVVEEVVEAEQAISQAALDQAVNEGMEA----------------TVV
MAV_2924|M.avium_104 -----AAQSAAVSTATANSTSTNTTKALQS-------------------L
Mflv_0325|M.gilvum_PYR-GCK DMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLRDPI
Mvan_0415|M.vanbaalenii_PYR-1 DVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLRDPL
MSMEG_0619|M.smegmatis_MC2_155 SVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGGQ-AILDFLKDPL
TH_3569|M.thermoresistible__bu TTQQIGSQATAADSGTALNLSDLIANLLQYYQDYLDQLFGPIVDFLRDPI
MAB_0669|M.abscessus_ATCC_1997 DVPGSPDQ---------------IMKMLQGFQQWFEKMG--FNPATSAVL
: . :
Mb1396c|M.bovis_AF2122/97 PQALQQL--AQPT-QGTTP---SSKLGGLWKTVSPHLSP---ISNIVSML
Rv1361c|M.tuberculosis_H37Rv PQALQQL--AQPT-KSIWP---FDQLSELWKAISPHLSP---LSNIVSML
MMAR_4240|M.marinum_M PQALQQL--AAPAPQGAST---ATAPKSLLQSVTSSFSLSN-LSTIVGME
MUL_0947|M.ulcerans_Agy99 PQALQQL--AATAPQGAST---ATAPKSLLQSVTSSFSSSN-LSTIVGME
MLBr_01182|M.leprae_Br4923 PQVDQQVNVDVATPQTAVPDSSSAAAPQLWGGFAQHLSP---INDTLSMI
MAV_2924|M.avium_104 AQPASSSTTATKAATTAASTTSTDPLSEIWFLLTGQTSLPTNLGTLVNGY
Mflv_0325|M.gilvum_PYR-GCK GNTFALITDFLTNPVQALITWGPFLLAVVYQAVSWVGASILYPSLFLLPL
Mvan_0415|M.vanbaalenii_PYR-1 GNTIKLITDFLTNPAQALITWGPFLAAVAYQAVSWVGASILYPSLLLLPL
MSMEG_0619|M.smegmatis_MC2_155 GNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNLVGWPTWGMIFASPF
TH_3569|M.thermoresistible__bu GNLFQLIDDFLTNPAGALVTWWPLLFAVAYQVFTNLVGWPTWAMILASPV
MAB_0669|M.abscessus_ATCC_1997 AVIMLFLYDLLWYPY-----YASYLLPFLIPALSGLSG-LAALMHLRPAA
. .
Mb1396c|M.bovis_AF2122/97 NNHVSMTN--SGVSMTNTLHSMLKGFAPAAAQAVETAAQNGVQ-------
Rv1361c|M.tuberculosis_H37Rv NNHVSMTN--SGVSMASTLHSMLKGFAPAAAQAVETAAQNGVQ-------
MMAR_4240|M.marinum_M NTHLSMAN--SGASIFKTMGDSVKGFIPSASKAAETAVEHAARN------
MUL_0947|M.ulcerans_Agy99 NTHLSMAN--SGASILKTMGDSVKGFIPSASKAAETAVEHAARN------
MLBr_01182|M.leprae_Br4923 NNHAGMAN--AGLSLVNGMGSAMKSLAPTTTKAAESAFKAMGS-------
MAV_2924|M.avium_104 SPFAGLFYNTEGLPYFSTGMANTFTQIAKSVGAIGGAAPAAAK-------
Mflv_0325|M.gilvum_PYR-GCK LATTLAIVAGVGQHLLSLLNTP-PAEEAAEEPAPAQSAPSRPDQQSFPAT
Mvan_0415|M.vanbaalenii_PYR-1 VATTLAIVLGVGAYLLENLPAP-AEDAPAEEPAASSPAPTRADQPSPAIA
MSMEG_0619|M.smegmatis_MC2_155 LIPALAALGITGLVLLIDHVLNNPVDVPAEDEAPQEVAAAPRTDQPLAVG
TH_3569|M.thermoresistible__bu LIPLAITLGVAGLVMIADQAQP-----PAEEAAPEEDVAAP---------
MAB_0669|M.abscessus_ATCC_1997 PGPVPAAALSPGDRPIRRPTQHVEPNLAALPLPTSSVVPSGG--------
* . .
Mb1396c|M.bovis_AF2122/97 ------------AMSSLGSQLGSSLGSSGLGAGVAANLGRAASVG-SLSV
Rv1361c|M.tuberculosis_H37Rv ------------AMSSLGSQLGSSLGSSGLGAGVAANLGRAASVG-SLSV
MMAR_4240|M.marinum_M ------------AVSMVGGGGPAGIG----GWAPQGGVGQALSVG-GLKV
MUL_0947|M.ulcerans_Agy99 ------------AVSMVGGGGPAGIG----GWAPQGGVGQALSVG-GLKV
MLBr_01182|M.leprae_Br4923 ------------AVQSTGRGLLGSSS----GGHVTAQLGRAASIG-SLRV
MAV_2924|M.avium_104 ------------ALPGLG-GLGGMLGGGAAAAHPVAALGGAGSIGGKLSV
Mflv_0325|M.gilvum_PYR-GCK MSAPPPPSGAPIAANTVSAGSPPAPGAPAAAAATFVPYVVAGRDPYEGFS
Mvan_0415|M.vanbaalenii_PYR-1 VSAPPPPSSAAATVGTVATGTAPAPGAPAAATASFVPYAVAGRDPGTGFS
MSMEG_0619|M.smegmatis_MC2_155 ISPAGVPGSAATAAAPAPAPAGTTVAAPAPAAATFVPYAVANRDPGEGFT
TH_3569|M.thermoresistible__bu ----------VRAEPQNPLPLTXXX-------------------------
MAB_0669|M.abscessus_ATCC_1997 -------SSVPVSTPTAPAHTVSSVPAPSAAISYAIPGLVP---PGVSFG
:
Mb1396c|M.bovis_AF2122/97 PPAWAAANQAVTPAARALPLTSLTSAAQTA--------------------
Rv1361c|M.tuberculosis_H37Rv PQAWAAANQAVTPAARALPLTSLTSAAQTA--------------------
MMAR_4240|M.marinum_M PQAWAEANQSVVPAARALPISPVTGAVEGA--------------------
MUL_0947|M.ulcerans_Agy99 PQAWAEANQAVVPAARALPISPVTGAVEGA--------------------
MLBr_01182|M.leprae_Br4923 PQTWTTASQPVTAATRALSPARVAVATESE--------------------
MAV_2924|M.avium_104 PVAWSGA-PATPALGHAIPVSSISAAPEAAGG------------------
Mflv_0325|M.gilvum_PYR-GCK PTVRDSTGAKAPAGTIPAAASGIAASAAERRKRRRRQKEEIKGRGYADAY
Mvan_0415|M.vanbaalenii_PYR-1 PTVRDSTSAKAPASGIPAAASGVAASAAERRKRRRRQKDEIAGRAYADAY
MSMEG_0619|M.smegmatis_MC2_155 PTLGNKSQVAAPASGVPAAASGVAASLASRRKRRRKKGAQIEERGYADAY
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997 PKSTEKSSESAVDTVAAVAAARGAVAAQARRRLRGKNKAEAGGR--RHEY
Mb1396c|M.bovis_AF2122/97 -------PGHMLGG-LPLGQLTNSGGG-FGGVSNALRMPPRAYVMPRVPA
Rv1361c|M.tuberculosis_H37Rv -------PGHMLGG-LPLGQLTNSGGG-FGGVSNALRMPPRAYVMPRVPA
MMAR_4240|M.marinum_M -------HGAPLPG-MPFGQLAGNGG---NGVSGVLRVTPKAYVMPRPPA
MUL_0947|M.ulcerans_Agy99 -------HGAPLPG-MPFGQLAGNGG---NGVSGVLRVTPKAYVMPRPPA
MLBr_01182|M.leprae_Br4923 -------SAPLLGGGLPMAPMVPGGGSGTGGVNTALRLQPRAFVMPRNPA
MAV_2924|M.avium_104 -------PGNLLGG-MPLAGAGAGGHG-----AAGPKYGFRPTVMARPPF
Mflv_0325|M.gilvum_PYR-GCK ADYEELPDDGPPEQPAPRVTASTRGAGPMGFAGTVSRGDEQAGGLTTLAG
Mvan_0415|M.vanbaalenii_PYR-1 ADYEPEPDDEPPVRQEPRIAATERGAGPMGFAGTVSRDAAQAGGLTTLPG
MSMEG_0619|M.smegmatis_MC2_155 MDYEE-PDEDPAPQPEPRVRASERGSDAMGFTGTVTRHDVTAAGLTTLTG
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997 LEETAGMGAT-ATADVPAYAATGRGTGPLGFAGTAPAAASTHVAATVRLS
Mb1396c|M.bovis_AF2122/97 AG---------------------------------------
Rv1361c|M.tuberculosis_H37Rv AG---------------------------------------
MMAR_4240|M.marinum_M AG---------------------------------------
MUL_0947|M.ulcerans_Agy99 AG---------------------------------------
MLBr_01182|M.leprae_Br4923 AG---------------------------------------
MAV_2924|M.avium_104 AG---------------------------------------
Mflv_0325|M.gilvum_PYR-GCK DSFGGGPREPMLPGTWDPDATDDRHTDGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 DPFGGGPKAPMLPGTWDPDTEPD------ERHNHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 DTFDDRPVTPMLPGTWDGDENPA------PSPDDPEGGPRR
TH_3569|M.thermoresistible__bu -----------------------------------------
MAB_0669|M.abscessus_ATCC_1997 -SDEARQVIPMLPSTWDAD-----------------GGDQN