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DFGSLPPEINSAKMYAGAGSGSILVAAEAWDSVAVDLYSAASSCQSVIWGLAFGQWVGASASLMGAAAAP YVAWLGATATRAELAANQARGAAVAYESAFAATVPPALILENRLQLVTLIATNIFGQNTPAIATTEAEYG EMWAQDAAAMYGYAGSAAMLAETLTPFEEAPEVANAGGLVNQTAAVGQAIDSAAAGQLMSNVPQALQQLA APAPQGASTATAPKSLLQSVTSSFSLSNLSTIVGMENTHLSMANSGASIFKTMGDSVKGFIPSASKAAET AVEHAARNAVSMVGGGGPAGIGGWAPQGGVGQALSVGGLKVPQAWAEANQSVVPAARALPISPVTGAVEG AHGAPLPGMPFGQLAGNGGNGVSGVLRVTPKAYVMPRPPAAG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4240 | - | - | 100% (393) | PPE family protein, PPE18 |
| M. marinum M | MMAR_1849 | - | 2e-74 | 43.06% (425) | PPE family protein |
| M. marinum M | MMAR_1847 | - | 5e-72 | 42.11% (399) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1228 | PPE18 | 1e-123 | 57.47% (395) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 8e-25 | 38.39% (211) | PPE protein |
| M. tuberculosis H37Rv | Rv1196 | PPE18 | 1e-121 | 56.82% (396) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 3e-65 | 39.95% (423) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0669 | - | 7e-28 | 36.99% (173) | PPE-family protein |
| M. avium 104 | MAV_2926 | - | 4e-74 | 42.45% (417) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 1e-28 | 36.20% (221) | PPE family protein |
| M. thermoresistible (build 8) | TH_3113 | - | 7e-29 | 28.91% (384) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_0947 | - | 0.0 | 97.96% (393) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 2e-28 | 39.90% (203) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
MAB_0669|M.abscessus_ATCC_1997 ----------MTAPIWMAEPPEVHSALLSAGPGPGAVLAAAVQWQEIGNN
TH_3113|M.thermoresistible__bu ----------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDE
MMAR_4240|M.marinum_M -------------MDFGSLPPEINSAKMYAGAGSGSILVAAEAWDSVAVD
MUL_0947|M.ulcerans_Agy99 -------------MDFGSLPPEFNSGKMYAGAGSGSILVAAEAWDSVAVD
Mb1228|M.bovis_AF2122/97 ------------MVDFGALPPEINSARMYAGPGSASLVAAAQMWDSVASD
Rv1196|M.tuberculosis_H37Rv ------------MVDFGALPPEINSARMYAGPGSASLVAAAQMWDSVASD
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
MAV_2926|M.avium_104 -----------MMLDYGTFPPEFNSARIYSGPGSGSLVAAASAWSSLAAE
: .** :* : *.*...: .*. * :. :
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
MAB_0669|M.abscessus_ATCC_1997 YANTAVELAQVLAGVRAGSWQGPSASEYVAAHLPYLAWLEQAAAESSVIA
TH_3113|M.thermoresistible__bu YRAAAVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAG
MMAR_4240|M.marinum_M LYSAASSCQSVIWGLAFGQWVGASASLMGAAAAPYVAWLGATATRAELAA
MUL_0947|M.ulcerans_Agy99 LYSAASSCQSVIWGLAFGQWVGASASLMGAAAAPYVAWLGATATQAELAA
Mb1228|M.bovis_AF2122/97 LFSAASAFQSVVWGLTVGSWIGSSAGLMVAAASPYVAWMSVTAGQAELTA
Rv1196|M.tuberculosis_H37Rv LFSAASAFQSVVWGLTVGSWIGSSAGLMVAAASPYVAWMSVTAGQAELTA
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLT-TFEGESAAALAERVTPYEKWLTQNAASAELTA
MAV_2926|M.avium_104 LNAAALSYDKVVTALASEEWLGSASASMASAVAPYVGWMSTTAAQAEEAA
:* : : * .: ** *: : . .
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
MAB_0669|M.abscessus_ATCC_1997 AQHETTAAAYNSALAAMPTLAELAANHITHGVLVGTNFFGINTIPIALNE
TH_3113|M.thermoresistible__bu AQLEAAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNE
MMAR_4240|M.marinum_M NQARGAAVAYESAFAATVPPALILENRLQLVTLIATNIFGQNTPAIATTE
MUL_0947|M.ulcerans_Agy99 NQARGAAVAYESAFAATVPPALILENRLQLVTLIATNIFGQNTPAIATTE
Mb1228|M.bovis_AF2122/97 AQVRVAAAAYETAYGLTVPPPVIAENRAELMILIATNLLGQNTPAIAVNE
Rv1196|M.tuberculosis_H37Rv AQVRVAAAAYETAYGLTVPPPVIAENRAELMILIATNLLGQNTPAIAVNE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
MAV_2926|M.avium_104 SQARAAAAAYEAALAASVPPPLIAANRMQVSQLQATNVLGQNTPLIAQLE
* :* *: :* . : *: * :*.:* *: ** *
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA
MAB_0669|M.abscessus_ATCC_1997 ADYVRMWVQAAATMSAYQATTEAMTSAIPPTQQPPAILSPG-GEARSDQS
TH_3113|M.thermoresistible__bu ADYARMWIQAATTMATYEAVASAAVSATPRTVAPPPILGAGTGESATAAI
MMAR_4240|M.marinum_M AEYGEMWAQDAAAMYGYAGSAAMLAETLTPFEEAPEVANAGG--------
MUL_0947|M.ulcerans_Agy99 AEYGEMWAQDAAAMYGYAGSAAMLAETLTPFEEAPEVANAGG--------
Mb1228|M.bovis_AF2122/97 AEYGEMWAQDAAAMFGYAAATATATATLLPFEEAPEMTSAGG--------
Rv1196|M.tuberculosis_H37Rv AEYGEMWAQDAAAMFGYAAATATATATLLPFEEAPEMTSAGG--------
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEVVEE
MAV_2926|M.avium_104 AQYGEYWAQDAAAMYSYAG-QSASASKVTPFQKAPQVTNPSG--------
*:* . * * *::* * . .*
Mflv_0325|M.gilvum_PYR-GCK DMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLRDPI
Mvan_0415|M.vanbaalenii_PYR-1 DVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLRDPL
MSMEG_0619|M.smegmatis_MC2_155 SVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGG-QAILDFLKDPL
MAB_0669|M.abscessus_ATCC_1997 DVPGSPDQIMKMLQG---------------------------FQQWFEKM
TH_3113|M.thermoresistible__bu TGAHVTAELRAAESRTLLDEINELIDRLFAPLFPPGFADALPDGLLGTLL
MMAR_4240|M.marinum_M ----LVNQTAAVGQAID---------------------------------
MUL_0947|M.ulcerans_Agy99 ----LVKQTAAVGQAID---------------------------------
Mb1228|M.bovis_AF2122/97 ----LLEQAAAVEEASD---------------------------------
Rv1196|M.tuberculosis_H37Rv ----LLEQAAAVEEASD---------------------------------
MLBr_01182|M.leprae_Br4923 VVEEVVEEVVEAEQAIS---------------------------------
MAV_2926|M.avium_104 ----QAAQSAAVSTATA---------------------------------
:
Mflv_0325|M.gilvum_PYR-GCK GNTFALITDFLTNPVQALITWGP------FLLAVVYQA----VSWVGASI
Mvan_0415|M.vanbaalenii_PYR-1 GNTIKLITDFLTNPAQALITWGP------FLAAVAYQA----VSWVGASI
MSMEG_0619|M.smegmatis_MC2_155 GNLGRLLTDFMTNPAGALATWWP------FLFGVAYQVFFNLVGWPTWGM
MAB_0669|M.abscessus_ATCC_1997 G--------FNPATSAVLAVIML------FLYDLLWYP---------YYA
TH_3113|M.thermoresistible__bu APLLPGATGDGPPMATIMSFLLMGLSNPAYLFPVLVYLLFTGVVHTTVAV
MMAR_4240|M.marinum_M ----------SAAAGQLMSN------------------------------
MUL_0947|M.ulcerans_Agy99 ----------SAAAGQLMSN------------------------------
Mb1228|M.bovis_AF2122/97 ----------TAAANQLMNN------------------------------
Rv1196|M.tuberculosis_H37Rv ----------TAAANQLMNN------------------------------
MLBr_01182|M.leprae_Br4923 ----------QAALDQAVNEGME---------------------------
MAV_2926|M.avium_104 ----------NSTSTNTTKA------------------------------
.
Mflv_0325|M.gilvum_PYR-GCK LYPSLFLLPLLATT-------LAIVAGVGQHLLSLLNTPPAEEAAEEPAP
Mvan_0415|M.vanbaalenii_PYR-1 LYPSLLLLPLVATT-------LAIVLGVGAYLLENLPAPAEDAPAEEPAA
MSMEG_0619|M.smegmatis_MC2_155 IFASPFLIPALAALG-----ITGLVLLIDHVLNNPVDVPAEDEAPQEVAA
MAB_0669|M.abscessus_ATCC_1997 SYLLPFLIPALSGLS-----GLAALMHLRPAAPGPVPA-AALSPGDRPIR
TH_3113|M.thermoresistible__bu SGMLAQLVPLMPALLPVAVAALGGLAGVWAGLSGLAGLAGLTAVPAADGG
MMAR_4240|M.marinum_M -------VPQALQQL----------------------------AAPAPQG
MUL_0947|M.ulcerans_Agy99 -------VPQALQQL----------------------------AATAPQG
Mb1228|M.bovis_AF2122/97 -------VPQALQQL----------------------------AQPT-QG
Rv1196|M.tuberculosis_H37Rv -------VPQALQQL----------------------------AQPT-QG
MLBr_01182|M.leprae_Br4923 ----ATVVPQVDQQVN--------------------------VDVATPQT
MAV_2926|M.avium_104 -------LQSLAQPAS--------------------------SSTTATKA
:
Mflv_0325|M.gilvum_PYR-GCK AQSAPSRPDQQSFPATMSAPPPPSGAPIAANTVSAGSPP-----APGAPA
Mvan_0415|M.vanbaalenii_PYR-1 SSPAPTRADQPSPAIAVSAPPPPSSAAATVGTVATGTAP-----APGAPA
MSMEG_0619|M.smegmatis_MC2_155 AP----RTDQP-LAVGISPAGVPGSAATAAAPAPAPAGT-----TVAAPA
MAB_0669|M.abscessus_ATCC_1997 RPTQHVEPNLAALPLPTSSVVPSGGSSVPVSTPTAPAHT-----VSSVPA
TH_3113|M.thermoresistible__bu ASAAPVPAGGPSLPSGSSAPPAPTG-SAAPTTGTAPGGA-----GSPPPA
MMAR_4240|M.marinum_M AST---ATAPKSLLQSVTSSFSLSNLSTIVGMENTHLS------MANSGA
MUL_0947|M.ulcerans_Agy99 AST---ATAPKSLLQSVTSSFSSSNLSTIVGMENTHLS------MANSGA
Mb1228|M.bovis_AF2122/97 TTP---SSKLGGLWKTVSP--HLSPISNMVSMANNHVS------MTNSGV
Rv1196|M.tuberculosis_H37Rv TTP---SSKLGGLWKTVSP--HRSPISNMVSMANNHMS------MTNSGV
MLBr_01182|M.leprae_Br4923 AVPDSSSAAAPQLWGGFAQ--HLSPINDTLSMINNHAG------MANAGL
MAV_2926|M.avium_104 ATTAASTTSTDPLSEIWFLLTGQTTLPTSLGSAVNGYSPFASLFYNTEGL
.
Mflv_0325|M.gilvum_PYR-GCK AAAATFVPYVVAGRDP-YEGFSPTVRDSTGAKAPAGTIPAAASGIAASAA
Mvan_0415|M.vanbaalenii_PYR-1 AATASFVPYAVAGRDP-GTGFSPTVRDSTSAKAPASGIPAAASGVAASAA
MSMEG_0619|M.smegmatis_MC2_155 PAAATFVPYAVANRDP-GEGFTPTLGNKSQVAAPASGVPAAASGVAASLA
MAB_0669|M.abscessus_ATCC_1997 PSAA--ISYAIPGLVPPGVSFGPKSTEKSSESAVDTVAAVAAARGAVAAQ
TH_3113|M.thermoresistible__bu GHSVPPAPHSAPPVGTSGPPYLIAAQPAPGVARRSAGARRAASIVEPAGS
MMAR_4240|M.marinum_M SIFKT-MGDSVKGFIP-SASKAAETAVEHAARNAVSMVGGGGPAGIGGWA
MUL_0947|M.ulcerans_Agy99 SILKT-MGDSVKGFIP-SASKAAETAVEHAARNAVSMVGGGGPAGIGGWA
Mb1228|M.bovis_AF2122/97 SMTNT-LSSMLKGFAP-AAAQAVETAAQNGVRAMSSLGSSLGSSGLGGGV
Rv1196|M.tuberculosis_H37Rv SMTNT-LSSMLKGFAPAAAAQAVQTAAQNGVRAMSSLGSSLGSSGLGGGV
MLBr_01182|M.leprae_Br4923 SLVNG-MGSAMKSLAP-TTTKAAESAFKAMGSAVQSTGRGLLGSSSGGHV
MAV_2926|M.avium_104 PYFSTGMANTFTQIAKSVGAIGGAAPAAAKALPGLGGLGGMLGGGAAAAH
.
Mflv_0325|M.gilvum_PYR-GCK ERRKRRRRQKEEIKGRGYADAYADYEELPDDGPPEQPAPRVTASTRGAGP
Mvan_0415|M.vanbaalenii_PYR-1 ERRKRRRRQKDEIAGRAYADAYADYEPEPDDEPPVRQEPRIAATERGAGP
MSMEG_0619|M.smegmatis_MC2_155 SRRKRRRKKGAQIEERGYADAYMDYEE-PDEDPAPQPEPRVRASERGSDA
MAB_0669|M.abscessus_ATCC_1997 ARRRLRGKNKAEAGGR--RHEYLEETAGMGAT-ATADVPAYAATGRGTGP
TH_3113|M.thermoresistible__bu AAAAAAARESAPIRRRRGQKDGLHGHRHEHQQPASMS-AATAPSAAGIRV
MMAR_4240|M.marinum_M PQGGVGQALSVG-GLKVPQAWAEANQSVVPAARALPISPVTGAVEGAHGA
MUL_0947|M.ulcerans_Agy99 PQGGVGQALSVG-GLKVPQAWAEANQAVVPAARALPISPVTGAVEGAHGA
Mb1228|M.bovis_AF2122/97 AAN-LGRAASVG-SLSVPQAWAAANQAVTPAARALPLTSLTSAAERGPGQ
Rv1196|M.tuberculosis_H37Rv AAN-LGRAASVG-SLSVPQAWAAANQAVTPAARALPLTSLTSAAERGPGQ
MLBr_01182|M.leprae_Br4923 TAQ-LGRAASIG-SLRVPQTWTTASQPVTAATRALSPARVAVATESESAP
MAV_2926|M.avium_104 PVAALGGAGSIGGKLSVPVAWSGA-PATPALGHAIPVSSISAAPEAAGGP
. .
Mflv_0325|M.gilvum_PYR-GCK MGFAGTVSRGD-EQAGGLTTLAGDSFGGGPREPMLPGTWDPDATDDRHTD
Mvan_0415|M.vanbaalenii_PYR-1 MGFAGTVSRDA-AQAGGLTTLPGDPFGGGPKAPMLPGTWDPDTEPD----
MSMEG_0619|M.smegmatis_MC2_155 MGFTGTVTRHD-VTAAGLTTLTGDTFDDRPVTPMLPGTWDGDENPAP---
MAB_0669|M.abscessus_ATCC_1997 LGFAGTAPAAASTHVAATVRLSSD--EARQVIPMLPSTWDAD--------
TH_3113|M.thermoresistible__bu LGGAGRISRTR-GSVPHAEITPGDPTEPSSPTDRAHRPAEPN--------
MMAR_4240|M.marinum_M --PLPG-MPFGQLAGNGGNGVSGV---LRVTPKAYVMPRPPAAG------
MUL_0947|M.ulcerans_Agy99 --PLPG-MPFGQLAGNGGNGVSGV---LRVTPKAYVMPRPPAAG------
Mb1228|M.bovis_AF2122/97 --MLGG-LPVGQMGARAGGGLSGV---LRVPPRPYVMPHSPAAG------
Rv1196|M.tuberculosis_H37Rv --MLGG-LPVGQMGARAGGGLSGV---LRVPPRPYVMPHSPAAG------
MLBr_01182|M.leprae_Br4923 --LLGGGLPMAPMVPGGGSGTGGVNTALRLQPRAFVMPRNPAAG------
MAV_2926|M.avium_104 GNLLGG-MPLAGAG-AGGHGAAGP----KYGFRPTVMARPPFAG------
. .
Mflv_0325|M.gilvum_PYR-GCK GRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 --ERHNHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 ---SPDDPEGGPRR
MAB_0669|M.abscessus_ATCC_1997 ---------GGDQN
TH_3113|M.thermoresistible__bu --------------
MMAR_4240|M.marinum_M --------------
MUL_0947|M.ulcerans_Agy99 --------------
Mb1228|M.bovis_AF2122/97 --------------
Rv1196|M.tuberculosis_H37Rv --------------
MLBr_01182|M.leprae_Br4923 --------------
MAV_2926|M.avium_104 --------------