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MGQVTDHWRAARLASALYDTAAMHDRVAAVGAKALWGLALRDLLAEVRHVGAAPPGAYVLDIPCGGGFAF RGLRAGQDCRYVAADISSDMLRRARSRATRFGVANLMEFTEADITCLPFPDNTFDLALTFNGLHCLPDPR AAVFELARVLKPGGILRGTTCVRGRGWRQDRFVTALQAAGFFGNTPGAGDVSRWLGEAGLEIVAARHSGS VELFEAVRPSA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2988 | - | - | 100% (221) | ubiquinone/menaquinone biosynthesis methyltransferases |
| M. avium 104 | MAV_5229 | - | 1e-12 | 31.80% (217) | methyltransferase type 11 |
| M. avium 104 | MAV_3373 | - | 3e-12 | 34.53% (139) | methyltransferase, UbiE/COQ5 family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1440c | - | 2e-14 | 31.08% (148) | putative methyltransferase |
| M. gilvum PYR-GCK | Mflv_4060 | - | 2e-09 | 35.64% (101) | methyltransferase type 11 |
| M. tuberculosis H37Rv | Rv1405c | - | 2e-14 | 31.08% (148) | putative methyltransferase |
| M. leprae Br4923 | MLBr_00551 | - | 4e-14 | 31.97% (147) | putative methyltransferase |
| M. abscessus ATCC 19977 | MAB_4018 | - | 3e-13 | 32.12% (165) | similarity with UbiE/COQ5 methyltransferase |
| M. marinum M | MMAR_2214 | - | 4e-12 | 30.41% (148) | methyltransferase |
| M. smegmatis MC2 155 | MSMEG_0098 | - | 5e-14 | 34.63% (205) | methyltransferase |
| M. thermoresistible (build 8) | TH_3395 | - | 1e-49 | 47.27% (220) | PUTATIVE putative ubiquinone/menaquinone biosynthesis |
| M. ulcerans Agy99 | MUL_1801 | - | 6e-12 | 30.41% (148) | methyltransferase |
| M. vanbaalenii PYR-1 | Mvan_3244 | - | 6e-11 | 35.25% (122) | methyltransferase type 11 |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_2988|M.avium_104 ------------------MGQVTDHWR--AARLASALYDTAAMHDRVAAV
TH_3395|M.thermoresistible__bu ------------------MADVAANWAGRGGRFAGGLYDFGVEREVLARP
Mb1440c|M.bovis_AF2122/97 --------------------------MTIDTPAREDQTLAATHRAMWALG
Rv1405c|M.tuberculosis_H37Rv --------------------------MTIDTPAREDQTLAATHRAMWALG
MMAR_2214|M.marinum_M --------------------------MTIDTPIREDVSLAATHRAMWALG
MUL_1801|M.ulcerans_Agy99 --------------------------MTIDTPIREDVSLAATHRAMWALG
MLBr_00551|M.leprae_Br4923 --------------------------MNLYTPIHEDQSLAAIHRAMWALG
Mflv_4060|M.gilvum_PYR-GCK -------------------------MATVDN--EDDRALKAKHRALWASG
MSMEG_0098|M.smegmatis_MC2_155 MDTALRRAMDLLIDPPAEPDFSKGYLDLLGRGDSTAPKNTGLIQKAWASP
MAB_4018|M.abscessus_ATCC_1997 -MLHHPTLADSLIDPARIDHPPRRDHGYLDVLGPESDEPVSVANRFMQSP
Mvan_3244|M.vanbaalenii_PYR-1 ------------------------------MNRAETALINSPPRRWLQR-
. .
MAV_2988|M.avium_104 GAKALWGLALRDLLA---------EVRHVGA------APPGAYVLDIPCG
TH_3395|M.thermoresistible__bu AGLLMWGTDTRLLFD---------SIRRIGD------LPDGTAVLDIPCG
Mb1440c|M.bovis_AF2122/97 DYALMAEEVMAPLGP---------ILVAAAG------IGPGVRVLDVAAG
Rv1405c|M.tuberculosis_H37Rv DYALMAEEVMAPLGP---------ILVAAAG------IGPGVRVLDVAAG
MMAR_2214|M.marinum_M DYALMAEEVMAPLGP---------ILVAAAG------IGPGVRVLDVAAG
MUL_1801|M.ulcerans_Agy99 DYALMAEEVMAPLGP---------ILVAAAG------IGPGVRVLDVAAG
MLBr_00551|M.leprae_Br4923 DYALMAEEVMAPLGP---------ILVTATG------IRPGMQVLDVAAG
Mflv_4060|M.gilvum_PYR-GCK DYPAVAAELIPSLGP---------ELVRACG------VRSGDRVLDVAAG
MSMEG_0098|M.smegmatis_MC2_155 LGSKLYDRAQLLNRR---------LVASTRPPVEWLRIPPGGTVLDIGCG
MAB_4018|M.abscessus_ATCC_1997 LLAAIYERAWRPMFTRGFSYGGKSTLKAHTALMDEIAGRGDHKILDVACG
Mvan_3244|M.vanbaalenii_PYR-1 ----LYEVPVLLRFG--------------GR------LPPGSGALEIGCG
: . *:: .*
MAV_2988|M.avium_104 GG-FAFRGLRAGQD-CRYVAADISSDMLRRARSRATRFG--VANLMEFTE
TH_3395|M.thermoresistible__bu GG-LALRGLRHGRR-LRYVAADISADMLARAQRRAATLG--RTD-VRFVV
Mb1440c|M.bovis_AF2122/97 SGNISLPAAKTG---ATVISTDLTPELLQRSQARAAQQG--LTL--QYQE
Rv1405c|M.tuberculosis_H37Rv SGNISLPAAKTG---ATVISTDLTPELLQRSQARAAQQG--LTL--QYQE
MMAR_2214|M.marinum_M SGNISLPAAKSG---ATVVSTDLTPELLQRSKARAAAQG--LTL--DYQE
MUL_1801|M.ulcerans_Agy99 SGNISLPAAKSG---ATVVSTDLTSELLQRSKARAAAQE--LTL--DYQE
MLBr_00551|M.leprae_Br4923 SGNISLPAAKTG---ATIVSTDLTPELLQRSQARATELG--LTL--EYRE
Mflv_4060|M.gilvum_PYR-GCK SGNASIPAAAAG---AVVTASDLTPELFDAGRRIAAERG--VAV--EWVE
MSMEG_0098|M.smegmatis_MC2_155 PGNITAQLARAAGLDGLALGVDISEPMLAR--AVAAEAG--RQVG--FVR
MAB_4018|M.abscessus_ATCC_1997 PGLYTRELAAQLGTAGVCIGLDLSGPMLRRAVRDNSAER--VDY----IR
Mvan_3244|M.vanbaalenii_PYR-1 SGYGSQLVLQRFG-AARIDAVDLDPAMIERARTRLAPYGDRVHLATGSAT
* : . *: :: :
MAV_2988|M.avium_104 ADITCLPFPDNTFDLALTFNGLHCLPDPRAAVFELARVLKPGGIL-----
TH_3395|M.thermoresistible__bu ADIERMPFGDGEFDCCVTFNGLHCVPDPAAAVAEIARCVKPGGRL-----
Mb1440c|M.bovis_AF2122/97 ANAQALPFADDEFDTVISAIGVMFAPDHQAAADELVRVCRPGGTIGVISW
Rv1405c|M.tuberculosis_H37Rv ANAQALPFADDEFDTVISAIGVMFAPDHQAAADELVRVCRPGGTIGVISW
MMAR_2214|M.marinum_M ANAQALPFGDSEFDTVISAIGVMFAPDHQCSANELARVCKTGGTIGVISW
MUL_1801|M.ulcerans_Agy99 ANAQALPFGDSEFDTVISAIGVMFAPDHQCSANELARVCKTGGTIGVISW
MLBr_00551|M.leprae_Br4923 ADAQALPFGDGEFDVVMSAIGVMFAPDHRRAASELVRVCRPNGTIGVISW
Mflv_4060|M.gilvum_PYR-GCK ADAEALPFPDDSFDVVMSCVGAMFAPHHQATADEIVRVTRPGGTLGLISW
MSMEG_0098|M.smegmatis_MC2_155 ADAQQLPFRDEVFDAATSLAVFQLIPDPVAAVSEIVRVLKPGGRV-----
MAB_4018|M.abscessus_ATCC_1997 GSAHSLPFADATFDTVVCLAALYLIPDPEQAVRELCRVAGPDGQIVVFT-
Mvan_3244|M.vanbaalenii_PYR-1 DLREALNADDGSYDAVFDFGIIHHIPDWRAAVAEAARVLIPGGRFY----
: * :* *. :. * * ..* .
MAV_2988|M.avium_104 -------------------RGTTCVRGRGWRQDRFVTALQAAGFFGNTPG
TH_3395|M.thermoresistible__bu -------------------IGDAVVRGAGRRQDALIAVFRRAGVFGPGGT
Mb1440c|M.bovis_AF2122/97 TCEGFFGRMLATIRPYRPSVSADLPPSALWGREAYVTGLLGDGVTGLKTA
Rv1405c|M.tuberculosis_H37Rv TCEGFFGRMLATIRPYRPSVSADLPPSALWGREAYVTGLLGDGVTGLKTA
MMAR_2214|M.marinum_M TPEGFFGRMLATIRPYRPSLSAALPPSALWGREAYARGLFGNHVSDIQTQ
MUL_1801|M.ulcerans_Agy99 TPEGFFGRMLATIRPYRPSLSAALPPSALWGREAYARGLFGNHVSDIQTQ
MLBr_00551|M.leprae_Br4923 TQEGFFGRMLATIRPYRPSLSAALPPAALWGREAYIRGLLDDTVTNVKTE
Mflv_4060|M.gilvum_PYR-GCK TPEGFIGHLFATMKPYAPPPPPGASPPPMWGSENHVEALFGDRVRDLTMR
MSMEG_0098|M.smegmatis_MC2_155 ---------------------AIMVPTAGAVKPVTFLARGGARIFGDDEL
MAB_4018|M.abscessus_ATCC_1997 ---------------------SLRTRAASLPGVTTAMRIGGFRAFGRDEV
Mvan_3244|M.vanbaalenii_PYR-1 -------------------FEEVTAHALSRPTYRLLFDHPTDDRFTAEDF
MAV_2988|M.avium_104 AGDVSR------------WLGEAGLEIVAARHSGSVELFEAVRPSA----
TH_3395|M.thermoresistible__bu TDELQG------------WLTRAGFEVEDFRRSGAVAHFTAVRS------
Mb1440c|M.bovis_AF2122/97 RGLLEVKRFDTAQAVHDYFKNNYGPTIEAYAHIGDNAVLAAELDRQLVEL
Rv1405c|M.tuberculosis_H37Rv RGLLEVKRFDTAQAVHDYFKNNYGPTIEAYAHIGDNAVLAAELDRQLVEL
MMAR_2214|M.marinum_M RGQLEVTRFQTAQAVHDYFKNHYGPTIEAYANIGDNAVLAAELDAQLVEL
MUL_1801|M.ulcerans_Agy99 RGQLEVTRFQTAQAVHDYFKNHYGPTIEAYANIGDNAVLAAELDAQLVEL
MLBr_00551|M.leprae_Br4923 RRQLEVKRFNSAEGVHNYFKNHYGPTIEAYTNIGDNSVLAAELDAQLTEL
Mflv_4060|M.gilvum_PYR-GCK RQTVRFDHCASPLDFREYWKRNYGPTLAAYRFNEDRPERLAELDAAFLDF
MSMEG_0098|M.smegmatis_MC2_155 GDIFEN----------------VGLVGVRVKTHGFIQWVRGTKL------
MAB_4018|M.abscessus_ATCC_1997 TG----------------WLRAQGWTDIDQTVTGQGQFIRARRAVALRVA
Mvan_3244|M.vanbaalenii_PYR-1 LDELGR----------------HGLVILGSVTRIQGDYLLGVAAKPLAAD
* .
MAV_2988|M.avium_104 ---------------------------
TH_3395|M.thermoresistible__bu ---------------------------
Mb1440c|M.bovis_AF2122/97 AAQY-LSDG----VMEWEYLLLTAEKR
Rv1405c|M.tuberculosis_H37Rv AAQY-LSDG----VMEWEYLLLTAEKR
MMAR_2214|M.marinum_M ADQY-LTDG----VMEWEYLVLTGTKK
MUL_1801|M.ulcerans_Agy99 ADQY-LTDG----VMEWEYLVLTGTKK
MLBr_00551|M.leprae_Br4923 AQKY-LTNS----TMGWEYLLLTAQKH
Mflv_4060|M.gilvum_PYR-GCK LTTWNQADGTDGTAYDAEYLLVTATKR
MSMEG_0098|M.smegmatis_MC2_155 ---------------------------
MAB_4018|M.abscessus_ATCC_1997 T--------------------------
Mvan_3244|M.vanbaalenii_PYR-1 GGR------------------------