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MTAEQVSQPPASGSSRFAVYDYVDGMERLVHAVQELSLARSLPDIQRIVRSSARELTGCDGATFVLRDND RCYYADEDAIAPLWKGSRFPMTSCISGWAMLNRDAAVIPDIYRDPRIPHNLYRPTFVKSLVMVPIRKLDP IGAIGNYWAEPHQPSEHEVRLLQALADSTSMAMENVAIYSEMEQRVRDRTAALERANEEIRRLSVTDELT GLNNRRGFYLLAGQKLSGSHRLGHACVLAFLDVDGLKQVNDEQGHDAGDMLIKDVAEVLRSIRRESDILA RIGGDEFCVMVTESDQDSAPLRERLAEAFAAFNATGDRPYRLSASVGLVRAPVFDTASVDELLARADELM YVEKKARRTAG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_4962 | - | - | 100% (361) | sensory box histidine kinase |
| M. avium 104 | MAV_1410 | - | 5e-20 | 36.31% (157) | cyclic diguanylate phosphodiesterase domain-containing protein |
| M. avium 104 | MAV_1132 | - | 6e-16 | 31.25% (208) | cyclic diguanylate phosphodiesterase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1389c | - | 7e-14 | 34.76% (164) | hypothetical protein Mb1389c |
| M. gilvum PYR-GCK | Mflv_4515 | - | 1e-135 | 66.67% (360) | diguanylate cyclase |
| M. tuberculosis H37Rv | Rv1354c | - | 8e-14 | 34.76% (164) | hypothetical protein Rv1354c |
| M. leprae Br4923 | MLBr_00397 | - | 2e-17 | 35.26% (156) | putative transporter protein |
| M. abscessus ATCC 19977 | MAB_0124 | - | 3e-16 | 38.96% (154) | hypothetical protein MAB_0124 |
| M. marinum M | - | - | - | - | - |
| M. smegmatis MC2 155 | MSMEG_2196 | - | 5e-11 | 31.06% (161) | sensory box/response regulator |
| M. thermoresistible (build 8) | TH_3406 | - | 1e-17 | 36.65% (161) | PUTATIVE diguanylate cyclase |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_3629 | - | 2e-17 | 38.10% (168) | diguanylate cyclase with PAS/PAC sensor |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_4962|M.avium_104 MTAEQVSQPPASGSSRFAVYDYVDGMERLVHAVQ--ELSLARSLPDIQRI
Mflv_4515|M.gilvum_PYR-GCK MSASAVTSPVEGRVTDTPDAEYVRGMARLLQAVQ--ELSLARSLPEIQRI
Mb1389c|M.bovis_AF2122/97 -MCNDTATPQLEELVTTVANQLMTVDAATSAEVS--QRVLAYLVEQLGVD
Rv1354c|M.tuberculosis_H37Rv -MCNDTATPQLEELVTTVANQLMTVDAATSAEVS--QRVLAYLVEQLGVD
MSMEG_2196|M.smegmatis_MC2_155 ------MSESLDVLVTSVATQLMAVEAATSVSVS--QQVLAELVSFFDVD
MLBr_00397|M.leprae_Br4923 -------------MDHTTKCDAEQYFQAIVTSMA--DGVIVVDIDGRIES
Mvan_3629|M.vanbaalenii_PYR-1 ---MKRLSPSAVAFLTFPVVYAVSILAGRATRLGGGEIALVWPAAAVATV
MAB_0124|M.abscessus_ATCC_1997 -MGAGEMTFGQEYRFATRALTVTRNLVPLKIAIG----LLCLSIVVLGTL
TH_3406|M.thermoresistible__bu --MLKALRRTWRKPDHYYWFTSFLAARRARTSTCRFIASITLILGLMPMV
:
MAV_4962|M.avium_104 VRSSARELTGCDGATFVLRDNDRCYYADEDAIAPLWKGSRFPMTSCISGW
Mflv_4515|M.gilvum_PYR-GCK VRTAARELTGCDGATFVLRDNGKCYYADEDAIAPLWKGSRFPMEICISGW
Mb1389c|M.bovis_AF2122/97 VSFLRHNDRDRRATRLVAEWPPRLNIPDPDPLRLIYFAD---ADPVFALC
Rv1354c|M.tuberculosis_H37Rv VSFLRHNDRDRRATRLVAEWPPRLNIPDPDPLRLIYFAD---ADPVFALC
MSMEG_2196|M.smegmatis_MC2_155 VSFLRHNDHRAHATRLVAEWPPRPVDAATDPIAVVHFAD---ADPVFAMA
MLBr_00397|M.leprae_Br4923 INPAATRILGLRAHDVVDMKHGHPFCFYDTDNQRVDLER-----------
Mvan_3629|M.vanbaalenii_PYR-1 WLLAARRFSRWQRVAHLSALALATFVVNLFTHATPQLSAWFVLVNLALAL
MAB_0124|M.abscessus_ATCC_1997 IQFHPLGPHGLWPRLIHGVLVASALVVGMCWVVLPWPRRRVAIAFVWWAD
TH_3406|M.thermoresistible__bu MLAGPAGPQSMPGRLIAVAVTVTALVITLIWLRDRWPSRNQSRVVSLAAG
MAV_4962|M.avium_104 AMLNRDAAVIPD-IYRDPRIPHNLYRPTFVKSLVMVPIRKLDP-------
Mflv_4515|M.gilvum_PYR-GCK AMLNREAAIIPD-IYLDGRIPHEAYRPTFVKSLVMAPIRKLDP-------
Mb1389c|M.bovis_AF2122/97 EHAKEPLVFRPEPATEDYQRLIEEARGVPVTSAAAVPLVSGEIT------
Rv1354c|M.tuberculosis_H37Rv EHAKEPLVFRPEPATEDYQRLIEEARGVPVTSAAAVPLVSGEIT------
MSMEG_2196|M.smegmatis_MC2_155 EHLKEPAVFRPEPLYDDYQRTIEAGRHIPATSMACVPLLSGDVT------
MLBr_00397|M.leprae_Br4923 ----------------------EVMRVVRREVTTVSKVVGIDQH------
Mvan_3629|M.vanbaalenii_PYR-1 VTVEIIHYRRDEVVLRDPTDLVRVIVAVTAGTVCAAALATMYLVPVTGAP
MAB_0124|M.abscessus_ATCC_1997 ISMVVGACTLSAPASRLGALAHMGLIGVFAAFLLGWRVLAVHCVFAT---
TH_3406|M.thermoresistible__bu LAIAVFAFTLPDPSAGLVWTAAFAVLAGYVALFHSARYATFTVLFAAIT-
MAV_4962|M.avium_104 -----------------IGAIGN-YWAEPHQPSEHEVRLLQALADSTS--
Mflv_4515|M.gilvum_PYR-GCK -----------------VGAIGN-YWAQERQPTPREVSLLQALADATS--
Mb1389c|M.bovis_AF2122/97 -----------------TGLLGF-IKFGDRKWHEAELNALMTIAT-----
Rv1354c|M.tuberculosis_H37Rv -----------------TGLLGF-IKFGDRKWHEAELNALMTIAT-----
MSMEG_2196|M.smegmatis_MC2_155 -----------------TGVLGF-VKFGDREWLPAELNALKAIAS-----
MLBr_00397|M.leprae_Br4923 -----------------SGQRLW-LSVNVSLLAYKAPPHSALVVS-----
Mvan_3629|M.vanbaalenii_PYR-1 AWETFGLFTARNGATALIGVAAW-LRLRDVRWTRPRLSPAATVEIIVTGG
MAB_0124|M.abscessus_ATCC_1997 --------------VAIFGLMGWNVRLGEATWFDQYVYSAPALSS-----
TH_3406|M.thermoresistible__bu -----------------AGVLSFELAKTAGVAAAVCGFVFITVVT-----
* :
MAV_4962|M.avium_104 -------------------MAMENVAIYSEMEQRVRDRTAALERANEEIR
Mflv_4515|M.gilvum_PYR-GCK -------------------IAMENVQIYAELEQRVRDRTAAVEQANEEIR
Mb1389c|M.bovis_AF2122/97 --------------------------LFAQVQARV--------AAEARLR
Rv1354c|M.tuberculosis_H37Rv --------------------------LFAQVQARV--------AAEARLR
MSMEG_2196|M.smegmatis_MC2_155 --------------------------LFAQVQARI--------EAEERLR
MLBr_00397|M.leprae_Br4923 ---------------------------FSDISAHH--------LSIERLT
Mvan_3629|M.vanbaalenii_PYR-1 VVGFVLVWIFWLSTGIPLGFLVLLPAMWVALRYSTTVSTVFLLVAAAWII
MAB_0124|M.abscessus_ATCC_1997 ---------------------------VVLLPIIIQVVVEGGRRSLKAIS
TH_3406|M.thermoresistible__bu ---------------------------FAVVCACN-----LLVGLLDVDV
:
MAV_4962|M.avium_104 RLSVTDELTGLNNRRGFYLLAGQKLSGSHRLGHACVLAFLDVDGLKQVND
Mflv_4515|M.gilvum_PYR-GCK QLSLTDDLTGLNNRRGFRLLAEAALLAARTHGHDCALAFLDVDGLKRVND
Mb1389c|M.bovis_AF2122/97 YLADHDDLTGLHNRRALLQHLDQRLAPGQPG--PVAALFLDLDRLKAIND
Rv1354c|M.tuberculosis_H37Rv YLADHDDLTGLHNRRALLQHLDQRLAPGQPG--PVAALFLDLDRLKAIND
MSMEG_2196|M.smegmatis_MC2_155 YLADHDHLTGLYNRRALMAHLEARLAPGQPG--PVAVMFFDLDRLKAIND
MLBr_00397|M.leprae_Br4923 YEATHDCLTGLANRRFAEDQITKSLQHDERS-RLAAVLLLDLDDFKVIND
Mvan_3629|M.vanbaalenii_PYR-1 YSTLSGRGAFIVPDMQLRALLAQAMVFSLTVLVLALALFRDSR-MRLIGQ
MAB_0124|M.abscessus_ATCC_1997 LAAHQDPLTGLLNRRGVQVALSSLLS-GQRATRIVAVVLVDVDELKELND
TH_3406|M.thermoresistible__bu LDADIEPLTGLLNRDAFYRSAGHLISRSRDDDRQLVIALINIDNLRLLRD
: : : : : : :: : :
MAV_4962|M.avium_104 EQGHDAGDMLIKDVAEVLRSIRRESDILARIGGDEFCVMVTE--SDQDSA
Mflv_4515|M.gilvum_PYR-GCK GIGHDAGDSLIVDVARVLRETLGPSAIVARLGGDEFCTLVPE--YSDGAA
Mb1389c|M.bovis_AF2122/97 YLGHAAGDQFIHVFAQRIGDALVGESLIARLGGDEFVLIPASPMSADAAQ
Rv1354c|M.tuberculosis_H37Rv YLGHAAGDQFIHVFAQRIGDALVGESLIARLGGDEFVLIPASPMSADAAQ
MSMEG_2196|M.smegmatis_MC2_155 YLGHTAGDAFISILAQRLQRGDDAPKLIARLGGDEFVVVPDDPMSLDEAT
MLBr_00397|M.leprae_Br4923 SLGHDVGDAVLQTVAQRLRSAVRPDDVVARLGGDEFIVLLRGPLSDMNAN
Mvan_3629|M.vanbaalenii_PYR-1 LEAARDRADQDSELLGAVLDSIHDSVVLADPDGRVVLQNARATDSGLVSD
MAB_0124|M.abscessus_ATCC_1997 RLGHDAGDESIRAVAAMLATTTRASDLTARMGGDEFMVVGFFDHADEATG
TH_3406|M.thermoresistible__bu TQGQAAADRARVAIGQTLRENTRHNAFVAHLGQDEFLIADTFSSTDSFPL
. . : . * . . .
MAV_4962|M.avium_104 PLRERLAEAFAAFNATGDRPYRLSASVGLVRAPVFDTASV----------
Mflv_4515|M.gilvum_PYR-GCK ALTARVQDAFRRFDARSSRPYQVMISVGVVEIPPTDVSPL----------
Mb1389c|M.bovis_AF2122/97 PLAERLRDQLKDHVAIGGEVLTRTVSIGVASG-TPGQHTP----------
Rv1354c|M.tuberculosis_H37Rv PLAERLRDQLKDHVAIGGEVLTRTVSIGVASG-TPGQHTP----------
MSMEG_2196|M.smegmatis_MC2_155 ALAYRLQSVLRERVTVDGEMLTRTVSIGIAQG-IPGKDST----------
MLBr_00397|M.leprae_Br4923 DVAKRLHTTLSESLVVDQLTVPIGASVGILEVRPDDRRRA----------
Mvan_3629|M.vanbaalenii_PYR-1 VVSAVHTPGLVDDMAASASHAPRDIVVSVEDSRILELATTPLSRQSQFTV
MAB_0124|M.abscessus_ATCC_1997 LIERIGARRFGIGPHRASVSMGSAMRSTSVAGFDFESLRR----------
TH_3406|M.thermoresistible__bu VERVRGAIATTPPRLTASIGVVSTPMRGLAVCPPETLLDE----------
MAV_4962|M.avium_104 -----------------------DELLARADELMYVEKKARRTAG-----
Mflv_4515|M.gilvum_PYR-GCK -----------------------EDLLSRADELMYAQKKAKSCAEI----
Mb1389c|M.bovis_AF2122/97 -----------------------SDLLRRADQAALAAKHAGGDSVA----
Rv1354c|M.tuberculosis_H37Rv -----------------------SDLLRRADQAALAAKHAGGDSVA----
MSMEG_2196|M.smegmatis_MC2_155 -----------------------SDVLNRADHAVLTAKGSGGNRVA----
MLBr_00397|M.leprae_Br4923 -----------------------ADILRDADSAMYAAKNKKQCAVTPQQ-
Mvan_3629|M.vanbaalenii_PYR-1 MAFRDVTEERRNARELREARDLFAGVLEAASEQAIVGTDPSGCITVFNNG
MAB_0124|M.abscessus_ATCC_1997 -------------------------AADEELRGAKIERRNGFHAVP----
TH_3406|M.thermoresistible__bu -------------------------LIAVASATMYEARRAGGNQAR----
MAV_4962|M.avium_104 --------------------------------------------------
Mflv_4515|M.gilvum_PYR-GCK -----------------------A--------------------------
Mb1389c|M.bovis_AF2122/97 -----------------------IFTADMSVSGELRNDIELHLRRGIESD
Rv1354c|M.tuberculosis_H37Rv -----------------------IFTADMSVSGELRNDIELHLRRGIESD
MSMEG_2196|M.smegmatis_MC2_155 -----------------------VFSDAMAMEIDFRNDIELHLQSVIEGG
MLBr_00397|M.leprae_Br4923 ---------------------LVPFVALIALFVFFTAAAGAKFYAPSNLL
Mvan_3629|M.vanbaalenii_PYR-1 AERLLGWTEEEMLGRTPMDFHYPPEVRARAEELGIPEGFEVFVHNVTPDA
MAB_0124|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3406|M.thermoresistible__bu -----------------------------------------YRKYPNPTA
MAV_4962|M.avium_104 --------------------------------------------------
Mflv_4515|M.gilvum_PYR-GCK --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 ALRLVYLPEVDLRTGDIVGTEALVRWQHPTRGLLAPGCFIPVAESINLAG
Rv1354c|M.tuberculosis_H37Rv ALRLVYLPEVDLRTGDIVGTEALVRWQHPTRGLLAPGCFIPVAESINLAG
MSMEG_2196|M.smegmatis_MC2_155 ALVLHYLPEIDMRTGEVLAAEALVRWEHPTRGLLSPDSFIGVAESINLAG
MLBr_00397|M.leprae_Br4923 VILQQTVVLAIVGYGMTFVIMAGSVDLSVGSIVALTGVTAALVAAQNQFA
Mvan_3629|M.vanbaalenii_PYR-1 AEIREWTFVRRDGGHVDVSLAVSLMTDERGTCVGYIGVATDITDQKAAER
MAB_0124|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3406|M.thermoresistible__bu VTEAHYPEQAADDF------------------------------------
MAV_4962|M.avium_104 --------------------------------------------------
Mflv_4515|M.gilvum_PYR-GCK --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 ELD------RWVLRRACNEFSEWQSAGLGHDALLRINVSAGQLVTGGFVD
Rv1354c|M.tuberculosis_H37Rv ELD------RWVLRRACNEFSEWQSAGLGHDALLRINVSAGQLVTGGFVD
MSMEG_2196|M.smegmatis_MC2_155 ELG------RWVLRTACAEFSRWRANGVGRNIVLRINVSPVQLVTDGFVE
MLBr_00397|M.leprae_Br4923 AIV------TALLVGLAAGMVNGIVFAYGKIPSFVSTLGMLQVCRGITLM
Mvan_3629|M.vanbaalenii_PYR-1 ALAESEERFRLAFDTAPVGMFMFDVTPDGTGRITRCNTTLADFLGRSTAD
MAB_0124|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3406|M.thermoresistible__bu --------------------------------------------------
MAV_4962|M.avium_104 --------------------------------------------------
Mflv_4515|M.gilvum_PYR-GCK --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 FVADTIGQHGLDASSVCLEITENVVVQDLHTARATLARLKEVG-------
Rv1354c|M.tuberculosis_H37Rv FVADTIGQHGLDASSVCLEITENVVVQDLHTARATLARLKEVG-------
MSMEG_2196|M.smegmatis_MC2_155 SVAGIMKEFGLPRGSVCLEITESVVVQDIETTRTTLTGLHNVG-------
MLBr_00397|M.leprae_Br4923 ISDSSAKPMPFHGILGAMGAMPWILIVCLFVTILAGILFQFTM-------
Mvan_3629|M.vanbaalenii_PYR-1 VLGSSTTELGADESTSSTKGLTGLPTLRKGEPWGAEVAFRRADGATVWGA
MAB_0124|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3406|M.thermoresistible__bu --------------------------------------------------
MAV_4962|M.avium_104 --------------------------------------------------
Mflv_4515|M.gilvum_PYR-GCK --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 -VHIAIDDFGTGYSAISLLQTLPIDTLKIDKTFVRQLGTNTSDLVIVRGI
Rv1354c|M.tuberculosis_H37Rv -VHIAIDDFGTGYSAISLLQTLPIDTLKIDKTFVRQLGTNTSDLVIVRGI
MSMEG_2196|M.smegmatis_MC2_155 -VQVAIDDFGTGYSVLSLLKSLPVDTLKIDRSFVAELGSNPGDLPIVRAV
MLBr_00397|M.leprae_Br4923 -FGRWVKAIG-GNERVATLAGVPTRGIKVAIFAICGLTAGLGGIVLASRL
Mvan_3629|M.vanbaalenii_PYR-1 VSASLVAPPGADPYGICLVEDITSRKRAEADLQFLALHDPLTGLANRTLL
MAB_0124|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3406|M.thermoresistible__bu --------------------------------------------------
MAV_4962|M.avium_104 --------------------------------------------------
Mflv_4515|M.gilvum_PYR-GCK --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 MTLAEGFQLD--------------------------------VVAEGVET
Rv1354c|M.tuberculosis_H37Rv MTLAEGFQLD--------------------------------VVAEGVET
MSMEG_2196|M.smegmatis_MC2_155 IALAGAFGLQ--------------------------------LVAEGVET
MLBr_00397|M.leprae_Br4923 GAGTPTAATG--------------------------------FEIDVIAA
Mvan_3629|M.vanbaalenii_PYR-1 MNRMEQALADEGRHVPGRVGLLFLDLDGFKPVNDTWGHAAGDEVLKAVAR
MAB_0124|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3406|M.thermoresistible__bu --------------------------------------------------
MAV_4962|M.avium_104 --------------------------------------------------
Mflv_4515|M.gilvum_PYR-GCK --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 EAAARILLDQRCYRAQGFLFSRPVPGEAMRHMLSARRLPPTCIPATDPAL
Rv1354c|M.tuberculosis_H37Rv EAAARILLDQRCYRAQGFLFSRPVPGEAMRHMLSARRLPPTCIPATDPAL
MSMEG_2196|M.smegmatis_MC2_155 ERAALTLLRHGCYRAQGFLLSKPILGSEMQTLLAKGRVPVHFSAAPRM--
MLBr_00397|M.leprae_Br4923 VVIGGTPLTGGLGRLSGTLIGAIIISMLSNGMVFMGVGNAASQIIKGIML
Mvan_3629|M.vanbaalenii_PYR-1 RIENSIRPGDTAARLGGDEFAVLCPVIGENGELHGVAERIQTELSRPLTL
MAB_0124|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3406|M.thermoresistible__bu --------------------------------------------------
MAV_4962|M.avium_104 --------------------------------------------------
Mflv_4515|M.gilvum_PYR-GCK --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 S-------------------------------------------------
Rv1354c|M.tuberculosis_H37Rv S-------------------------------------------------
MSMEG_2196|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_00397|M.leprae_Br4923 AAAVFVFLQRRKIGIIK---------------------------------
Mvan_3629|M.vanbaalenii_PYR-1 IGGQSYDQLSASVGVAMSGCGRTAEELLHHADRLMYHAKRQGNGGLVGDH
MAB_0124|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3406|M.thermoresistible__bu --------------------------------------------------
MAV_4962|M.avium_104 -----
Mflv_4515|M.gilvum_PYR-GCK -----
Mb1389c|M.bovis_AF2122/97 -----
Rv1354c|M.tuberculosis_H37Rv -----
MSMEG_2196|M.smegmatis_MC2_155 -----
MLBr_00397|M.leprae_Br4923 -----
Mvan_3629|M.vanbaalenii_PYR-1 TPAGA
MAB_0124|M.abscessus_ATCC_1997 -----
TH_3406|M.thermoresistible__bu -----