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VGAGEMTFGQEYRFATRALTVTRNLVPLKIAIGLLCLSIVVLGTLIQFHPLGPHGLWPRLIHGVLVASAL VVGMCWVVLPWPRRRVAIAFVWWADISMVVGACTLSAPASRLGALAHMGLIGVFAAFLLGWRVLAVHCVF ATVAIFGLMGWNVRLGEATWFDQYVYSAPALSSVVLLPIIIQVVVEGGRRSLKAISLAAHQDPLTGLLNR RGVQVALSSLLSGQRATRIVAVVLVDVDELKELNDRLGHDAGDESIRAVAAMLATTTRASDLTARMGGDE FMVVGFFDHADEATGLIERIGARRFGIGPHRASVSMGSAMRSTSVAGFDFESLRRAADEELRGAKIERRN GFHAVP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_0124 | - | - | 100% (356) | hypothetical protein MAB_0124 |
| M. abscessus ATCC 19977 | MAB_1867 | - | 1e-83 | 47.06% (340) | hypothetical protein MAB_1867 |
| M. abscessus ATCC 19977 | MAB_3940c | - | 8e-31 | 31.66% (259) | hypothetical protein MAB_3940c |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1389c | - | 5e-13 | 34.62% (156) | hypothetical protein Mb1389c |
| M. gilvum PYR-GCK | Mflv_0112 | - | 4e-26 | 26.97% (330) | diguanylate cyclase |
| M. tuberculosis H37Rv | Rv1354c | - | 5e-13 | 34.62% (156) | hypothetical protein Rv1354c |
| M. leprae Br4923 | MLBr_00397 | - | 1e-17 | 34.04% (141) | putative transporter protein |
| M. marinum M | - | - | - | - | - |
| M. avium 104 | MAV_2738 | - | 6e-20 | 42.14% (159) | diguanylate cyclase |
| M. smegmatis MC2 155 | MSMEG_2196 | - | 1e-14 | 37.18% (156) | sensory box/response regulator |
| M. thermoresistible (build 8) | TH_3406 | - | 5e-17 | 25.97% (308) | PUTATIVE diguanylate cyclase |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_0679 | - | 5e-27 | 35.68% (227) | diguanylate cyclase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0112|M.gilvum_PYR-GCK MVDGTVRTLLRQWWNQRDDYQWRIDFLRTRGLLPVLRYIIAGIGGSLGVL
Mvan_0679|M.vanbaalenii_PYR-1 ---MGLREFLLTWWRQPHEFDWTARYFRARGLLRLHQVFIGCFSLLYGLT
Mb1389c|M.bovis_AF2122/97 ---MCNDTATPQLEELVTTVANQLMTVDAATSAEVSQRVLAYLVEQLGVD
Rv1354c|M.tuberculosis_H37Rv ---MCNDTATPQLEELVTTVANQLMTVDAATSAEVSQRVLAYLVEQLGVD
MSMEG_2196|M.smegmatis_MC2_155 --------MSESLDVLVTSVATQLMAVEAATSVSVSQQVLAELVSFFDVD
MAB_0124|M.abscessus_ATCC_1997 --------MGAGEMTFGQEYRFATRALTVTRNLVPLKIAIGLLCLSIVVL
MAV_2738|M.avium_104 -------MRLRADAGSVFYRTQQARMLRIFLGATTFLYAYGVVFTLFPIR
TH_3406|M.thermoresistible__bu -----MLKALRRTWRKPDHYYWFTSFLAARRARTSTCRFIASITLILGLM
MLBr_00397|M.leprae_Br4923 --------------------MDHTTKCDAEQYFQAIVTSMADGVIVVDID
. :
Mflv_0112|M.gilvum_PYR-GCK SVYNAFVPPGADG-VLIRTGWAILAVGSLGWAARWALGSWPTVRESAALV
Mvan_0679|M.vanbaalenii_PYR-1 ALLTVVWAYYDGGSVAARVLVISIAASSCVLGVIWVFGPWPTERQSVAFA
Mb1389c|M.bovis_AF2122/97 VSFLRHNDR---------------DRRATRLVAEWPPRLNIPDPDPLRLI
Rv1354c|M.tuberculosis_H37Rv VSFLRHNDR---------------DRRATRLVAEWPPRLNIPDPDPLRLI
MSMEG_2196|M.smegmatis_MC2_155 VSFLRHNDH---------------RAHATRLVAEWPPRPVDAATDPIAVV
MAB_0124|M.abscessus_ATCC_1997 GTLIQFHPLGPHG-LWPRLIHGVLVASALVVGMCWVVLPWPRRRVAIAFV
MAV_2738|M.avium_104 AGLTLSNPAGG------------IVAVGLGLGALAWLAARPDKPAPATVT
TH_3406|M.thermoresistible__bu PMVMLAGPAGPQS-MPGRLIAVAVTVTALVITLIWLRDRWPSRNQSRVVS
MLBr_00397|M.leprae_Br4923 GRIESINPA---------------ATRILGLRAHDVVDMKHGHP------
Mflv_0112|M.gilvum_PYR-GCK VFVDVMMTVSALLFGDPTLAMSGIPILLCAGGYVVFFHGPRLHLVHIAWC
Mvan_0679|M.vanbaalenii_PYR-1 VYADVAVVAVMACYQDAFTAMPGLALLAANGIYIVVVHGPRALVLHLAFT
Mb1389c|M.bovis_AF2122/97 YFADADPVFALCEHAKEPLVFR---PEPATEDYQRLIEEARGVPVTSAAA
Rv1354c|M.tuberculosis_H37Rv YFADADPVFALCEHAKEPLVFR---PEPATEDYQRLIEEARGVPVTSAAA
MSMEG_2196|M.smegmatis_MC2_155 HFADADPVFAMAEHLKEPAVFR---PEPLYDDYQRTIEAGRHIPATSMAC
MAB_0124|M.abscessus_ATCC_1997 WWADISMVVGACTLSAPASRLGALAHMGLIGVFAAFLLGWRVLAVHCVFA
MAV_2738|M.avium_104 AIVATPIVMAFHR---------------VIIAEFVCLIAPMFLAMYLRAF
TH_3406|M.thermoresistible__bu LAAGLAIAVFAFTLPDPSAGLVWTAAFAVLAGYVALFHSARYATFTVLFA
MLBr_00397|M.leprae_Br4923 --------------------------FCFYDTDNQRVDLEREVMRVVRRE
.
Mflv_0112|M.gilvum_PYR-GCK TASVVGIAIW-LAVSDPVFGPQLAVSRAII--ALAVTVCVLPALQFGFWL
Mvan_0679|M.vanbaalenii_PYR-1 -AAVFAVTYW-LAIAQATAPVSVITVRLLV--LLPTVIGVPVIVQSYLLA
Mb1389c|M.bovis_AF2122/97 VPLVSGEITT-GLLGFIKFGDRKWHEAELN--ALMTIATLFAQVQARVAA
Rv1354c|M.tuberculosis_H37Rv VPLVSGEITT-GLLGFIKFGDRKWHEAELN--ALMTIATLFAQVQARVAA
MSMEG_2196|M.smegmatis_MC2_155 VPLLSGDVTT-GVLGFVKFGDREWLPAELN--ALKAIASLFAQVQARIEA
MAB_0124|M.abscessus_ATCC_1997 TVAIFGLMGWNVRLGEATWFDQYVYSAPALSSVVLLPIIIQVVVEGGRRS
MAV_2738|M.avium_104 YSPRRGAALVAVLAGLSVAALAVAPTPKLSIDYAIFVIAIIGAAESFGLL
TH_3406|M.thermoresistible__bu AITAG------VLSFELAKTAGVAAAVCGFVFITVVTFAVVCACNLLVGL
MLBr_00397|M.leprae_Br4923 VTTVSKVVGIDQHSGQRLWLSVNVSLLAYKAPPHSALVVSFSDISAHHLS
.
Mflv_0112|M.gilvum_PYR-GCK LQDSSMQSLTDPLTELTNRRGLAVSVKRLNTDARA-DATLCALLIDVDRF
Mvan_0679|M.vanbaalenii_PYR-1 LRMGADDALHDPLTRLYNRRGLDVHLAELVAPG---GVQVGVLALDIDKF
Mb1389c|M.bovis_AF2122/97 EARLRYLADHDDLTGLHNRRALLQHLDQRLAPGQ--PGPVAALFLDLDRL
Rv1354c|M.tuberculosis_H37Rv EARLRYLADHDDLTGLHNRRALLQHLDQRLAPGQ--PGPVAALFLDLDRL
MSMEG_2196|M.smegmatis_MC2_155 EERLRYLADHDHLTGLYNRRALMAHLEARLAPGQ--PGPVAVMFFDLDRL
MAB_0124|M.abscessus_ATCC_1997 LKAISLAAHQDPLTGLLNRRGVQVALSSLLSGQRA-TRIVAVVLVDVDEL
MAV_2738|M.avium_104 TRALVTAACTDPLTGLLNRAGWEIATADLLSRTRSATATVTVVALDIDNF
TH_3406|M.thermoresistible__bu LDVDVLDADIEPLTGLLNRDAFYRSAGHLISRSRDDDRQLVIALINIDNL
MLBr_00397|M.leprae_Br4923 IERLTYEATHDCLTGLANRRFAEDQITKSLQHDER-SRLAAVLLLDLDDF
: : ** * ** .::* :
Mflv_0112|M.gilvum_PYR-GCK KSVNDTFGHAVGDDVLIRTARRIRASVPED---AVVVRWGGEEFLVVDRI
Mvan_0679|M.vanbaalenii_PYR-1 KAINDRHGHDAGDRVLVAVAEAARTAVTDLGVRSVTARTGGEEFVVVVEG
Mb1389c|M.bovis_AF2122/97 KAINDYLGHAAGDQFIHVFAQRIGDALVGES---LIARLGGDEFVLIPAS
Rv1354c|M.tuberculosis_H37Rv KAINDYLGHAAGDQFIHVFAQRIGDALVGES---LIARLGGDEFVLIPAS
MSMEG_2196|M.smegmatis_MC2_155 KAINDYLGHTAGDAFISILAQRLQRGDDAPK---LIARLGGDEFVVVPDD
MAB_0124|M.abscessus_ATCC_1997 KELNDRLGHDAGDESIRAVAAMLATTTRASD---LTARMGGDEFMVVG--
MAV_2738|M.avium_104 KTLNDTEGHVAGDEYLVRCAAFWRQVAPAGA---VLARFGGDEFAVCI--
TH_3406|M.thermoresistible__bu RLLRDTQGQAAADRARVAIGQTLRENTRHNA---FVAHLGQDEFLIADTF
MLBr_00397|M.leprae_Br4923 KVINDSLGHDVGDAVLQTVAQRLRSAVRPDD---VVARLGGDEFIVLLRG
: :.* *: ..* . . .: * :** :
Mflv_0112|M.gilvum_PYR-GCK PG--NQAETVAERIRAAVAEPAEPTVTVSIGLATCERADIDL------ID
Mvan_0679|M.vanbaalenii_PYR-1 GT--QTVRRLATLLHDAVARCDAATVPTVSIGAAAARVDGDLG--GAVRT
Mb1389c|M.bovis_AF2122/97 PMSADAAQPLAERLRDQLKDHVAIGGEVLTRTVSIGVASGTPGQ-HTPSD
Rv1354c|M.tuberculosis_H37Rv PMSADAAQPLAERLRDQLKDHVAIGGEVLTRTVSIGVASGTPGQ-HTPSD
MSMEG_2196|M.smegmatis_MC2_155 PMSLDEATALAYRLQSVLRERVTVDGEMLTRTVSIGIAQGIPGK-DSTSD
MAB_0124|M.abscessus_ATCC_1997 --FFDHADEATGLIERIGARRFGIGPHRASVSMGSAMRSTSVAG-FDFES
MAV_2738|M.avium_104 ---------ADHHPTSAKADQFVASVRRHTPDTSVGTASGAGAS-ADIAS
TH_3406|M.thermoresistible__bu SS-TDSFPLVERVRGAIATTPPRLTASIGVVSTPMRGLAVCPPE-TLLDE
MLBr_00397|M.leprae_Br4923 PLSDMNANDVAKRLHTTLSESLVVDQLTVPIGASVGILEVRPDDRRRAAD
Mflv_0112|M.gilvum_PYR-GCK VISAADAAMYEAKADG-----GNKVVITAEAA------------------
Mvan_0679|M.vanbaalenii_PYR-1 MIELADAAMYRAKHAG-----GNQTVIVGDAVAAGD--------------
Mb1389c|M.bovis_AF2122/97 LLRRADQAALAAKHAG-----GDSVAIFTADMSVSGELRNDIELHLRRGI
Rv1354c|M.tuberculosis_H37Rv LLRRADQAALAAKHAG-----GDSVAIFTADMSVSGELRNDIELHLRRGI
MSMEG_2196|M.smegmatis_MC2_155 VLNRADHAVLTAKGSG-----GNRVAVFSDAMAMEIDFRNDIELHLQSVI
MAB_0124|M.abscessus_ATCC_1997 LRRAADEELRGAKIER-----RNGFHAVP---------------------
MAV_2738|M.avium_104 LYAAADAELYSAKRRR-----RDPGLRPARG-------------------
TH_3406|M.thermoresistible__bu LIAVASATMYEARRAG-----GNQARYRKYPNPTAVTEAHYPEQAADDF-
MLBr_00397|M.leprae_Br4923 ILRDADSAMYAAKNKKQCAVTPQQLVPFVALIALFVFFTAAAGAKFYAPS
: *. *: :
Mflv_0112|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0679|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 ESDALRLVYLPEVDLRTGDIVGTEALVRWQHPTRGLLAPGCFIPVAESIN
Rv1354c|M.tuberculosis_H37Rv ESDALRLVYLPEVDLRTGDIVGTEALVRWQHPTRGLLAPGCFIPVAESIN
MSMEG_2196|M.smegmatis_MC2_155 EGGALVLHYLPEIDMRTGEVLAAEALVRWEHPTRGLLSPDSFIGVAESIN
MAB_0124|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_2738|M.avium_104 --------------------------------------------------
TH_3406|M.thermoresistible__bu --------------------------------------------------
MLBr_00397|M.leprae_Br4923 NLLVILQQTVVLAIVGYGMTFVIMAGSVDLSVGSIVALTGVTAALVAAQN
Mflv_0112|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0679|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 LAGELDRWVLRRACNEFSEWQSAGLGHDALLRINVSAGQLVTGGFVDFVA
Rv1354c|M.tuberculosis_H37Rv LAGELDRWVLRRACNEFSEWQSAGLGHDALLRINVSAGQLVTGGFVDFVA
MSMEG_2196|M.smegmatis_MC2_155 LAGELGRWVLRTACAEFSRWRANGVGRNIVLRINVSPVQLVTDGFVESVA
MAB_0124|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_2738|M.avium_104 --------------------------------------------------
TH_3406|M.thermoresistible__bu --------------------------------------------------
MLBr_00397|M.leprae_Br4923 QFAAIVTALLVGLAAGMVNGIVFAYGKIPSFVSTLGMLQVCRGITLMISD
Mflv_0112|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0679|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 DTIGQHGLDASSVCLEITENVVVQDLHTARATLARLKEVGVHIAIDDFGT
Rv1354c|M.tuberculosis_H37Rv DTIGQHGLDASSVCLEITENVVVQDLHTARATLARLKEVGVHIAIDDFGT
MSMEG_2196|M.smegmatis_MC2_155 GIMKEFGLPRGSVCLEITESVVVQDIETTRTTLTGLHNVGVQVAIDDFGT
MAB_0124|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_2738|M.avium_104 --------------------------------------------------
TH_3406|M.thermoresistible__bu --------------------------------------------------
MLBr_00397|M.leprae_Br4923 SSAKPMPFHGILGAMGAMPWILIVCLFVTILAGILFQFTMFGRWVKAIG-
Mflv_0112|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0679|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 GYSAISLLQTLPIDTLKIDKTFVRQLGTNTSDLVIVRGIMTLAEGFQLDV
Rv1354c|M.tuberculosis_H37Rv GYSAISLLQTLPIDTLKIDKTFVRQLGTNTSDLVIVRGIMTLAEGFQLDV
MSMEG_2196|M.smegmatis_MC2_155 GYSVLSLLKSLPVDTLKIDRSFVAELGSNPGDLPIVRAVIALAGAFGLQL
MAB_0124|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_2738|M.avium_104 --------------------------------------------------
TH_3406|M.thermoresistible__bu --------------------------------------------------
MLBr_00397|M.leprae_Br4923 GNERVATLAGVPTRGIKVAIFAICGLTAGLGGIVLASRLGAGTPTAATGF
Mflv_0112|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0679|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 VAEGVETEAAARILLDQRCYRAQGFLFSRPVPGEAMRHMLSARRLPPTCI
Rv1354c|M.tuberculosis_H37Rv VAEGVETEAAARILLDQRCYRAQGFLFSRPVPGEAMRHMLSARRLPPTCI
MSMEG_2196|M.smegmatis_MC2_155 VAEGVETERAALTLLRHGCYRAQGFLLSKPILGSEMQTLLAKGRVPVHFS
MAB_0124|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_2738|M.avium_104 --------------------------------------------------
TH_3406|M.thermoresistible__bu --------------------------------------------------
MLBr_00397|M.leprae_Br4923 EIDVIAAVVIGGTPLTGGLGRLSGTLIGAIIISMLSNGMVFMGVGNAASQ
Mflv_0112|M.gilvum_PYR-GCK ------------------------
Mvan_0679|M.vanbaalenii_PYR-1 ------------------------
Mb1389c|M.bovis_AF2122/97 PATDPALS----------------
Rv1354c|M.tuberculosis_H37Rv PATDPALS----------------
MSMEG_2196|M.smegmatis_MC2_155 AAPRM-------------------
MAB_0124|M.abscessus_ATCC_1997 ------------------------
MAV_2738|M.avium_104 ------------------------
TH_3406|M.thermoresistible__bu ------------------------
MLBr_00397|M.leprae_Br4923 IIKGIMLAAAVFVFLQRRKIGIIK